Emerging Roles of Transforming Growth Factor Signaling in Diabetic Retinopathy

Diabetic retinopathy (DR) is a serious complication of diabetes mellitus affecting about one third of diabetic adults. Despite its prevalence, treatment options are limited and often implemented only in the later stages of the disease. To date, the pathogenesis of DR has been extensively characterized in the context of elevated glucose, insulin, and VEGF signaling, although a growing number of other growth factors and molecules, including transforming growth factor (TGF-) are being recognized as important contributors and/or therapeutic targets. Here, we review the complex roles of TGF- signaling in DR pathogenesis and progression. J. Cell. Physiol. 232: 486-489, 2017. (c) 2016 Wiley Periodicals, Inc.