期刊
JOURNAL OF CELL SCIENCE
卷 129, 期 24, 页码 4607-4621出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.192633
关键词
ANKLE2; SIRT2; Cell cycle; Nuclear envelope
类别
资金
- Max F. Perutz Laboratories
- Vienna Science and Technology Fund (WWTF) [LS14-001]
- Austrian Science Fund (FWF) [W1238] Funding Source: Austrian Science Fund (FWF)
Sirtuin 2 (SIRT2) is an NAD-dependent deacetylase known to regulate microtubule dynamics and cell cycle progression. SIRT2 has also been implicated in the pathology of cancer, neurodegenerative diseases and progeria. Here, we show that SIRT2 depletion or overexpression causes nuclear envelope reassembly defects. We link this phenotype to the recently identified regulator of nuclear envelope reassembly ANKLE2. ANKLE2 acetylation at K302 and phosphorylation at S662 are dynamically regulated throughout the cell cycle by SIRT2 and are essential for normal nuclear envelope reassembly. The function of SIRT2 therefore extends beyond the regulation of microtubules to include the regulation of nuclear envelope dynamics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据