Article
Nutrition & Dietetics
Su-Yeon Lee, Kyung-Sook Chung, So-Ri Son, So Young Lee, Dae Sik Jang, Jong-Kil Lee, Hyun-Jae Kim, Chang-Seon Na, Sun-Hee Lee, Kyung-Tae Lee
Summary: A botanical mixture of extracts from Inula japonica and Potentilla chinensis (EEIP) improves high-fat diet-induced obesity by inhibiting adipogenesis and improving gut microbiota.
Article
Agriculture, Multidisciplinary
Md Shamim Rahman, Inseok Kang, Youri Lee, Md Ahasun Habib, Byeong Jo Choi, Jong Soon Kang, Doo-Sang Park, Yong-Sik Kim
Summary: The study demonstrates the role of Bifidobacterium longum subsp. infantis YB0411 in inhibiting adipogenesis by reducing triglyceride accumulation and related gene expression, lowering levels of autophagic markers, and exerting anti-obesity effects through AMP-activated protein kinase. YB supplementation also significantly reduced body weight and fat accretion in mice with high-fat-diet-induced obesity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Qiong Shen, Yu-te Zhong, Xiang-xiang Liu, Jun-nan Hu, Si-min Qi, Ke Li, Zi Wang, Hong-yan Zhu, Xin-dian Li, Ying-ping Wang, Wei Li
Summary: In this study, the ameliorative effects of platycodin D (PD) on high-fat diet (HFD)/streptozotocin (STZ)-induced type 2 diabetes (T2D) mice were investigated. PD treatment improved body weight gain and maintained glucose homeostasis. PD also reduced liver tissue pathologies and abnormal liver function caused by T2D. Additionally, PD decreased hepatic glycogen decomposition and lipid levels, as well as hepatic fat accumulation. The results suggest that PD modulation of hepatic glycolipid metabolism abnormalities shows promise for T2D therapy in the future.
Article
Nutrition & Dietetics
So-Won Heo, Kyung-Sook Chung, Young-Seo Yoon, Soo-Yeon Kim, Hye-Shin Ahn, Yu-Kyong Shin, Sun-Hee Lee, Kyung-Tae Lee
Summary: Obesity is a global threat to public health, leading to diseases such as type 2 diabetes and non-alcoholic fatty liver disease. In this study, we found that a herbal extract called EECM has anti-obesity effects by inhibiting adipogenesis and lipogenesis and regulating adipogenic hormones. EECM was also effective in reducing body weight gain, body fat accumulation, and adipocyte and lipid accumulation in mice. It induced thermogenic factors in brown adipose tissue and restored gut microbiome composition. EECM may serve as a promising therapeutic agent for preventing obesity.
Article
Plant Sciences
Lulu Zhang, Xiuteng Zhou, Huijian Chen, Liangzhen You, Ting Zhang, Meng Cheng, Yudi Yao, Xin Pan, Xinzhou Yang
Summary: Mulberry (Morus alba L.) is not only a tasty food but also a beneficial medicinal substance that has been historically used to treat diabetes. Recent research has shown that the ethyl acetate extract of Morus alba L. fruits (EMF) has hypoglycemic and hypolipidemic properties, but the specific mechanisms are unclear.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Immunology
Yue Kai, Jingtao Gao, Hu Liu, Yubing Wang, Chenrui Tian, Sheng Guo, Ling He, Min Li, Zhongwei Tian, Xiangfeng Song
Summary: This study found that IL-33 can optimize lipid aggregation and ameliorate the inflammatory response in obesity. Both in vitro and in vivo experiments showed that IL-33 treatment significantly improved metabolic parameters in mice, regulating lipid metabolism and inflammatory response, suggesting IL-33 as a novel therapeutic target for obesity and related metabolic diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Food Science & Technology
Shuai Yu, Hongmei Li, Taihua Cui, Mingxun Cui, Chunxiang Piao, Shitong Wang, Ming Ju, Xin Liu, Guanghong Zhou, Hongyan Xu, Guanhao Li
Summary: Onion peel extract has potential anti-obesity effects by reducing lipid accumulation, lowering blood lipid levels, and decreasing body weight. Further research is needed to develop natural anti-obesity foods and supplements based on onion peel extract.
Article
Agriculture, Multidisciplinary
Jing Zhou, Ji Zhang, Jiayi Li, Yiqiu Guan, Ting Shen, Fu Li, Xueqin Li, Xiaojun Yang, Weicheng Hu
Summary: Ginsenoside F2 (GF2) may prevent obesity by inhibiting adipocyte differentiation through regulating adipokines and activating the AMPK pathway, resulting in reduced body weight gain and adipose tissue weight in obese mice.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Food Science & Technology
Jinhee Song, Hana Lee, Huijin Heo, Junsoo Lee, Younghwa Kim
Summary: We investigated the effects of chrysoeriol on fat cell formation and breakdown and identified the underlying mechanisms. Chrysoeriol inhibited fat accumulation in adipocytes and downregulated the expression of key genes involved in fat synthesis. Furthermore, chrysoeriol activated a protein kinase that promotes fat breakdown and increased the levels of free glycerol and fatty acids. Overexpression of specific enzymes for fat breakdown contributed to the enhanced lipolysis induced by chrysoeriol. Overall, chrysoeriol exhibited anti-adipogenic and lipolytic properties in fat cells.
Article
Food Science & Technology
Ji-Eun Lee, Sung Gi Min, Sung Wook Hong, Jae-Hwan Kim, Gwang-Ho Kim, Ye-Rang Yun
Summary: Red yeast rice, fermented rice with Monascus purpureus, showed anti-obesity effect by reducing triglyceride content and obesity-related gene expression in vitro. In vivo, oral administration of red yeast rice for 8 weeks significantly decreased body weight and serum lipid profiles without liver damage. Red yeast rice inhibited lipid accumulation in adipocytes and provided a better understanding of the health benefits of kimchi.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Cell Biology
Xin Lv, Jun Qiu, Tao Hao, Haoran Zhang, Haiping Jiang, Yang Tan
Summary: The study demonstrated that TSA inhibited adipogenesis in 3T3-L1 preadipocytes by activating the AMPK pathway, leading to decreased lipid accumulation. Furthermore, TSA was also able to reverse the weight gain and adipose tissue increase induced by a high-fat diet in obese mouse models.
Article
Chemistry, Medicinal
Min Yeong Choi, Jeong Won Choi, Hyeok Jin Choi, Seung Woo Im, Gwang Hun Park, Jin Boo Jeong
Summary: This study investigated the anti-obesity activities of Hovenia dulcis branch extract (HDB) in vitro and in vivo, and found that HDB inhibited lipid accumulation and reduced body weight and fat weight in obese mice. HDB also decreased blood cholesterol and triglyceride levels, indicating its potential use as a functional food agent for weight reduction.
Article
Biochemistry & Molecular Biology
Hong Zhang, Yunhui Zhang, Tong Mu, Jianxin Cao, Xiaoxia Liu, Xingbin Yang, Daoyuan Ren, Ke Zhao
Summary: This study aimed to investigate the relationship between inulin, a dietary fiber, and gut microbiota, as well as the impact on distal intestine function. The results showed that inulin supplementation significantly reduced body weight, fat deposition, and fasting blood glucose levels, and induced changes in cecal microbiota structure and ileum transcriptomic profiling. Inulin also reversed the expression levels of certain bacterial species and intestinal genes. In conclusion, inulin may alleviate high-fat diet-induced fat deposition and metabolic disorders through regulating lipid metabolism in the ileum, with the interaction between sPLA2s and gut microbes playing important roles in the process.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Yu-te Zhong, Qiong Shen, Yu-ting Yang, Ruo-bing Zhang, Li-chun Zhao, Wei Li
Summary: In this study, the major dihydrochalcone compound trilobatin (TRI) was purified from sweet tea and its effect in preventing glycolipid metabolism disorder was investigated using a type 2 diabetic mice model induced by a high-fat diet (HFD) combined with streptozotocin (STZ). The results showed that TRI administration improved elevated blood lipids, liver function, fatty liver, glucose metabolism disorders, and insulin sensitivity. Additionally, TRI was found to inhibit AMPK-mediated gluconeogenesis and fatty acid anabolism, suggesting its mechanism in ameliorating glycolipid metabolism disorder.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Nutrition & Dietetics
Tomohiko Nakao, Shiro Otaki, Yuri Kominami, Soichi Watanabe, Miho Ito, Teruki Aizawa, Yusuke Akahori, Hideki Ushio
Summary: L-fucose (Fuc) demonstrates potent anti-obesity effects in mice, however, the underlying mechanisms are not fully understood. This study investigates the effects of Fuc on lipid metabolism and insulin signaling in 3T3-L1 adipocytes. Fuc treatment suppresses lipid accumulation and activates the AMPK pathway, responsible for regulating fatty acid oxidation and lipolysis. Fuc also promotes glucose uptake via Akt activation in an insulin-resistant state. These findings provide insights into the mechanism of Fuc's anti-obesity effects and its potential as a therapeutic compound.
Article
Biochemistry & Molecular Biology
Bitna Kweon, Yo-Han Han, Ji-Ye Kee, Jeong-Geon Mun, Hee Dong Jeon, Dae Hwan Yoon, Byung-Min Choi, Seung-Heon Hong
Article
Critical Care Medicine
Barbora Konecna, Jinbong Park, Woon-Yong Kwon, Barbora Vlkova, Quanzhi Zhang, Wei Huang, Hyo In Kim, Michael B. Yaffe, Leo E. Otterbein, Kiyoshi Itagaki, Carl J. Hauser
Summary: The study found that sepsis can cause active release of mtDAMPs from cells, which may impact innate immunity. The release of mitochondrial DNA has a suppressive effect on chemotaxis of neutrophils, while respiratory burst remains unaffected.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2021)
Article
Nutrition & Dietetics
Yo-Han Han, Jeong-Geon Mun, Hee Dong Jeon, Dae Hwan Yoon, Byung-Min Choi, Ji-Ye Kee, Seung-Heon Hong
Article
Pharmacology & Pharmacy
Seon Yeon Cho, Seona Lim, Kwang Seok Ahn, Hyun Jeong Kwak, Jinbong Park, Jae-Young Um
Summary: This study demonstrates that farnesol induces thermogenesis in brown adipose tissue by activating AMP-activated protein kinase alpha, promoting lipolytic enzyme activity, and increasing expression of oxidative phosphorylation complexes and peroxisomes. These findings suggest that farnesol may be a potential treatment for obesity by promoting energy consumption through heat generation.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Min-Kyoung Shin, Yong-Deok Jeon, Seung-Heon Hong, Sa-Haeng Kang, Ji-Ye Kee, Jong-Sik Jin
Summary: Recent research has shown that tracheloside (TCS) can inhibit the proliferation of colorectal cancer (CRC) cells and induce cell cycle arrest and apoptosis through its antioxidant properties. In addition, TCS was found to inhibit the metastasis of CT26 cells, suggesting it may be a novel therapeutic agent for inhibiting metastatic phenotypes of murine CRC cells.
Article
Biochemistry & Molecular Biology
Woo Yong Park, Gahee Song, Ja Yeon Park, Kwan-Il Kim, Kwang Seok Ahn, Hyun Jeong Kwak, Jungtae Leem, Jae-Young Um, Jinbong Park
Summary: The extract of Gardenia jasminoides fruit induces thermogenic action by activating mitochondrial function via PPAR gamma activation, suggesting potential as an anti-obesity agent with a novel mechanism involving thermogenic action in white adipocytes.
Article
Nutrition & Dietetics
Woo Yong Park, Gahee Song, Joon Hak Noh, Taegon Kim, Jae Jin Kim, Seokbeom Hong, Jinbong Park, Jae-Young Um
Summary: The study investigated the pharmacological effect of RSWE on alcoholic fatty liver disease (AFLD) and found that RSWE has the potential to improve AFLD by inhibiting de novo lipogenesis in the liver. Supplementation with RSWE decreased liver fat accumulation and improved tissue structure in both mouse and cell models.
Article
Biochemistry & Molecular Biology
Changhwan Yeo, Chae Ryeong Ahn, Jai-Eun Kim, Young Woo Kim, Jinbong Park, Kwang Seok Ahn, In Jin Ha, Yoon Jae Lee, Seung Ho Baek, In-Hyuk Ha
Summary: This study demonstrates the anti-inflammatory and articular regeneration effects of Chaenomeles Fructus (CF) on rat chondrocytes with osteoarthritis, suggesting it as a promising therapeutic option for the treatment of OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ga Yeong Yi, Min Ju Kim, Hyo In Kim, Jinbong Park, Seung Ho Baek
Summary: Despite advancements in diagnosis and treatment, cancer remains a critical threat to health. Hyperthermia (HT) is a promising and cost-effective treatment strategy for cancer. This review summarizes studies on the anti-cancer effects of HT and its detailed mechanisms, as well as the combination therapies that can overcome the limitations of HT.
Article
Plant Sciences
Ja Yeon Park, Woo Yong Park, Jinbong Park, Kwang Seok Ahn, Jun Hee Lee, Hyun Jeong Kwak, Jae-Young Um
Summary: This study found that a water extract of Glycyrrhiza uralensis Fischer has potential therapeutic effects on BPH by inhibiting AR-5AR2 signaling and activating apoptosis signaling to reduce BPH development. Unlike finasteride, GUWE does not impact sperm count, suggesting lower toxicity and a safer alternative option for BPH treatment.
Article
Nutrition & Dietetics
Jeong-Geon Mun, Hee Dong Jeon, Dae Hwan Yoon, Yoon Seung Lee, Shin Young Park, Jong-Sik Jin, Noh-Joon Park, Ji-Ye Kee
Summary: The supercritical extract of Cannabis sativa has been shown to inhibit the proliferation and metastasis of colorectal cancer cells, suggesting its potential as a therapeutic option for colorectal cancer treatment.
Article
Biochemistry & Molecular Biology
Woo Yong Park, Gahee Song, Mina Boo, Hyo In Kim, Ja Yeon Park, Se Jin Jung, Minji Choi, Beomsu Kim, Young Doo Kim, Myung-Ho Kim, Kwan-Il Kim, Hyun Jeong Kwak, Jungtae Leem, Jae-Young Um, Jinbong Park
Summary: Obesity is a global health burden. The AMGB decoction, a multi-herb decoction, has shown clinical anti-obesity effects by suppressing body weight gain and obesity-related parameters, as well as inducing lipolysis in adipose tissues.
Article
Biochemistry & Molecular Biology
Chae Ryeong Ahn, Hyo In Kim, Jai-Eun Kim, In Jin Ha, Kwang Seok Ahn, Jinbong Park, Young Woo Kim, Seung Ho Baek
Summary: Gastric cancer has a high incidence and mortality rate with poor prognosis. Hyperthermia therapy combined with Ponciri Fructus Immaturus (PF) showed synergistic effects in suppressing AGS gastric cancer cell proliferation, inducing cell cycle arrest, and inhibiting metastasis-related factors. The combination treatment also increased reactive oxygen species (ROS) levels and suppressed heat shock factor 1 and heat shock proteins (HSPs), suggesting a potential promising therapy for gastric cancer.
Review
Biochemistry & Molecular Biology
Yohan Han, Hyo In Kim, Jinbong Park
Summary: The lack of research evidence and trials on cancer-induced cachexia limits the therapeutic potential of natural products. This review summarizes single natural product extracts for cancer-induced cachexia and discusses their effects on cachexia induced by anticancer drugs. The inclusion of mice models encourages future research on cancer-induced cachexia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Critical Care Medicine
Quanzhi Zhang, Woon Yong Kwon, Barbora Vlkova, Ingred Rica, Elzbieta Kaczmarek, Jinbong Park, Hyo In Kim, Barbora Konecna, Francoise Jung, Garry Douglas, Leo E. Otterbein, Carl J. Hauser, Kiyoshi Itagaki
Summary: Injury-induced mtFPs inhibit the migration of neutrophils to infected alveoli, but instillation of exogenous human neutrophils into the airway prevents the development of post-traumatic pneumonia in recipients.