Article
Clinical Neurology
Florian Lange, Carolina Soares, Jonas Roothans, Rita Raimundo, Hazem Eldebakey, Benedikt Weigl, Robert Peach, Christine Daniels, Thomas Musacchio, Jens Volkmann, Maria Jose Rosas, Martin M. Reich
Summary: Deep brain stimulation is effective for alleviating dystonia motor symptoms, but delayed symptom control and lack of therapeutic biomarkers and optimal programming settings complicate postoperative management. This study prospectively tested machine-predicted programming settings and found that they significantly reduced dystonia symptoms compared to clinical programming.
Article
Clinical Neurology
Vanessa M. Holanda, Robert Stephen Eisinger, Leonardo Almeida, Takashi Tsuboi, Huimin Wang, Michael S. Okun, Wissam Deeb, Addie Patterson, Aparna Wagle Shukla, Janine Lobo Lopes, Kelly Douglas Foote
Summary: This study aimed to evaluate the evolution of GPi DBS targeting in patients with dystonia or PD. During 15 years of follow-up, lead locations in the PD group migrated laterally, posteriorly, and dorsally, whereas leads in the dystonia group showed a trend in the dorsal direction. The evolving target may result from improvements in targeting techniques and clinical feedback intraoperatively and post-operatively.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Shiro Horisawa, Kotaro Kohara, Taku Nonaka, Atsushi Fukui, Tatsuki Mochizuki, Mutsumi Iijima, Takakazu Kawamata, Takaomi Taira
Summary: This study retrospectively analyzed the efficacy and adverse events of unilateral pallidothalamic tractotomy in 35 patients with cervical dystonia. The results showed significant improvement in symptoms after a follow-up period of 13.9 months, but there were also some adverse events.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Clinical Neurology
Suzhen Lin, Yimei Shu, Chencheng Zhang, Lingbing Wang, Peng Huang, Yixin Pan, Jianqing Ding, Bomin Sun, Dianyou Li, Yiwen Wu
Summary: This study compared the effectiveness of targeting the globus pallidus internus (GPi) and the subthalamic nucleus (STN) in patients with isolated dystonia. The results showed that STN-DBS had superior effects at 1 month, 1 year, and 3 years, while GPi-DBS was better for axis symptoms, particularly for trunk involvement. STN-DBS was also more effective for symptoms involving the eyes and generalized dystonia, and required less electrical energy.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Ruili Zhang, Yingnan Nie, Wen Dai, Shouyan Wang, Xinyi Geng
Summary: This study investigated the relationship between neural oscillation balance in the globus pallidus internus (GPi) and dystonic severity under different muscular contraction conditions. The balance between neural oscillations was found to be related to muscular contraction conditions and correlated with the severity of dystonia. The balance between low and high beta oscillations was positively correlated with dystonic severity and could potentially serve as a new biomarker for closed-loop deep brain stimulation in patients with dystonia.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Clinical Neurology
Joshua K. Wong, Janine Melo Lobo Jofili Lopes, Wei Hu, Anson Wang, Ka Loong Kelvin Au, Tamara Stiep, Jessica Frey, Jon B. Toledo, Robert S. Raike, Michael S. Okun, Leonardo Almeida
Summary: This study compares the safety and tolerability of active recharge biphasic DBS (bDBS) with conventional clinical DBS (clinDBS) in patients with primary dystonia. Results show that bDBS is safe and well-tolerated in all 10 subjects, with greater immediate improvement compared to clinDBS after 4 hours of stimulation.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Tariq Parker, Ashley L. B. Raghu, James J. FitzGerald, Alexander L. Green, Tipu Z. Aziz
Summary: Dual thalamo-pallidal stimulation demonstrates great flexibility and efficacy in managing complex movement disorders, but also has limitations.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Leon Sobesky, Lukas Goede, Vincent J. J. Odekerken, Qiang Wang, Ningfei Li, Clemens Neudorfer, Nanditha Rajamani, Bassam Al-Fatly, Martin Reich, Jens Volkmann, Rob M. A. de Bie, Andrea A. Kuehn, Andreas Horn
Summary: This study investigated the connectivity profiles of deep brain stimulation electrodes in patients with Parkinson's disease and found a common functional network between subthalamic and pallidal stimulation that is associated with optimal clinical improvements. Furthermore, the study showed that connectivity maps based on different motor symptom subscores can predict treatment outcomes.
Review
Clinical Neurology
Stephen Tisch, Kishore Raj Kumar
Summary: GPi DBS is an effective intervention for refractory dystonia, with factors such as disease duration and subtype influencing outcomes. Other factors affecting variability in results include body distribution, pattern of dystonia, and DBS-related factors. Different monogenic forms of dystonia may respond differently to DBS.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Wentao Zheng, Gaoquan Lv, Yunwei Lu, Jiayu Liu, Qingpei Hao, Hu Ding, Yezu Liu, Ruen Liu
Summary: Bilateral globus pallidus internus deep brain stimulation (GPi-DBS) is a safe and effective treatment approach for Meige syndrome, improving motor function and quality of life without cognitive and mood side effects.
Article
Surgery
Marek Balaz, Jiri Buril, Tereza Jurkova, Eva Koritakova, Dusan Hrabovsky, Jonas Kunst, Petra Bartova, Jan Chrastina
Summary: This study aims to compare the preplanned trajectories for deep brain stimulation (DBS) with the final trajectories selected after electrophysiological monitoring, and to discuss the factors responsible for the differences. The results showed significant differences between the preplanned and final trajectories, but no predictors for these differences were identified. There was also no association between the anatomical-electrophysiological differences and clinical outcome.
FRONTIERS IN SURGERY
(2023)
Article
Neurosciences
Shiro Horisawa, Kotaro Kohara, Masato Murakami, Atsushi Fukui, Takakazu Kawamata, Takaomi Taira
Summary: The Forel field has potential for the treatment of cervical dystonia, Parkinson's disease, and dystonia. Recent studies have shown promising results for the efficacy of FF-DBS in treating dystonia.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Review
Neurosciences
Houyou Fan, Zijian Zheng, Zixiao Yin, Jianguo Zhang, Guohui Lu
Summary: Both GPi-DBS and STN-DBS are safe and effective in treating dystonia, with patients showing different levels of symptom improvement and quality of life enhancement depending on the type of dystonia. Patients with primary dystonia respond better to DBS in terms of efficacy.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Neurosciences
Suzhen Lin, Lingbing Wang, Yimei Shu, Shunyu Guo, Tao Wang, Hongxia Li, Chencheng Zhang, Bomin Sun, Dianyou Li, Yiwen Wu
Summary: Bilateral STN-DBS plus unilateral PVP may be an effective rescue procedure for patients with isolated dystonia who experienced suboptimal movement improvement following GPi-DBS.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Kantharuby Tambirajoo, Luciano Furlanetti, Michael Samuel, Keyoumars Ashkan
Summary: Adult-onset dystonic syndromes presenting with dystonic opisthotonus are rare, and often refractory to medical management. In this study, three patients showed rapid and sustained clinical improvement of symptoms following GPi-DBS, with the ability to resume daily activities and reintegrate into society. Thorough investigation and tailored management are necessary for this highly disabling condition with varying etiologies.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Oncology
Marta Lopes, Bruno Carvalho, Rui Vaz, Paulo Linhares
JOURNAL OF NEURO-ONCOLOGY
(2018)
Article
Medicine, Research & Experimental
Vasco Abreu, Rui Vaz, Virginia Rebelo, Maria Jose Rosas, Clara Chamadoira, Martin J. Gillies, Tipu Z. Aziz, Erlick A. C. Pereira
Review
Clinical Neurology
Ana Aires, Tiago Gomes, Paulo Linhares, Filipe Cunha, Maria Jose Rosas, Rui Vaz
CLINICAL NEUROLOGY AND NEUROSURGERY
(2018)
Article
Clinical Neurology
Maria Molinos, Carla Cunha, Catarina R. Almeida, Raquel M. Goncalves, Paulo Pereira, Pedro Santos Silva, Rui Vaz, Mario A. Barbosa
Article
Clinical Neurology
Claudia Pereira, Pedro Santos Silva, Marisa Cunha, Rui Vaz, Paulo Pereira
WORLD NEUROSURGERY
(2018)
Article
Clinical Neurology
Ricardo Rodrigues, Pedro Santos Silva, Marisa Cunha, Rui Vaz, Paulo Pereira
WORLD NEUROSURGERY
(2018)
Article
Clinical Neurology
Jose Costa, Pedro Santos Silva, Marisa Cunha, Mariana Almeida, Rui Vaz, Paulo Pereira
WORLD NEUROSURGERY
(2018)
Article
Computer Science, Information Systems
Gonalo Pimentel, Susana Rodrigues, Pedro Alberto Silva, Antonio Vilarinho, Rui Vaz, Joao Paulo Silva Cunha
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2019)
Article
Clinical Neurology
Fabia Silva, Pedro Santos Silva, Rui Vaz, Paulo Pereira
ACTA NEUROCHIRURGICA
(2019)
Article
Clinical Neurology
Mariana Branco, Paulo Linhares, Bruno Carvalho, Patricia Santos, Bruno M. Costa, Rui Vaz
CLINICAL NEUROLOGY AND NEUROSURGERY
(2019)
Article
Biochemistry & Molecular Biology
Marta Viana-Pereira, Daniel Antunes Moreno, Paulo Linhares, Julia Amorim, Rui Nabico, Sandra Costa, Rui Vaz, Rui Manuel Reis
MOLECULAR BIOLOGY REPORTS
(2020)
Article
Oncology
Bruno Carvalho, Rafaela Goncalves Lopes, Paulo Linhares, Andreia Costa, Claudia Caeiro, Ana Catarina Fernandes, Nuno Tavares, Ligia Osorio, Rui Vaz
JOURNAL OF NEURO-ONCOLOGY
(2020)
Article
Chemistry, Analytical
Elodie Murias Lopes, Maria do Carmo Vilas-Boas, Duarte Dias, Maria Jose Rosas, Rui Vaz, Joao Paulo Silva Cunha
Article
Clinical Neurology
Rui Tuna, Bruno Carvalho, Ligia Castro, Rui Vaz, Paulo Linhares
INTERDISCIPLINARY NEUROSURGERY-ADVANCED TECHNIQUES AND CASE MANAGEMENT
(2020)
Review
Rheumatology
Carla Cunha, Ana J. Silva, Paulo Pereira, Rui Vaz, Raquel M. Goncalves, Mario A. Barbosa
ARTHRITIS RESEARCH & THERAPY
(2018)
Review
Clinical Neurology
Oday Atallah, Amr Badary, Yasser F. Almealawy, Vivek Sanker, Wireko Andrew Awuah, Toufik Abdul-Rahman, Sura N. Alrubaye, Bipin Chaurasia
Summary: This study investigates unexpected deaths resulting from primary brain tumors and analyzes the contributing variables. The findings reveal that unexpected deaths are a complex phenomenon, with headache being the most common initial symptom and meningiomas and astrocytomas being the most common lesions.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Alexandra E. Quimby, Mandy K. Salmon, Christopher H. Zhao, John Y. K. Lee, Douglas C. Bigelow, Michael J. Ruckenstein, Jason A. Brant
Summary: The study found that socioeconomic factors including race, health insurance, and income have an impact on the quality of life at the time of vestibular schwannoma diagnosis. Black/African American and uninsured/self-pay patients had lower quality of life, while patients with higher income had higher quality of life.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Review
Clinical Neurology
Arosha S. Dissanayake, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: This study systematically reviews models that aim to provide patient-specific predictions of pre-treatment rebleeding risk in patients with aneurysmal subarachnoid hemorrhage. The reported discriminative performance of the models varied, and no model showed consistently low bias risk and clinical applicability in all domains. Only one model was formulated using a patient cohort that underwent contemporary, evidence-based aneurysm treatment practices, but this model lacked calibration or clinical utility.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Colin Kok Ann Teo, Yilong Zheng, Jeremy Bingyuan Lin, Hock Luen Teoh, Bernard Poon Lap Chan, Vijay Kumar Sharma, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo
Summary: This study retrospectively reviewed the clinical characteristics and outcomes after surgical revascularization for adult Moyamoya disease (MMD) in a Southeast Asian cohort. The incidence of postoperative transient ischemic attack (TIA)/stroke was 25.9%, with most cases occurring within 7 days postoperatively. Risk factors for 30-day postoperative TIA/stroke included a higher number of preoperative TIAs/strokes and indirect revascularization.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Cheng-Chi Lee, Abel Po-Hao Huang, Ching-Chang Chen, Zhuo-Hao Liu, Mun-Chun Yeap, Ko-Ting Chen, Peng-Wei Hsu, Kuo-Chen Wei, Chun-Ting Chen, Yu-Chi Wang, Ting-Wei Chang, Chi-Cheng Chuang
Summary: Using a novel portable neuroendoscopic system for minimally invasive evacuation of intracerebral hemorrhage (ICH) has shown positive outcomes in reducing hematoma volume and improving neurological function without any death or rebleeding incidents.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Michael M. Haglund, Bruce M. McCormack, Daniel M. Williams, Alexander C. Lemons, Erik M. Summerside
Summary: This study evaluated the long-term radiographic outcomes of patients receiving tissue-sparing posterior cervical fusion (PCF) for the treatment of pseudarthrosis. The results showed that patients achieved rates of arthrodesis similar to open PCF, with fewer postoperative complications and long-term soft tissue pain.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Dong-Dong Meng, Zhe Ruan, Yong-Lan Tang, Zhao-Hua Ji, Yue Su, Tuo Xu, Bo-Zhou Cui, Da-Lin Ren, Ting Chang, Qian Yang
Summary: Depression symptom level, MG severity classification and family's monthly per capita income are independent factors related to the caregivers' disease family burden for MG patients. The daily activity burden of the family and the economic burden of the family were the heaviest among the six dimensions of the caregivers' family disease burdens.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Tugba Ozudogru Celik, Umit Gorgulu, Safiye Gul Kenar, Nadide Koca, Elif Yalcin, Ipek Koymen, Evren Yasar
Summary: This study investigated the forward head posture (FHP), thoracic kyphosis, and their relationship in individuals with migraine compared to healthy controls. The results showed that patients with migraine had a greater FHP and thoracic kyphosis. This suggests that a 3-dimensional objective measurement could be a reliable tool for evaluating posture analysis in clinical practice.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Jason A. Chen, Ari D. Kappel, Erickson F. Torio, David I. Bass, Abdullah Feroze, Nirav J. Patel
Summary: This report presents a case of a 63-year-old woman with a ruptured giant ICA terminus aneurysm, who underwent coil embolization followed by parent vessel sacrifice and high-flow bypass.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Sandeep Kandregula, Sneha Sai Mannam, Shahbaz Saad, Saarang Patel, Visish M. Srinivasan
Summary: A 39-year-old female with a history of smoking and a family predisposition to unruptured aneurysms presented with clinical symptoms of intermittent right-sided headaches, flashes of light, and pulsatile tinnitus. Diagnostic evaluations identified a right occipital arteriovenous malformation (AVM). Treatment involved partial embolization of primary arterial feeders followed by surgical resection, resulting in a successful outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Ari D. Kappel, Jason A. Chen, Joshua I. Chalif, David I. Bass, Erickson F. Torio, Abdullah H. Feroze, Nirav J. Patel
Summary: A 48-year-old male with progressive congestive myelopathy underwent surgical clipping to treat a craniocervical DAVF. Intraoperatively, ICG was used to confirm the solitary inflow.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Aryeh Zolin, Cenai Zhang, Hwai Ooi, Harini Sarva, Hooman Kamel, Neal S. Parikh
Summary: In people with Parkinson's disease, comorbid liver fibrosis is associated with more rapid cognitive decline across multiple domains.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)