Review
Pharmacology & Pharmacy
Andrew S. Mikhail, Ayele H. Negussie, Michal Mauda-Havakuk, Joshua W. Owen, William F. Pritchard, Andrew L. Lewis, Bradford J. Wood
Summary: TACE has been a common practice for four decades, injecting chemotherapy drugs into tumor blood supplies. However, recent advancements in technology and pharmacology offer promising opportunities for personalized and more effective treatments using DEE microspheres.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Article
Oncology
Katharina Carolin Albrecht, Rene Aschenbach, Ioannis Diamantis, Niklas Eckardt, Ulf Teichgraeber
Summary: The study retrospectively evaluated the outcomes of 141 DEB-TACE treatments in 83 patients, indicating that superselective DEB-TACE can be considered an effective and safe treatment option with low procedure-related complications.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Qi-Jiong Li, Min-Ke He, Huan-Wei Chen, Wan-Qiang Fang, Yuan-Min Zhou, Li Xu, Wei Wei, Yao-Jun Zhang, Ying Guo, Rong-Ping Guo, Min-Shan Chen, Ming Shi
Summary: This study compared the overall survival of patients with unresectable large hepatocellular carcinoma treated with FOLFOX-HAIC or TACE as first-line therapy. The results showed that FOLFOX-HAIC significantly improved overall survival compared to TACE, with higher treatment response rate and longer progression-free survival.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Zhigang Fu, Xun Li, Fei Cai, Yinpeng Yuan, Xiaolin Zhang, Jingxia Qin, Yonghui Liang
Summary: The study compared the efficacy and safety of microspheres and PVA for BAE treatment in patients with hemoptysis. Results showed no significant differences in technical success, clinical success, recurrence rates, mortality, adverse events, hemoptysis-free survival, and overall survival between the two groups.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Oncology
Qiao Ke, Lei Wang, Weimin Wu, Xinhui Huang, Ling Li, Jingfeng Liu, Wuhua Guo
Summary: Postoperative adjuvant hepatic artery infusion chemotherapy (HAIC) can improve the long-term prognosis of hepatocellular carcinoma (HCC) patients, especially those with microvascular or macrovascular invasion. Patients would benefit from SR+HAIC regardless of chemotherapy regimens and courses, and further validation is needed.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Eldad Elnekave, Eytan Ben Ami, Sivan Shamai, Idit Peretz, Shlomit Tamir, Elchanan Bruckheimer, Amos Stemmer, Joseph Erinjeri, Abed Abu Quider, Max Seidensticker, Moritz Wildgruber, Jens Ricke, Antoinette Anazodo, Kin Fen Fung, Alona Zer, Shifra Ash
Summary: The arterial doxorubicin eluting embolization (DEE) approach is effective in reducing the tumor volume of desmoid fibromatoses (DFs) with limited systemic drug exposure and low toxicity.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yoshihisa Kodama, Yasuo Sakurai, Koji Yamasaki, Keiki Yokoo
Summary: This study aimed to compare the frequencies of anterior spinal arteries identified by CTA and arteriography alone, finding significantly higher rates in the ICBT and ICA groups compared to the BA group. The false-negative rate of anterior spinal artery was 71% in the ICBT arteriography alone assessment, explaining the occurrence of spinal ischemia in arteriography-negative cases.
BRITISH JOURNAL OF RADIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yonghua Bi, Kewei Ren, Jianzhuang Ren, Ji Ma, Xinwei Han
Summary: DEB-TACE loaded with oxaliplatin has shown promising outcomes in treating unresectable or recurrent HCC patients, with high response rates and good safety profiles.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ahmed A. Bessar, Mohamad G. Nada, Fady M. Wadea, Ashraf E. Elsayed, Ahmed Farag, Manar A. Bessar
Summary: The study aimed to investigate whether hepatic hilar and celiac plexus nerve blocks are effective for patients undergoing DEE-TACE. The results showed that the nerve block group experienced less pain during and after the procedure and required less analgesia, but the differences resolved by week 2.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2021)
Article
Engineering, Biomedical
Aimi Zhang, Zhisheng Xiao, Qiufang Liu, Panli Li, Fei Xu, Jianjun Liu, Huiquan Tao, Liangzhu Feng, Shaoli Song, Zhuang Liu, Gang Huang
Summary: Researchers synthesized a new embolic agent, CaCO3-ALG MSs, which can neutralize tumor pH and enhance therapeutic outcome. Animal experiments and imaging results showed that TAE treatment with CaCO3-ALG MSs had significant improvement compared to other methods, highlighting the potential of pH neutralization in improving cancer treatment.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Medicine, General & Internal
Fengjuan Jia, Guodong Xia, Qingliang Zhu, Shuangyu Yu, Nan Hu, Hailong Zhang
Summary: This case report presents a rare complication of chronic pancreatitis, a right hepatic artery pseudoaneurysm, in a 42-year-old male patient. The patient was successfully treated with intravascular embolization. The importance of careful evaluation, early detection, and prompt treatment for pseudoaneurysm caused by chronic pancreatitis is highlighted.
Review
Oncology
Stepan M. Esagian, Christos D. Kakos, Emmanouil Giorgakis, Lyle Burdine, J. Camilo Barreto, Michail N. Mavros
Summary: The role of postoperative TACE after liver resection for HCC is still unclear, with existing evidence suggesting potential benefits but limited to Eastern Asian populations. High-quality randomized clinical trials are needed to confirm the oncologic benefits and applicability of adjuvant TACE.
Article
Chemistry, Multidisciplinary
Xiyu Zhu, Minghui Duan, Lin Zhang, Jiasheng Zhao, Sheng Yang, Rui Shen, Sen Chen, Linlin Fan, Jing Liu
Summary: Multifunctional microspheres (SA/LM/DOX) with high drug loading and multimodal imaging capability have been developed by adsorbing silanized LM particles on sulfonated agarose microspheres (SA). These microspheres have the function of heating and accelerating drug release under an 808 nm near-infrared (NIR) laser, and can be tracked using computed tomography (CT), magnetic resonance imaging (MRI), and B-scan ultrasonography (US).
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Surgery
Mauricio Gonzalez-Urquijo, David Hinojosa-Gonzalez, Victor Hugo Viteri-Perez, Alejandro Llausas-Villarreal, Andrea Becerril-Gaitan, Mirna Gonzalez-Gonzalez, Mario Alejandro Fabiani
Summary: This study compared the surgical outcomes of patients who underwent preoperative embolization before carotid body tumor (CBT) resection with those who underwent resection alone. The results showed that preoperative embolization was associated with significantly lower blood loss and lower neck hematomas.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Health Care Sciences & Services
Alexis Coussy, Eva Jambon, Yann Le Bras, Christian Combe, Laurence Chiche, Nicolas Grenier, Clement Marcelin
Summary: This study investigated the long-term safety and efficacy of hepatic transarterial embolization (TAE) in patients with symptomatic polycystic liver disease (PLD). The results showed that TAE using microspheres and microcoils is a safe and effective treatment that improves symptoms and reduces hepatic cyst volume in PLD patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Tae-Hyung Kim, Sungmin Woo, Sanam Ebrahimzadeh, Matthew D. F. McInnes, Scott R. Gerst, Richard K. Do
Summary: This study aimed to evaluate the proportion of hepatocellular adenoma (HCA) that shows iso- or hyperintensity in the hepatobiliary phase (HBP) of gadoxetic acid-enhanced MRI, stratified by HCA subtype, and to assess its diagnostic performance for differentiating focal nodular hyperplasia (FNH) from HCA. The pooled proportion of HBP iso- or hyperintensity was determined for each subtype and compared using metaregression. The results showed that HCA subtypes other than H-HCA exhibit varying proportions of HBP iso- or hyperintensity, ranging from 11% (U-HCA) to 59% (B-HCA). Clinical Impact: Radiologists should be aware of the low specificity of HBP iso- or hyperintensity for differentiating FNH from certain HCA subtypes.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Richard K. G. Do
AMERICAN JOURNAL OF ROENTGENOLOGY
(2023)
Article
Biophysics
Ramin Jafari, Richard Kinh Gian Do, Maria Divina LaGratta, Maggie Fung, Ersin Bayram, Ty Cashen, Ricardo Otazo
Summary: The study developed a deep learning technique called GRASPnet for fast reconstruction of dynamic contrast-enhanced MRI. GRASPnet reduced the reconstruction time to a few seconds using 2D or 3D convolutional kernels and performed well in quantitative analysis.
NMR IN BIOMEDICINE
(2023)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Tae-Hyung Kim, Sanam Ebrahimzadeh, Scott R. Gerst, Richard K. Do
AMERICAN JOURNAL OF ROENTGENOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lisa Bodei, Nitya Raj, Richard K. Do, Audrey Mauguen, Simone Krebs, Diane Reidy-Lagunes, Heiko Schoder
Summary: This study aims to validate the roles of two circulating biomarkers, the PRRT prediction quotient (PPQ) as a predictive marker for response and the NETest as a monitoring biomarker, in peptide receptor radionuclide therapy (PRRT) for neuroendocrine tumors (NETs). Tissue-based genetic alterations were also evaluated for predicting progression-free survival (PFS).
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Oncology
Marsha Reyngold, Sana D. Karam, Carla Hajj, Abraham J. Wu, John Cuaron, Stephanie Lobaugh, Ellen D. Yorke, Shannan Dickinson, Bernard Jones, Yevgeniy Vinogradskiy, Amita Shukla-Dave, Richard Kinh Gian Do, Carlie Sigel, Zhigang Zhang, Christopher H. Crane, Karyn A. Goodman
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Richa Patel, Anum Aslam, Neehar D. Parikh, Benjamin Mervak, Eman Mubarak, Lily Higgins, Kayli Lala, Jack F. Conner, Valerie Khaykin, Mustafa Bashir, Richard Kinh Gian Do, Lauren M. B. Burke, Elainea N. Smith, Charles Y. Kim, Kimberly L. Shampain, Dawn Owen, Mishal Mendiratta-Lala
Summary: With the increase in hepatocellular carcinoma (HCC) and liver-directed therapies, the assessment of lesion response has become more complex. The Liver Imaging Reporting and Data Systems (LI-RADS) treatment response algorithm (LI-RADS TRA) was created to standardize the evaluation of response after locoregional therapy (LRT) using contrast-enhanced CT or MRI. This article reviews the expected MR imaging findings after different forms of LRT, explains the application of LI-RADS TRA for different types of LRT, explores emerging literature on LI-RADS TRA, and highlights future updates to the algorithm.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Multidisciplinary Sciences
Luis A. Rojas, Zachary Sethna, Kevin C. Soares, Cristina Olcese, Nan Pang, Erin Patterson, Jayon Lihm, Nicholas Ceglia, Pablo Guasp, Alexander Chu, Rebecca Yu, Adrienne Kaya Chandra, Theresa Waters, Jennifer Ruan, Masataka Amisaki, Abderezak Zebboudj, Zagaa Odgerel, George Payne, Evelyna Derhovanessian, Felicitas Mueller, Ina Rhee, Mahesh Yadav, Anton Dobrin, Michel Sadelain, Marta Luksza, Noah Cohen, Laura Tang, Olca Basturk, Mithat Goenen, Seth Katz, Richard Kinh Do, Andrew S. Epstein, Parisa Momtaz, Wungki Park, Ryan Sugarman, Anna M. Varghese, Elizabeth Won, Avni Desai, Alice C. Wei, Michael I. D'Angelica, T. Peter Kingham, Ira Mellman, Taha Merghoub, Jedd D. Wolchok, Ugur Sahin, Oezlem Tuereci, Benjamin D. Greenbaum, William R. Jarnagin, Jeffrey Drebin, Eileen M. O'Reilly, Vinod P. Balachandran
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a high mortality rate, but it can be targeted using mutation-derived T cell neoantigens as vaccines. In this phase I trial, researchers synthesized individualized mRNA neoantigen vaccines from PDAC tumors and administered them to patients along with atezolizumab, autogene cevumeran, and mFOLFIRINOX chemotherapy. The results showed that the autogene cevumeran vaccine induced neoantigen-specific T cells in patients, and those with vaccine-expanded T cells had a longer recurrence-free survival.
Review
Radiology, Nuclear Medicine & Medical Imaging
Victoria Chernyak, Kathryn J. Fowler, Richard K. G. Do, Aya Kamaya, Yuko Kono, An Tang, Donald G. Mitchell, Jeffrey Weinreb, Cynthia S. Santillan, Claude B. Sirlin
Summary: Since its release in 2011, LI-RADS has evolved from a single algorithm for HCC diagnosis to a multialgorithm system covering all major liver imaging modalities. It has achieved global adoption in clinical care and research and unified HCC diagnostic systems in the US. However, there are still gaps in knowledge, such as challenges in surveillance, diagnostic population definition, and reporting. Future directions will focus on addressing these challenges and incorporating advanced technologies to create a probability-based system for liver cancer diagnosis and prognostication.
Article
Computer Science, Information Systems
Abhishek Midya, Jayasree Chakraborty, Rami Srouji, Raja R. Narayan, Thomas Boerner, Jian Zheng, Linda M. Pak, John M. Creasy, Luz A. Escobar, Kate A. Harrington, Mithat Gonen, Michael I. D'Angelica, T. Peter Kingham, Richard K. G. Do, William R. Jarnagin, Amber L. Simpson
Summary: The liver is a common site for various types of tumors. This study demonstrates the feasibility of using a deep learning approach to automatically classify liver tumors from CT scans and extract features not visible to the naked eye. The proposed computer-assisted system serves as a novel non-invasive diagnostic tool for objectively classifying the most common liver tumors.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Review
Oncology
Ramesh Paudyal, Akash D. Shah, Oguz Akin, Richard K. G. Do, Amaresha Shridhar Konar, Vaios Hatzoglou, Usman Mahmood, Nancy Lee, Richard J. Wong, Suchandrima Banerjee, Jaemin Shin, Harini Veeraraghavan, Amita Shukla-Dave
Summary: Computed tomography (CT) and magnetic resonance imaging (MRI) are widely used in clinical oncology and the introduction of artificial intelligence (AI) has brought about greater efficiency and efficacy in patient care. However, there are still challenges in implementing AI tools in medical imaging, which need to be addressed. In this review, the challenges and potential solutions of using AI tools in lung CT and MRI of the abdomen, pelvis, and head and neck region are discussed.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jon S. Heiselman, Brett L. Ecker, Liana Langdon-Embry, Eileen M. O'Reilly, Michael I. Miga, William R. Jarnagin, Richard K. G. Do, Natally Horvat, Alice C. Wei, Jayasree Chakraborty
Summary: This study retrospectively analyzed the imaging data of 30 patients with pancreatic ductal adenocarcinoma (PDAC) who underwent neoadjuvant chemotherapy. Longitudinal image registration methods were used to quantitatively assess changes in tumor volume and burden during the treatment interval. The results showed that changes in tumor burden derived from registration-based measurements were significant predictors of overall survival and recurrence-free survival, and outperformed other clinical comparators. These findings may contribute to improving clinical outcome prediction and treatment selection for PDAC.
JOURNAL OF MEDICAL IMAGING
(2023)
Article
Oncology
Steven B. Maron, Walid Chatila, Henry Walch, Joanne F. Chou, Nicholas Ceglia, Ryan Ptashkin, Richard Kinh Gian Do, Viktoriya Paroder, Neeta Pandit-Taskar, Jason S. Lewis, Tiago Biachi De Castria, Shalom Sabwa, Fiona Socolow, Lara Feder, Jasmine Thomas, Isabell Schulze, Kwanghee Kim, Arijh Elzein, Viktoria Bojilova, Matthew Zatzman, Umesh Bhanot, Rebecca J. Nagy, Jeeyun Lee, Marc Simmons, Michal Segal, Geoffrey Yuyat Ku, David H. Ilson, Marinela Capanu, Jaclyn F. Hechtman, Taha Merghoub, Sohrab Shah, Nikolaus Schultz, David B. Solit, Yelena Y. Janjigian
Summary: The study highlights the clinical significance of identifying baseline intrapatient heterogeneity and serial ctDNA monitoring in HER2-positive esophagogastric cancer patients. These factors can be used to identify early evidence of treatment resistance, guiding proactive therapy escalation or deescalation.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Lydia Elbatarny, Richard K. G. Do, Natalie Gangai, Firas Ahmed, Shalini Chhabra, Amber L. Simpson
Summary: The lack of standardization among radiologists in writing radiological reports impacts the ability to interpret cancer response to treatment at a large scale. This study examines the utility of applying natural language processing (NLP) to the large-scale interpretation of disease responses using a standardized oncologic response lexicon (OR-RADS) to facilitate real world evidence (RWE) collection. The study demonstrates the feasibility of using NLP to predict disease response in cancer patients, surpassing human performance, and encourages the use of standardized OR-RADS categories to improve large-scale prediction accuracy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Linda C. Chu, Zhen J. Wang, Avinash Kambadakone, Elizabeth M. Hecht, Jin He, Amol K. Narang, Daniel A. Laheru, Hina Arif-Tiwari, Priya Bhosale, Candice W. Bolan, Olga R. Brook, Abraham F. Bezuidenhout, Richard K. G. Do, Samuel J. Galgano, Ajit H. Goenka, Alexander R. Guimaraes, David M. Hough, Naveen Kulkarni, Ott Le, Lyndon Luk, Lorenzo Mannelli, Michael Rosenthal, Guillermo Sangster, Zarine K. Shah, Erik Soloff, Parag P. Tolat, Marc Zins, Elliot K. Fishman, Eric P. Tamm, Atif Zaheer
Summary: This article assesses the practice patterns and develops consensus recommendations for postoperative imaging and interpretation in patients with pancreatic ductal adenocarcinoma (PDAC). The results reveal significant variations in postoperative surveillance of PDAC, and differentiating tumor recurrence from postoperative inflammatory changes remains challenging.
ABDOMINAL RADIOLOGY
(2023)