Article
Microbiology
Le Wang, Guangping Huang, Rong Hou, Dunwu Qi, Qi Wu, Yonggang Nie, Zhenqiang Zuo, Rui Ma, Wenliang Zhou, Yingjie Ma, Yibo Hu, Zhisong Yang, Li Yan, Fuwen Wei
Summary: This study identified 97 flavonoids in bamboo for the first time and found that more than 70% of flavonoid monomers were utilized by gut microbiota. The variation of flavonoids in bamboo leaves and shoots influenced seasonal microbial fluctuation, while the flavonoid content in the diet was linked to microbial diversity and the presence of specific bacterial species.
Review
Plant Sciences
Anna Koprivova, Stanislav Kopriva
Summary: Plants communicate with microorganisms through metabolites exuded from roots, which play a crucial role in modulating the functions of plant associated microbiota. Recent research has identified various metabolites involved in this communication network, but there are still significant knowledge gaps to be filled in future studies.
CURRENT OPINION IN PLANT BIOLOGY
(2022)
Review
Genetics & Heredity
Antero Salminen
Summary: The interaction between gut microbiota and intestinal host tissues has an impact on brain functions, and microbial dysbiosis is associated with brain disorders such as neuropsychiatric conditions and Alzheimer's disease. Tryptophan metabolites and short-chained fatty acids play important roles in the communication between the microbiota and the brain. The aryl hydrocarbon receptor (AhR) is a major target of tryptophan metabolites in brain microvessels, and its activation affects brain vascular integrity and various physiological processes.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Microbiology
Guiqing Liu, Li Cao, Richou Han
Summary: The study confirms that gut bacteria contribute to the degradation of plant toxins to enhance the development of herbivorous insects, providing fundamental knowledge for the development of effective methods for beneficial insect rearing and pest control.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Microbiology
Xing-Xing Liao, Xiao-Yun Wu, Yu-Long Zhou, Jia-Jun Li, You-Liang Wen, Jun-Jie Zhou
Summary: Cardiovascular diseases and depression have a high comorbidity rate, but previous studies have mainly focused on individual diseases and lack research on the common pathophysiology of both diseases in comorbid states. Modern high-throughput technologies have shown that gut microbiome metabolites play important roles in the pathophysiology of AS and depression. This review summarizes the important findings on the role of gut microbiome metabolites in depression and AS disease, aiming to identify potential biological targets for the early diagnosis and treatment of AS co-depression disorders.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jing Wei, Xing-Ke Yang, Shou-Ke Zhang, Kari A. Segraves, Huai-Jun Xue
Summary: This study uses metatranscriptomic analyses to explore the detoxification mechanisms of Altica flea beetles and their gut symbionts. The results show that Altica beetle species and diet have a significant impact on gene expression patterns in both the beetles and their gut symbionts. The enrichment of genes involved in the degradation of plant secondary metabolites suggests that Altica flea beetles may rely on their gut microbiota to adapt to and feed on host plants.
Article
Chemistry, Multidisciplinary
Weifeng Lin, Louis P. Conway, Miroslav Vujasinovic, J-Matthias Lohr, Daniel Globisch
Summary: The study developed a new chemical biology tool to overcome analytical challenges in metabolite analysis, enabling detection of over 200 metabolites in human fecal, urine, and plasma samples. This comprehensive mass spectrometric analysis enhances metabolomics-driven biomarker discovery.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Agricultural Engineering
Yanmei Li, Juan Jin, Peirong Li, Qian Wang, Leilei Xu, Gehong Wei, Zhefei Li
Summary: Increasing evidence has shown that spatial distance affects the composition of plant endophytic microbiomes, particularly the leaf endophytic bacteria and root endophytic fungi. Moreover, regional variation also influences the contents of secondary metabolites in the endophytic compartments. These findings highlight the importance of plant microbiomes and the role of key microbiota constituents in regulating plant secondary metabolites.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Review
Biochemistry & Molecular Biology
Alexey A. Tinkov, Airton C. Martins, Daiana Silva Avila, Victor A. Gritsenko, Anatoly Skalny, Abel Santamaria, Eunsook Lee, Aaron B. Bowman, Michael Aschner
Summary: Manganese (Mn) exposure can lead to alterations in gut microbiota diversity and metabolite production, potentially contributing to neurotoxicity. Transplantation of healthy microbiota may alleviate Mn-induced neurotoxicity, highlighting the significant role of gut flora in Mn-mediated effects.
Article
Biochemistry & Molecular Biology
Takeo Koshida, Tomohito Gohda, Takuya Sugimoto, Takashi Asahara, Rin Asao, Isao Ohsawa, Hiromichi Gotoh, Maki Murakoshi, Yusuke Suzuki, Yuichiro Yamashiro
Summary: The composition of the gut microbiome differs between patients with chronic kidney disease (CKD) undergoing hemodialysis (HD) and those with normal renal function (NRF). This difference is associated with altered levels of stool organic acids, systemic inflammation, and accumulation of uremic toxins (UTs). Furthermore, the levels of UTs, inflammatory markers, and stool organic acids differ significantly between patients with NRF and those undergoing HD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Ling Wang, Yi-Xuan Tu, Lu Chen, Yuan Zhang, Xue-Ling Pan, Shu-Qiao Yang, Shuai-Jie Zhang, Sheng-Hui Li, Ke-Chun Yu, Shuo Song, Hong-Li Xu, Zhu-Cheng Yin, Jun-Qiu Yue, Qian-Lin Ni, Tang Tang, Jiu-Liang Zhang, Min Guo, Shuai Zhang, Fan Yao, Xin-Jun Liang, Zhen-Xia Chen
Summary: Men have higher incidence and mortality rates of colorectal cancer (CRC) than women. This study explains the sexual dimorphism in CRC by examining sex-biased gut microbiota and metabolites. The results show that male mice and pseudo-germ mice receiving fecal samples from males have larger tumors and impaired gut barrier function. Changes in gut microbiota composition, including increased pathogenic bacteria and decreased probiotic bacteria, were observed in male mice and pseudo-germ mice. Sex-biased gut metabolites contribute to the sex dimorphism in CRC through glycerophospholipids metabolism pathway. Modulating sex-biased gut microbiota and metabolites could be a potential therapeutic strategy for CRC.
Article
Food Science & Technology
Muhammad Shahid Riaz Rajoka, Hafiza Mahreen Mehwish, Yongai Xiong, Xun Song, Nazim Hussain, Qinchang Zhu, Zhendan He
Summary: This review discusses the roles of microbiota and nanomaterials in cancer therapy, microbiota interventions via nanomaterials, microbial inspiration via nanomaterials, and challenges associated with using nanomaterials in humans and animals. The potential of nanomaterials to alter the cancer-causing microbiome/microbiota and their metabolites, as well as the cancer microenvironment, suggests novel strategies for cancer treatment. Further in vivo clinical trials are needed to determine the exact mechanisms of action in treating cancer with nanomaterials.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Yuhan Yin, Anna Sichler, Josef Ecker, Melanie Laschinger, Gerhard Liebisch, Marcus Hoering, Marijana Basic, Andre Bleich, Xue-Jun Zhang, Ludwig Kuebelsbeck, Johannes Plagge, Emely Scherer, Dirk Wohlleber, Jianye Wang, Yang Wang, Marcella Steffani, Pavel Stupakov, Yasmin Gaertner, Fabian Lohoefer, Carolin Mogler, Helmut Friess, Daniel Hartmann, Bernhard Holzmann, Norbert Hueser, Klaus-Peter Janssen
Summary: Hepatocyte growth and proliferation depend on membrane phospholipid biosynthesis, which is significantly influenced by short-chain fatty acids (SCFAs) generated through bacterial fermentation. Antibiotic treatment and dysbiosis not only affect gut microbiota, but also impair hepatic lipid synthesis and liver regeneration.
JOURNAL OF HEPATOLOGY
(2023)
Article
Agricultural Engineering
Yanmei Li, Juan Jin, Peirong Li, Qian Wang, Leilei Xu, Gehong Wei, Zhefei Li
Summary: Increasing evidence suggests that spatial distance has a stronger impact on root-associated microbiomes than on plant endophytic microbiomes. This study investigated the endophytic community structure of Astragalus membranaceus in different regions of China and found that regional variation had a greater effect on the endophytic community, especially on leaf endophytic bacteria and root endophytic fungi. Furthermore, the contents of secondary metabolites in the endophytic compartments were also affected by regional variation.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Review
Medicine, General & Internal
Yue Ma, Xiaolin Liu, Jun Wang
Summary: Research on the gut microbiome and related diseases is expanding rapidly, and new perspectives on disease development and treatment are being offered. This review explores the changes in gut microbial metabolites within complex diseases and discusses the potential causal effects of these metabolites on diseases.