A coarse grained protein model with internal degrees of freedom. Application to α-synuclein aggregation

Intrinsically disordered proteins: emerging interaction specialists

(2015) Peter Tompa et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

An elementary singularity-free Rotational Brownian Dynamics algorithm for anisotropic particles

(2015) Ioana M. Ilie et al.   JOURNAL OF CHEMICAL PHYSICS

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

(2015) Samuel I A Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Prediction of a stable associated liquid of short amyloidogenic peptides

(2015) Jurriaan A. Luiken et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

(2015) Samuel I A Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Self-Assembly of Protein Fibrils into Suprafibrillar Aggregates: Bridging the Nano- and Mesoscale

(2014) Slav A. Semerdzhiev et al.   ACS Nano

A Mitocentric View of Parkinson's Disease

(2014) Nele A. Haelterman et al.   Annual Review of Neuroscience

Solution conditions define morphological homogeneity of α-synuclein fibrils

(2014) Arshdeep Sidhu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

α-Synuclein oligomers distinctively permeabilize complex model membranes

(2014) Anja N. D. Stefanovic et al.   FEBS Journal

Membrane interactions and fibrillization of α-synuclein play an essential role in membrane disruption

(2014) Himanshu Chaudhary et al.   FEBS LETTERS

Minimal Model of Self-Assembly: Emergence of Diversity and Complexity

(2014) Bogdan Barz et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Comparison of Structure Determination Methods for Intrinsically Disordered Amyloid-β Peptides

(2014) K. Aurelia Ball et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease

(2014) Meredith A. Chabrier et al.   NEUROBIOLOGY OF DISEASE

Crucial role of nonspecific interactions in amyloid nucleation

(2014) Anđela Šarić et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Computational approaches to understanding protein aggregation in neurodegeneration

(2014) R. L. Redler et al.   Journal of Molecular Cell Biology

The intersection of amyloid beta and tau in glutamatergic synaptic dysfunction and collapse in Alzheimer's disease

(2013) Johanna L. Crimins et al.   AGEING RESEARCH REVIEWS

The N-terminus of α-synuclein is essential for both monomeric and oligomeric interactions with membranes

(2013) Nikolai Lorenzen et al.   FEBS LETTERS

Parkinson's Disease and Alpha Synuclein: Is Parkinson's Disease a Prion-Like Disorder?

(2013) C. Warren Olanow et al.   MOVEMENT DISORDERS

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Structural and functional characterization of two alpha-synuclein strains

(2013) Luc Bousset et al.   Nature Communications

Protein Misfolded Oligomers: Experimental Approaches, Mechanism of Formation, and Structure-Toxicity Relationships

(2012) Francesco Bemporad et al.   CHEMISTRY & BIOLOGY

Mimicking Phosphorylation at Serine 87 Inhibits the Aggregation of Human  -Synuclein and Protects against Its Toxicity in a Rat Model of Parkinson's Disease

(2012) A. Oueslati et al.   JOURNAL OF NEUROSCIENCE

Agrochemicals, α-Synuclein, and Parkinson’s Disease

(2012) Blanca A. Silva et al.   MOLECULAR NEUROBIOLOGY

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

The Role of Alpha-Synuclein Oligomerization and Aggregation in Cellular and Animal Models of Parkinson’s Disease

(2012) Oi Wan Wan et al.   PLoS One

Intrinsically disordered proteins: a 10-year recap

(2012) Peter Tompa   TRENDS IN BIOCHEMICAL SCIENCES

Alpha-synuclein: from secretion to dysfunction and death

(2012) O Marques et al.   Cell Death & Disease

Connecting Macroscopic Observables and Microscopic Assembly Events in Amyloid Formation Using Coarse Grained Simulations

(2012) Noah S. Bieler et al.   PLoS Computational Biology

Folding and misfolding of alpha-synuclein on membranes

(2011) Igor Dikiy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

What Drives Amyloid Molecules To Assemble into Oligomers and Fibrils?

(2011) Jeremy D. Schmit et al.   BIOPHYSICAL JOURNAL

Coarse-grained models for protein aggregation

(2011) Chun Wu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The role of the C-terminus of human α-synuclein: Intra-disulfide bonds between the C-terminus and other regions stabilize non-fibrillar monomeric isomers

(2011) Dong-Pyo Hong et al.   FEBS LETTERS

Low-resolution structure of a vesicle disrupting  -synuclein oligomer that accumulates during fibrillation

(2011) L. Giehm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How Fast-Folding Proteins Fold

(2011) K. Lindorff-Larsen et al.   SCIENCE

Principles governing oligomer formation in amyloidogenic peptides

(2010) John E Straub et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A Pathologic Cascade Leading to Synaptic Dysfunction in  -Synuclein-Induced Neurodegeneration

(2010) D. A. Scott et al.   JOURNAL OF NEUROSCIENCE

Amyloid Fibril Polymorphism Is under Kinetic Control

(2010) Riccardo Pellarin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Simulations of nucleation and elongation of amyloid fibrils

(2009) Jianing Zhang et al.   JOURNAL OF CHEMICAL PHYSICS

Tryptophan Fluorescence Reveals Structural Features of α-Synuclein Oligomers

(2009) B.D. van Rooijen et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Properties of Pore-Forming Oligomers of α-Synuclein

(2009) Hai-Young Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High Precision Transport Properties of Cylinders by the Boundary Element Method

(2009) Sergio R. Aragon et al.   MACROMOLECULES

Structure-neurotoxicity relationships of amyloid  -protein oligomers

(2009) K. Ono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrinsically Disordered Proteins in Human Diseases: Introducing the D2 Concept

(2008) Vladimir N. Uversky et al.   Annual Review of Biophysics

Concentration Dependence of α-Synuclein Fibril Length Assessed by Quantitative Atomic Force Microscopy and Statistical-Mechanical Theory

(2008) Martijn E. van Raaij et al.   BIOPHYSICAL JOURNAL

Free Rotational Diffusion of Rigid Particles with Arbitrary Surface Topography: A Brownian Dynamics Study Using Eulerian Angles

(2008) Tom Richard Evensen et al.   MACROMOLECULAR THEORY AND SIMULATIONS

Brownian Dynamics Simulations of Rotational Diffusion Using the Cartesian Components of the Rotation Vector as Generalized Coordinates

(2008) Tom Richard Evensen et al.   MACROMOLECULAR THEORY AND SIMULATIONS

Use of the Rotation Vector in Brownian Dynamics Simulation of Transient Electro-Optical Properties

(2008) Tom Richard Evensen et al.   MACROMOLECULAR THEORY AND SIMULATIONS

The fold of  -synuclein fibrils

(2008) M. Vilar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular dynamics simulations of alanine rich β-sheet oligomers: Insight into amyloid formation

(2002) Buyong Ma et al.   PROTEIN SCIENCE