Review
Endocrinology & Metabolism
Li-Mei Li, Bei-Ge Jiang, Liang-Liang Sun
Summary: Diabetes is a highly heterogeneous metabolic disease with different types and clinical manifestations. Distinguishing between types and defining subtypes is a major challenge in precise treatment. T2D is the main type of diabetes, and certain gene variants have been shown to increase the risk of T2D. HNF1 alpha gene mutations can cause different types of diabetes and exhibit high polymorphism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jorge Valencia-Ortega, Renata Saucedo, Martha A. Sanchez-Rodriguez, Jose G. Cruz-Duran, Edgar G. Ramos Martinez
Summary: Gestational diabetes mellitus is the most common metabolic complication in pregnancy, involving various factors in its pathophysiology. Studies have observed that alterations in DNA methylation patterns and certain microRNA levels are related to the disease characteristics, highlighting the need for further research in this area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Yan Xie, Wenni Zhou, Xiang Tao, Hui Lv, Zhongping Cheng
Summary: This study investigated plasma proteins in gestational diabetes mellitus (GDM) patients to identify predictive markers for the development of preeclampsia (PE). The levels of soluble transferrin receptor (sTfR), ceruloplasmin (CP) and apolipoprotein E (ApoE) in plasma were found to have potential clinical applications for early screening.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Multidisciplinary Sciences
Ugochinyere Vivian Ukah, Robert W. Platt, Nathalie Auger, Kaberi Dasgupta, Natalie Dayan
Summary: This study developed a prediction model for type 2 diabetic complications in patients with gestational diabetes mellitus (GDM) using administrative data from Quebec, Canada. The model includes multiple factors and shows moderate accuracy and the ability to identify high-risk patients.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Dominik Franciszek Dluski, Ewa Wolinska, Maciej Skrzypczak
Summary: Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance that appears or is diagnosed for the first time during pregnancy. Studies have shown that GDM can impact both pregnancy and offspring development, leading to long-term adverse health outcomes. Epigenetic changes such as histone modification, DNA methylation, and altered ncRNA function, including miRNAs, play a role in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Olimpia Mora-Janiszewska, Anna Faryniak-Zuzak, Dorota Darmochwal-Kolarz
Summary: Gestational diabetes mellitus (GDM) is a significant global problem that induces diabetogenic and obesogenic changes in an offspring's DNA through epigenetic mechanisms. Alterations in microbiota play a crucial role in this process. Identification of specific epigenetic marks may provide key solutions for personalized medicine. This manuscript summarizes available data on epigenetic changes among women with GDM and their offspring, in relation to microbiome alterations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Gareth W. Davison, Rachelle E. Irwin, Colum P. Walsh
Summary: The prevalence of type 2 diabetes continues to rise globally. Lifestyle factors such as poor dietary intake and lack of exercise may contribute to disease onset and progression. Metabolic connections and epigenetic alterations play a crucial role in regulating DNA methylation and gene transcription in the context of type 2 diabetes.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Endocrinology & Metabolism
Mary Diaz-Santana, Katie M. O'Brien, Yong-Moon Mark Park, Dale P. Sandler, Clarice R. Weinberg
Summary: This study found that a history of gestational diabetes mellitus, whether occurring once or multiple times, significantly increases the risk of developing type 2 diabetes. The risk increases steeply with each additional affected pregnancy, and although it attenuates over time after the affected pregnancies, it remains elevated for >35 years.
Article
Endocrinology & Metabolism
Mary V. Diaz-Santana, Katie M. O'Brien, Yong-Moon Mark Park, Dale P. Sandler, Clarice R. Weinberg
Summary: Gestational diabetes mellitus is strongly associated with an increased risk of type 2 diabetes, and this risk persists for over 35 years. The risk of type 2 diabetes is higher with each additional pregnancy affected by gestational diabetes mellitus, and the association weakens over time.
Article
Public, Environmental & Occupational Health
Shih-Chun Pan, Ching-Chun Huang, Bing-Yu Chen, Wei-Shan Chin, Yue Leon Guo
Summary: This study aimed to determine whether air pollutants modify the effects of gestational diabetes mellitus (GDM) on the occurrence of diabetes mellitus (DM). The results showed that exposure to high levels of PM2.5 and O-3 increases the risk of DM, and GDM acts synergistically with PM2.5 exposure in DM development.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Endocrinology & Metabolism
Yujin Shin, Joon Ho Moon, Tae Jung Oh, Chang Ho Ahn, Jae Hoon Moon, Sung Hee Choi, Hak Chul Jang
Summary: This study suggests that higher postpartum muscle mass is associated with a lower risk of prediabetes and type 2 diabetes in Korean women with gestational diabetes mellitus. This association was observed in normal weight women but not in overweight women.
DIABETES & METABOLISM JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Agostino Milluzzo, Andrea Maugeri, Martina Barchitta, Laura Sciacca, Antonella Agodi
Summary: Observational studies have shown that epigenetics play a role in the development of type 2 diabetes retinopathy (T2DR), with miRNA, lnc-RNA, and DNA methylation being involved. However, the use of epigenetic markers in diagnosing and staging T2DR faces challenges, requiring further targeted investigations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nutrition & Dietetics
Ester Vitacolonna, Maria Masulli, Luisa Palmisano, Liborio Stuppia, Marica Franzago
Summary: This review clarifies the effects of various inositol and probiotic supplements in the prevention and treatment of gestational diabetes (GDM). It also discusses the epigenetic aspects of probiotic intervention and the potential implications of these findings in guiding appropriate supplementation regimens during pregnancy.
Review
Biochemistry & Molecular Biology
Lukasz Ustianowski, Jakub Udzik, Joanna Szostak, Anna Goracy, Klaudia Ustianowska, Andrzej Pawlik
Summary: This narrative review discusses the role of genetic and epigenetic factors in the pathogenesis of gestational diabetes mellitus (GDM) and explores the risk factors of GDM, including obesity, advanced maternal age, and polycystic ovary syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Pandora L. Wander, Costas A. Christophi, Maria Rosario G. Araneta, Edward J. Boyko, Daniel A. Enquobahrie, Dana Dabelea, Ronald B. Goldberg, Steven E. Kahn, Catherine Kim, Xavier Pi-Sunyer, William C. Knowler
Summary: This study found associations between adiposity and adiposity-related biomarkers with incident type 2 diabetes among parous women, including positive associations of alanine aminotransferase and VAT, and an inverse association with adiponectin. Leptin showed different effects on T2D risk in women with and without a history of gestational diabetes mellitus.
Letter
Endocrinology & Metabolism
Alicia R. Jones, Peter R. Ebeling, Helena Teede, Frances Milat, Amanda J. Vincent
CLINICAL ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Micheal O. Breasail, Camille Pearse, Ayse Zengin, Landing Jarjou, Cyrus Cooper, Peter R. Ebeling, Ann Prentice, Kate A. Ward
Summary: This study aimed to describe musculoskeletal aging in Gambian adults. The results showed bone loss in all sites and a faster rate of loss in women in some indicators. Therefore, musculoskeletal health is an important challenge for resource-limited countries.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
Alexander H. Seeto, Mina Tadrous, Abadi K. Gebre, Joshua R. Lewis, Howard A. Fink, Peter R. Ebeling, Alexander J. Rodriguez
Summary: The study conducted a network meta-analysis to evaluate cardiovascular adverse events of osteoporosis medications in postmenopausal women. It found that abaloparatide, oral bisphosphonates, teriparatide, and menopausal hormone therapy were less likely to increase the risk of CAEs compared to placebo, while romosozumab was more likely to have an increased risk.
Article
Nutrition & Dietetics
Aninda Rahman, Mary Waterhouse, Catherine Baxter, Briony Duarte Romero, Donald S. A. McLeod, Bruce K. Armstrong, Peter R. Ebeling, Dallas R. English, Gunter Hartel, Michael G. Kimlin, Rachel O'Connell, Jolieke C. van der Pols, Alison J. Venn, Penelope M. Webb, David C. Whiteman, Rachel E. Neale
Summary: Observational studies suggest an inverse association between 25-hydroxy vitamin D (25(OH)D) concentration and pain, but intervention trials have inconsistent findings. In this large placebo-controlled trial, vitamin D supplementation with 60000 IU of vitamin D-3/month had negligible effect on bodily pain.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Computer Science, Interdisciplinary Applications
Enhao Zhang, Saeed Miramini, Minoo Patel, Martin Richardson, Peter Ebeling, Lihai Zhang
Summary: Mechanical stability is crucial for fracture healing process as excessive interfragmentary movement may lead to persistent and enhanced inflammatory response. The impact of mechanical instability on inflammation in diabetic condition is relatively limited. This study presents a numerical model to investigate the role of mechanical stability in inflammatory response during early stage of healing.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Nutrition & Dietetics
Jakub Mesinovic, Alexander J. Rodriguez, Mavil May Cervo, Anoohya Gandham, Cecilia L. H. Xu, Costas Glavas, Barbora de Courten, Ayse Zengin, Peter R. Ebeling, David Scott
Summary: This study aimed to investigate the effects of vitamin D supplementation on physical function, body composition, and metabolic health in overweight and obese older adults. The results showed that vitamin D supplementation had no significant effects on most physical function, body composition, and metabolic health parameters, but it improved stair climb times and waist circumference during exercise. Future research should explore the effects of vitamin D on muscle power and body composition in populations with vitamin D deficiency.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Endocrinology & Metabolism
Elisabeth Ng, Claudia Ashkar, Ego Seeman, Hans G. Schneider, Hanh Nguyen, Peter R. Ebeling, Shoshana Sztal-Mazer
Summary: This study found that a certain percentage of patients in osteoporosis clinics, hospital patients, and atypical femoral fracture patients had low serum alkaline phosphatase (ALP) levels. Low ALP can be a screening tool for hypophosphatasia, a condition that may be aggravated by antiresorptive therapy.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Ayse Zengin, Micheal O. Breasail, Camille M. Parsons, Landing M. Jarjou, Ramatoulie E. Janha, Modou Jobe, Ann Prentice, Cyrus Cooper, Peter R. Ebeling, Kate A. Ward
Summary: This study investigated the sex differences in associations between cardiac workload, arterial stiffness, peripheral vascular calcification (PVC) and physical function in Gambian adults. The results revealed significant differences between men and women in these associations, with the differences partly mediated by fat mass index.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Endocrinology & Metabolism
Wei Zhou, Jeroen G. J. van Rooij, Denise M. van de Laarschot, Zografia Zervou, Hennie Bruggenwirth, Natasha M. Appelman-Dijkstra, Peter R. Ebeling, Serwet Demirdas, Annemieke J. M. H. Verkerk, M. Carola Zillikens
Summary: A study in the Netherlands found that atypical femur fractures (AFFs) can occur in patients with monogenic bone disorders, even without bisphosphonate use. The study revealed that approximately 25% of AFF patients had clinical features of monogenic bone disorders, including osteogenesis imperfecta and hypophosphatasia. These findings highlight the importance of careful clinical evaluation in AFF patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Editorial Material
Endocrinology & Metabolism
Peter R. Ebeling
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
Alex Shoung, Nicholas Shoung, Rachael Hii, Nitesh Nerlekar, Peter R. Ebeling, Alexander J. Rodriguez
Summary: Bisphosphonates are commonly used for bone and mineral disorders, but their potential impact on electrical disturbances in the heart is uncertain. This study reviewed the literature on electrocardiogram findings in patients receiving intravenous bisphosphonates and found a weak association between bisphosphonate infusion and prolonged QTc interval. However, there is insufficient evidence to support a link between bisphosphonates and other ECG changes that could lead to atrial fibrillation.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Medicine, General & Internal
Rebekah Jane Moles, Lin Perry, Justine M. Naylor, Jacqueline Center, Peter Ebeling, Gustavo Duque, Gabor Major, Christopher White, Christopher Yates, Matthew Jennings, Mark Kotowicz, Thach Tran, Dana Bliuc, Lei Si, Kathryn Gibson, Benjamin Joseph Basger, Patrick Bolton, Stephen Barnett, Geraldine Hassett, Ayano Kelly, Barbara Bazarnik, Wafaa Ezz, Kate Luckie, Stephen Ross Carter
Summary: This paper describes a protocol for a randomized controlled trial to determine the efficacy of a home medication review (HMR) service for patients who have sustained minimal trauma fractures (MTFs). The trial will evaluate the impact of the HMR service on patients' intake of sedative/anticholinergic drugs, adherence to antiosteoporosis medications, and other secondary outcomes.
Article
Endocrinology & Metabolism
Tomasz J. Block, Cat Shore-Lorenti, Roger Zebaze, Peter G. Kerr, Anna Kalff, Andrew Charles Perkins, Peter R. Ebeling, Frances Milat
Summary: This case describes a young man who presented with severe osteoporosis and deranged bone microarchitecture causing multiple fractures. Genetic testing revealed a pathogenic variant in the RUNX1 gene, which is known to play a key role in bone development and homeostasis. This highlights the importance of considering rare causes of osteoporosis in young patients with unexplained fractures.
Review
Endocrinology & Metabolism
Lisa Grech, Kiran Laurence, Peter R. Ebeling, Marc Sim, Ayse Zengin
Summary: People with multiple sclerosis are at a higher risk of osteoporosis, falls, and fractures. However, current guidelines for osteoporosis prevention, screening, diagnosis, and management in this population are inadequate.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Review
Endocrinology & Metabolism
Andrea Giustina, Roger Bouillon, Bess Dawson-Hughes, Peter R. Ebeling, Marise Lazaretti-Castro, Paul Lips, Claudio Marcocci, John P. Bilezikian
Summary: This paper presents the findings of the 5th International Conference Controversies in Vitamin D held in Italy. The conference aimed to discuss the relationship between Vitamin D and aging. The results indicate that vitamin D deficiency can lead to various skeletal and extra-skeletal outcomes, and older adults are at a higher risk due to factors such as reduced sun exposure. Strategies to prevent negative outcomes include sun exposure, food fortification, and supplementation. The most effective and practical strategy for the aging population is vitamin D supplementation.
