Article
Obstetrics & Gynecology
Sophie Jansen, Genevieve Leduc-Robert, Faten F. AbdelHafez, Arianne Albert, Ulrike Mayer, Mohamed A. Bedaiwy
Summary: This study, conducted through a retrospective chart review, found that thyroperoxidase antibody positivity does not significantly impact thyroid stimulating hormone levels during pregnancies. However, treatment with levothyroxine in patients with subclinical hypothyroidism can increase the live birth rate.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Freddy J. K. Toloza, Omar M. M. El Kawkgi, Horace J. J. Spencer, Sherin Elsa Mathews, Andrea Garcia, Augusto Gamboa, Nabeel Mirza, Sneha Mohan, Sebastian Vallejo, Marija Bogojevic, Rene Rodriguez-Gutierrez, Naykky M. Singh M. Ospina, Juan P. P. Brito, Spyridoula Maraka
Summary: This study investigated the frequency and factors associated with thyroid hormone replacement therapy among patients with subclinical hypothyroidism (SCH). The study found that female sex and higher levels of thyroid-stimulating hormone (TSH) were associated with higher odds of treatment. Additionally, the study found that the importance of confirmatory thyroid function tests before making treatment decisions was underutilized.
Article
Endocrinology & Metabolism
Francesca Orsolini, Elena Gianetti, Chiara Terrenzio, Lucia Montanelli, Elena Benelli, Brunella Bagattini, Emilio Fiore, Massimo Tonacchera
Summary: This study evaluated the role of thyroid autoantibodies in adverse pregnancy outcomes. The results showed that the presence and titer of thyroid autoantibodies do not have a negative impact on gestation if thyroid function is adequately controlled. Although not significant, suboptimal thyroid hormone status may have a greater impact on pregnancy outcomes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Anna Capozzi, Giovanni Scambia, Stefano Lello
Summary: Subclinical hypothyroidism (SCH) is a common condition among women, with a potential impact on reproductive health, pregnancy outcomes, and menopausal women. While LT4 therapy has shown benefits in certain cases, such as in women with thyroid peroxidase antibody (TPOAb) positivity and elevated TSH levels, the data on the effective impact of LT4 treatment remains conflicting. More research is needed to establish the benefits of LT4 therapy, especially in menopausal women.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Review
Nursing
Caitlin E. Mayhew, Kristin R. Simonson, Esther R. Ellsworth Bowers
Summary: Maternal thyroid hormones play a critical role in fetal growth and development during pregnancy. This review aims to provide clinicians with current evidence on the adverse effects of hypothyroidism in pregnancy, including recurrent pregnancy loss. It also discusses clinical presentation, evidence-based screening guidelines, and treatments for hypothyroidism during pregnancy.
JOURNAL OF MIDWIFERY & WOMENS HEALTH
(2022)
Article
Endocrinology & Metabolism
Balsam Bohlega, Afshan Zahedi, George Tomlinson, Denice S. Feig
Summary: The study found that using a weight-based dosing method of starting thyroxine for women newly diagnosed with subclinical hypothyroidism during pregnancy increased the odds of reaching the target TSH range within 4-8 weeks. This approach should be considered by clinicians when initiating treatment during pregnancy.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Jiajia Chen, Jing Zhu, Xianping Huang, Shenzhi Zhao, Huiqiu Xiang, Panpan Zhou, Tong Zhou, Zhangye Xu
Summary: This study aimed to evaluate the intellectual development of offspring born to mothers with SCH-TPOAb(-). The results showed that TSH levels were correlated with the intellectual development of offspring, and early treatment in SCH-TPOAb(-) pregnant women with TSH levels between 4.0 and 10.0 mIU/L significantly improved the intellectual development levels of the approximately two-year-old offspring.
Article
Endocrinology & Metabolism
Mengjie Zhang, Wenjing Ni, Lina Zhang, Kuanlu Fan, Yu Sun, Chao Liu, Shuhang Xu
Summary: This study aimed to investigate the correlation between thyroid autoimmune disease (TAI) and hypothyroidism in the elderly aged 65 years and above. The results showed that TAI was a risk factor for hypothyroidism in the elderly, but a significant correlation was not identified in the 80-year-old age group.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Isabelle Runkle, Maria Paz de Miguel, Ana Barabash, Martin Cuesta, Angel Diaz, Alejandra Duran, Cristina Familiar, Nuria Garcia de la Torre, Miguel Angel Herraiz, Nuria Izquierdo, Angel Diaz, Clara Marcuello, Pilar Matia, Veronica Melero, Carmen Montanez, Immaculada Moraga, Natalia Perez-Ferre, Noelia Perez, Carla Assaf-Balut, Miguel Angel Rubio, Jorge Gabriel Ruiz-Sanchez, Concepcion Sanabria, Maria Jose Torrejon, Johanna Valerio, Laura del Valle, Alfonso Calle-Pascual
Summary: The optimal maternal levels of thyroid hormones during the first trimester have not been established, but studies suggest that at gestational week 8, TSH <2.5 mu IU/mL and FT4 >7.5 pg/mL correspond to the 75.8% and 17.9% percentiles, respectively. Early initiation of levothyroxine treatment is beneficial for improving gestation progression in pregnant women with suboptimal TSH/FT4 levels.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
A. Amouzegar, M. Dehghani, H. Abdi, L. Mehran, S. Masoumi, F. Azizi
Summary: This study aimed to clarify the natural history of subclinical hypothyroidism (SCH) and the predictive factors for its progression. The results showed that TPOAb and TSH levels were predictors for the development of overt hypothyroidism (OH) in individuals with SCH.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Article
Obstetrics & Gynecology
Zheng Wang, Astrid E. P. Cantineau, Annemieke Hoek, Rik van Eekelen, Ben W. Mol, Rui Wang
Summary: In assisted reproductive technology (ART) research, live birth is considered an important outcome but its interpretation can be misleading when solely focused on. This review presents an overview of the definitions of live birth and demonstrates through clinical examples the impact of variations in live birth on research findings, highlighting the importance of considering other outcomes such as multiple pregnancy, pregnancy loss, and maternal and offspring health outcomes. A holistic outcome assessment beyond live birth is necessary to inform evidence-based decision making in ART research.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2023)
Article
Endocrinology & Metabolism
Louise Knosgaard, Stig Andersen, Annebirthe Bo Hansen, Peter Vestergaard, Stine Linding Andersen
Summary: This study assessed maternal thyroid function in early pregnancy and found that the use of repeated blood samples can significantly influence the classification of thyroid function. The results emphasize the importance of focusing on the severity of thyroid function abnormalities in pregnant women.
EUROPEAN THYROID JOURNAL
(2022)
Review
Endocrinology & Metabolism
Pietro Locantore, Andrea Corsello, Caterina Policola, Alfredo Pontecorvi
Summary: Thyroid diseases, especially subclinical thyroid diseases, in pregnancy have varying impacts on pregnancy outcomes. Treatment with thyroxine is recommended in certain cases of subclinical hypothyroidism, but further studies are required for a more precise approach to managing thyroid dysfunction during pregnancy.
MINERVA ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Freddy J. K. Toloza, Arash Derakhshan, Tuija Mannisto, Sofie Bliddal, Polina Popova, David M. Carty, Liangmiao Chen, Peter Taylor, Lorena Mosso, Emily Oken, Eila Suvanto, Sachiko Itoh, Reiko Kishi, Judit Bassols, Juha Auvinen, Abel Lopez-Bermejo, Suzanne J. Brown, Laura Boucai, Aya Hisada, Jun Yoshinaga, Ekaterina Shilova, Elena N. Grineva, Tanja G. M. Vrijkotte, Jordi Sunyer, Ana Jimenez-Zabala, Isolina Riano-Galan, Maria-Jose Lopez-Espinosa, Larry J. Prokop, Naykky Singh Ospina, Juan P. Brito, Rene Rodriguez-Gutierrez, Erik K. Alexander, Layal Chaker, Elizabeth N. Pearce, Robin P. Peeters, Ulla Feldt-Rasmussen, Monica Guxens, Leda Chatzi, Christian Delles, Jeanine E. Roeters van Lennep, Victor J. M. Pop, Xuemian Lu, John P. Walsh, Scott M. Nelson, Tim I. M. Korevaar, Spyridoula Maraka
Summary: This study examined the association between abnormalities in thyroid function tests and the risk of gestational hypertension and pre-eclampsia. The results showed that subclinical hypothyroidism was associated with a higher risk of pre-eclampsia, and there was a U-shaped association between thyroid-stimulating hormone (TSH) and pre-eclampsia. Other thyroid function test abnormalities were not significantly associated with gestational hypertension or pre-eclampsia.
LANCET DIABETES & ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Ting Leng, Xue Li, Hong Zhang
Summary: The study found that levothyroxine therapy was beneficial for pregnant women with recurrent pregnancy loss, reducing the risk of miscarriage and increasing the live birth rate. However, for normal pregnant women, there was no significant difference in live birth rate and pregnancy loss rate between the treatment and control groups.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Review
Pharmacology & Pharmacy
Lindsay D. Levine, Tiffany L. Holland, Keewan Kim, Lindsey A. Sjaarda, Sunni L. Mumford, Enrique F. Schisterman
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2019)
Article
Public, Environmental & Occupational Health
Edwina H. Yeung, Hyojun Park, Carrie Nobles, Sunni L. Mumford, Robert Silver, Enrique F. Schisterman
ANNALS OF EPIDEMIOLOGY
(2019)
Article
Public, Environmental & Occupational Health
Carrie J. Nobles, Pauline Mendola, Sunni L. Mumford, Keewan Kim, Lindsey Sjaarda, Micah Hill, Robert M. Silver, Ashley I. Naimi, Neil J. Perkins, Enrique F. Schisterman
Article
Public, Environmental & Occupational Health
Jonathan S. Schildcrout, Sebastien Haneuse, Ran Tao, Leila R. Zelnick, Enrique F. Schisterman, Shawn P. Garbett, Nathaniel D. Mercaldo, Paul J. Rathouz, Patrick J. Heagerty
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2020)
Article
Public, Environmental & Occupational Health
Neil J. Perkins, Jennifer Weck, Sunni L. Mumford, Lindsey A. Sjaarda, Emily M. Mitchell, Anna Z. Pollack, Enrique F. Schisterman
Article
Public, Environmental & Occupational Health
Tiffany L. Holland, Keewan Kim, Carrie J. Nobles, Ya-Ling Lu, Indulaxmi Seeni, Sunni L. Mumford, Stephen E. Gilman, Lindsay D. Levine, Victoria C. Andriessen, Enrique F. Schisterman
Article
Public, Environmental & Occupational Health
Karen C. Schliep, Sunni L. Mumford, Robert M. Silver, Brian Wilcox, Rose G. Radin, Neil J. Perkins, Noya Galai, Jihye Park, Keewan Kim, Lindsey A. Sjaarda, Torie Plowden, Enrique F. Schisterman
Article
Obstetrics & Gynecology
Q. E. Harmon, K. Kissell, A. M. Z. Jukic, K. Kim, L. Sjaarda, N. J. Perkins, D. M. Umbach, E. F. Schisterman, D. D. Baird, S. L. Mumford
HUMAN REPRODUCTION
(2020)
Article
Public, Environmental & Occupational Health
Elizabeth A. DeVilbiss, Joseph B. Stanford, Sunni L. Mumford, Lindsey A. Sjaarda, Keewan Kim, Jessica R. Zolton, Neil J. Perkins, Enrique F. Schisterman
Summary: Research suggests that in fertile women with regular menstrual cycles, sporadic anovulation may not be a significant factor affecting pregnancy rates, while increasing the frequency of unscheduled intercourse can significantly reduce time to pregnancy and improve pregnancy rates.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2021)
Article
Medicine, General & Internal
Ashley Naimi, Neil J. Perkins, Lindsey A. Sjaarda, Sunni L. Mumford, Robert W. Platt, Robert M. Silver, Enrique F. Schisterman
Summary: The study suggests that adherence to preconception-initiated low-dose aspirin has a positive impact on reproductive outcomes, with at least 4 days of aspirin intake per week potentially improving results for women who have had 1 or 2 pregnancy losses.
ANNALS OF INTERNAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Alexandra C. Purdue-Smithe, Keewan Kim, Victoria C. Andriessen, Anna Z. Pollack, Lindsey A. Sjaarda, Robert M. Silver, Enrique F. Schisterman, Sunni L. Mumford
Summary: This study examined whether preconception leukocyte telomere length was associated with fecundability, pregnancy loss, and live birth among women with a history of 1-2 prior pregnancy losses trying to conceive naturally. The results indicated that there was no significant association between preconception telomere length and these pregnancy outcomes.
HUMAN REPRODUCTION
(2021)
Article
Public, Environmental & Occupational Health
Sonia M. Grandi, Stefanie N. Hinkle, Sunni L. Mumford, Lindsey A. Sjaarda, Katherine L. Grantz, Pauline Mendola, James L. Mills, Anna Z. Pollack, Edwina Yeung, Cuilin Zhang, Enrique F. Schisterman
Summary: This study examined whether giving birth to male infants increases the risk of maternal mortality. The results showed that women who give birth to male infants do not have an increased risk of all-cause and cause-specific mortality, suggesting that giving birth to male infants may not influence the long-term health of women.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Michael S. Bloom, Neil J. Perkins, Lindsey A. Sjaarda, Sunni L. Mumford, Aijun Ye, Keewan Kim, Daniel L. Kuhr, Carrie J. Nobles, Matthew T. Connell, Enrique F. Schisterman
Summary: This study aimed to investigate the association between adiposity and anovulation, and the results showed that higher adiposity was associated with a greater risk of anovulation, possibly through pathways other than testosterone. This may help understand the relationship between obesity and infertility among women, leading to targeted interventions for preventing female infertility.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2021)