Article
Biochemical Research Methods
Qianying Sheng, Ling Wang, Leyuan Zhang, Xue Wang, Shengxu Qian, Minbo Lan, Guangyan Qing, Xinmiao Liang
Summary: Natural products are complex samples that contain a wide range of compounds. Effective analytical techniques are essential for understanding and controlling the quality of these products. This study proposes a design concept of bidirectional fi-cyclodextrin (fi-CD)-modified chromatographic stationary phase for the separation of bufadienolides extracted from toad. The fi-CD-based stationary phase can be used for both hydrophilic interaction liquid chromatography (HILIC) and reversed-phase liquid chromatography (RPLC), enabling high-efficiency two-dimensional separation of bufadienolides.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Chemistry, Analytical
Carla Orlandi, Carine Jacques, Helene Duplan, Laurent Debrauwer, Emilien L. Jamin
Summary: Liquid chromatography-mass spectrometry (LC-MS)-based metabolomics often requires separate workflows for hydrophilic interaction liquid chromatography (HILIC) and reversed-phase (RP) chromatography, resulting in substantial sample consumption and analysis time. We developed an integrated workflow that combines HILIC and RP separations using heart-cutting trapping, allowing the coverage of both polar and nonpolar metabolites with a single sample injection for each ionization mode. This approach traps certain compounds from the first chromatographic dimension for later separation in the second dimension, reducing overall analysis time and avoiding signal measurements during the solvent front. Applying this approach to the analysis of human plasma, we were able to detect hundreds of metabolites with minimal sample consumption.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Carla Orlandi, Carine Jacques, Helene Duplan, Laurent Debrauwer, Emilien L. Jamin
Summary: We developed an integrated workflow combining hydrophilic interaction liquid chromatography (HILIC) and reversed-phase (RP) chromatography to cover polar and nonpolar metabolites with only one sample injection. This approach involves trapping compounds eluted from the first chromatographic dimension for later separation in the second dimension. Through optimization of chromatographic and ionization conditions, we developed two independent miniaturized one-dimensional HILIC and RP methods, which were then merged into a two-dimensional micro LC-MS method by optimizing the trapping conditions. This approach reduces analysis time and allows for the detection of hundreds of metabolites without significant loss.
ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Analytical
Eliise Tammekivi, Christophe Geantet, Chantal Lorentz, Karine Faure
Summary: This review summarizes the studies published since 2010 on the utilization of gas chromatography (GC) or liquid chromatography (LC) as one dimension in two-dimensional (2D) chromatographic analysis for characterizing and monitoring the valorization processes of various biowastes. The article highlights the challenges and prospects of using 2D chromatography for analyzing polar, poorly volatile, and thermally unstable compounds in biowastes. The different 2D setups used for monitoring biowaste conversion processes are also discussed.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Yu-Ping Yang, Ji-Kai Chen, Ping Guo, Yan-Rui Lu, Cai-Fang Liu, Bang-Jin Wang, Jun-Hui Zhang, Sheng-Ming Xie, Li-Ming Yuan
Summary: A spherical chiral porous organic polymer (POPs) COP-1 was synthesized and used as a novel chiral stationary phase (CSPs) for mixed-mode high-performance liquid chromatography (HPLC) enantioseparation. The COP-1-packed column exhibited excellent separation performance and showed good chiral recognition complementarity with other columns.
Article
Chemistry, Applied
Wu Li, Junhong Huang, Lin Zheng, Wanshun Liu, Liqi Fan, Baoguo Sun, Guowa Su, Jucai Xu, Mouming Zhao
Summary: This study designed and constructed a fast stop-flow two-dimensional liquid chromatography tandem mass spectrometry system for the research of bioactive peptides in food-derived protein hydrolysates. The optimized system showed high efficiency in peptide separation and identification. This will contribute to the understanding of peptide composition and facilitate the exploration of bioactive peptides in food-derived protein hydrolysates.
Article
Chemistry, Analytical
Zhanpeng Shang, Yungang Tian, Ming Xiong, Yang Yi, Xue Qiao, Yanfang Yang, Min Ye
Summary: In this study, an efficient strategy using offline two-dimensional liquid chromatography/mass spectrometry (2DLC/MS) coupled with mass defect filter (MDF) technology was established to systematically characterize prenylated phenolics in Glycyrrhiza uralensis. By investigating the tandem mass spectrometry fragmentation features and purifying compounds for structural verification, the prenylation types of a large number of prenylated phenolics in G. uralensis were rapidly characterized.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Chemistry, Analytical
Lucile Lecas, Sylvie Nuccio, Rene de Vaumas, Karine Faure
Summary: Quil-A is a purified extract of saponins with strong immunoadjuvant activity, often used as a totum of the Quillaja Saponaria bark extract. Quality control is based on monitoring specific saponins, but a reference fingerprint with comprehensive two-dimensional liquid chromatography offers rapid detection of nonconform samples. Different chromatography methods were optimized to provide insights into sample degradation and specific loss of components.
JOURNAL OF SEPARATION SCIENCE
(2021)
Article
Chemistry, Applied
Jing Wang, Yang Zhao, Yang Yang, Xin Chen, Yu Jin, Yanxiong Ke
Summary: In this study, hydrophilic interaction liquid chromatography (HILIC) methods and a two-dimensional reversed-phase liquid chromatography/HILIC (2D-RPLC/HILIC) for the separation of steviol glycosides (SGs) were developed. The PA column exhibited superior hydrophilicity, higher selectivity, and better resolution. HILIC-UV methods with water/acetonitrile or water/ethanol as elution systems were developed for the separation of SGs. The preparative separation of minor SGs from stevia extracts was successfully achieved using 2D-RPLC/HILIC.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Environmental Sciences
Jinjian Zhong, Xin Liu, Linzhou Chen, Kan Li, Qingkun Hu, Ke Wu, Jidan Zhou, Yuesen Shi, Huajun Fan
Summary: A novel method using online heart-cutting two-dimensional liquid chromatography (2D-LC) coupled to solid-phase extraction (SPE) was developed for simultaneous separation and detection of chiral antidepressants in wastewater matrix. The method achieved complete enantioseparation and satisfactory transformation between 2D-LCs. The three analytes, namely mirtazapine, bupropion, and fluoxetine, showed good linearity and low LOD and LOQ values. The method was successfully applied to determine the racemates and enantiomers of these antidepressants in wastewater samples, providing an efficient approach for pollution assessment and illicit drug control.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Sylwia Studzinska, Feiyang Li, Michal Szumski, Boguslaw Buszewski, Michael Laemmerhofer
Summary: The aim of this research was to develop a simple and efficient ion-pair reagent-free chromatographic method for the separation and qualitative determination of oligonucleotide impurities. The optimized method included the application of cholesterol stationary phase, with mobile phase containing 20 mM ammonium formate (pH 6.5) and methanol, allowing good separation and identification of most impurities within 25 min.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Liana S. Roca, Andrea F. G. Gargano, Peter J. Schoenmakers
Summary: Bottom-up proteomics often deals with small amounts of complex samples that cannot be directly analyzed by mass spectrometry. To better understand sample composition, liquid chromatography (LC) and two-dimensional liquid chromatography (2D-LC) can be combined with mass spectrometry. In this study, a low-flow, actively modulated LC x LC system was developed to separate complex peptide mixtures, allowing for efficient analysis of small sample amounts and improved peak capacity compared to one-dimensional separation.
ANALYTICA CHIMICA ACTA
(2021)
Review
Chemistry, Analytical
Samuel W. Foster, Deklin Parker, Sangeeta Kurre, John Boughton, Dwight R. Stoll, James P. Grinias
Summary: Multi-dimensional liquid chromatography techniques are important for analyzing complex mixtures. The use of D-2 parallel column arrays allows for increased separation times and peak capacities without reducing the sampling rate. This method can also reduce total analysis time and increase complementarity.
ANALYTICA CHIMICA ACTA
(2022)
Article
Biochemical Research Methods
Matthew J. Sorensen, Kelsey E. Miller, James W. Jorgenson, Robert T. Kennedy
Summary: In this study, a two-dimensional liquid chromatography-mass spectrometry method was developed for lipidomics analysis of human plasma. The method achieved good orthogonality and high peak capacity, and detected over 1000 lipids from a small amount of plasma sample.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Chemistry, Physical
Abdus Salam Sarkar, Emmanuel Stratakis
Summary: The exfoliation and dispersion behavior of Germanium (II) monosulfide (GeS) and Tin (II) monosulfide (SnS) nanosheets in various organic solvents were investigated, resulting in significant yields of isolated GeS and SnS flakes in 2-propanol and N-Methyl-2-pyrrolidone. The isolated flakes are few-layer nanosheets suitable for scalable solution processable printed electronic device applications.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Keke Gao, Rui Xu, Yunxiang Chen, Zongtao Zhang, Jiashuo Shao, Haipeng Ji, Liying Zhang, Shasha Yi, Deliang Chen, Junhua Hu, Yanfeng Gao
Summary: The paper presents a strategy to enhance the electrochemical properties of lithium-sulfur batteries by using TiO2-carbon nanocomposites embedded hierarchical porous carbon interlayers. The interlayers effectively immobilize polysulfides and improve the redox reaction kinetics, resulting in improved battery performance.
CHINESE CHEMICAL LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Yue-Ju Yang, Shi-Xiong Li, De-Liang Chen, Zheng-Wen Long
Summary: This theoretical research investigates the structural evolution, electronic properties, and photoelectron spectra of selenium-doped boron clusters SeBn0/- (n = 3-16) using particle swarm optimization (CALYPSO) software and density functional theory calculations. The results show that the lowest energy structures of SeBn0/- (n = 3-16) clusters tend to be quasi-planar or planar. The addition of a Se atom modifies and improves some of the pure boron cluster structures. The research enriches the geometrical structures of small doped boron clusters and provides insights for boron-based nanomaterials.
Article
Environmental Sciences
Jintao Zhang, Qinglong You, Guoyu Ren, Safi Ullah, Inom Normatov, Deliang Chen
Summary: Changes in thermal comfort conditions due to global warming have unequal impacts on different regions based on income levels, with high-income regions experiencing an improvement while low-income regions are expected to worsen. The overall impact on the global population is negative, highlighting the need for prioritized support for climate mitigation and adaptation in developing nations.
Article
Environmental Sciences
Li -Jun Fan, Zhong-Wei Yan, Deliang Chen, Zhen LI
Summary: Central Asia is highly sensitive and vulnerable to changes in precipitation due to global warming. In this study, a statistical downscaling model based on quantile delta mapping was used to assess and project precipitation extremes in the region. The model effectively reduced biases and adjusted the distributional biases in the downscaled daily precipitation and indices, and accurately captured the spatial patterns of observed precipitation indices.
ADVANCES IN CLIMATE CHANGE RESEARCH
(2023)
Article
Environmental Sciences
Lorenzo Minola, Jessika Lonn, Cesar Azorin-Molina, Chunlue Zhou, Erik Engstrom, Lennart Wern, Sverker Hellstrom, Gangfeng Zhang, Cheng Shen, Alessandro Pezzoli, Deliang Chen
Summary: This study examines the long-term variability of wind speed in Sweden since 1926. The results show distinct phases of change, including slowdowns and stabilization periods. Three reanalysis products are evaluated for their ability to simulate past wind variations, and it is found that large-scale atmospheric circulation patterns play a significant role in driving the low-frequency variability. However, changes in factors such as surface roughness are crucial for explaining periods of strong terrestrial stilling.
Article
Forestry
Cong Gao, Chunming Shi, Yuxin Lou, Ran An, Cheng Sun, Guocan Wu, Yuandong Zhang, Miaogen Shen, Deliang Chen
Summary: To reconstruct the past Arctic temperature variations, the authors screened 1116 tree-ring width and density records and applied four detrending functions. They selected 338-396 records that showed significant correlations with instrumental temperature data and combined them into a proxy record. The reconstruction explained 45-57% of the instrumental temperature variance since 1950, and the estimated Arctic warming amplitudes were consistent with temperature anomaly datasets.
Article
Environmental Sciences
Ruzhen Yao, Shenghai Li, Deliang Chen
Summary: The Tibetan Plateau has undergone significant warming in recent decades, leading to glacier melt and impacts on river runoff. This study used glacier mass balance measurements and hydrological modeling to analyze the contributions of two glacierized basins to river runoff and investigate their responses to climate changes. The results highlight the dominant role of precipitation changes in these basins, which have small glacier meltwater contributions.
Article
Meteorology & Atmospheric Sciences
Kailun Gao, Ji Wang, Deliang Chen, Wenting Hu, Yingjuan Zhang, Anmin Duan, Xiaoxiao Zhang
Summary: A record-breaking extreme heavy snowfall event occurred in northern China from 6-8 November 2021, causing severe socioeconomic impacts. This study compares the synoptic processes and moisture supply differences between the North China and Northeast China regions during this event, aiming to provide insights for better prediction and forecasting of extreme heavy snowfalls in northern China. The findings highlight the distinctive contributions of different moisture sources to local precipitation, as well as the potential role of the Arctic Oscillation in indicating cold-air outbreaks during this event.
JOURNAL OF METEOROLOGICAL RESEARCH
(2023)
Article
Energy & Fuels
A. T. D. Perera, Kavan Javanroodi, Dasaraden Mauree, Vahid M. Nik, Pietro Florio, Tianzhen Hong, Deliang Chen
Summary: Dense urban morphologies exacerbate the urban heat island phenomenon, making cities more susceptible to extreme climate events. A modelling framework is developed to assess the combined impact of climate variations and urban densification on renewable energy integration in European cities, revealing significant changes in wind speed and temperature and increased energy demand. Failure to consider extreme climate events will reduce power supply reliability, particularly in dense urban areas of southern Europe.
Article
Geosciences, Multidisciplinary
Wenting Wang, Shuiqing Yin, Zeng He, Deliang Chen, Hao Wang, Andreas Klik
Summary: This study improves the accuracy of future rainfall erosivity projections in China by selecting five CMIP6-based and bias-adjusted Global Climate Models (GCMs). The results show that GFDL-ESM4, IPSL-CM6A-LR, and UKESM1-0LL models outperform others in estimating rainfall erosivity, especially in regions prone to water erosion. The study projects an increase in rainfall erosivity for most regions in China, indicating the need for enhanced soil and water conservation measures to mitigate the challenges posed by global warming.
Article
Geosciences, Multidisciplinary
Cheng Shen, Huishuang Yuan, Zhibo Li, Xiaoye Yang, Lorenzo Minola, Youli Chang, Deliang Chen
Summary: This study examines the changes in the near-surface wind speed in China from 1979 to 2020. It reveals a consistent decline in wind speed followed by an increasing trend, with the exception of March where a distinct hiatus is observed. The reduction in wind speed during March is primarily attributed to the southward shift of the East Asian subtropical jet, resulting in decreased temperature gradient and weakened eddy activities.
GEOPHYSICAL RESEARCH LETTERS
(2023)
Article
Environmental Sciences
Xuan Liu, Ming-Xiang Yang, Ning-Peng Dong, Wei-Ning Xie, Zhen Guan, Fan Wen, Hao Wang, Deliang Chen
Summary: This study investigates the changes in summer precipitation in the Three-River Headwaters region using observational and ERA5 reanalysis data. The results show an increasing trend in summer precipitation with a significant dry-to-wet transition in 2002. The study also attributes the transition and increased precipitation to changes in atmospheric circulations and water vapor transport.
ADVANCES IN CLIMATE CHANGE RESEARCH
(2023)
Article
Environmental Sciences
Bo Su, Hong-Yu Zhao, Heng Ma, Can Zhang, Deliang Chen, Bin Chen, Yi Huang, Shi-Wei Liu, Tong Zhang, Cun-De Xiao
Summary: This study evaluates the supply and demand potentials of China's glacier water resources and their effects, taking into account the downstream countries' demand. The study reveals the spatial and temporal matches between the supply and demand potentials. It finds that some basins rely heavily on glacier meltwater for water supply, but there are also risks and pressures due to decreasing glacier runoff and increasing population.
ADVANCES IN CLIMATE CHANGE RESEARCH
(2023)
Article
Engineering, Civil
Chi Zhang, Xu Zhang, Qiuhong Tang, Deliang Chen, Jinchuan Huang, Shaohong Wu, Yubo Liu
Summary: Precipitation over the Tibetan Plateau is influenced by systems such as the Asian monsoons, the westerlies, and local circulations. The Indian monsoon, the westerlies, and local circulations are the main systems affecting precipitation over the entire Tibetan Plateau. The East Asian summer monsoon primarily affects the eastern Tibetan Plateau. The Indian monsoon has the greatest influence on precipitation in the southern and central grid cells, while the westerlies have the greatest influence on precipitation in the northern and western grid cells. Local circulations have the strongest influence on the central and eastern grid cells.
JOURNAL OF HYDROLOGY
(2024)
Article
Geosciences, Multidisciplinary
Qin Wen, Chenyu Zhu, Deliang Chen, Mengyu Liu, Liang Ning, Mi Yan, Jian Liu, Zhengyu Liu
Summary: This study separates the heat flux and freshwater feedback in the AMOC change and finds that they dominate at different timescales. It provides important insights into understanding the mechanism of AMOC under global warming.
GEOPHYSICAL RESEARCH LETTERS
(2023)
