Lysosome acidification by photoactivated nanoparticles restores autophagy under lipotoxicity

Autophagy is a major regulator of beta cell insulin homeostasis

(2016) Yael Riahi et al.   DIABETOLOGIA

Autophagy: a druggable process that is deregulated in aging and human disease

(2015) Guido Kroemer   JOURNAL OF CLINICAL INVESTIGATION

Rapamycin Improves Palmitate-Induced ER Stress/NFκB Pathways Associated with Stimulating Autophagy in Adipocytes

(2015) Jiajing Yin et al.   MEDIATORS OF INFLAMMATION

Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

(2015) Ju-Hyun Lee et al.   Cell Reports

Calcium channel blockers as potential therapeutics for obesity-associated autophagy defects and fatty liver pathologies

(2014) Hwan-Woo Park et al.   Autophagy

Autophagy and human disease: emerging themes

(2014) Jaime L Schneider et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Inhibition of Autophagic Turnover in β-Cells by Fatty Acids and Glucose Leads to Apoptotic Cell Death

(2014) Shakeel U. R. Mir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitate Induces ER Stress and Autophagy in H9c2 Cells: Implications for Apoptosis and Adiponectin Resistance

(2014) Min Park et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity

(2014) Bharat Jaishy et al.   JOURNAL OF LIPID RESEARCH

Improved physiological properties of gravity-enforced reassembled rat and human pancreatic pseudo-islets

(2014) R. A. Zuellig et al.   Journal of Tissue Engineering and Regenerative Medicine

Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD

(2014) Á González-Rodríguez et al.   Cell Death & Disease

In Vitro Activity of Paclitaxel-Loaded Polymeric Expansile Nanoparticles in Breast Cancer Cells

(2013) Kimberly Ann V. Zubris et al.   BIOMACROMOLECULES

Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells

(2013) Gemma L. Pearson et al.   DIABETOLOGIA

Abnormality of autophagic function and cathepsin expression in the liver from patients with non-alcoholic fatty liver disease

(2013) Yuka Fukuo et al.   HEPATOLOGY RESEARCH

Microscopy and tunable resistive pulse sensing characterization of the swelling of pH-responsive, polymeric expansile nanoparticles

(2013) Aaron H. Colby et al.   Nanoscale

Biologically Responsive Polymeric Nanoparticles for Drug Delivery

(2012) Yolonda L. Colson et al.   ADVANCED MATERIALS

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Acidic Nanoparticles Are Trafficked to Lysosomes and Restore an Acidic Lysosomal pH and Degradative Function to Compromised ARPE-19 Cells

(2012) Gabriel C. Baltazar et al.   PLoS One

Rapamycin Causes Upregulation of Autophagy and Impairs Islets Function Both In Vitro and In Vivo

(2011) M. Tanemura et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Factors Controlling Nanoparticle Pharmacokinetics: An Integrated Analysis and Perspective

(2011) S.M. Moghimi et al.   Annual Review of Pharmacology and Toxicology

Hepatic steatosis inhibits autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression

(2011) Yoshihiro Inami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fatty Acids Suppress Autophagic Turnover in β-Cells

(2011) Guy Las et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Local drug delivery strategies for cancer treatment: Gels, nanoparticles, polymeric films, rods, and wafers

(2011) Jesse B. Wolinsky et al.   JOURNAL OF CONTROLLED RELEASE

Strategies in the design of nanoparticles for therapeutic applications

(2010) Robby A. Petros et al.   NATURE REVIEWS DRUG DISCOVERY

Mitochondrial Turnover and Aging of Long-Lived Postmitotic Cells: The Mitochondrial–Lysosomal Axis Theory of Aging

(2009) Alexei Terman et al.   ANTIOXIDANTS & REDOX SIGNALING

Glucolipotoxicity of the pancreatic beta cell

(2009) Vincent Poitout et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mitochondrial Networking Protects  -Cells From Nutrient-Induced Apoptosis

(2009) A. J.A. Molina et al.   DIABETES

An Integrated Multifunctional Nanosystem from Command Nanoparticles and Enzymes

(2009) Mikhail Motornov et al.   Small

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

(2008) Chie Ebato et al.   Cell Metabolism

Protective Role of Autophagy in Palmitate-Induced INS-1 β-Cell Death

(2008) Sung-E Choi et al.   ENDOCRINOLOGY

A review of stimuli-responsive nanocarriers for drug and gene delivery

(2008) Srinivas Ganta et al.   JOURNAL OF CONTROLLED RELEASE