Article
Surgery
Stefano Andrianello, Elisa Bannone, Giovanni Marchegiani, Giuseppe Malleo, Salvatore Paiella, Alessandro Esposito, Roberto Salvia, Claudio Bassi
Summary: It was found that postoperative acute pancreatitis is a common event after distal pancreatectomy and it is closely associated with postoperative pancreatic fistula. Factors influencing postoperative acute pancreatitis include neoadjuvant therapy, age, duct size, pancreatic thickness, resection level, and histology type. Postoperative acute pancreatitis may increase the risk of further complications for patients.
Article
Medicine, General & Internal
Daegwang Yoo, Seo Young Park, Dae Wook Hwang, Jae Hoon Lee, Ki Byung Song, Woohyung Lee, Yejong Park, Eunsung Jun, Song Cheol Kim
Summary: Analysis of data from a previously published randomized controlled trial found that postoperative acute pancreatitis (POAP) in patients undergoing PD was not significantly associated with postoperative complications including pancreatic fistula (POPF).
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Surgery
Zhouyu Wu, Kezhen Zong, Baoyong Zhou, Kunli Yin, Anlan Zhang, Ming Li
Summary: Postoperative acute pancreatitis (POAP) is a specific complication after pancreatectomy, which may affect the healing of pancreatoenteric anastomoses, leading to postoperative pancreatic fistulas (POPFs), abdominal infections, and even progressive systemic reactions, negatively affecting patients' prognoses and causing death.
FRONTIERS IN SURGERY
(2023)
Article
Multidisciplinary Sciences
Nithya Bhasker, Fiona R. Kolbinger, Nadiia Skorobohach, Alex Zwanenburg, Steffen Loeck, Juergen Weitz, Ralf-Thorsten Hoffmann, Marius Distler, Stefanie Speidel, Stefan Leger, Jens-Peter Kuehn
Summary: This retrospective study developed risk models for predicting clinically relevant postoperative pancreatic fistula (CR-POPF) using preoperative radiomic features, volumes of pancreatic structures, and clinical data. The combined radiomic and clinical signature performed well, showing high accuracy in predicting CR-POPF. The preoperative signature showed strong correlation with the gold standard intraoperative risk stratification model.
SCIENTIFIC REPORTS
(2023)
Article
Gastroenterology & Hepatology
Jillian W. Bonaroti, Mazen S. Zenati, Amr I. Al-abbas, Caroline J. Rieser, Amer H. Zureikat, Melissa E. Hogg, Herbert J. Zeh, Brian A. Boone
Summary: The study on POP patients after pancreatic resection revealed that patients with grade C POP had a significantly decreased overall survival and were less likely to receive adjuvant chemotherapy, further contributing to a decrease in survival time.
Article
Surgery
O. Radulova-Mauersberger, F. Oehme, L. Missel, C. Kahlert, T. Welsch, J. Weitz, Marius Distler
Summary: This study aimed to analyze the predictive value of hyperamylasemia after pancreatectomy for morbidity and the decision to perform rescue completion pancreatectomy. It was found that postoperative hyperamylasemia was associated with postoperative pancreatic fistula, rescue completion pancreatectomy, and other major complications.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Surgery
Haoda Chen, Chao Wang, Ziyun Shen, Weishen Wang, Yuanchi Weng, Xiayang Ying, Xiaxing Deng, Baiyong Shen
Summary: This study aimed to characterize postpancreatectomy acute pancreatitis (PPAP) after pancreaticoduodenectomy (PD) in a high-volume center. The results showed that PPAP had a high incidence rate and was associated with postoperative pancreatic fistula, major complications, and biliary leak. Some cases of PPAP presented as an inflammatory process in the early postoperative period, but could also lead to necrotizing pancreatitis or other severe clinical scenarios.
Review
Gastroenterology & Hepatology
Juanita N. Chui, Sumit Sahni, Jaswinder S. Samra, Anubhav Mittal
Summary: Postoperative pancreatic fistula (POPF) is a severe complication following pancreatic surgery, and its pathophysiology is poorly understood. Recent studies have shown that postoperative or post-pancreatectomy acute pancreatitis (PPAP) plays a critical role in the development of POPF.
Article
Surgery
Kwang Yeol Paik, Ji Seon Oh, Eung Kook Kim
Summary: This study found that higher serum amylase level immediate after PD is correlated with POPF occurrence, with high fistula risk grade and post pancreatectomy acute pancreatitis being predictive factors for POPF. Comprehensive management is important for patients with higher serum amylase levels to mitigate the risk of POPF.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Surgery
DeFei Hong, HuaGen Li, XiaoLong Liu, Peiqiang Jiang, Guangsheng Yu, Xueqing Liu, Jianhua Liu, YaHui Liu, Jun Liu, Wan Yee Lau
Summary: This prospective multicenter study aimed to investigate the incidence of postoperative pancreatice fistula and the technique of pancreaticojejunostomy in laparoscopic pancreaticoduodenectomy (LPD). The results showed that the pancreaticojejunostomy technique in LPD is safe, simple, and reproducible, with favorable clinical outcomes.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Surgery
Naoki Ikenaga, Takao Ohtsuka, Kohei Nakata, Yusuke Watanabe, Yasuhisa Mori, Masafumi Nakamura
Summary: The study found a high incidence of postoperative acute pancreatitis after pancreatoduodenectomy and distal pancreatectomy, with different impacts on patients. Patients with clinically relevant postoperative acute pancreatitis were more likely to develop severe complications.
Article
Oncology
Bo Li, Ning Pu, Qiangda Chen, Yong Mei, Dansong Wang, Dayong Jin, Wenchuan Wu, Lei Zhang, Wenhui Lou
Summary: This study established a diagnostic nomogram based on postoperative objective parameters that can predict the development of CR-POPF after PD with good discriminative ability and predictive accuracy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Surgery
Hang Zhang, Yechen Feng, Duoji Suolang, Chao Dang, Renyi Qin
Summary: This study found that higher postoperative fluid balance is associated with increased morbidity and longer hospital stay after pancreaticoduodenectomy (PD) compared to lower fluid balance. Surgeons should closely monitor the occurrence of complications in patients with a high fluid balance.
LANGENBECKS ARCHIVES OF SURGERY
(2022)
Article
Oncology
Amir Ashraf Ganjouei, Fernanda Romero-Hernandez, Jaeyun Jane Wang, Megan Casey, Willow Frye, Daniel Hoffman, Kenzo Hirose, Eric Nakakura, Carlos Corvera, Ajay V. Maker, Kimberly S. Kirkwood, Adnan Alseidi, Mohamed A. Adam
Summary: In this study, a user-friendly risk calculator was developed using machine learning algorithms and preoperatively known variables to predict clinically-relevant postoperative pancreatic fistula (CR-POPF) following pancreaticoduodenectomy (PD). The calculator can be used in the preoperative setting to inform clinical decision-making and patient counseling.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Dong Wang, Huajun Lin, Chengjian Guan, Xiaodong Zhang, Peixin Li, Chenglin Xin, Xiaobao Yang, Zhewen Feng, Yiyang Min, Xiaozhe Gu, Wei Guo
Summary: This study evaluated the effect of preoperative biliary drainage (PBD) on surgery-related complications and patient survival in pancreaticobiliary malignancies. The results showed that PBD did not affect the incidence of complications after pancreaticoduodenectomy and patient survival. However, prolonged biliary drainage time may increase the overall incidence of postoperative complications and severe complications.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Hanna Koppatz, Ville Sallinen, Heikki Makisalo, Arno Nordin
Summary: This study reports outcomes and quality of life after repair of major bile duct injury (BDI) and compares repairs by hepatobiliary surgeons to non-hepatobiliary surgeons. The findings suggest that initial repair of severe BDI should be performed by a hepatobiliary surgeon, but long-term quality of life is not affected by even severe BDI, and quality of life is not associated with the grade of the outcome.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Urology & Nephrology
Verner Eerola, Ilkka Helantera, Anna But, Marko Lempinen, Heikki Makisalo, Arno Nordin, Helena Isoniemi, Ville Sallinen
Summary: This study analyzed the impact of procurement delay on kidney allograft outcomes, finding a nonlinear association with delayed graft function and a linear association with graft loss. Longer procurement delays were associated with noninferior or even better kidney allograft outcomes.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Surgery
Elisa Makarainen, Matti Tolonen, Ville Sallinen, Panu Mentula, Ari Leppaniemi, Mirella Ahonen-Siirtola, Juha Saarnio, Pasi Ohtonen, Filip Muysoms, Tero Rautio
Summary: The PREEMER trial is a randomized controlled trial aiming to investigate the prevention of incisional hernia in emergency settings. A total of 244 patients will be enrolled and randomly assigned to either the retrorectus mesh group or the no mesh group. Primary and secondary outcomes, including the incidence of hernia, complications, infections, reoperations, and quality of life, will be assessed.
Article
Surgery
Johannes M. Salusjarvi, Laura E. Koskenvuo, Juha P. Mali, Panu J. Mentula, Ari K. Leppaniemi, Ville J. Sallinen
Summary: This study retrospectively analyzed patients who underwent Hartmann's procedure for acute diverticulitis between 2006 and 2017, with follow-up until March 2021. The study found that one-third of the patients died, half underwent stoma reversal, and one-fifth did not undergo stoma reversal. Risk factors for non-reversal included old age, a need for outside assistance, low Helsinki Staging for Acute Diverticulitis stage, and higher C-reactive protein level upon hospital admission.
Article
Surgery
Kaisa Ahopelto, Ville Sallinen, Ilkka Helantera, Akseli Bonsdorff, Juulia Grasberger, Ines Beilmann-Lehtonen, Heikki Makisalo, Arno Nordin, Fernanda Ortiz, Johanna Savikko, Eija Tukiainen, Aki Uutela, Agneta Ekstrand, Marko Lempinen
Summary: This study retrospectively analyzed 166 cases of simultaneous pancreas-kidney transplantation performed at Helsinki University Hospital from March 14, 2010 to March 14, 2020. The results showed that this surgical approach is a safe and effective treatment for patients with type 1 diabetes and kidney failure, with high pancreas graft survival rate and successful kidney transplantation.
CLINICAL TRANSPLANTATION
(2023)
Review
Surgery
Akseli Bonsdorff, Ville Sallinen
Summary: Currently, there is no outstanding prediction model for postoperative pancreatic fistula (POPF), and many studies lack adherence to correct methodology or reporting guidelines. The use of preoperative computed tomography (CT) scans to predict POPF shows promising results. Further research is needed to reach a consensus on the most important predictors and to improve the transportability and generalizability of the prediction models.
SCANDINAVIAN JOURNAL OF SURGERY
(2023)
Article
Multidisciplinary Sciences
Laura L. Meijer, Yrjo Vaalavuo, Sara Regner, Ville Sallinen, Aurora Lemma, Urban Arnelo, Roberto Valente, Sofia Westermark, David An, John A. G. Moir, Ellen A. Irwin, Esther A. Biesel, Ulrich T. Hopt, Stefan Fichtner-Feigl, Uwe A. Wittel, Maximilian Weniger, Henning Karle, Frank W. Bloemers, Robert Sutton, Richard M. Charnley, Dietrich A. Ruess, Peter Szatmary
Summary: This retrospective cohort study evaluated clinical characteristics and long-term outcomes in patients with pancreatic injury. The study found that pancreatic trauma is rare but associated with significant short-term and long-term morbidity. Surgical therapy and opioid analgesia affected the quality of life of patients.
Article
Surgery
Kaisa Ahopelto, Akseli Bonsdorff, Juulia Grasberger, Marko Lempinen, Arno Nordin, Ilkka Helanterae, Ville Sallinen
Summary: This study compared the use of pasireotide and octreotide in reducing complications after simultaneous pancreas-kidney transplantation (SPK). The results showed that pasireotide was associated with lower postoperative morbidity within 90 days compared to octreotide. This suggests that pasireotide may be a better choice in pancreas transplantation surgery.
TRANSPLANT INTERNATIONAL
(2023)
Article
Surgery
Akseli Bonsdorff, Poya Ghorbani, Ilkka Helantera, Timo Tarvainen, Tea Kontio, Hanna Belfrage, Jukka Siren, Arto Kokkola, Ernesto Sparrelid, Ville Sallinen
Summary: This study developed and validated a new fistula risk score for distal pancreatectomy, which showed satisfactory predictive ability for postoperative pancreatic fistula. The score is based on preoperative clinical indicators and radiological parameters, and can categorize patients into different risk groups.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Surgery
Paulina Salminen, Suvi Sippola, Jussi Haijanen, Pia Nordstrom, Tuomo Rantanen, Tero Rautio, Ville Sallinen, Eliisa Loyttyniemi, Saija Hurme, Ville Tammilehto, Johanna Laukkarinen, Heini Savolainen, Sanna Merilainen, Ari Leppaniemi, Juha Gronroos
Summary: This study conducted a double-blind placebo-controlled trial on uncomplicated acute appendicitis and found that omission of antibiotics did not significantly affect treatment success rate. Therefore, a non-inferiority trial against placebo is warranted for adults with CT-confirmed mild appendicitis.
BRITISH JOURNAL OF SURGERY
(2022)
Letter
Surgery
Marcus Holmberg, Hanna Koppatz, Anders Jansson, Jens Georg Hillingso, Peter Noergaard Larsen, Kristoffer Lassen, Ville Sallinen, Sheraz Yaqub, Ernesto Sparrelid
BRITISH JOURNAL OF SURGERY
(2022)