5-HT2A SNPs Alter the Pharmacological Signaling of Potentially Therapeutic Psychedelics

Classic serotonergic psychedelics for mood and depressive symptoms: a meta-analysis of mood disorder patients and healthy participants

(2021) Nicole L. Galvão-Coelho et al.   PSYCHOPHARMACOLOGY

Trial of Psilocybin versus Escitalopram for Depression

(2021) Robin Carhart-Harris et al.   NEW ENGLAND JOURNAL OF MEDICINE

LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1

(2021) Ramona M. Rodriguiz et al.   Scientific Reports

Molecular insights into psychedelic drug action

(2021) Samuel T. Slocum et al.   JOURNAL OF NEUROCHEMISTRY

Psychedelic Psychiatry’s Brave New World

(2020) David Nutt et al.   CELL

TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome

(2020) Reid H. J. Olsen et al.   Nature Chemical Biology

Long-term effects of psychedelic drugs: A systematic review

(2020) Jacob S. Aday et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor

(2020) Kuglae Kim et al.   CELL

Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects

(2020) Friederike Holze et al.   NEUROPSYCHOPHARMACOLOGY

5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) used in a naturalistic group setting is associated with unintended improvements in depression and anxiety

(2019) Alan K. Davis et al.   AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE

5-HT 2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology

(2018) Yao Peng et al.   CELL

The epidemiology of 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT) use: Benefits, consequences, patterns of use, subjective effects, and reasons for consumption

(2018) Alan K Davis et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Classic Psychedelics: An integrative review of epidemiology, mystical experience, brain network function, and therapeutics

(2018) Matthew W. Johnson et al.   PHARMACOLOGY & THERAPEUTICS

Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor

(2018) Katrin H Preller et al.   eLife

GPCRdb in 2018: adding GPCR structure models and ligands

(2017) Gáspár Pándy-Szekeres et al.   NUCLEIC ACIDS RESEARCH

Psilocybin with psychological support for treatment-resistant depression: six-month follow-up

(2017) R. L. Carhart-Harris et al.   PSYCHOPHARMACOLOGY

Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens

(2016) Anna Rickli et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial

(2016) Roland R Griffiths et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial

(2016) Stephen Ross et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The role of kinetic context in apparent biased agonism at GPCRs

(2016) Carmen Klein Herenbrink et al.   Nature Communications

LSD-assisted psychotherapy for anxiety associated with a life-threatening disease: A qualitative study of acute and sustained subjective effects

(2014) Peter Gasser et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Activation of Serotonin 2A Receptors Underlies the Psilocybin-Induced Effects on   Oscillations, N170 Visual-Evoked Potentials, and Visual Hallucinations

(2013) M. Kometer et al.   JOURNAL OF NEUROSCIENCE

Structural Basis for Molecular Recognition at Serotonin Receptors

(2013) C. Wang et al.   SCIENCE

Structural Features for Functional Selectivity at Serotonin Receptors

(2013) D. Wacker et al.   SCIENCE

A Simple Method for Quantifying Functional Selectivity and Agonist Bias

(2011) Terry Kenakin et al.   ACS Chemical Neuroscience

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

Structure and Function of the Third Intracellular Loop of the 5-Hydroxytryptamine2A Receptor: The Third Intracellular Loop Is α-Helical and Binds Purified Arrestins

(2003) Edward I. Gelber et al.   JOURNAL OF NEUROCHEMISTRY