Article
Medicine, General & Internal
Marouf Mouhammad Alhalabi
Summary: This study aimed to estimate the in-hospital mortality rate and risk factors associated with peptic ulcer bleeding among adult inpatients at Damascus Hospital, Syria. The mortality rate was found to be 3.4%, with an average age of 61.76 +/- 16.02 years. The most common comorbidities were hypertension, diabetes mellitus, and ischemic heart disease. Non-steroidal anti-inflammatory drugs (NSAIDs) were frequently used and posed a significant risk, highlighting the importance of raising awareness about their risks.
Article
Surgery
Carlos Robles-Medranda, Roberto Oleas, Juan Alcivar-Vasquez, Miguel Puga-Tejada, Jorge Baquerizo-Burgos, Hannah Pitanga-Lukashok
Summary: The study showed that OTSC treatment is effective and feasible as a first-line therapy for high-risk bleeding peptic ulcers, with comparable costs and patient outcomes as combined therapy, along with a shorter procedure time.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Jun-young Seo, Jin Hee Noh, Ji Yong Ahn, Sang Yong Cho, Seung-pyo Oh, Boram Cha, Hee Kyong Na, Jeong Hoon Lee, Kee Wook Jung, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Summary: This study compared the clinical outcomes of marginal ulcer bleeding (MUB) with peptic ulcer bleeding (PUB). The results showed that MUB had a higher rebleeding rate and a higher mortality rate compared to PUB. Prophylactic use of proton pump inhibitors (PPIs) may reduce the risk of rebleeding in MUB.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Gastroenterology & Hepatology
Chuan-Guo Guo, Ka Shing Cheung, Feifei Zhang, Esther W. Chan, Lijia Chen, Ian C. K. Wong, Wai K. Leung
Summary: This retrospective study in Hong Kong found that patients failed by initial H. pylori eradication have an increased risk of upper gastrointestinal bleeding compared to patients who responded to the initial therapy, and the risk increased progressively with longer time until retreatment. Therefore, early retreatment within 3 months should be considered to minimize subsequent risk of upper gastrointestinal bleeding.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Medicine, General & Internal
Jin Young Yoon, Jae Myung Cha, Ha Il Kim, Min Seob Kwak
Summary: This study in South Korea found clear seasonal variations in peptic ulcer and peptic ulcer bleeding, with the highest incidence rates in winter. However, acute pancreatitis did not show significant seasonal variations. Gender and age did not have significant impacts on the seasonal variations of these diseases.
Article
Gastroenterology & Hepatology
Samuel Hui, Andy Lim, Elaine Koh, Joshua Abasszade, Aparna Morgan, Pei Y. Tan, Christopher Lemoh, Marcus Robertson
Summary: The prevalence of Vitamin C deficiency (VCD) is high in patients with upper gastrointestinal bleeding (UGIB) and is associated with poor outcomes, including higher mortality, rebleeding, and prolonged hospitalization.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Tamer Akay, Metin Leblebici
Summary: This study compared endoscopic techniques for peptic ulcer bleeding and found that high-dose epinephrine injection can improve early bleeding and permanent hemostasis rates, but does not significantly impact late hemostasis and urgent surgical need.
Article
Gastroenterology & Hepatology
Belete Assefa, Abilo Tadesse, Zenahebezu Abay, Alula Abebe, Tsebaot Tesfaye, Melaku Tadesse, Ayenew Molla
Summary: This study aimed to investigate the prevalence and risk factors of peptic ulcer disease among dyspeptic patients in Northwest Ethiopia. The results showed that 49% of dyspeptic patients had active H. pylori infection, and 35% of patients were diagnosed with peptic ulcer disease. H. pylori infection and NSAIDs/ASA use were identified as risk factors for peptic ulcer disease.
BMC GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Michael Milek Nielsen, Ove B. Schaffalitzky de Muckadell, Stig Borbjerg Laursen
Summary: In patients with controlled PUB undergoing endoscopic treatment, second-look endoscopy with DEP-guided evaluation and treatment is safe and associated with a very low risk of rebleeding. It may be considered in high-risk patients as an alternative to DEP use during index endoscopy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Jasmine H. E. Chang, Tiffany J. Y. Lye, Hong Zhi Zhu, Nicholas L. Syn, Sarah S. Tang, Apoorva Gogna, Weng Hoong Chan, Hock Soo Ong, Jeremy Tian Hui Tan, Chin Hong Lim
Summary: Prophylactic TAE in high-risk bleeding peptic ulcer patients demonstrates lower rates of rebleeding and mortality, with high success rates and low complications. There are no significant differences in reintervention rates and length of hospitalization when compared to standard endoscopic therapy alone.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2021)
Review
Medicine, General & Internal
Jacob E. Kurlander, Geoffrey D. Barnes, Aaron Fisher, J. Gonzalez Juan, Danielle Helminski, Sameer D. Saini, Neil Sengupta, Yu-Xiao Yang, James Scheiman, Loren Laine
Summary: By conducting a systematic review and meta-analysis of observational studies, it was found that proton pump inhibitors (PPIs) can reduce the risk of upper gastrointestinal bleeding in patients using anticoagulants, especially in those with a higher risk of bleeding.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Hsu-Heng Yen, Ping-Yu Wu, Tung-Lung Wu, Siou-Ping Huang, Yang-Yuan Chen, Mei-Fen Chen, Wen-Chen Lin, Cheng-Lun Tsai, Kang-Ping Lin
Summary: The management of peptic ulcer bleeding is clinically challenging, and the perception and interpretation of the Forrest classification vary among different endoscopists. In this study, endoscopic still images of patients with peptic ulcer bleeding were reviewed and compared among endoscopists of different experience levels. The results showed good agreement of the Forrest classification among endoscopists in a single institution, and distinct patterns were found for low-risk and high-risk lesions. This study provides quantitative analysis and explanation of the distinct patterns of bleeding ulcers from endoscopy images.
Review
Gastroenterology & Hepatology
Nicolas Chapelle, Myriam Martel, Marc Bardou, Majid Almadi, Alan N. Barkun
Summary: This study systematically reviewed the effectiveness of Doppler endoscopic probe (DEP) in nonvariceal upper gastrointestinal bleeding (NVUGIB) and found that DEP-related information improves prediction of rebleeding and DEP-guided management reduces overall rebleeding, bleeding-related mortality, and need for surgery in NVUGIB patients.
DIGESTIVE ENDOSCOPY
(2023)
Review
Medicine, General & Internal
Hsu-Heng Yen, Ping-Yu Wu, Mei-Fen Chen, Wen-Chen Lin, Cheng-Lun Tsai, Kang-Ping Lin
Summary: With a decreasing incidence of peptic ulcer bleeding, the experience of managing patients with PUB among young endoscopists has declined accordingly. Artificial Intelligence (AI) has shown great potential in the field of gastroenterology, particularly in enhancing human performance. The introduction of AI technologies may soon impact endoscopists' clinical practice by improving the quality of care for patients with PUB.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Karen Clarke, Nicole Adler, Deepak Agrawal, Dimpal Bhakta, Suchita Shah Sata, Sarguni Singh, Arjun Gupta, Amit Pahwa, Emily Pherson, Alexander Sun, Frank Volpicelli, Hyung J. Cho
Summary: Proton pump inhibitors are widely used for the treatment of acid-related gastrointestinal disorders and stress ulcer prophylaxis. However, their use may lead to significant complications such as fractures, Clostridium difficile infection, acute kidney injury, chronic kidney disease, and hypomagnesemia. In the hospital setting, proton pump inhibitors are often overused and inappropriately continued after discharge.
AMERICAN JOURNAL OF MEDICINE
(2022)
