Article
Biochemistry & Molecular Biology
Hala Shokr, Irundika H. K. Dias, Doina Gherghel
Summary: The study found that oxysterol levels are related to retinal microvascular function, and abnormal levels of oxysterols may indicate early risk for cardiovascular diseases as individuals age.
Article
Biochemistry & Molecular Biology
Stefano Masi, Samuele Ambrosini, Shafeeq A. Mohammed, Sebastiano Sciarretta, Thomas F. Luescher, Francesco Paneni, Sarah Costantino
Summary: The prevalence of obesity and cardiometabolic phenotypes is increasing globally, with epigenetic modifications emerging as a key regulator of gene transcription in vascular diseases. Deciphering the vascular epigenome is challenging but crucial for developing targeted therapies for obesity-related conditions.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Andreas Daiber, Omar Hahad, Ioanna Andreadou, Sebastian Steven, Steffen Daub, Thomas Muenzel
Summary: Global epidemiological studies highlight the significance of chronic non-communicable diseases like atherosclerosis and metabolic disorders in premature mortality and morbidity, with cardiovascular diseases such as ischemic heart disease contributing significantly to the global disease burden and socioeconomic health costs. Research demonstrates a link between oxidative stress markers and major cardiovascular diseases, emphasizing the role of reactive oxygen and nitrogen species in conditions like hyperlipidemia, hypertension, and diabetes. In vivo redox biomarkers are discussed for their clinical relevance, while the potential prognostic value and limitations of these markers are critically examined.
Review
Medicine, Research & Experimental
Qian Yan, Shasha Liu, Yang Sun, Chen Chen, Songwei Yang, Meiyu Lin, Junpeng Long, Jiao Yao, Yuting Lin, Fan Yi, Lei Meng, Yong Tan, Qidi Ai, Naihong Chen, Yantao Yang
Summary: Cardiovascular diseases have a significant impact on global mortality rates, and oxidative stress plays a crucial role in their pathogenesis and advancement. Herbal monomers can inhibit oxidative stress in cardiovascular diseases by activating multiple signaling pathways and protecting cardiac health.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Margalida Monserrat-Mesquida, Magdalena Quetglas-Llabres, Cristina Bouzas, Silvia Garcia, David Mateos, Cristina Gomez, Jose M. Gamez, Henrik E. Poulsen, Josep A. Tur, Antoni Sureda
Summary: This study aimed to assess the effects of a 2-year nutritional and lifestyle intervention on oxidative and inflammatory status in individuals at high cardiovascular disease risk. The results showed a greater reduction in abdominal obesity, blood pressure, and triglyceride levels after the intervention. Furthermore, an improvement in oxidative stress and proinflammatory status was observed.
Article
Biochemistry & Molecular Biology
Michela Cirillo, Flavia Rita Argento, Monica Attanasio, Matteo Becatti, Irene Ladisa, Claudia Fiorillo, Maria Elisabetta Coccia, Cinzia Fatini
Summary: This study aimed to explore cardiometabolic markers and oxidative stress and evaluate the effects of the Mediterranean Diet (MD) in modulating these markers. The results showed that after a 3-month intervention with MD, there was a significant reduction in total cholesterol and LDL-c, and an increase in B12 and E vitamins, folate, and zinc. Additionally, oxidative stress markers also improved significantly. Therefore, improving lifestyle, especially adopting the Mediterranean diet, can improve metabolic and oxidative profiles and enhance overall health-related quality of life.
Review
Biochemistry & Molecular Biology
Muhammad Ammar Zahid, Shahenda Salaheldin Abdelsalam, Hicham Raiq, Aijaz Parray, Hesham Mohamed Korashy, Asad Zeidan, Mohamed A. Elrayess, Abdelali Agouni
Summary: A timely and adequate response to stress is crucial for maintaining cell function, and disruptions in defense mechanisms against stress can lead to various pathologies. Aging and cardiovascular diseases can reduce the effectiveness of these defense mechanisms. Sestrin2 (SESN2) is a stress-inducible protein that can protect cells by increasing antioxidants, temporarily halting stressful reactions, and promoting autophagy. Maintaining sufficient levels/activity of SESN2 may prevent cardiovascular aging and disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Nerea Mendez-Barbero, Jorge Oller, Ana B. Sanz, Adrian M. Ramos, Alberto Ortiz, Marta Ruiz-Ortega, Sandra Rayego-Mateos
Summary: Cardiovascular disease (CVD) often accompanies chronic kidney disease (CKD), and patients with both conditions have an increased risk of all-cause mortality ranging from 20% to 500%. Maintaining mitochondrial homeostasis appears to be a promising therapeutic strategy for the cardio-renal syndrome (CRS). This review explores the role of mitochondrial dysfunction in cardiovascular and renal diseases and how it may guide the development of novel therapeutic strategies for CRS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Agata Rolnik, Beata Olas
Summary: This article reviews the effects of preparations of vegetables from the Asteraceae and Cucurbitaceae families on the cardiovascular system and cardiovascular diseases. Various plants demonstrate antioxidant and antiplatelet activities, which play a key role in the prevention and treatment of cardiovascular diseases. Additionally, these vegetables have potential for lipid-lowering effects, obesity prevention, and body weight control.
Article
Biochemistry & Molecular Biology
Belinda J. Dunning, Arno R. Bourgonje, Marian L. C. Bulthuis, Jan Alexander, Jan O. Aaseth, Anders Larsson, Harry van Goor, Urban Alehagen
Summary: This study aimed to evaluate the effect of supplementation with selenium and coenzyme Q10 on serum free thiols and to study associations with the risk of cardiovascular mortality in elderly community-dwelling individuals. The results showed that supplementation with selenium and coenzyme Q10 significantly improved serum free thiol levels and reduced the risk of cardiovascular mortality in elderly individuals.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Francesco Versaci, Valentina Valenti, Maurizio Forte, Vittoria Cammisotto, Cristina Nocella, Simona Bartimoccia, Leonardo Schirone, Sonia Schiavon, Daniele Vecchio, Luca D'Ambrosio, Giulia Spinosa, Alessandra D'Amico, Isotta Chimenti, Francesco Violi, Giacomo Frati, Pasquale Pignatelli, Sebastiano Sciarretta, Daniele Pastori, Roberto Carnevale
Summary: This study provides evidence that the autophagy process may represent a mechanism for increased cardiovascular risk in the AF population, and demonstrates its correlation with oxidative stress, platelet activation, and endothelial dysfunction.
Article
Biochemistry & Molecular Biology
Martin F. F. Bourgonje, Amaal E. E. Abdulle, Lyanne M. M. Kieneker, Sacha la Bastide-van Gemert, Stephan J. L. Bakker, Ron T. T. Gansevoort, Sanne J. J. Gordijn, Harry van Goor, Arno R. R. Bourgonje
Summary: Oxidative stress is important in cardiovascular disease, and current biomarkers are insufficient for predicting cardiovascular events. This study assessed the utility of redox-related biomarkers in predicting cardiovascular events and all-cause mortality in a population-based cohort. The levels of homocysteine, gamma-GT, HDL cholesterol, bilirubin, and protein-adjusted free thiol were analyzed, and lower levels of protein-adjusted R-SH were associated with an increased risk of cardiovascular events and all-cause mortality in men. The study highlights the value of R-SH levels in cardiovascular risk assessment and the importance of other oxidative stress-related biomarkers.
Article
Food Science & Technology
Eliana Akemi Komino, Leticia Pereira Afonso Ramos, Adriele Vieira de Souza, Douglas Carvalho Caixeta, Vinicius Prado Bittar, Ana Luiza Borges, Francoise Vasconcelos Botelho, Foued Salmen Espindola, Allisson Benatti Justino
Summary: Dyslipidemia and oxidative stress have a direct relationship with cardiovascular diseases. Annona crassiflora Mart. (ACM), known for its folk medicine uses to alleviate inflammation and pain, is rich in polyphenols that have high antioxidant capacity. This study aimed to investigate the antioxidant properties of ACM in hyperlipidemic mice. Results showed that the crude ethanol extract (CEAc) and the polyphenols-rich fraction (PFAc) from ACM fruit peel improved the glutathione system and enhanced antioxidant activities in the heart, indicating its potential as a cardioprotective antioxidant.
Article
Biochemistry & Molecular Biology
Min Wang, Zhao-hui Huang, Yong-hong Zhu, Ping He, Qiu-Ling Fan
Summary: There is a positive association between the Composite Dietary Antioxidant Index (CDAI) and chronic kidney disease (CKD) in adults in the United States. Further large-scale prospective studies are needed to analyze the role of CDAI in CKD.
Review
Biochemistry & Molecular Biology
Melania Gaggini, Rudina Ndreu, Elena Michelucci, Silvia Rocchiccioli, Cristina Vassalle
Summary: This review presents evidence on the structure and generation of ceramides, and discusses their role in cardiometabolic disease, as well as the current translational opportunities and challenges for ceramide application in the cardiometabolic clinical settings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)