Article
Medicine, General & Internal
Vipin Thampi, Roopa Hariprasad, Amrita John, Suzanne Nethan, Kavitha Dhanasekaran, Vipin Kumar, Praveen Birur, J. S. Thakur, Richard Lilford, Nasir M. Rajpoot, Paramjit Gill
Summary: Visual screening for oral cancer showed a substantial reduction in mortality in a trial in Kerala, India, while utilizing community health workers has been proposed as a strategy to address the shortage of medical personnel in resource-deficient regions. A cross-sectional study in Uttar Pradesh, India, found that trained community health workers, after initial supervision by qualified dentists, were able to perform oral cancer screening programs effectively, suggesting their feasibility in resource-constrained settings.
Review
Oncology
Jie-Ru You, Ya-Ting Chen, Chia-Yu Hsieh, Sin-Yu Chen, Tzu-Yao Lin, Jing-Syuan Shih, Guan-Ting Chen, Sheng-Wei Feng, Tzu-Yu Peng, Chia-Yu Wu, I-Ta Lee
Summary: Oral submucous fibrosis (OSF) is a potentially malignant disorder, and specific molecular biomarkers associated with OSF have been identified. This study aims to provide an up-to-date and comprehensive review of molecular biomarkers for OSF investigated within the last five years, categorizing them based on cytological characteristics and sampling methodologies. The study offers a coherent and informative overview of these biomarkers, aiding fellow researchers in the development of practical diagnostic methods for detecting early-stage OSF.
Article
Medicine, General & Internal
Ann-Joy Cheng, Guo-Rung You, Che-Jui Lee, Ya-Ching Lu, Shang-Ju Tang, Yi-Fang Huang, Yu-Chen Huang, Li-Yu Lee, Kang-Hsing Fan, Yen-Chao Chen, Shiang-Fu Huang, Joseph Tung-Chieh Chang
Summary: Liquid biopsy is a rapidly growing field for minimally invasive pathological data acquisition. The study identified salivary miR-196b as an effective biomarker for oral precancer lesion and early detection of head-neck squamous carcinoma, providing potential for early screening high-risk groups.
Article
Immunology
Scott Christley, Jared Ostmeyer, Lisa Quirk, Wei Zhang, Bradley Sirak, Anna R. Giuliano, Song Zhang, Nancy Monson, Jasmin Tiro, Elena Lucas, Lindsay G. Cowell
Summary: Cervical cancer ranks fourth in frequency and mortality among women globally, with Pap test and hrHPV testing as current screening methods. However, these tests have limitations in sensitivity and distinguishing persistent infection. A study found that enhanced T cell clonal expansion in the cervical cytology sample may predict risk transition, suggesting potential for improving screening accuracy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Desiree Guel, Negusse Habtemichael, Dimo Dietrich, Jorn Dietrich, Dorothee Goesswein, Aya Khamis, Eric Deuss, Julian Kuenzel, Guenter Schneider, Sebastian Strieth, Roland H. Stauber
Summary: This study identified a novel biomarker, cKRT24, as a tumor suppressor in HNSCC, which may serve as a new target to support current treatments. Low cKRT24 expression correlated with poor overall survival, and further experiments confirmed its role in inhibiting tumor growth in both cell lines and animal studies.
BIOLOGICAL CHEMISTRY
(2022)
Article
Oncology
Xinyi Zhang, Frederico O. Gleber-Netto, Shidan Wang, Roberta Rayra Martins-Chaves, Ricardo Santiago Gomez, Nadarajah Vigneswaran, Arunangshu Sarkar, William N. N. William Jr, Vassiliki Papadimitrakopoulou, Michelle Williams, Diana Bell, Doreen Palsgrove, Justin Bishop, John V. V. Heymach, Ann M. M. Gillenwater, Jeffrey N. N. Myers, Renata Ferrarotto, Scott M. M. Lippman, Curtis Rg Pickering, Guanghua Xiao
Summary: Convolutional neural networks-based histology image analysis can accelerate the discovery of better oral cancer progression risk models by predicting the development of oral leukoplakia. This can contribute to early intervention and decrease morbidity and mortality of oral cancer.
Article
Microbiology
Shriya Sawant, Jinesh Dugad, Deepak Parikh, Sathiyaraj Srinivasan, Harinder Singh
Summary: Dysbiosis of the oral microbiome is linked to oral cancer, and tobacco chewing is a risk factor associated with oral dysbiosis. This study investigated the oral bacterial diversity of Indian oral cancer patients and tobacco chewers, identifying potential biomarkers for the Indian population. The results showed differences in the abundance of certain bacterial genera between the study groups, and functional predictions highlighted gene expression variations related to specific metabolic processes.
Article
Oncology
Chi T. Viet, Xinyu Zhang, Ke Xu, Gary Yu, Kesava Asam, Carissa M. Thomas, Nicholas F. Callahan, Coleen Doan, Paul C. Walker, Khanh Nguyen, Stephanie C. Kidd, Steve C. Lee, Anupama Grandhi, Clint T. Allen, Simon Young, James C. Melville, Jonathan W. Shum, Dan T. Viet, Alan S. Herford, Dylan F. Roden, Manuel L. Gonzalez, Jiang F. Zhong, Bradley E. Aouizerat
Summary: This study utilized MethylCap-Seq technique along with brush swab samples to develop a non-invasive methylation profiling method in oral squamous cell carcinoma patients. The results demonstrated that brush swab samples provide adequate DNA yield and methylation resolution comparable to tissue samples, indicating a promising approach for methylome studies in OSCC patients.
BIOMARKER RESEARCH
(2021)
Review
Oncology
Jing Wang, Najun Lv, Xinxin Lu, Rongtao Yuan, Zhenggang Chen, Jiangbo Yu
Summary: Oral cancer is a leading type of cancer in Asia and lacks accurate diagnostic methods and efficient treatment strategies, resulting in a high mortality rate. miRNAs serve as important biomarkers for early detection and potential therapeutic targets in oral cancer.
Review
Biochemistry & Molecular Biology
Alexandra Roi, Simina Boia, Laura-Cristina Rusu, Ciprian Ioan Roi, Eugen Radu Boia, Mircea Rivis
Summary: Oral cancer is a challenging disease with a high incidence and poor survival rate. The use of liquid biopsy and identification of potential biomarkers, particularly miRNAs, in body fluids such as serum, plasma, and saliva samples offer promising perspectives for early diagnosis of oral cancer. These biomarkers can provide important information about the initiation, development, progression, and metastasis of oral malignancy, and can contribute to the development of personalized medicine and targeted therapies.
Review
Medicine, General & Internal
Yee-Fun Su, Yi-Ju Chen, Fa-Tzu Tsai, Wan-Chun Li, Ming-Lun Hsu, Ding-Han Wang, Cheng-Chieh Yang
Summary: Oral cancer is a common head and neck malignancy with a 5-year survival rate below 50%. There are challenges in determining the risk of OPMD progressing to cancer. Various diagnostic technologies have been developed to detect oral diseases and cancer early.
Article
Oncology
Kristian Reinholdt, Louise Thirstrup Thomsen, Christian Munk, Christian Dehlendorff, Gitte Lerche Aalborg, Bendix Carstensen, Marit Eika Jorgensen, Susanne K. Kjaer
Summary: This study found that women with diabetes had higher rates of anogenital precancers and cancers, but lower rates of cervical precancer. The differences could be explained by biological mechanisms and/or behavioral factors, such as smoking and cervical screening participation.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Mariam El-Zein, David Cheishvili, Moshe Szyf, Eduardo L. Franco
Summary: In this study, new methylation markers were identified and validated for their role in cervical intraepithelial neoplasia (CIN) grades and cervical cancer. The methylation state of CA10, DPP10, FMN2 and HAS1 genes were evaluated in independent study populations using next-generation sequencing. The Marker Polygenic Score (MPS) calculated from these genes accurately predicted cervical cancer and showed potential for use in clinical settings. Further evaluation of these biomarkers in prospective studies is needed.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Dermatology
John T. Connelly, Nuria Gavara, Kristina Sliogeryte, Liisa M. Blowes
Summary: Atomic force microscopy (AFM) is a powerful technique for nanoscale imaging and mechanical analysis of biological specimens, particularly advantageous for the analysis of cells and tissues in their near-native state. In dermatology, AFM has led to important insights into our understanding of the biomechanics of normal healthy skin and the pathogenesis of various skin diseases.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Alexandro Barbosa de Azevedo, Teresa Cristina Ribeiro Bartholomeu dos Santos, Marcio Ajudarte Lopes, Fabio Ramoa Pires
Summary: The study analyzed the clinical and histological characteristics of a series of oral mucosal lesions, finding that most cases occurred in middle-aged females, with the tongue, lower lip, and buccal mucosa being the most commonly affected sites, and the majority of lesions were leukoplakias with histological findings predominantly showing mild dysplasia.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2021)
Article
Multidisciplinary Sciences
Crismita Dmello, Sharada Sawant, Hunain Alam, Prakash Gangadaran, Saie Mogre, Richa Tiwari, Zinia D'Souza, Manish Narkar, Rahul Thorat, Komal Patil, Devendra Chaukar, Shubhada Kane, Milind Vaidya
Article
Biochemistry & Molecular Biology
Fiona Chalmers, Saie Mogre, Jeongin Son, Nicholas Blazanin, Adam B. Glick
MOLECULAR CARCINOGENESIS
(2019)
Article
Multidisciplinary Sciences
Tulin Dadali, Anne R. Diers, Shiva Kazerounian, Senthil K. Muthuswamy, Pallavi Awate, Ryan Ng, Saie Mogre, Carrie Spencer, Katerina Krumova, Hannah E. Rockwell, Justice McDaniel, Emily Y. Chen, Fei Gao, Karl T. Diedrich, Vijetha Vemulapalli, Leonardo O. Rodrigues, Viatcheslav R. Akmaev, Khampaseuth Thapa, Manuel Hidalgo, Arindam Bose, Vivek K. Vishnudas, A. James Moser, Elder Granger, Michael A. Kiebish, Stephane Gesta, Niven R. Narain, Rangaprasad Sarangarajan
Summary: Reactive oxygen species (ROS) play a role in triggering cell signaling events to promote and maintain tumorigenicity. Chemotherapy and radiation can induce ROS to elicit cell death, making it possible to target ROS pathways for effective anti-cancer therapeutics. Coenzyme Q(10) is shown to increase ROS generation when delivered to increase mitochondrial Q-pool, resulting in anti-cancer effects in a pancreatic cancer model.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Saie Mogre, Vidhi Makani, Swapnita Pradhan, Pallavi Devre, Shyam More, Milind Vaidya, Crismita Dmello
Summary: Oral carcinogenesis is a multistep process, with a substantial proportion of oral tumors developing from potentially malignant disorders. Current clinical and histological methods have limited ability to predict malignancy progression, highlighting the need for developing new biological markers. Vimentin, as demonstrated by extensive research, plays a significant role in oral cancer progression and can serve as a prognostic biomarker.
Article
Oncology
Crismita Dmello, Aaron Sonabend, Victor A. Arrieta, Daniel Y. Zhang, Deepak Kanojia, Li Chen, Andrew Gould, Jiangshan Zhang, Seong Jae Kang, Jan Winter, Craig Horbinski, Christina Amidei, Balazs Gyorffy, Alex Cordero, Catalina Lee Chang, Brandyn Castro, Patrick Hsu, Atique U. Ahmed, Maciej S. Lesniak, Roger Stupp, Adam M. Sonabend
Summary: By analyzing genome-wide CRISPR knockout screen results and patient data, researchers identified endoplasmic reticulum protein SSR3 as a potential predictive biomarker for susceptibility to Paclitaxel in breast cancer and glioblastoma.
CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Saie Mogre, Nicholas Blazanin, Hailey Walsh, Jack Ibinson, Chase Minnich, Chih-Chi Andrew Hu, Adam B. Glick
Summary: The study found that TGF beta 1 plays a critical role in regulating tumor progression and can induce ER stress. The results showed that TGF beta 1 suppresses the phosphorylation and activation of IRE1 alpha through activating the PERK pathway, thereby exerting tumor-suppressive effects. In addition, TGF beta 1 also partially depends on the PERK-induced IRE1 alpha dephosphorylation and inactivation through PERK-dependent IRE1 alpha phosphatase.
MOLECULAR CARCINOGENESIS
(2022)
Article
Developmental Biology
Fiona E. Chalmers, Saie Mogre, Bipin Rimal, Jeongin Son, Andrew D. Patterson, Douglas B. Stairs, Adam B. Glick
Summary: The IRE1 alpha-XBP1s signaling pathway is crucial for the proliferation and maturation of basal keratinocytes in the mouse tongue and esophageal epithelium, with its absence resulting in mucosal thinning and feeding impairment.
DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Edgar Petrosyan, Jawad Fares, Luis G. Fernandez, Ragini Yeeravalli, Crismita Dmello, Joseph T. Duffy, Peng Zhang, Catalina Lee-Chang, Jason Miska, Atique U. Ahmed, Adam M. Sonabend, Irina Balyasnikova, Amy B. Heimberger, Maciej S. Lesniak
Summary: Immunotherapy has had success in halting cancer progression, but it has not been effective for primary brain malignancies, which remain a globally lethal disease. Understanding how tumor cells survive and propagate within the unique microenvironment of the central nervous system (CNS) is crucial. Cancer genetic aberrations and metabolic abnormalities lead to persistent endoplasmic reticulum (ER) stress, which promotes tumor growth, invasion, therapeutic resistance, and reprogramming of immune cells. Targeting ER stress is a potential therapeutic approach for primary CNS tumors.
MOLECULAR CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
Crismita Dmello, Junfei Zhao, Li Chen, Andrew Gould, Brandyn Castro, Victor A. Arrieta, Daniel Y. Zhang, Kwang-Soo Kim, Deepak Kanojia, Peng Zhang, Jason Miska, Ragini Yeeravalli, Karl Habashy, Ruth Saganty, Seong Jae Kang, Jawad Fares, Connor Liu, Gavin Dunn, Elizabeth Bartom, Matthew J. Schipma, Patrick D. Hsu, Mahmoud S. Alghamri, Maciej S. Lesniak, Amy B. Heimberger, Raul Rabadan, Catalina Lee-Chang, Adam M. Sonabend
Summary: This study identifies Chek2 as the most important kinase that promotes evasion of glioma cells from immune recognition. Genetic depletion or pharmacological inhibition of Chek2 enhances antigen presentation, STING pathway activation, and PD-L1 expression, leading to survival benefits in preclinical glioma models. Analysis of human GBMs shows a negative correlation between Chek2 expression and antigen presentation/T-cell activation. These results suggest that Chek2 may be a promising target for improving response to immune checkpoint blockade therapy.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Victor A. Arrieta, Crismita Dmello, Daniel J. McGrail, Daniel J. Brat, Catalina Lee-Chang, Amy B. Heimberger, Dhan Chand, Roger Stupp, Adam M. Sonabend
Summary: Immune checkpoint blockade (ICB) has revolutionized modern cancer therapy, arousing great interest in the neuro-oncology community. While several reports show that subsets of patients with glioma exhibit durable responses to immunotherapy, the efficacy of this treatment has not been observed for unselected patient populations, preventing its broad clinical implementation for gliomas and glioblastoma (GBM).
JOURNAL OF CLINICAL INVESTIGATION
(2023)