期刊
ACS APPLIED MATERIALS & INTERFACES
卷 14, 期 28, 页码 31737-31750出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.2c08593
关键词
glycosaminoglycan; curcumin; hydrogel; anti-inflammation; wound healing
资金
- National Key Research and Development Program of China [2017YFC1103503]
- National Natural Science Foundation of China [51973013]
- Beijing Outstanding Young Scientist Program [BJJWZYJH01201910010024]
This study proposes a glycosaminoglycan-based hydrogel delivery system that combines the bioactivities of polysaccharides and drugs to regulate the wound microenvironment. The hydrogel effectively reduces immune cell influx and down-regulates inflammation, leading to accelerated wound healing.
Chronic wounds cannot proceed through the normal, orderly, and timely sequence of repair. The adverse cycle between excess reactive oxide species (ROS) and a persistent inflammatory response is an important mechanism of impaired wound healing. Herein, by combining the intrinsic bioactivities of natural polysaccharides and natural drugs, a glycosaminoglycan-based hydrogel delivery system is proposed to regulate the wound microenvironment. Dynamic supramolecular cross-linking enables the hydrogel to easily encapsulate the drug and fully fill the wound area. As the backbone of the hydrogel, heparin captures inflammatory chemokines at the wound site, while hyaluronic acid mimics the function of ECM. The hydrophobic drug curcumin has been ingeniously encapsulated in the hydrogel through micellization, thereby exerting good ROS scavenging ability and anti-inflammatory activity. Evaluations in diabetic mice showed that this antioxidant and anti-inflammatory hydrogel was effective in reducing the influx of immune cells at the wound site and in down-regulating the inflammatory response. Accelerated wound healing was also observed, as evidenced by faster re-epithelialization and better ECM remodeling. The proposed hydrogel can regulate the microenvironment of wounds from multiple aspects and thereby achieve regression of wound repair, which may provide a new therapeutic strategy for chronic wounds.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据