Article
Integrative & Complementary Medicine
Thaddeus H. Gugu, Geraldine C. Agu, Emmanuel M. Uronnachi, Salome A. Chime
Summary: This study aimed to formulate, characterize, and evaluate the in vitro and in vivo properties of ibuprofen formulated as solid lipid microspheres (SLMs) for enhanced delivery. The results indicated that SLMs exhibited good anti-inflammatory properties with gastroprotective action.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Nutrition & Dietetics
Shuaishuai Zhou, Zi Wang, Yanling Hao, Peng An, Junjie Luo, Yongting Luo
Summary: Dandelion polysaccharides may play an important role in attenuating atherosclerosis by antioxidative and anti-inflammatory effects.
Article
Pharmacology & Pharmacy
Neeraj K. Garg, Nikunj Tandel, Sanjay Kumar Bhadada, Rajeev K. Tyagi
Summary: In this study, an NLC-based hydrogel formulation of ACE was developed and characterized, showing high stability and superior skin delivery efficiency. Compared with conventional marketed gel formulations, the NLC-based gel formulation of ACE may offer promising advantages as a nanoscale lipid carrier for topical applications.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Clinical Neurology
Giovanni Iolascon, Sergio Gimenez, Dorottya Mogyorosi
Summary: Aceclofenac is an oral NSAID recommended for treating inflammation and pain in various conditions. Studies have shown that it is as effective as other NSAIDs in reducing pain and improving functional capacity in chronic pain conditions, with a more favorable gastrointestinal profile.
JOURNAL OF PAIN RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Leon Yoon Ho, Zi Shun Xiang, Renuga Gopal, Saif A. Khan
Summary: This paper demonstrates a microfluidics-enabled process for engineering monodisperse solid lipid microparticles with uniform drug loading and particle size, making it applicable to various drugs and lipid formulations. The method utilizes a volatile solvent and microfluidic flow extrusion to achieve high precision in particle size and drug loading, enhancing monodispersity and enabling the formulation of SLMs with diverse solid-state outcomes for different drugs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Sang Yeol Lee
Summary: Matrix metalloproteinases (MMPs) play crucial roles in cancer metastasis and chronic inflammatory diseases, while ginsenosides have therapeutic potentials. Ginsenosides exhibit anti-metastatic and anti-inflammatory activities by suppressing MMPs through regulation of various signaling pathways.
Article
Nutrition & Dietetics
Teresa Vezza, Jose Garrido-Mesa, Patricia Diez-Echave, Laura Hidalgo-Garcia, Antonio J. Ruiz-Malagon, Federico Garcia, Manuel Sanchez, Marta Toral, Miguel Romero, Juan Duarte, Enrique Guillamon, Alberto Banos, Rocio Moron, Julio Galvez, Alba Rodriguez-Nogales, Maria Elena Rodriguez-Cabezas
Summary: The study found that propyl propane thiosulfonate (PTSO) helps reduce weight gain, improve plasma markers, and attenuate obesity-associated inflammation, improving gut barrier integrity.
Article
Engineering, Biomedical
Xinming Wang, Hongpeng Shi, Shixing Huang, Yecen Zhang, Xiaojun He, Qiang Long, Bei Qian, Yiming Zhong, Zhaoxi Qi, Qiang Zhao, Xiaofeng Ye
Summary: This study presents a new platform for cardiac repair by embedding nanostructured lipid carriers (NLCs) into a cardiac extracellular matrix (ECM) hydrogel. The ECM-NLC hydrogel enables sustained and localized delivery of biomolecules into the heart, showing improved therapeutic efficacy for cardiovascular diseases.
Article
Plant Sciences
Ju-Hsin Cheng, Ho-Cheng Wu, Chia-Hung Yen, Tsong-Long Hwang, Horng-Huey Ko, Hsun-Shuo Chang
Summary: Non-alcoholic fatty liver disease (NAFLD) is a liver disease caused by the accumulation of excess lipids. The research aimed to investigate the bioactive components of Formosan plants that could reduce lipid droplet accumulation. The study found that the methanolic extract of Elaeagnus glabra Thunb. showed excellent anti-LD accumulation activity and isolated several compounds with potential therapeutic effects.
Article
Pharmacology & Pharmacy
Dan Huang, Xindong Wang, Yunhong Zhu, Juexiao Gong, Junqing Liang, Yanfei Song, Yiyan Zhang, Linsheng Liu, Cong Wei
Summary: The study demonstrated the anti-atherosclerotic effect of Bazi Bushen capsule through experiments with Ovx/ApoE(-/-) mice and human umbilical vein endothelial cells, indicating a potential mechanism involving GPER1-dependent anti-inflammatory and anti-apoptotic actions.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ying Zhang, Mei Wu, Linghui Zhang, Yuze Song
Summary: The aim of this study was to investigate the anti-atherosclerotic effect of α-pinene against high-fat diet-induced atherosclerotic alterations in male Wistar rats. After being fed with a high-fat diet for 28 days, the rats were divided into four groups. Treatment with α-pinene significantly improved cardiac-related indicators, lipid profile, antioxidant state, and levels of inflammatory markers compared to the high-fat diet-induced atherosclerosis group. Furthermore, α-pinene downregulated the expression of lipid-regulating genes in the rats with high-fat diet-induced atherosclerosis. Experimental findings suggest that α-pinene can slow down the progression of atherosclerosis by improving the lipid profile, restoring antioxidant capabilities, reducing inflammation, and regulating lipid metabolism.
LATIN AMERICAN JOURNAL OF PHARMACY
(2023)
Article
Allergy
Pascal Haimerl, Ulrike Bernhardt, Sonja Schindela, Fiona D. R. Henkel, Antonie Lechner, Ulrich M. Zissler, Xavier Pastor, Dominique Thomas, Alexander Cecil, Yan Ge, Mark Haid, Cornelia Prehn, Janina Tokarz, Matthias Heinig, Jerzy Adamski, Carsten B. Schmidt-Weber, Adam M. Chaker, Julia Esser-von Bieren
Summary: This study revealed a potential metabolic and epigenetic reprogramming in macrophages of N-ERD patients, including decreased DNA methylation, abnormal metabolic profiles, and increased expression of chemokines indicating persistent proinflammatory activation.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Chemistry, Medicinal
Katie Shiels, Alexandros Tsoupras, Ronan Lordan, Constantina Nasopoulou, Ioannis Zabetakis, Patrick Murray, Sushanta Kumar Saha
Summary: This study investigated the anti-inflammatory and antithrombotic activities of lipids from the microalgae Chlorococcum sp. isolated from the Irish coast. The results showed strong activities in glyco- and phospho-lipid fractions, indicating the potential health benefits of these novel bioactive lipids. Further research is needed for commercial technology development and biosafety analysis of using this microalga as a sustainable source for bioactive lipids production.
Article
Plant Sciences
Karina Ervik, Amalie F. Reinertsen, Duco S. Koenis, Jesmond Dalli, Trond V. Hansen
Summary: The methyl ester of resolvin D5(n-3 DPA), a lipid mediator derived from the omega-3 fatty acid n-3 docosapentaenoic acid, was successfully synthesized in a stereoselective manner. The physical properties of the synthetic material were compared to those of materials from human blood and mouse exudates. In biological experiments, the synthetic RvD5(n-3 DPA) displayed potent leukocyte-directed activities.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Medicine, Research & Experimental
Jiaojiao Wang, Dihui Xu, Lili Shen, Jing Zhou, Xiang Lv, Hongyue Ma, Nianguang Li, Qinan Wu, Jinao Duan
Summary: Bufotenine shows great potential as a novel anti-inflammatory and analgesic agent by regulating lipid metabolism pathways, providing a systemic evidence for its actions and mechanism in reducing inflammatory pain disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Calister E. Ugwu, Franklin C. Kenechukwu, Edith O. Diovu, Helen O. Udodeme, Mumuni A. Momoh, Ebele B. Onuigbo, Anthony A. Attama
Summary: This study developed biopolymer-based microparticles for colon-targeted drug delivery using modified gelatin capsules. The microparticles showed high encapsulation efficiency and sustained drug release in the lower gastrointestinal tract, leading to improved and controlled colon delivery of aceclofenac.
Article
Multidisciplinary Sciences
Mumuni A. Momoh, Kenechukwu C. Franklin, Chinazom P. Agbo, Calister E. Ugwu, Musiliu O. Adedokun, Ofomata C. Anthony, Omeje E. Chidozie, Augustine N. Okorie