期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 101, 期 2, 页码 714-722出版社
ENDOCRINE SOC
DOI: 10.1210/jc.2015-3437
关键词
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资金
- National Institutes of Health [K23-DK093713, RC1-DK086918, R56-DK095451, P30-DK036836]
- Harvard Catalyst and The Harvard Clinical and Translational Science Center (National Center for Research Resources)
- Harvard Catalyst and The Harvard Clinical and Translational Science Center (National Center for Advancing Translational Sciences) [8UL1TR000170-05]
- Harvard Catalyst and The Harvard Clinical and Translational Science Center (KL2/MeRIT Program Award) [UL1 RR 025758]
- Harvard Catalyst and The Harvard Clinical and Translational Science Center (Harvard University and its affiliated academic healthcare centers)
- Joslin Clinical Research Center
- Marietta Blau Grant from the Osterreichischer Austausdienst [ICM-2010-02797]
- Herbert Graetz Fund
- Covidien
- Lifescan, a division of Johnson and Johnson
- Nestle
- NovoNordisk
- NNF Center for Basic Metabolic Research [Holst Group] Funding Source: researchfish
Context: Roux-en-Y gastric bypass (RYGB) leads to high-turnover bone loss, but little is known about skeletal effects of laparoscopic adjustable gastric banding (LAGB) or mechanisms underlying bone loss after bariatric surgery. Objective: To evaluate effects of RYGB and LAGB on fasting and postprandial indices of bone remodeling. Design and Setting: Ancillary investigation of a prospective study at 2 academic institutions. Participants: Obese adults aged 21-65 years with type 2 diabetes who underwent RYGB (n = 11) or LAGB (n = 8). Outcomes: Serum C-terminal telopeptide (CTX), procollagen type 1 N-terminal propeptide (P1NP), and PTH were measured during a mixed meal tolerance test at baseline, 10 days and 1 year after surgery. Changes in 25-hydroxyvitamin D, polypeptide YY (PYY), glucagon-like peptide-1, glucose-dependent insulinotropic peptide, and insulin were also assessed. Results: Fasting CTX increased 10 days after RYGB but not LAGB (+69 +/- 23% vs +12 +/- 12%, P < .001), despite comparable weight loss at that time. By 1 year, fasting CTX and P1NP increased more after RYGB than LAGB (CTX +221 +/- 60% vs +15 +/- 6%, P < 0.001; P1NP +93 +/- 25% vs -9 +/- 10%, P < .001) and weight loss was greater with RYGB. Changes in CTX were independent of PTH and 25-hydroxyvitamin D but were associated with increases in fasting PYY. Postprandial suppression of CTX was more pronounced after RYGB than LAGB at 10 days and 1 year postoperatively. Conclusions: RYGB is accompanied by early increases in fasting indices of bone remodeling, independent of weight loss or changes in PTH or 25-hydroxyvitamin D. LAGB did not affect bone markers. PYY and other enterohormonal signals may play a role in RYGB-specific skeletal changes.
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