Article
Medical Laboratory Technology
Andres M. Acosta, Justine Barletta, Guru Sonpavde, Stuart Schnitt, Michelle S. Hirsch
Summary: E-cadherin, B-Cat, and p-120 exhibit membranous staining in conventional and micropapillary UC, while abnormal staining of E-Cad and p-120 in PC-UC and SUC aids in diagnosis.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Food Science & Technology
William Crowe, Xiaobei Pan, James Mackle, Adam Harris, Gary Hardiman, Christopher T. Elliott, Brian D. Green
Summary: The consumption of processed meat, particularly those with preservative salts such as sodium nitrite, has been linked to the development of colorectal cancer. This study found that nitrite-containing sausages may exacerbate the development of colorectal cancer in mice, leading to increased tumor growth and higher levels of lipid peroxidation. Additionally, these sausages were associated with alterations in gut microbiota and metabolic profiles.
NPJ SCIENCE OF FOOD
(2022)
Article
Multidisciplinary Sciences
Natoya J. Peart, Jae Yeon Hwang, Mathieu Quesnel-Vallieres, Matthew J. Sears, Yuequin Yang, Peter Stoilov, Yoseph Barash, Juw Won Park, Kristen W. Lynch, Russ P. Carstens
Summary: Epithelial splicing regulatory proteins ESRP1 and ESRP2 play crucial roles in the regulation of alternative splicing during mammalian development, particularly in genes involved in maintaining epithelial cell function. Through eCLIP and RNA-Seq analyses, it was found that ESRP1 primarily functions in splicing regulation by directly binding to specific sites to promote exon inclusion or skipping. Additionally, ESRP1 also exhibits widespread binding in the untranslated regions of genes related to epithelial cell function, suggesting its involvement in post-transcriptional regulation beyond splicing.
Article
Multidisciplinary Sciences
Douglas B. Stairs, Mary E. Landmesser, Cesar Aliaga, Kun-Ming Chen, Yuan-Wan Sun, Karam El-Bayoumy
Summary: This study focuses on the impact of tobacco smoke exposure on head and neck squamous cell carcinoma, uncovering dysregulated biological processes in oral squamous cell carcinomas induced by DBPDE, with downregulated p120ctn expression identified in both early and invasive stages of the disease. Additionally, increased proliferation, inflammation, neovascularization, and recruitment of immune cells were observed, along with strong EGFR expression. The study also suggests that the chemopreventive agent black raspberry (BRB) may inhibit DBPDE induced OSCC by increasing p120ctn expression.
Article
Oncology
Giovanni Nicolao Berta, Federica Di Scipio, Zhiqian Yang, Alessandra Oberto, Giuliana Abbadessa, Federica Romano, Maria Elisabetta Carere, Adriano Ceccarelli, Emilio Hirsch, Barbara Mognetti
Summary: The study revealed that the lack or inhibition of PI3K gamma can delay preneoplastic and exophytic lesions in oral carcinogenesis. WT mice showed higher expression of prognostic markers and certain cell types, while tongues isolated from transgenic mice had more abundant T lymphocytes. A specific PI3K gamma inhibitor significantly impaired the vitality of oral cancer cells.
Article
Oncology
Liwei Ma, Ting Shen, Hui Peng, Jianjun Wu, Wenjin Wang, Xing Gao
Summary: This study found that overexpression of PTPRZ1 promotes the malignancy of OSF by regulating the phosphorylation of p120/beta-catenin. This finding provides clues for the identification of novel drug targets.
JOURNAL OF ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Chaoxiong Wang, Xichen Zheng, Jinlan Zhang, Xiaoyi Jiang, Jia Wang, Yuwei Li, Xiaonan Li, Guanghui Shen, Jiayin Peng, Peixuan Zheng, Yunqing Gu, Jiaojiao Chen, Moubin Lin, Changwen Deng, Hai Gao, Zhigang Lu, Yun Zhao, Min Luo
Summary: A CRISPR-Cas9 screen in a mouse model identifies CD300ld as a critical immune suppressor present on PMN-MDSCs, which is required for tumor immune resistance and could be a potential target for cancer immunotherapy.
Article
Endocrinology & Metabolism
Lisa Y. Lawson, Michael D. Brodt, Nicole Migotsky, Christopher J. Chermside-Scabbo, Ramya Palaniappan, Matthew J. Silva
Summary: The secretion of Wnt ligands is essential for adult bone homeostasis, and inhibiting their secretion results in decreased bone formation and increased resorption. Additionally, osteoblast-derived Wnts play a crucial role in mediating the bone anabolic response to tibial loading.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Neurosciences
Kathleen A. Beeson, Gary L. Westbrook, Eric Schnell
Summary: The study shows that alpha2δ-2 protein plays a crucial role in influencing the coupling of postsynaptic voltage-dependent calcium channels in neurons, affecting neuronal output regulation.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Gastroenterology & Hepatology
Jieyun Jiang, Courtney Turpin, Guofang (Shirley) Qiu, Mei Xu, Eun Lee, Terry D. Hinds, Martha L. Peterson, Brett T. Spear
Summary: Zhx2 acts as an oncogene in DEN-induced HCC model, and its expression is associated with clinical pathological parameters in patients with HCC.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Engineering, Environmental
Meng-Yu Wang, Meng-Ya Li, Han Ning, Rong-Yue Xue, Jia-Hui Liang, Ning Wang, Xiao-San Luo, Gang Li, Albert L. Juhasz, Lena Q. Ma, Hong-Bo Li
Summary: The study found that the bioavailability of cadmium in vegetables is strongly negatively correlated with cadmium concentration, with pakchoi having lower cadmium intake compared to water spinach and amaranth due to its higher calcium and lower phytate concentrations. This inhibits intestinal absorption of cadmium.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Gastroenterology & Hepatology
Yi Zhang, Hongwei Xu, Guofei Cui, Binyong Liang, Xiangzheng Chen, Sungjin Ko, Silvia Affo, Xinhua Song, Yi Liao, Jianguo Feng, Pan Wang, Haichuan Wang, Meng Xu, Jingxiao Wang, Giovanni M. Pes, Silvia Ribback, Yong Zeng, Aatur Singhi, Robert F. Schwabe, Satdarshan P. Monga, Matthias Evert, Liling Tang, Diego F. Calvisi, Xin Chen
Summary: YAP induces cholangiocarcinogenesis through TEAD-dependent transcriptional activation and interaction with ss-Catenin. ss-Catenin binds to YAP in iCCA and is required for YAP's full transcriptional activity, revealing the functional crosstalk between YAP and ss-Catenin pathways in cholangiocarcinogenesis.
Article
Cardiac & Cardiovascular Systems
Chengzhen Huang, Tong Ding, Yuan Zhang, Xunkai Li, Xin Sun, Shuangjie Lv, Yanyan Hao, Lina Bai, Ning Liu, Yifan Xie, Houzao Chen, Yu Nie
Summary: The protein p66Shc plays a crucial role in heart regeneration by promoting neonatal mouse cardiomyocyte proliferation and facilitating heart regeneration. The study also reveals that p66Shc regulates cardiomyocyte proliferation through the activation of beta-catenin signaling. These findings provide new insights into senescence signaling in heart regeneration.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jordan A. Naumann, Prokopios P. Argyris, Michael A. Carpenter, Harshita B. Gupta, Yanjun Chen, Nuri A. Temiz, Yufan Zhou, Cameron Durfee, Joshua Proehl, Brenda L. Koniar, Silvestro G. Conticello, David A. Largaespada, William L. Brown, Hideki Aihara, Rachel I. Vogel, Reuben S. Harris
Summary: Although well-known as antiviral factors, the APOBEC3 family of single-stranded DNA cytosine deaminases are also prominent sources of mutation in cancer, with its signature single-base substitutions evident in over 70% of human malignancies. Recent studies have shown that APOBEC3A and APOBEC3B can promote tumor formation in vivo. This research investigates the molecular mechanism of APOBEC3A-driven tumor development and demonstrates that APOBEC3A is a master driver that fuels tumor formation through a DNA deamination-dependent mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Suchetana B. Dutta, Gerit Arne Linneweber, Maheva Andriatsilavo, Peter Robin Hiesinger, Bassem A. Hassan
Summary: The development of neuronal connectivity requires stabilization of dynamic axonal branches at synapse formation sites. In the study using Drosophila brain as a model system, it was found that epidermal growth factor receptor (EGFR) activity plays a crucial role in regulating circuit wiring during two distinct temporal intervals. EGFR is required for primary axonal branching early on, and then independently required later to prevent degradation of the synaptic active zone protein Bruchpilot (Brp). This temporally restricted molecular mechanism is essential for coupling axonal branching and synaptic stabilization.
Article
Cell Biology
Zhongjian Xie, Yuanyuan Tang, Mao-Qiang Man, Chandrama Shrestha, Daniel D. Bikle
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Clinical Neurology
Ming-Xiang Zou, Guo-Hua Lv, Xiao-Bin Wang, Wei Huang, Jing Li, Yi Jiang, Xiao-Ling She
Article
Dermatology
Wenlin Wu, Hong Fan, Yi Jiang, Liyan Liao, Lusha Li, Juan Zhao, Huiling Zhang, Chandrama Shrestha, Zhongjian Xie
EXPERIMENTAL DERMATOLOGY
(2018)
Article
Multidisciplinary Sciences
Hui Huang, Yongjun Wang, Yong Cao, Boda Wu, Yonggui Li, Liangliang Fan, Zhiping Tan, Yi Jiang, Jianguang Tang, Jianzhong Hu, Xiaoliu Shi
SCIENTIFIC REPORTS
(2017)
Article
Clinical Neurology
Guo-Hua Lv, Ming-Xiang Zou, Fu-Sheng Liu, Yi Zhang, Wei Huang, An Ye, Qian-Shi Zhang, Xiao-Bin Wang, Jing Li, Yi Jiang, Xiao-Ling She
Article
Clinical Neurology
Ming-Xiang Zou, Bo-Wen Zheng, Fu-Sheng Liu, Xiao-Bin Wang, Jia-Rui Hu, Wei Huang, Zhe-Hao Dai, Qian-Shi Zhang, Fu-Bing Liu, Hua Zhong, Yi Jiang, Xiao-Ling She, Xiao-Bing Li, Guo-Hua Lv, Jing Li
Review
Allergy
Min Song, Shan Cai, Hong Luo, Yi Jiang, Min Yang, Yan Zhang, Hong Peng, Ping Chen
ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY
(2019)
Article
Cell Biology
Lusha Li, Shangli Ji, Chandrama Shrestha, Yi Jiang, Liyan Liao, Feng Xu, Zhenming Liu, Daniel D. Bikle, Zhongjian Xie
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Anesthesiology
Keith Candiotti, Chandrama Shrestha, Mariana Rubini Silva Ceschim
BEST PRACTICE & RESEARCH-CLINICAL ANAESTHESIOLOGY
(2020)
Article
Oncology
Ming-Xiang Zou, Ke-Miao Guo, Guo-Hua Lv, Wei Huang, Jing Li, Xiao-Bin Wang, Yi Jiang, Xiao-Ling She
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2018)