Beyond the SNARE: Munc18-1 chaperones α-synuclein

Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation

(2016) Ye Jin Chai et al.   JOURNAL OF CELL BIOLOGY

Normal Molecular Specification and Neurodegenerative Disease-Like Death of Spinal Neurons Lacking the SNARE-Associated Synaptic Protein Munc18-1

(2016) C. Law et al.   JOURNAL OF NEUROSCIENCE

Distinct Functions of Syntaxin-1 in Neuronal Maintenance, Synaptic Vesicle Docking, and Fusion in Mouse Neurons

(2016) Gülçin Vardar et al.   JOURNAL OF NEUROSCIENCE

STXBP1encephalopathy

(2016) Hannah Stamberger et al.   NEUROLOGY

α-Synuclein: Experimental Pathology

(2016) Masato Hasegawa et al.   Cold Spring Harbor Perspectives in Medicine

Analysis of conditional heterozygous STXBP1 mutations in human neurons

(2015) Christopher Patzke et al.   JOURNAL OF CLINICAL INVESTIGATION

Definition of a Molecular Pathway Mediating  -Synuclein Neurotoxicity

(2015) J. Burre et al.   JOURNAL OF NEUROSCIENCE

The trans-SNARE-regulating function of Munc18-1 is essential to synaptic exocytosis

(2015) Chong Shen et al.   Nature Communications

The Synaptic Function of α-Synuclein

(2015) Jacqueline Burré   Journal of Parkinsons Disease

Munc18-1-regulated stage-wise SNARE assembly underlying synaptic exocytosis

(2015) Lu Ma et al.   eLife

Increased Polyubiquitination and Proteasomal Degradation of a Munc18-1 Disease-Linked Mutant Causes Temperature-Sensitive Defect in Exocytosis

(2014) Sally Martin et al.   Cell Reports

Metabolic Turnover of Synaptic Proteins: Kinetics, Interdependencies and Implications for Synaptic Maintenance

(2013) Laurie D. Cohen et al.   PLoS One

Munc18-1 domain-1 controls vesicle docking and secretion by interacting with syntaxin-1 and chaperoning it to the plasma membrane

(2011) Gayoung A. Han et al.   MOLECULAR BIOLOGY OF THE CELL

CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity

(2010) Manu Sharma et al.   NATURE CELL BIOLOGY

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy

(2008) Hirotomo Saitsu et al.   NATURE GENETICS