Reversible cytotoxic lesion of the corpus callosum following SARS-CoV-2 mRNA vaccine administration: a finding to be aware of

Cytotoxic lesions of the corpus callosum (CLOCCs) are a clinical-radiological spectrum of disorders secondary to several etiopathogeneses. Cytotoxic lesions of the corpus callosum are typically associated with mild clinical symptoms including fever, headache, confusion, and altered mental status. We present a case of a 51-year-old Caucasian woman who developed a reversible lesion of the splenium of the corpus callosum associated with small round-shaped white matter hyperintensities after the first dose of SARS-CoV-2 mRNA vaccine. Magnetic resonance imaging is fundamental for diagnosis and no treatment is generally required.

Automated summary

Cytotoxic lesions of the corpus callosum (CLOCCs) are a spectrum of disorders caused by various etiopathogeneses. They are typically associated with mild clinical symptoms and can be diagnosed using magnetic resonance imaging. We present a case of reversible splenial lesion of the corpus callosum after vaccination with SARS-CoV-2 mRNA vaccine. No treatment is generally required.