Article
Gastroenterology & Hepatology
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kurschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Geraud, Sergij Goerdt, Philipp-Sebastian Koch
Summary: This study established an HHT mouse model with liver vascular malformations and investigated the role of ALK1 signaling in liver vessel formation and metabolic function. The results showed that hepatic endothelial ALK1 signaling protects from development of vascular malformations and preserves organ-specific endothelial differentiation and angiocrine signaling.
Article
Oncology
Hongyuan Lu, Cen Wu, Xiao-wen Jiang, Qingchun Zhao
Summary: This study found that the ADAM-17 inhibitor ZLDI-8 significantly inhibits angiogenesis and vasculogenic mimicry (VM) in drug-resistant NSCLC by suppressing the Notch1-HIF1αVEGF signaling pathway. This study lays the foundation for the discovery of drugs that inhibit angiogenesis and VM in drug-resistant NSCLC.
Article
Biochemistry & Molecular Biology
Xiang-Yu Guo, Tian-Tian Liu, Wen-Jie Zhu, Hai-Ting Liu, Guo-Hao Zhang, Lin Song, Rui-Nan Zhao, Xu Chen, Peng Gao
Summary: This study reveals the tumor-suppressor role of circKDM4B in breast cancer, especially in inhibiting tumor growth, metastasis, and angiogenesis, making it a potential therapeutic target for breast cancer progression.
Article
Medicine, Research & Experimental
Xinpei Gu, Shuhui Chen, Zhaojin Wang, Qianwen Bu, Shuhong An
Summary: This study demonstrates the important role of LZTS3 in colorectal cancer, shedding light on its tumor-suppressing function and the underlying molecular mechanism.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Review
Cell Biology
Abdellah Akil, Ana K. Gutierrez-Garcia, Rachael Guenter, J. Bart Rose, Adam W. Beck, Herbert Chen, Bin Ren
Summary: The Notch signaling pathway is crucial in determining the fate of vascular endothelial cells, angiogenesis, and tumor progression, particularly in the development of CSCs and therapeutic resistance. Cross-talk between Notch pathway and other signaling pathways plays a vital role in promoting various aspects of tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Po- Liu, An-Chen Chang, Jiun-Lin Lai, Tien-Huang Lin, Chun-Hao Tsai, Po-Chun Chen, Ya-Jing Jiang, Liang-Wei Lin, Wei-Chien Huang, Shun-Fa Yang, Chih-Hsin Tang
Summary: Melatonin has shown potential in treating bone metastases by directly affecting osteoclast differentiation and activity, promoting osteoclast apoptosis, and regulating cancer cell-associated osteoclast differentiation through signaling pathways. In animal models, melatonin treatment reduced tumor volume and osteolytic lesions, highlighting its promise as a therapeutic option for bone metastases.
Article
Neurosciences
Renzheng Huan, Jianhe Yue, Jinhai Lan, Jia Wang, Yuan Cheng, Jiqin Zhang, Ying Tan
Summary: In this study, the multifunctional neuropeptide hypocretin-1 was found to inhibit glioblastoma proliferation, migration, and invasion, and induce apoptosis through the NOTCH signaling pathway. These findings suggest that hypocretin-1 could be a potential therapeutic agent for glioblastoma treatment.
BRAIN RESEARCH BULLETIN
(2023)
Article
Cell Biology
Hao Yan, Liangsong Zhu, Jin Zhang, Zongming Lin
Summary: The study found that high expression of KDM4D in ccRCC is associated with lower overall survival rates and higher pathological grades, promoting tumor growth by influencing genes related to vessel morphogenesis. It was also revealed that KDM4D can interact directly with the JAG1 gene promoter to advance tumor angiogenesis.
CELL DEATH DISCOVERY
(2021)
Article
Oncology
Mary E. Vail, Rae H. Farnsworth, Linda Hii, Stacey Allen, Sakshi Arora, Robin L. Anderson, Ross A. Dickins, Akira Orimo, Sunny Z. Wu, Alexander Swarbrick, Andrew M. Scott, Peter W. Janes
Summary: We have identified the cell guidance receptor EphA3 on distinct stromal/fibroblast-like cell types in the tumour microenvironment (TME) that promote growth and angiogenesis. Knockdown of EphA3 expression in the TME reduced mesenchymal stromal/fibroblast-like cells in tumours, with corresponding reductions in tumour vasculature and tumour growth, and increased immune infiltrate. Our results highlight the potential of EphA3 as a therapeutic target for tumour angiogenesis and tumour growth.
Article
Cardiac & Cardiovascular Systems
Hiroki Tanaka, Baohui Xu, Haojun Xuan, Yingbin Ge, Yan Wang, Yankui Li, Wei Wang, Jia Guo, Sihai Zhao, Keith J. Glover, Xiaoya Zheng, Shuai Liu, Kazunori Inuzuka, Naoki Fujimura, Yuko Furusho, Toru Ikezoe, Takahiro Shoji, Lixin Wang, Weiguo Fu, Jianhua Huang, Naoki Unno, Ronald L. Dalman
Summary: Interleukin-19, an immunosuppressive cytokine, was found to be upregulated in both human and experimental abdominal aortic aneurysms (AAAs). Treatment with interleukin-19 suppressed aneurysm formation and progression in mice, while downregulating the expression of various inflammatory mediators. This suggests that interleukin-19 may play a significant role in the development and progression of AAAs.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Meicen Zhou, Wenbao Lu, Bingwei Li, Xiaochen Yuan, Mingming Liu, Jianqun Han, Xueting Liu, Ailing Li
Summary: Roquin2 is identified as a novel breast cancer suppressor that inhibits tumor angiogenesis by selectively downregulating the expression of proangiogenic genes. Overexpression of Roquin2 can inhibit breast tumor-induced angiogenesis, while silencing Roquin2 enhances tumor angiogenesis. In vivo induction of Roquin2 significantly suppresses breast tumor growth, metastasis, and angiogenesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Pathology
Min-Jung Kang, Soovin Lee, Usuk Jung, Chanchal Mandal, Heekyung Park, William G. Stetler-Stevenson, Young-Sik Kim, Ji Wook Moon, Sun-Hwa Park, Junseo Oh
Summary: The study demonstrated that the inhibitor R-III could effectively reduce tumor angiogenesis and growth induced by HSCs, providing a promising therapeutic strategy for liver fibrosis-related tumor progression.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Selvaraj Vimalraj
Summary: Angiogenesis is the formation of new blood vessels from existing ones. Abnormal angiogenesis, seen in tumor microenvironments, is characterized by distorted and leaky blood vessels with various shapes and high perfusion efficiency. Tumor angiogenesis plays a crucial role in cancer growth, invasion, and metastasis, and is tightly regulated by signaling networks. Targeting multiple signaling pathways involved in angiogenesis is important for effective antiangiogenic therapy. New therapeutic approaches, such as blocking specific proteins or genes, are being explored to dissect alternative angiogenesis mechanisms in tumor microenvironments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Cell Biology
Ruonan Wang, Ziyan Yang, Liang Liang, Xingxing Feng, Bo Che, Xiaoyan Zhang, Qijun Zheng, Xianchun Yan, Hua Han
Summary: This study demonstrates that Notch signaling regulates endothelial cell migration and sprouting through miR-223-3p and Fbxw7. Upregulation of miR-223-3p inhibits endothelial cell migration, leading to impaired lumen formation and sprouting in angiogenesis. Furthermore, miR-223-3p regulates the expression of multiple genes involved in axon guidance, extracellular matrix remodeling, and angiogenesis. These findings provide new insights into the downstream mechanisms of Notch signaling in angiogenesis.
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2022)
Article
Oncology
Eun-Jin Go, Hannah Yang, Seung Joon Lee, Hyun Gul Yang, Jin A. Shin, Won Suk Lee, Hye Seong Lim, Hong Jae Chon, Chan Kim
Summary: PB101 inhibits tumor growth by suppressing angiogenesis and enhancing CD8+ T cell infiltration into the tumors. It also synergizes with anti-PD-L1 to trigger strengthened antitumor immunity, providing a potential treatment option for advanced cancers.
Article
Neurosciences
Zongwei Yue, Isaac G. Freedman, Peter Vincent, John P. Andrews, Christopher Micek, Mark Aksen, Reese Martin, David Zuckerman, Quentin Perrenoud, Garrett T. Neske, Lim-Anna Sieu, Xiao Bo, Jessica A. Cardin, Hal Blumenfeld
Article
Clinical Neurology
Sujatha Sankaran, John P. Andrews, Madeline Chicas, Robert M. Wachter, Mitchel S. Berger
JOURNAL OF NEUROSURGERY
(2020)
Article
Orthopedics
Lynn Ann Forrester, Lauren J. Seo, Leah J. Gonzalez, Caixia Zhao, Scott Friedlander, Alice Chu
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2020)
Article
Clinical Neurology
Edward F. Chang, Garret Kurteff, John P. Andrews, Robert G. Briggs, Andrew K. Conner, James D. Battiste, Michael E. Sughrue
Editorial Material
Orthopedics
Nana O. Sarpong, Lynn Ann Forrester, William N. Levine
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2020)
Article
Neurosciences
Jingwen Xu, Maria Milagros Galardi, Brian Pok, Kishan K. Patel, Charlie W. Zhao, John P. Andrews, Shobhit Singla, Cian P. McCafferty, Li Feng, Eric T. Musonza, Adam J. Kundishora, Abhijeet Gummadavelli, Jason L. Gerrard, Mark Laubach, Nicholas D. Schiff, Hal Blumenfeld
JOURNAL OF NEUROSCIENCE
(2020)
Editorial Material
Clinical Neurology
John P. Andrews, Andrew K. Chan, Praveen V. Mummaneni
OPERATIVE NEUROSURGERY
(2021)
Review
Clinical Neurology
John P. Andrews, Rushikesh S. Joshi, Matheus P. Pereira, Taemin Oh, Alexander F. Haddad, Kaitlyn M. Pereira, Robert C. Osorio, Kevin C. Donohue, Zain Peeran, Sweta Sudhir, Saket Jain, Angad Beniwal, Ashley S. Chopra, Narpal S. Sandhu, Tarik Tihan, Lewis Blevins, Manish K. Aghi
Summary: This study reviewed clinical data on PP1 and SS3 adenomas, finding that PP1 tumors are not necessarily more aggressive than non-PP1 tumors. Further research is needed to identify consistently more clinically aggressive subtypes of pituitary adenomas.
WORLD NEUROSURGERY
(2021)
Article
Orthopedics
Kyle L. McCormick, Liana J. Tedesco, Hasani W. Swindell, Lynn Ann Forrester, Charles M. Jobin, William N. Levine
Summary: The study evaluated the statistical robustness of clinical trials regarding shoulder arthroplasty using the Fragility Index and found that most outcomes had a Fragility Index smaller than the number of patients lost to follow-up, with the majority of outcomes being statistically insignificant.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2021)
Article
Orthopedics
Sean Haimowitz, Jacob Veliky, Lynn Ann Forrester, Joseph Ippolito, Kathleen Beebe, Alice Chu
Summary: This study investigates the role of subspecialty and demographic factors in research productivity and academic advancement among orthopaedic surgeons. The findings suggest that subspecialty selection is associated with academic rank and research productivity, and female surgeons have lower research productivity compared to their male counterparts.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Article
Orthopedics
Lynn Ann Forrester, Fei Fang, Timothy Jacobsen, Yizhong Hu, Iden Kurtaliaj, Benjamin D. Roye, X. Edward Guo, Nadeen O. Chahine, Stavros Thomopoulos
Summary: By studying a mouse model of transient neonatal shoulder paralysis, it was found that a brief period of paralysis in early life could lead to early signs of osteoarthritis in adult cartilage and bone.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Clinical Neurology
John P. Andrews, Nathan Cahn, Benjamin A. Speidel, Jason E. Chung, Deborah F. Levy, Stephen M. Wilson, Edward F. Chang, Mitchel S. Berger
Summary: This study examined the neuroanatomical areas most likely to result in Broca's aphasia following surgical lesions. The results showed that Broca's aphasia is typically associated with resections of the ventral sensorimotor cortex and supramarginal gyri. The fluency scores were negatively correlated with the resected components of these areas.
JOURNAL OF NEUROSURGERY
(2023)
Review
Sport Sciences
Ahmad F. Bayomy, Lynn Ann Forrester, Stephen G. Crowley, Charles A. Popkin
Summary: The use of eponyms in orthopedics literature has been criticized, but understanding these terms can lead to informed application in scientific discourse, patient care, and medical education, potentially promoting future innovation and research in pediatric orthopedic pathologies.
OPEN ACCESS JOURNAL OF SPORTS MEDICINE
(2021)
Article
Orthopedics
Lynn Ann Forrester, Eugene Jang, Michelle M. Lawson, Ana Capi, Wakenda K. Tyler
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS GLOBAL RESEARCH AND REVIEWS
(2020)
Article
Clinical Neurology
John P. Andrews, Michael McDermott, Line Jacques
INTERDISCIPLINARY NEUROSURGERY-ADVANCED TECHNIQUES AND CASE MANAGEMENT
(2020)