Article
Immunology
Caitao Dong, Chao Song, Ziqi He, Qianlin Song, Tianbao Song, Junwei Liu, Yunhe Xiong, Xiaozhe Su, Jiawei Zhou, Sixing Yang, Wenbiao Liao
Summary: This study found that SchB can alleviate nephrolithiasis by regulating GSK3 beta/Nrf2 signaling-mediated ferroptosis. The results showed that SchB can attenuate oxidative stress and inflammatory response, and protect against renal injury and crystal deposition in vitro and in vivo.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Muhammad Ali Khan, Purba Nag, Anca Grivei, Kurt T. K. Giuliani, Xiangju Wang, Vishal Diwan, Wendy Hoy, Helen Healy, Glenda Gobe, Andrew J. Kassianos
Summary: The pathogenesis of crystal nephropathy involves deposition of intratubular crystals, tubular obstruction and cell death. This study investigated the modes of adenine-induced tubular cell death and found that baicalein can act as a novel cell death inhibitor. Baicalein inhibits cell death by modulating the mitochondrial antioxidant enzyme SOD2.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Weiwei Zhang, Wusan Wang, Chaozhuang Shen, Xiaohu Wang, Zhichen Pu, Qin Yin
Summary: Schisandrin B shows potential as a therapeutic approach for treating ulcerative colitis by reducing inflammation, suppressing NLRP3 inflammasome, inducing the AMPK/Nrf2 signaling pathway, and reducing ROS-induced mitochondrial damage, as demonstrated in mouse models of colitis.
Article
Biochemistry & Molecular Biology
Patrick C. Baer, Ann-Kathrin Neuhoff, Ralf Schubert
Summary: Renal proximal tubular epithelial cells (PTCs) play a central role in renal inflammation. In response to inflammation, PTCs undergo changes in gene expression and release extracellular vesicles (EVs) containing inflammation-specific cargo molecules. Understanding the molecular mechanisms of kidney inflammation is crucial for identifying targets in the prevention or treatment of acute kidney injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Benjamin Koch, Dominik C. Fuhrmann, Ralf Schubert, Helmut Geiger, Thimoteus Speer, Patrick C. Baer
Summary: Inflammation is closely related to the development of diabetic kidney disease. Gliflozins, as SGLT-2 inhibitors, have been shown to reduce inflammation and slow down the progression of diabetic nephropathy. In this study using human renal proximal tubular epithelial cells, gliflozins were found to have an anti-inflammatory effect by inhibiting the expression of pro-inflammatory factors and the adhesion molecule ICAM-1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Sophia Szymkowiak, Nathan Sandler, David L. Kaplan
Summary: Chronic kidney disease and kidney failure are increasing globally, with a lack of corresponding improvement in available therapies. Using silk fibroin protein scaffolds to support kidney cells can mimic the structure of the kidney and support a larger number of cells with more even distribution under perfused conditions.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Urology & Nephrology
Yasuhiro Yoshimura, Yoshiharu Muto, Kohei Omachi, Jeffrey H. Miner, Benjamin D. Humphreys
Summary: This study reveals the regulatory mechanisms of HNF4A and HNF4G during human proximal tubule differentiation. The experimental strategy can be applied more broadly to investigate transcriptional regulation in human kidney development.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Urology & Nephrology
Christophe Sirac, Vecihi Batuman, Paul W. Sanders
Summary: Plasma and B cell dyscrasias causing overproduction of monoclonal immunoglobulin free light chains can affect the kidneys in various ways. The disorders may or may not meet cancer criteria and can result in a range of proximal tubule syndromes.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Developmental Biology
Kathryn Duvall, Lauren Crist, Alison J. Perl, Naomi Pode Shakked, Praneet Chaturvedi, Raphael Kopan
Summary: Notch signaling is crucial for the maturation of nephron epithelia, with studies at both the cellular and organoid levels confirming its importance. The research found that Notch signaling plays a role in the segmentation of proximal and distal domains within the nephron.
Review
Physiology
Andrew M. Hall, Sophie de Seigneux
Summary: Damage to the proximal tubule is the most common cause of acute kidney injury in humans. Current diagnostic and treatment options are limited, and a deeper understanding of pathogenic mechanisms at a cellular level is needed. Recent studies have shown significant changes in proximal tubule metabolism during acute kidney injury, highlighting potential targets for intervention. This article emphasizes the current state of the field and highlights three emerging areas worthy of attention: axial heterogeneity in determining baseline susceptibility, insult specific pathogenic mechanisms, and the link between tubular metabolism and whole-body homeostasis.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2022)
Article
Toxicology
Tom T. G. Nieskens, Otto Magnusson, Patrik Andersson, Magnus Soderberg, Mikael Persson, Anna-Karin Sjogren
Summary: Research demonstrated that SPC5001 ASO induced kidney injury in in vitro systems, showcasing its translational potential in the medical field.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Oncology
Jennifer Eymael, Martijn van den Broek, Laura Miesen, Valerie Villacorta Monge, Bartholomeus T. van den Berge, Fieke Mooren, Vicky Luna Velez, Jelmer Dijkstra, Meyke Hermsen, Peter Bandi, Michiel Vermeulen, Saskia de Wildt, Brigith Willemsen, Sandrine Florquin, Roy Wetzels, Eric Steenbergen, Rafael Kramann, Marcus Moeller, Michiel F. Schreuder, Jack Fm Wetzels, Johan van der Vlag, Jitske Jansen, Bart Smeets
Summary: Scattered tubular cells (STCs) in the proximal tubule increase in number after acute kidney injury. STCs are preferentially located within the inner bends of the tubule and their number increases with age. STCs represent a transient state of dedifferentiated proximal tubule epithelial cells (PTECs) showing metabolic shift towards glycolysis, facilitating cellular survival after kidney injury.
JOURNAL OF PATHOLOGY
(2023)
Article
Developmental Biology
Mary Taglienti, Daniel Graf, Valerie Schumacher, Jordan A. Kreidberg
Summary: The mammalian kidney is composed of nephrons, which are formed through mesenchymal-to-epithelial transformation by nephron progenitor cells. Bmp7 plays a major role in determining nephron number and driving their proliferation, ultimately contributing to the development of a mature kidney.
Article
Cell Biology
Majdoleen Ahmad, Ifat Abramovich, Bella Agranovich, Alina Nemirovski, Eyal Gottlieb, Liad Hinden, Joseph Tam
Summary: Tubulopathy is crucial in the pathophysiology of diabetic kidney disease (DKD), particularly the role of GLUT2 in promoting glucose reabsorption and glucotoxicity, as well as regulating SGLT2 expression in kidney proximal tubule cells (KPTCs). Reduction/deletion of KPTC-GLUT2 has shown promising results in ameliorating DKD, making it a potential therapeutic target. However, the molecular mechanisms underlying the deleterious effects of GLUT2 in KPTCs remain unclear.
Article
Pharmacology & Pharmacy
Yi Yang, Milos Mihajlovic, Floris Valentijn, Tri Q. Nguyen, Roel Goldschmeding, Rosalinde Masereeuw
Summary: Accumulating evidence suggests that senescence of kidney tubule epithelial cells leads to fibrosis. In this study, the researchers investigated the use of a specific cell line, ciPTEC-OAT1, as an in vitro model to study kidney senescence and the response to senolytics. They found that culturing ciPTEC-OAT1 at 37 degrees C induced a senescence phenotype characterized by increased expression of cell cycle arrest and anti-apoptosis markers, SASP factors, and responsiveness to senolytics treatment.
FRONTIERS IN PHARMACOLOGY
(2022)