Article
Biochemistry & Molecular Biology
Ya He, Maohong Luo, Shan Lei, Zhirui Zeng, Tengxiang Chen, Yingmin Wu, Dongyan Wang, Long Wang, Lu Wang
Summary: Luteoloside has exhibited anti-inflammatory, antiviral, and antitumor properties. Its effect on neuroblastoma cells was investigated in this study. Luteoloside inhibited the proliferation of neuroblastoma cells by activating the p38 MAPK pathway, indicating its potential as an anticancer drug for treating neuroblastoma.
Article
Pharmacology & Pharmacy
Wen Yin, Xu Fu, Wenwen Chang, Li Han, Jiahao Meng, Aijia Cao, Xiaomin Ren, Zhongxiong Fan, Suqin Zhou
Summary: This study provides strong evidence that esculetin can potentially be used as an anticancer agent in ovarian cancer. It induces apoptosis by increasing excessive ROS levels and inhibiting the JAK2/STAT3 signaling pathway. It also reduces cell viability, migration, and invasion, and causes G0/G1 phase cell cycle arrest by downregulating downstream targets of STAT3.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Article
Genetics & Heredity
Xuming Hu, Huan Luo, Chunfeng Dou, Xujing Chen, Yi Huang, Liping Wang, Songlei Xue, Zhen Sun, Shihao Chen, Qi Xu, Tuoyu Geng, Xin Zhao, Hengmi Cui
Summary: Metformin induces apoptosis in macrophages, especially M1 macrophages, via G0S2 induction, providing a novel anti-inflammatory mechanism.
Article
Biochemistry & Molecular Biology
Magdalena Delgado, Randall R. Rainwater, Billie Heflin, Alicja Urbaniak, Kaitlynn Butler, Mari Davidson, Reine M. Protacio, Giulia Baldini, Andrea Edwards, Megan R. Reed, Kevin D. Raney, Timothy C. Chambers
Summary: This study found that microtubule depolymerization induces different cell death pathways depending on the specific phase of the cell cycle. Cell death in M phase is associated with mitochondrial-mediated apoptosis, while cell death in G1 phase is associated with loss of mitochondrial transmembrane potential, parylation, nuclear translocation of apoptosis-inducing factor and endonuclease G, and supra-nucleosomal DNA fragmentation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Toxicology
Haiyan Yin, Yinuo Sun, Bailiu Ya, Yan Guo, Hao Zhao, Lili Zhang, Fan Wang, Weiwei Zhang, Qianqian Yang
Summary: The ototoxic side effect of cisplatin, which limits its clinical application and affects patients' quality of life, can be attenuated by apelin-13 through inhibiting apoptosis and regulating several molecular mechanisms. Apelin-13 protects cochlear hair cells and spiral ganglion neurons from damage, reduces apoptosis, preserves mitochondrial membrane potential, inhibits ROS production, and regulates the expression and phosphorylation of various factors involved in ototoxicity.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Shohei Fukada, Kouji Ohta, Miyuki Sakuma, Misaki Akagi, Hiroki Kato, Takako Naruse, Takayuki Nakagawa, Hideo Shigeishi, Hiromi Nishi, Masaaki Takechi, Tomonao Aikawa
Summary: This study found that Sunitinib treatment can cause cell injury and apoptosis in oral keratinocytes, which is promoted by p38 activation and STAT3 downregulation. These findings suggest that oral mucosal complications may be associated with the cytotoxic effects of Sunitinib on oral keratinocytes.
Article
Pharmacology & Pharmacy
Jiayan Liu, Tao Mi, Zhaoxia Zhang, Liming Jin, Maoxian Li, Chenghao Zhanghuang, Mujie Li, Jinkui Wang, Xin Wu, Zhaoying Wang, Xiaojun Tan, Zhang Wang, Dawei He
Summary: Malignant rhabdoid tumor of the kidney (MRTK) has a poor prognosis and is unresponsive to radiotherapy and chemotherapy. In this study, BKM120 was identified as a potential therapeutic agent for MRTK by inhibiting the PI3K/Akt signaling pathway to induce cell apoptosis and cycle arrest. Both in vitro and in vivo experiments confirmed the inhibitory effects of BKM120 on MRTK.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Peijie Liu, Hongrui Zhang, Fulian Qu, Liying Lv, Fengqian Shen, Ning Li, Xiaojing Tie, Yan Zhang
Summary: This study investigated the effects of Sarsasapogenin (SAR), a sapogenin derived from the Chinese herbal medicine Anemarrhena asphodeloides Bunge, on pancreatic cancer. SAR was found to inhibit cell growth and promote apoptosis in pancreatic cancer cells through the production of reactive oxygen species (ROS). Furthermore, SAR was shown to block the JAK/STAT3 pathway and induce mitochondrial dysfunction, suggesting its potential as a therapeutic agent for pancreatic cancer.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biotechnology & Applied Microbiology
Seung-On Lee, Ah-Won Kwak, Mee-Hyun Lee, Ji-Hye Seo, Seung-Sik Cho, Goo Yoon, Jung-Il Chae, Sang Hoon Joo, Jung-Hyun Shim
Summary: PPT induces G1 arrest and apoptosis in HCT116 cells through ROS generation and activation of the p38 MAPK signaling pathway.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lisenn Lalier, Francois Vallette, Stephen Manon
Summary: This review examines the role of mitochondrial import machineries in the localization of Bcl-2 family members and how these machineries regulate the function of pro- and anti-apoptotic proteins in resting and apoptotic cells.
Article
Biochemistry & Molecular Biology
Chao-Yu Hsu, Wei-Ting Yang, Ju-Hwa Lin, Chien-Hsing Lu, Kai-Cheng Hu, Tsuo-Hung Lan, Chia-Che Chang
Summary: Sertindole has been found to have antiproliferative effects on bladder cancer cells by inhibiting the STAT3/BCL-xL signaling pathway, suggesting its potential as a therapeutic strategy for bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Zhiping Dong, Xiaoshan Liang, Qiang Zhang, Suhui Luo, Huan Liu, Xuan Wang, Na Sai, Xumei Zhang
Summary: In this study, it was found that folic acid deficiency exacerbates brain injury in ischemic stroke models by regulating mitoSTAT3 phosphorylation levels, indicating a potential involvement of mitoSTAT3 in mitochondrial damage.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Multidisciplinary Sciences
Francisco J. Sanchez-Rivera, Jeremy Ryan, Yadira M. Soto-Feliciano, Mary Clare Beytagh, Lucius Xuan, David M. Feldser, Michael T. Hemann, Jesse Zamudio, Nadya Dimitrova, Anthony Letai, Tyler Jacks
Summary: The level of mitochondrial apoptotic priming is a critical determinant of cell fate upon p53 reactivation, with cells having high initial priming tending to undergo apoptosis and cells with low priming tending to survive and arrest in the cell cycle. Manipulating the priming levels through BCL-2 or BCL-XL expression or inhibition can affect the outcome of p53 restoration, highlighting mitochondrial apoptotic priming as a key factor in determining cell fate. Moreover, less primed cells can be forced into apoptotic cell fate following p53 activation using p53-independent drugs that increase apoptotic priming.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Jeonghyeon Seo, Da Eun Lee, Seong Mi Kim, Eunjung Kim, Jin-Kyung Kim
Summary: The study found that LicA, a major active component of licorice, has anticancer activity against ovarian cancer cells. LicA inhibited cell viability and induced G2/M phase arrest in SKOV3 cells. LicA also induced apoptosis by increasing reactive oxygen species levels, reducing mitochondrial membrane potential, and promoting caspase activation and cytochrome c release. Furthermore, LicA reduced STAT3 protein levels and downstream signaling, suggesting its potential as an anti-cancer agent.
Article
Pharmacology & Pharmacy
Ying Hou, Rong Liu, Mengwei Xia, Chong Sun, Bingling Zhong, Jie Yu, Nana Ai, Jin-Jian Lu, Wei Ge, Bo Liu, Xiuping Chen
Summary: NAN triggers G1 phase cell cycle arrest and caspase-independent apoptosis in CRC cells through downregulation of cyclin D1 and inhibition of eEF1A-targeted translation.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Guoliang Wang, Qing Liu, Young M. Yang, Soo-Ung Lee, Jee-Soo Han, Kyoung-Jin Jang, Dong Y. Kang, Nipin Sp, Zhandong Li, Tao Tong
Summary: Gamma-PGA, a naturally occurring biopolymer, has various favorable properties such as water solubility, biodegradability, and biocompatibility, making it suitable for diverse applications in medicine including as a vaccine adjuvant, tissue engineering material, and contrast agent.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nipin Sp, Dong Young Kang, Jin-Moo Lee, Se Won Bae, Kyoung-Jin Jang
Summary: 6-Gingerol, an active polyphenol in ginger, has been found to induce DNA damage response, cell cycle arrest, mitochondrial apoptosis, and suppression of tumorsphere formation in breast cancer cells by increasing ROS levels and activating p53-dependent intrinsic apoptosis signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Dong Young Kang, Nipin Sp, Eun Seong Jo, Alexis Rugamba, Hyoung Do Kim, Il Ho Kim, Jong-Chan Park, Se Won Bae, Kyoung-Jin Jang, Young Mok Yang
Summary: JAK2 and STAT3 signaling pathway plays a major role in LPS-induced inflammation, with NTS showing a protective effect against cell death and inhibiting expression of inflammatory factors. This suggests that NTS could be a potential drug candidate for inflammation treatment.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Dong Young Kang, Nipin Sp, Jin-Moo Lee, Kyoung-Jin Jang
Summary: Targeted therapy using natural compounds, such as ursolic acid (UA), shows promising effects against non-small cell lung cancer by inhibiting proliferation, inducing cell cycle arrest and apoptosis, and suppressing tumor angiogenesis through EGFR/JAK2/STAT3 signaling pathway.
Article
Biology
Nipin Sp, Dong Young Kang, Hyoung Do Kim, Alexis Rugamba, Eun Seong Jo, Jong-Chan Park, Se Won Bae, Jin-Moo Lee, Kyoung-Jin Jang
Summary: The study found that sulfur compounds NTS and MSM can inhibit LPS-induced inflammatory responses by suppressing TLR4 activation and NF-kappa B signaling, reducing nuclear binding of NF-kappa B to proinflammatory cytokines COX-2, IL-1 beta, and IL-6, as well as inhibiting ROS accumulation and DNA damage.
Article
Biochemistry & Molecular Biology
Nipin Sp, Dong Young Kang, Jin-Moo Lee, Kyoung-Jin Jang
Summary: Tumor immune escape is a common process in NSCLC where PD-L1 expression plays a vital role. Nobiletin, a natural flavonoid, inhibits PD-L1 expression through the EGFR/JAK2/STAT3 signaling, independent of p53, and enhances anti-tumor immunity through miR-197 regulation. Nobiletin also synergizes with anti-PD-1 monoclonal antibody to induce PD-1/PD-L1 blockade in NSCLC, proposing it as a modulator for cancer immunotherapy in the tumor microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Alexis Rugamba, Dong Young Kang, Nipin Sp, Eun Seong Jo, Jin-Moo Lee, Se Won Bae, Kyoung-Jin Jang
Summary: Natural compound silibinin extracted from milk thistle has shown anticancer activity in non-small cell lung cancer (NSCLC) through inhibition of cell proliferation, induction of G0/G1 cell cycle arrest and apoptosis, inhibition of tumor angiogenesis, migration, and invasion. Silibinin binds to EGFR, downregulates phosphorylated EGFR expression, inhibits downstream pathways, and reduces expression of matrix metalloproteinase, PD-L1, and vascular endothelial growth factor, suggesting its potential as a candidate for tumor immunotherapy and cancer stem cell-targeted therapy.
Article
Agronomy
Jong-Chan Park, Nipin Sp, Hyoung Do Kim, Dong Young Kang, Il Ho Kim, Se Won Bae, Young Yang, Kyoung-Jin Jang
Summary: The study shows that sulfur can be applied to crop leaves as nontoxic sulfur (NTS) in trace amounts to positively affect plant growth and increase yields. Additionally, when NTS and trace elements are applied together, they have a synergistic effect, enhancing the expression of plant hormones and improving chlorophyll content and ROS scavenging ability.
Article
Biochemistry & Molecular Biology
Shankara Narayanan Varadarajan, Krupa Ann Mathew, Aneesh Chandrasekharan, Santhik Subhasingh Lupitha, Asha Lekshmi, Minsa Mini, Pramod Darvin, T. R. Santhoshkumar
Summary: The study demonstrates a high-throughput adaptable method using genetically encoded fluorescent probes for real-time quantitative detection of cell death and cell cycle in cancer cells grown as 3D structures. The method successfully identified two lead compounds that induced caspase activation in 2D and 3D cultures, showing potential for drug discovery applications.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Cell Biology
Dong Young Kang, Nipin Sp, Eun Seong Jo, Jin-Moo Lee, Kyoung-Jin Jang
Summary: The study investigated the role of iron/heme metabolism in induced inflammatory conditions, indicating that iron and heme formation and synthesis play a crucial role in enhancing inflammatory responses. It was also found that inhibiting heme synthesis or the TLR4/NF-kappa B signaling pathway can effectively suppress inflammatory responses.
Article
Oncology
Dong Young Kang, Nipin Sp, Kyoung-Jin Jang, Eun Seong Jo, Se Won Bae, Young Mok Yang
Summary: Embryonic cancer cells (CSCs) possess the ability to cause various types of cancer and are more dangerous than other cancer cells. Ursolic acid (UA), a natural compound, has been found to exhibit anticancer effects against various cancer cells. This study demonstrates that UA induces cell apoptosis and inhibits proliferation in embryonic CSCs. These findings suggest that UA could be a potential candidate for targeting CSCs and suppressing cancer emergence.
JOURNAL OF ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Dong Young Kang, Nipin Sp, Se Won Bae, Kyoung-Jin Jang
Summary: This study investigated the anti-hypoxic activity and cytoprotective effect of methylsulfonylmethane (MSM) in CoCl2-induced hypoxic mouse myoblast culture. The results showed that MSM prevented CoCl2-induced cytotoxicity and normalized or reduced molecular markers of hypoxia. Additionally, MSM inhibited the CoCl2-induced JAK2/STAT5b/Cyclin D1 and PI3K/AKT signaling pathways and prevented oxidative stress and DNA repair inhibition. These findings suggest that MSM could be a potential drug for reducing the effects of hypoxia in animals and humans.
Article
Medicine, Research & Experimental
Gaurav Jerath, Pramod Darvin, Yvonne Christian, Vishal Trivedi, T. R. Santhosh Kumar, Vibin Ramakrishnan
Summary: A novel peptide-based drug delivery system with syndiotactic polypeptide backbone was designed to enhance cellular uptake, successfully delivering the anticancer drug methotrexate to breast cancer models with significant reduction in primary tumor and metastasis.
MOLECULAR PHARMACEUTICS
(2022)
Article
Oncology
Alessandro La Ferlita, Nipin Sp, Marina Goryunova, Giovanni Nigita, Raphael E. Pollock, Carlo M. Croce, Joal D. Beane
Summary: Soft-tissue sarcomas (STS), a rare and diverse group of tumors, have various subtypes characterized by differences in tumor biology and clinical outcomes. Small non-coding RNAs (sncRNAs), including miRNAs and tRNA-derived ncRNAs, play important roles in STS tumorigenesis and differentiation. However, the translation of these findings into clinical applications, such as biomarkers or therapeutic targets, remains challenging. This review summarizes the current understanding of sncRNAs in STS, with a focus on liposarcoma, and discusses their potential as novel biomarkers and therapeutic targets.
MOLECULAR CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jaehoon Cho, Hyeonbi Jung, Dong Young Kang, Nipin Sp, Wooshik Shin, Junhak Lee, Byung Gyu Park, Yoon A. Kang, Kyoung-Jin Jang, Se Won Bae
Summary: This study found that PCA derivatives can effectively reduce melanin production in melanoma cells and have antioxidant effects, thus can be used in developing cosmetics with skin-whitening and antioxidant effects.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)