Review
Immunology
Rui Qin, Gengren Tian, Junbao Liu, Lu Cao
Summary: Endometriosis is a common gynecological disease that is associated with an imbalance of sex hormones, immune inflammation, and tumor characteristics. Recent studies have shown an association between the gut microbiota and endometriosis, suggesting that regulating gut microbiota may be beneficial for the treatment of endometriosis patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
A. Raquel Esteves, Mario F. Munoz-Pinto, Daniela Nunes-Costa, Emanuel Candeias, Diana F. Silva, Joao D. Magalhaes, A. Raquel Pereira-Santos, I. Luisa Ferreira, Susana Alarico, Igor Tiago, Nuno Empadinhas, Sandra Morais Cardoso
Summary: This study aims to demonstrate that the effects of microbial toxin BMAA in the gut may trigger some cases of PD, and it can spread from the gut to the brain, leading to the development of PD. This finding is crucial for understanding the pathological progression of PD.
Article
Agriculture, Dairy & Animal Science
Shengyu Xu, Xiaojun Jiang, Xinlin Jia, Xuemei Jiang, Lianqiang Che, Yan Lin, Yong Zhuo, Bin Feng, Zhengfeng Fang, Jian Li, Jianping Wang, Zhihua Ren, De Wu
Summary: This study aimed to investigate the impact of dietary silymarin supplementation on inflammatory responses and fecal microbiota in lactating sows, as well as the relationship between inflammatory factors and fecal microbiota. The results showed that silymarin supplementation decreased inflammatory responses in lactating sows and changed the composition of fecal microbiota. The altered microbiota was associated with variations in inflammatory factors, suggesting that silymarin can modulate gut microbiota and improve the health of lactating sows.
Review
Nutrition & Dietetics
Jiaxin Long, Jinlong Wang, Yang Li, Shuai Chen
Summary: This review provides a systematic overview of the link between gut microbiota and associated metabolites to the pathogenesis of ischemic stroke (IS), highlighting the potential implications of gut microbiota-dependent intervention in the treatment of IS.
FRONTIERS IN NUTRITION
(2022)
Article
Multidisciplinary Sciences
Joshua R. Fletcher, Colleen M. Pike, Ruth J. Parsons, Alissa J. Rivera, Matthew H. Foley, Michael R. McLaren, Stephanie A. Montgomery, Casey M. Theriot
Summary: Through the analysis of tcdR mutants in two strains of Clostridioides difficile and omics, this study found that toxin-induced inflammation significantly alters the metabolism pathways of C. difficile and the gut microbiota. The host cell gene expression characteristics promote the in vivo growth of C. difficile. Furthermore, inflammation induced by C. difficile toxin activity excludes Bacteroides genus members that can utilize essential nutrients released from collagen degradation.
NATURE COMMUNICATIONS
(2021)
Review
Agriculture, Dairy & Animal Science
Jean-Paul Lalles, Carlos A. Montoya
Summary: Recent studies on alternatives to in-feed antibiotics have focused on the impact on immune response and gut function, with functional nutrients and probiotics showing promising anti-inflammatory properties in young pigs.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2021)
Review
Immunology
Ting Zhao, Yuanyuan Wei, Youyang Zhu, Zhaohu Xie, Qingshan Hai, Zhaofu Li, Dongdong Qin
Summary: RA is a chronic autoimmune disease primarily affecting joints, with microbial infection being a crucial trigger. Changes in gut microbiota composition are closely linked to immune dysfunction in RA. Better understanding of gut microbiota alterations can aid in the development of novel therapeutic approaches.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jongoh Shin, Jung-Ran Noh, Donghui Choe, Namil Lee, Yoseb Song, Suhyung Cho, Eun-Jung Kang, Min-Jeong Go, Seok Kyun Ha, Jae-Hoon Kim, Yong-Hoon Kim, Kyoung-Shim Kim, Byoung-Chan Kim, Chul-Ho Lee, Byung-Kwan Cho
Summary: This study investigated the changes in gut microbial communities during aging in mouse models using various techniques such as co-housing and oral administration of probiotics. The taxonomy and functional potential of bacterial communities were characterized through 16S rRNA sequencing and shotgun metagenomic sequencing. The generated dataset expands the resources for understanding the gut microbiome related to aging and rejuvenation.
Review
Biochemistry & Molecular Biology
Ali Shahbazi, Ali Sepehrinezhad, Edris Vahdani, Raika Jamali, Monireh Ghasempour, Shirin Massoudian, Sajad Sahab Negah, Fin Stolze Larsen
Summary: Hepatic encephalopathy (HE), a common neuropsychiatric complication of advanced liver disease, negatively impacts quality of life and hospital stay. Recent evidence suggests that gut microbiota plays a significant role in brain development and maintenance of cerebral homeostasis. Microbiota metabolites offer new therapeutic options for neurological disorders, including HE, by modulating gut microbiota and blood-brain barrier (BBB) integrity. However, the mechanisms underlying microbiota dysbiosis and its effects on BBB in HE remain unclear.
Review
Biochemistry & Molecular Biology
Shafaque Rahman, Mohammed Ghiboub, Joanne M. Donkers, Evita van de Steeg, Eric A. F. van Tol, Theodorus B. M. Hakvoort, Wouter J. de Jonge
Summary: Research on intestinal function models helps to understand intestinal physiology and functions in health and disease states. However, the translation to human in vivo situation remains problematic due to the failure of these models to fully reflect the complex in vivo environment. Although traditional models are still in use, more sophisticated intestinal models have been developed in recent years.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Xueli Yang, Tian Chang, Qian Yuan, Wei Wei, Pingping Wang, Xiaojian Song, Huijuan Yuan
Summary: This study investigates the variations in gut microbiota (GM) and vaginal microbiota (VM) in postmenopausal women with osteoporosis. The results show that changes in bone mineral density are associated with changes in GM and VM, with GM being more closely correlated with postmenopausal osteoporosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Endocrinology & Metabolism
Olivia D. Cooney, Prabhakar R. Nagareddy, Andrew J. Murphy, Man K. S. Lee
Summary: Probiotics have been highlighted for their role in modifying the gut microbiome, potentially reducing the severity of various chronic diseases and regulating bone mass. Targeting the gut microbiome may offer a potential alternative avenue for improving bone health, as gut-related diseases have been shown to impact bone health.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Immunology
Xing Lyu, Jieli Chen, Xingjie Gao, Jie Yang
Summary: As a set of inflammatory disorders, spondyloarthritis (SpA) exhibits distinct pathophysiological, clinical, radiological, and genetic characteristics. Gut dysbiosis has been linked to the development of SpA, and modulation of the gut microbiota may contribute to its prevention. New microbiome therapies, such as probiotics, are used as adjuvant therapy in the treatment of SpA.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Lili Li, Min Wang, Jun Bao, Nannan Wang, Yuezhen Huang, Shasha He, Bin Chen, Fuhua Yan
Summary: This study found that periodontitis may impact systemic bone homeostasis through regulation of gut microbiota, indicating the importance of periodontitis in bone health.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Kearsley M. Dillon, Holly A. Morrison, Chadwick R. Powell, Ryan J. Carrazzone, Veronica M. Ringel-Scaia, Ethan W. Winckler, R. McAlister Council-Troche, Irving C. Allen, John B. Matson
Summary: This study presents a persulfide donor NDP-NAC that releases NAC-SSH in response to E. coli nitroreductase, leading to gastroprotective effects in mice and modulation of beneficial gut bacteria. It also reduces opportunistic pathogen populations in the gut, suggesting the potential of targeted delivery of reactive sulfur species for maintaining gut health or treating microbiome-related diseases.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)