Article
Public, Environmental & Occupational Health
Dana Hyassat, Saba Al-Saeksaek, Duha Naji, Awn Mahasneh, Yousef Khader, Mousa Abujbara, Mohammad El-Khateeb, Kamel Ajlouni
Summary: This study investigated the prevalence and patterns of dyslipidemia among patients with type 2 diabetes and its associated risk factors. The results showed that combined dyslipidemia, characterized by high triglycerides and low HDL-cholesterol, was the most common type. Factors such as diabetes duration, statin non-compliance, HbA1c level, and smoking were associated with different types of dyslipidemia.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Tadesse Asmamaw Dejenie, Endeshaw Chekol Abebe, Misganaw Asmamaw Mengstie, Mohammed Abdu Seid, Natnael Atnafu Gebeyehu, Getachew Asmare Adella, Gizchew Ambaw Kassie, Amanuel Yosef Gebrekidan, Molalegn Mesele Gesese, Kirubel Dagnaw Tegegne, Denekew Tenaw Anley, Sefineh Fenta Feleke, Melkamu Aderajew Zemene, Anteneh Mengist Dessie, Natnael Moges, Yenealem Solomon Kebede, Berihun Bantie, Dagnew Getnet Adugna
Summary: This study investigated the value of serum cystatin C levels and dyslipidemia in detecting diabetic nephropathy in patients with type 2 diabetes mellitus. The results showed significant lipoprotein abnormalities and increased serum cystatin C levels in type 2 diabetes patients with nephropathy. The study also found a significant correlation between dyslipidemia and serum cystatin C levels. Therefore, serum cystatin C and dyslipidemia may serve as sensitive and non-invasive biomarkers for diabetic nephropathy.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Pharmacology & Pharmacy
Zahra Namkhah, Damoon Ashtary-Larky, Fatemeh Naeini, Cain C. T. Clark, Omid Asbaghi
Summary: The meta-analysis found that vitamin C supplementation significantly decreased TG and TC levels in T2DM patients, but did not affect LDL and HDL. Duration of treatment and dose of vitamin C were found to influence the improvement of lipid profile in T2DM patients. Results suggest that long-term vitamin C supplementation may be more beneficial for improving lipid profile in diabetic populations.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Wenke Cheng, Jingqi Zhuang, Siwei Chen
Summary: This study investigated the relationship between atherosclerotic indices and the prevalence of hypertension in Chinese adults without type 2 diabetes mellitus. The results showed that atherosclerotic indices were higher in the hypertensive population compared to the normotensive population, and systolic and diastolic blood pressure were positively correlated with these indices. The cholesterol index and non-HDL-C were identified as independent risk factors for hypertension prevalence.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Jeongmin Lee, Min-Hee Kim, Jung-Min Lee, Sang-Ah Chang
Summary: This study aimed to investigate the effects of pitavastatin therapy on serum adiponectin levels and high-molecular-weight (HMW) adiponectin in patients with type 2 diabetes, as well as their correlation with insulin sensitivity. The results showed that pitavastatin therapy did not significantly change serum adiponectin or HMW adiponectin levels, and it did not affect insulin sensitivity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Tamas Szili-Torok, Stephan J. L. Bakker, Uwe J. F. Tietge
Summary: A study found that increased levels of triglycerides, even within the normal range, are associated with an increased risk of type 2 diabetes in healthy individuals. This suggests the importance of lowering triglyceride levels for diabetes prevention and encourages lifestyle changes in the general population.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Environmental Sciences
Jinqiu Yao, Fei Wang, Ying Zhang, Zefang Zhang, Jiao Bi, Jia He, Peiwen Li, Xu Han, Yue Wei, Xiaomin Zhang, Huan Guo, Meian He
Summary: The study found that serum BPA concentration was associated with changes in blood lipid levels and dyslipidemia risk in middle-elderly Chinese adults. Serum BPA levels were positively related to total cholesterol, LDL-c, and Non-HDL-c levels. Increased Ln-BPA was associated with increased Delta TC, Delta Non-HDL-c, Delta TC/HDL-c, and Delta Non-HDL-c/HDL-c. The associations were observed in females but not in males.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Endocrinology & Metabolism
Shanshan Chen, Shuo Li, Xinxin Zhang, Yuxin Fan, Ming Liu
Summary: In this cross-sectional study, higher levels of dehydroepiandrosterone were significantly associated with a lower risk of dyslipidemia in adult men with type 2 diabetes mellitus. However, rising levels of dehydroepiandrosterone sulfate, androstenedione, and total testosterone showed no significant correlations with the risk of dyslipidemia in male patients with T2DM. Further prospective research is needed to confirm the role of dehydroepiandrosterone in the development of dyslipidemia.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Environmental Sciences
Yanqun Ba, Qixin Guo, Shasha Meng, Guoxin Tong, Ying He, Yihong Guan, Beibei Zheng
Summary: This study examined the relationship between serum terpenes and the prevalence of dyslipidemia. The study found that serum terpenes were positively associated with the prevalence of dyslipidemia.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Endocrinology & Metabolism
Hao Dai, Yu Qian, Hui Lv, Liying Jiang, Hemin Jiang, Min Shen, Heng Chen, Yang Chen, Shuai Zheng, Qi Fu, Tao Yang, Kuanfeng Xu
Summary: The JAZF1 rs864745 variant is not associated with type 2 diabetes and type 1 diabetes, but it is related to islet function and lipid metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Yahui Wen, Heng Zhang, Ning Yang, Xia Gao, Zhe Chen, Jia Liu, Guang Wang
Summary: This study found that serum IL-27 levels were compensatorily increased in patients with subclinical hypothyroidism or hypothyroidism and were independently associated with NAFLD. Circulating IL-27 levels could predict the occurrence of NAFLD in hypothyroidism. These results suggested that altering the circulating levels of IL-27 may be a potential therapeutic target for NAFLD.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jiahao Zhu, Lingling Sun, Jing Yang, Jiayao Fan, Lap Ah Tse, Yingjun Li
Summary: The study found significant associations between T2D and fasting insulin levels with increased serum urate concentrations, suggesting a potential link between fasting insulin and risk of gout. However, genetic predisposition to urate and gout did not show associations with T2D or any of the 4 glycemic traits investigated. Further research is needed to explore the underlying biological mechanisms of these relationships.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Xiaoyu Ding, Xiaona Chang, Jiaxuan Wang, Nannan Bian, Yu An, Guang Wang, Jia Liu
Summary: The study found that serum Metrnl levels were reduced in individuals with overweight or obesity and were independently associated with adverse lipid profile. This finding suggests that modifying circulating Metrnl levels may serve as a potential therapeutic target for atherogenic dyslipidemia.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria Arif, Tanmoy Mondal, Asifa Majeed, Christopher A. Loffredo, Brent E. Korba, Somiranjan Ghosh
Summary: This study describes the association between PPAR alpha expression and fasting blood glucose, HbA1c levels, and lipid levels in patients with type 2 diabetes mellitus. The results show that PPAR alpha expression is not associated with physical and biochemical parameters measured in this study and is independent of blood lipids and glycemic control. Further research is necessary to better understand the biological parameters of PPAR alpha expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Qiuhui Xuan, Chunxiu Hu, Yinan Zhang, Qingqing Wang, Xinjie Zhao, Xinyu Liu, Congrong Wang, Weiping Jia, Guowang Xu
Summary: Using a pseudotargeted lipidomics approach, this study evaluated complex lipid changes in patients with diabetes mellitus (DM) before the diagnosis of type 2 diabetes mellitus (T2DM), and identified novel lipid markers for screening prediabetes mellitus (PreDM) and T2DM.
FRONTIERS IN ENDOCRINOLOGY
(2022)
