Article
Biochemistry & Molecular Biology
Tao Fan, Shuofeng Li, Chu Xiao, He Tian, Yujia Zheng, Yu Liu, Chunxiang Li, Jie He
Summary: CCL20 plays a role in promoting lung adenocarcinoma progression, with high expression associated with poor prognosis and activation of EMT, inflammatory response, and TNF pathway. Knockdown of CCL20 inhibits EMT process and cell proliferation in lung adenocarcinoma. Low CCL20 expression improves response to anti-PD-L1 therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Alyssa M. Kaiser, Alberto Gatto, Kathryn J. Hanson, Richard L. Zhao, Nitin Raj, Michael G. Ozawa, Jose A. Seoane, Kathryn T. Bieging-Rolett, Mengxiong Wang, Irene Li, Winston L. Trope, Douglas Z. Liou, Joseph B. Shrager, Sylvia K. Plevritis, Aaron M. Newman, Capucine Van Rechem, Laura D. Attardi
Summary: Lung cancer is the leading cause of cancer deaths worldwide, and mutations in the TP53 gene are linked to poor prognosis in lung adenocarcinomas (LUADs). This study reveals that p53 suppresses LUAD by promoting alveolar type 1 (AT1) differentiation. Through direct DNA binding, chromatin remodeling, and induction of AT1 cell characteristic genes, p53 induces an AT1 differentiation program during tumor suppression. Additionally, p53 plays a role in alveolar regeneration after injury by regulating AT2 cell self-renewal and promoting transitional cell differentiation into AT1 cells.
Review
Medicine, General & Internal
Lin Jiang, Jingbo Zhang, Yan Xu, Heng Xu, Mengzhao Wang
Summary: The phosphosphatidylinositol-3-kinase (PI3K) signaling pathway plays a crucial role in the development of lung cancer. Traditional treatment methods have limited efficacy, but molecular targeted therapy has improved survival and prognosis for patients. There is a growing body of research focusing on NSCLC and the PI3K signaling pathway.
CHINESE MEDICAL JOURNAL
(2022)
Article
Medicine, Research & Experimental
Xiaofeng Yu, Ying Li, Guodong Jiang, Jian Fang, Zhaolei You, Guangyuan Shao, Zheng Zhang, Aihong Jiao, Xiaonu Peng
Summary: This study revealed that FGF21 is upregulated in lung cancer and can promote cell growth and migration by activating the SIRT1/PI3K/AKT signaling pathway, indicating FGF21 as a potential therapeutic target for lung cancer treatment.
Article
Biochemistry & Molecular Biology
Yujing Zhang, Gang Shi, Hantao Zhang, Qi Xiong, Fuyi Cheng, Huiling Wang, Jieyan Luo, Yong Zhang, Pengyi Shi, Jia Xu, Jiamei Fu, Na Chen, Lin Cheng, Yiming Li, Lei Dai, Yang Yang, Dechao Yu, Shuang Zhang, Hongxin Deng
Summary: The study demonstrated that dexamethasone can promote breast cancer cell metastasis through the GR-PI3K-SGK1-CTGF pathway in tumor cells. Targeting SGK1 could be a potential strategy for the treatment of breast cancer metastasis.
Article
Environmental Sciences
Lulu Niu, Wenwen Li, Xin Chen, Xiaosan Su, Jingjing Dong, Quanyang Liao, Xuhong Zhou, Shaoqing Shi, Ruifen Sun
Summary: The active constituent 1-Monopalmitin (1-Mono) in Mougeotia nummuloides and Spirulina major inhibits the proliferation of lung cancer cells and induces apoptosis through the PI3K/Akt pathway. It also suppresses autophagy, and combining with autophagy inhibitor Chloroquine enhances its cytotoxicity.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Cell Biology
Hefei Li, Yushan Zhang, Xiaomei Lan, Jianhua Yu, Changshuang Yang, Zhijian Sun, Ping Kang, Yi Han, Daping Yu
Summary: Lung cancer is the leading cause of cancer death globally. Cisplatin is a common DNA-damaging drug used in treatment, but resistance often develops. Halofuginone has been identified as a sensitizing agent in lung cancer, inhibiting cell proliferation and inducing apoptosis by affecting PI3K/AKT and MAPK signaling pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Guangsu Xun, Wei Hu, Bing Li
Summary: It was found that STMN1 was overexpressed in lung cancer tissues and associated with worse survival rates of lung cancer patients. PTEN loss promoted STMN1 expression via the PI3K/AKT pathway, regulating the oncogenic function of STMN1 in lung cancer.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Yuzhen Wang, Yingchun Wang, Wen Liu, Lu Ding, Xiaodi Zhang, Bo Wang, Zheng Tong, Xuetian Yue, Chunyang Li, Liyun Xu, Zhuanchang Wu, Xiaohong Liang, Chunhong Ma, Lifen Gao
Summary: The study found that T-cell immunoglobulin and mucin domain-containing molecule 4 (TIM-4) promotes the growth and proliferation of lung cancer cells by enhancing mitochondrial fusion and oxidative phosphorylation pathway.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Ali Daneshkhah, Sravya Prabhala, Parvathi Viswanathan, Hariharan Subramanian, Jianan Lin, Andrew S. Chang, Ankit Bharat, Hemant Kumar Roy, Vadim Backman
Summary: The structure of supranucleosomal chromatin is involved in gene expression regulation and has been linked to carcinogenesis. A new optical spectroscopic technique called csPWS has been developed to detect chromatin changes in buccal mucosa as a biomarker for lung cancer prediction. The use of artificial intelligence enhances the diagnostic performance of csPWS.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Rui Zhang, Mengxue Dong, Juchuanli Tu, Fengkai Li, Qiaodan Deng, Jiahui Xu, Xueyan He, Jiajun Ding, Jie Xia, Dandan Sheng, Zhaoxia Chang, Wei Ma, Haonan Dong, Yi Zhang, Lixing Zhang, Lu Zhang, Suling Liu
Summary: Our previous studies have shown that CCL20 contributes to tumor progression and chemoresistance by regulating breast cancer stem cell self-renewal. This study demonstrates that CCL20 also affects breast cancer progression by remodeling the tumor microenvironment, particularly through the enrichment of PMN-MDSCs. The interaction between PMN-MDSCs and BCSCs in CCL20(high)-expressing breast cancer can be targeted for therapeutic intervention.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Multidisciplinary Sciences
Kamila Baran, Jacek Kordiak, Slawomir Jablonski, Ewa Brzezianska-Lasota
Summary: This study evaluated the expression levels of CCR6/CCL20 mRNA and non-coding RNAs (ncRNAs) such as miR-150 and linc00673 in NSCLC tissue. It was found that CCL20 mRNA was upregulated while CCR6 mRNA was downregulated in tumor tissue. In addition, the expression levels of miR-150 and linc00673 in serum extracellular vesicles showed associations with tumor staging and histopathological type.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
S. M. Jamshedur Rahman, Sheau-Chiann Chen, Yi-Ting Wang, Yuqian Gao, Athena A. Schepmoes, Thomas L. Fillmore, Tujin Shi, Heidi Chen, Karin D. Rodland, Pierre P. Massion, Eric L. Grogan, Tao Liu
Summary: This study validated candidate proteins in the bronchial epithelial cells of individuals at high risk for lung cancer and found significant overexpression of these proteins in the high-risk group. These proteins may serve as biomarkers for early detection of lung cancer.
Article
Gastroenterology & Hepatology
Chaochao Xu, Lina Fan, Yifeng Lin, Weiyi Shen, Yadong Qi, Ying Zhang, Zhehang Chen, Lan Wang, Yanqin Long, Tongyao Hou, Jianmin Si, Shujie Chen
Summary: In this study, it was found that F. nucleatum plays a crucial role in promoting CRC metastasis by activating CCL20 and inducing M2 macrophage polarization. Moreover, the regulatory micro-RNA miR-1322 was identified to be involved in this process by regulating CCL20.
Article
Genetics & Heredity
Noman Qureshi, Jincheng Chi, Yanan Qian, Qianwen Huang, Shaoyin Duan
Summary: In this study, we found potential bio-markers for early lung cancer detection by analyzing the gene expression of nasal epithelium.
FRONTIERS IN GENETICS
(2022)
Article
Automation & Control Systems
Weijia Zheng, YangQuan Chen, Xiaohong Wang, Yong Chen, Meijin Lin
Summary: In this paper, an enhanced fractional order sliding mode control (FOSMC) method is proposed to improve the control performance of fractional order uncertain systems with multiple mis-matched disturbances. The multiple disturbances and uncertainties are estimated by finite-time disturbance observers and a fractional order extended state observer. A fractional order switching law is designed for fast convergence of system states. The proposed method incorporates feedforward compensation, the fractional order switching law, and an auxiliary state for input saturation. Numerical examples and a motor speed control problem are used to demonstrate the effectiveness of the proposed method through performance comparisons with existing control methods.
Article
Engineering, Electrical & Electronic
Fei Shan, Suchang Yoo, Jae-Yun Lee, Han-Lin Zhao, Xiao-Lin Wang, Seong Gon Choi, Heung Gyoon Ryu, Yong Jin Jeong, Sung-Jin Kim
Summary: In this paper, a multi-stacked IZO TFT with exceptional electronic characteristics is prepared, and the plasma treatment is used to improve the performance of the device and optimize the crystal structure and surface smoothness.
JOURNAL OF ELECTRICAL ENGINEERING & TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Wang Zhao, Hao Su, Weifeng He, Xiaorong Wang, Xiaoyu Cui, Sihai Luo
Summary: Electro-spark deposition (ESD) is an effective method for welding and fabricating coatings, but it can introduce severe surface defects that deteriorate the material performance. This study investigated the effect of key factors on surface features of WC-10 wt.% Co coatings and found that pulse energy, deposition layers, and their interaction significantly affect coating defects. It was also discovered that ultra-low efficiency deposition in the later stage of ESD can effectively repair coating defects.
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
(2023)
Article
Obstetrics & Gynecology
Jie Dong, Qian Xu, Shuqiang Chen, Hui Lei, Jingjing Wang, Song Yan, Chenxi Qian, Xiaohong Wang
Summary: "Offspring conceived by assisted reproductive technologies (ART) have an increased risk of gestational complications, which are related to placental dysfunction. This study used proteomics and phospho-proteomics to investigate the underlying mechanisms responsible for the changes in ART placentas. The findings suggest that ART leads to altered cell junctions, renin-angiotensin system, amino acid transport, and increased mTOR signaling in mouse placentas."
REPRODUCTIVE SCIENCES
(2023)
Article
Engineering, Electrical & Electronic
Qiyue Xie, Wenqian Zhou, Lin Ma, Zhisheng Chen, Wanneng Wu, Xiaoli Wang
Summary: In this paper, the whale optimization algorithm (WOA) is introduced to optimize the threshold for steel plate surface defect image segmentation. An improved WOA method is proposed to overcome the limitations of the original WOA. The experimental results show that the proposed algorithm outperforms the traditional Otsu algorithm and achieves more accurate segmentation of steel plate surface defect image.
SIGNAL IMAGE AND VIDEO PROCESSING
(2023)
Article
Biotechnology & Applied Microbiology
Huiyang Li, Xiaoyu Liang, Youlu Chen, Kaijing Liu, Xue Fu, Chuangnian Zhang, Xiaoli Wang, Jing Yang
Summary: In this study, a wound dressing composed of konjac glucomannan and gallic acid was developed, which could accelerate wound healing by promoting macrophage polarization and reducing reactive oxygen species levels. In vivo experiments showed that it had excellent anti-inflammatory properties.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Zhifei Xu, Zizheng Gao, Huangxi Fu, Yan Zeng, Ying Jin, Bo Xu, Yuanteng Zhang, Zezheng Pan, Xueqin Chen, Xiaochen Zhang, Xiaohong Wang, Hao Yan, Xiaochun Yang, Bo Yang, Qiaojun He, Peihua Luo
Summary: This study identified a distinct mechanism of trastuzumab-induced cardiac complications through the promotion of PTX3 excretion in vascular endothelial cells, leading to impaired contractility of cardiomyocytes. Inhibition of the EGFR/STAT3 signaling pathway reduced the release of PTX3, thereby blocking the cardiac side effects caused by trastuzumab.
CARDIOVASCULAR RESEARCH
(2023)
Article
Chemistry, Physical
Yuandong Xu, Lili Sun, Hui Guo, Yaqing Wei, Haoyang Feng, Binyang Liu, Jing Yu, Yajun Wei, Xia Zhang
Summary: The Zeolitic imidazolate frameworks (ZIF) and the peanut shell carbon (PSC) composite (ZIF-8 @PSC) nanocomposite is successfully fabricated and exhibits superior current response for simultaneously detecting Pb2+ and Cd2+. The suitable pore structure, specific surface area, and low internal resistance of the ZIF-8 @PSC contribute to the enhanced current signals. The method shows excellent selectivity, stability, repeatability, and reproducibility.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Psychiatry
Jingjing Shi, Xiaohong Wang, Na Zhao, Chuanyi Kang, Liying Yang, Yue Zheng, Jiacheng Liu, Lei Feng, Xuequan Zhu, Caina Ma, Wenyuan Wu, Gang Wang, Jian Hu
Summary: This study compared the sex differences of residual somatic symptoms (RSS) in patients with first-episode depression (FED). The results showed that RSS is common in FED patients, with females more likely to experience stomach pain and males more likely to experience trouble sleeping. Additionally, quality of life plays an essential role in RSS in both genders. Therefore, sex differences should be considered when assessing the relationship between RSS and therapeutic effect in depression.
Article
Engineering, Environmental
Jiachen Yan, Guohong Liu, Hanle Chen, Song Hu, Xiaohong Wang, Bing Yan, Xiliang Yan
Summary: A comprehensive online database on the toxicity of ionic liquids (ILs) has been developed to aid in the design of environmentally friendly ILs using machine learning. The ILTox database contains manually curated data, including 1183 ILs and over 6700 pieces of toxicity data across different organisms. Machine learning models have been constructed using this database to analyze the relationship between IL structures and toxicities. The database has been used for virtual screening of desired IL properties from a large pool of ILs and has proven to be a valuable resource in understanding IL toxicity.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2023)
Article
Psychiatry
Ruoheng Lin, Qiguang Li, Ziwei Liu, Shaoling Zhong, Qiaoling Sun, Huijuan Guo, Hui Cao, Xiangbin Zhang, Yuhang Hu, Jiansong Zhou, Xiaoping Wang
Summary: This study investigated EEG microstates in violent patients with schizophrenia. The results showed differences in EEG microstate parameters between violent and non-violent patients, which could help clinicians identify schizophrenia patients with a risk for violence and develop early intervention strategies.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Engineering, Electrical & Electronic
Zhifeng Pan, Xiaohong Wang, Thi Thu Giang Hoang, Lianfang Tian
Summary: In response to the accuracy deterioration of SRF-PLL caused by non-ideal grid conditions and limitations of LADRC-PLL, this paper proposes an enhanced three-phase PLL that combines IMAF and LADRC. Through the use of LESO and IMAF in a specific control structure, the proposed IMAF-LADRC-PLL achieves satisfactory steady-state accuracy without compromising dynamic performance. Experimental results show that the proposed IMAF-LADRC-PLL outperforms traditional strategies in terms of dynamic performance and maintaining phase-locked accuracy.
INTERNATIONAL JOURNAL OF ELECTRICAL POWER & ENERGY SYSTEMS
(2023)
Article
Chemistry, Multidisciplinary
Caiyan Lai, Bingdong Yan, Run Yuan, Delun Chen, Xiaohong Wang, Mingyu Wang, Heyu He, Jinchun Tu
Summary: In this study, a heterojunction composed of a TiO2 nanosheet and layered Ti3C2 was synthesized. The TiO2/Ti3C2 composites exhibited increased surface area and extended light absorption range, leading to prolonged lifetime of photogenerated carriers. A photoelectrochemical DNA biosensor based on the TiO2/Ti3C2 heterostructure was constructed and comprehensively studied. The sensor displayed stability and sensitivity for DNA detection in the range of 10 nM-10 fM, with a lower detection limit of 6 fM. It provided potential for early diagnosis of various diseases by detecting target DNA.
Article
Engineering, Environmental
Fan Yao, Guangzheng Ye, Weixiao Peng, Guangyi Zhao, Xiaohong Wang, Yuqin Wang, Wenfu Zhu, Yujun Jiao, Haomin Huang, Daiqi Ye
Summary: This study investigates the hydrothermal carbonization (HTC) of glucose and precisely determines the pore structure of the obtained hydrochar by controlling the main factors of the hydrothermal process. The results provide guidance and an effective reference for the pore size adjustment of porous-activated biochar developed for the adsorption of pollutants.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Jia-Tong Ren, Ding Wei, Bo-Jun Tan, Rui Hu, Yu-Chen Gao, Xiao-Hong Wang, Wei-Tao Yang
Summary: Developing MOF-based catalysts with superior catalytic properties for the thermal decomposition of RDX is crucial for efficient combustion of RDX-based propellants. In this study, micro-sized Co-ZIF-L with star-like morphology exhibited remarkable catalytic capability, lowering the RDX decomposition temperature by 42.9°C and increasing the heat release by 50.8% compared to all previously reported MOFs and even ZIF-67. The unique structure of SL-Co-ZIF-L activated the exothermic C-N fission pathway, promoting the decomposition process at low temperatures.