Self-Assembly of a Multifunction DNA Tetrahedron for Effective Delivery of Aptamer PL1 and Pcsk9 siRNA Potentiate Immune Checkpoint Therapy for Colorectal Cancer

PCSK9 promotes tumor growth by inhibiting tumor cell apoptosis in hepatocellular carcinoma

(2021) Shi-Zhe Zhang et al.   Experimental Hematology & Oncology

Development of a Pemetrexed/Folic Acid Nanoformulation: Synthesis, Characterization, and Efficacy in a Murine Colorectal Cancer Model

(2020) Justin G. Rosch et al.   ACS Omega

A novel HDGF-ALCAM axis promotes the metastasis of Ewing sarcoma via regulating the GTPases signaling pathway

(2020) Yang Yang et al.   ONCOGENE

The Folate Pathway Inhibitor Pemetrexed Pleiotropically Enhances Effects of Cancer Immunotherapy

(2019) David A. Schaer et al.   CLINICAL CANCER RESEARCH

Effect of an siRNA Therapeutic Targeting PCSK9 on Atherogenic Lipoproteins: Pre-Specified Secondary End Points in ORION 1

(2018) Kausik K. Ray et al.   CIRCULATION

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

(2018) Daniele V. F. Tauriello et al.   NATURE

Peptide Blocking of PD-1/PD-L1 Interaction for Cancer Immunotherapy

(2017) Chunlin Li et al.   Cancer Immunology Research

Pembrolizumab for patients with melanoma or non-small-cell lung cancer and untreated brain metastases: early analysis of a non-randomised, open-label, phase 2 trial

(2016) Sarah B Goldberg et al.   LANCET ONCOLOGY

Enhancing aptamer function and stability via in vitro selection using modified nucleic acids

(2016) Kirsten N. Meek et al.   METHODS

A Novel PD-L1-targeting Antagonistic DNA Aptamer With Antitumor Effects

(2016) Wei-Yun Lai et al.   Molecular Therapy-Nucleic Acids

Aptamer Nanomedicine for Cancer Therapeutics: Barriers and Potential for Translation

(2015) Yeh-Hsing Lao et al.   ACS Nano

Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

(2015) Padmanee Sharma et al.   CELL

Combination cancer immunotherapies tailored to the tumour microenvironment

(2015) Mark J. Smyth et al.   Nature Reviews Clinical Oncology

Functional DNA-Containing Nanomaterials: Cellular Applications in Biosensing, Imaging, and Targeted Therapy

(2014) Hao Liang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Oligonucleotide Aptamers: New Tools for Targeted Cancer Therapy

(2014) Hongguang Sun et al.   Molecular Therapy-Nucleic Acids

Functional DNA Nanostructures for Theranostic Applications

(2013) Hao Pei et al.   ACCOUNTS OF CHEMICAL RESEARCH

Smart Drug Delivery Nanocarriers with Self-Assembled DNA Nanostructures

(2013) Jiang Li et al.   ADVANCED MATERIALS

At the Bedside: CTLA-4- and PD-1-blocking antibodies in cancer immunotherapy

(2013) Margaret K. Callahan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

At the Bench: Preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy

(2013) Andrew M. Intlekofer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

(2012) Hyukjin Lee et al.   Nature Nanotechnology

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular Evolution of Functional Nucleic Acids with Chemical Modifications

(2010) Masayasu Kuwahara et al.   MOLECULES

The Chemical Biology of Aptamers

(2009) Günter Mayer   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

(2008) M. Frank-Kamenetsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanotechnology and aptamers: applications in drug delivery

(2008) Etgar Levy-Nissenbaum et al.   TRENDS IN BIOTECHNOLOGY