Article
Medicine, Research & Experimental
Vitor F. Martins, Samuel A. LaBarge, Alexandra Stanley, Kristoffer Svensson, Chao-Wei Hung, Omer Keinan, Theodore P. Ciaraldi, Dion Banoian, Ji E. Park, Christina Ha, Byron Hetrick, Gretchen A. Meyer, Andrew Philp, Larry L. David, Robert R. Henry, Joseph E. Aslan, Alan R. Saltiel, Carrie. E. McCurdy, Simon Schenk
Summary: This study highlights the fundamental role of acetylation and p300/CBP in the direct regulation of insulin-stimulated glucose transport in skeletal muscle and adipocytes.
Article
Cell Biology
Hannah L. Black, Rachel Livingstone, Cynthia C. Mastick, Mohammed Al Tobi, Holly Taylor, Angeline Geiser, Laura Stirrat, Dimitrios Kioumourtzoglou, John R. Petrie, James G. Boyle, Nia J. Bryant, Gwyn W. Gould
Summary: The knockout of syntaxin-4 in 3T3-L1 adipocytes was found to significantly reduce insulin-stimulated glucose transport and adiponectin secretion, but had only modest effects on the translocation capacity of the cells and the exocytic and endocytic rates of GLUT4.
JOURNAL OF CELL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yuta Homma, Mitsunori Fukuda
Summary: The study identified VPS52 as an effector protein responsible for Rab6-dependent secretory cargo trafficking, with its knockout resulting in attenuated secretion and lysosomal accumulation of secretory cargos.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Johanna Saell, Maria Lindahl, Andreas M. Fritzen, Claes Fryklund, Franziska Kopietz, Emma Nyberg, Anna Warvsten, Bjorn Moren, Marc Foretz, Bente Kiens, Karin G. Stenkula, Olga Goransson
Summary: This study demonstrates that SIK2 is downregulated in obese ob/ob mice and that SIK activity is required for intact glucose uptake in primary human and mouse adipocytes. The underlying mechanism involves direct effects on the insulin signaling pathway, likely at the level of phosphatidylinositol (3,4,5)-trisphosphate (PIP3) generation or breakdown.
Article
Biochemistry & Molecular Biology
Fumitaka Kawakami, Motoki Imai, Yuki Isaka, Mark R. Cookson, Hiroko Maruyama, Makoto Kubo, Matthew J. Farrer, Makoto Kanzaki, Rei Kawashima, Tatsunori Maekawa, Shun Tamaki, Yoshifumi Kurosaki, Fumiaki Kojima, Kenichi Ohba, Takafumi Ichikawa
Summary: This study demonstrates the negative impact of LRRK2 on glucose tolerance in high-fat diet-induced mice. In adipose tissue, LRRK2 kinase activity suppresses Rab8 and Rab10-mediated GLUT4 membrane translocation, exacerbating glucose intolerance.
Article
Neurosciences
Stewart W. C. Masson, Jonathan S. T. Woodhead, Randall F. D'Souza, Sophie C. Broome, Caitlin MacRae, Hyun C. Cho, Robert D. Atiola, Tumanu Futi, Jessica R. Dent, Peter R. Shepherd, Troy L. Merry
Summary: Beta-catenin plays a crucial role in regulating glucose uptake during exercise/contraction, potentially through facilitating actin cytoskeleton remodelling to support glucose transport.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Endocrinology & Metabolism
Belen Picatoste, Lucie Yammine, Rosemary A. Leahey, David Soares, Emma F. Johnson, Paul Cohen, Timothy E. McGraw
Summary: Deleting Rab10 from brown adipocytes reduces insulin-stimulated glucose transport, leading to whole-body metabolic imbalance and insulin resistance, particularly in female mice. This effect is independent of the thermogenic function of brown adipocytes, highlighting a metabolism-specific role in female mice.
MOLECULAR METABOLISM
(2021)
Article
Plant Sciences
Tianli Li, Gan Ai, Xiaowei Fu, Jin Liu, Hai Zhu, Ying Zhai, Weiye Pan, Danyu Shen, Maofeng Jing, Ai Xia, Daolong Dou
Summary: This study characterizes the functional properties of the core RXLR effector RXLR242 in P. capsici and its manipulation of host plant immunity. RXLR242 interacts with RAB proteins and disrupts protein trafficking, thereby promoting Phytophthora infection.
MOLECULAR PLANT PATHOLOGY
(2022)
Article
Microbiology
Karsten Meier, Lana H. Jachmann, Goezde Tuerkoez, Mohammed Rizwan Babu Sait, Lucia Perez, Oliver Kepp, Raphael H. Valdivia, Guido Kroemer, Barbara S. Sixt
Summary: This study revealed the key role of CpoS protein from Chlamydia trachomatis in the modulation of inclusion membrane and membrane trafficking, as well as its ability to suppress interferon response through interaction with Rab GTPases. These findings advance our understanding of how intracellular bacteria shape and protect their growth niche.
Article
Biochemistry & Molecular Biology
Roni Rahimi, Israel Malek, Tali Lerrer-Goldshtein, Yoav Elkis, Irit Shoval, Avi Jacob, Sally Shpungin, Uri Nir
Summary: The study investigates the regulatory role of TMF1 in GLUT4-mediated glucose uptake and insulin-directed functioning, showing that TMF1 is essential for the formation of insulin responsive, GLUT4-containing vesicles. Absence of TMF1 leads to impaired glucose uptake, resulting in hyperglycemia and decreased body weight in mice, indicating a novel effector in insulin-regulated glucose homeostasis.
Article
Endocrinology & Metabolism
Nino-Cristiano Chilelli, Alessia Faggian, Francesca Favaretto, Gabriella Milan, Chiara Compagnin, Francesca Dassie, Silvia Bettini, Marco Roverso, Roberta Seraglia, Annunziata Lapolla, Roberto Vettor
Summary: The accumulation of intracellular AGEs increases the expression of RAGE and GLP1R while reducing glucose uptake in adipocytes, suggesting a potential link between alterations in GLP1 signaling and insulin resistance. Further research is needed to clarify the role of this pathway and whether reducing AGEs accumulation in adipocytes can improve insulin responsiveness.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Kiko Hasegawa, Nobuyuki Takenaka, Kenya Tanida, Man Piu Chan, Mizuki Sakata, Atsu Aiba, Takaya Satoh
Summary: Rac1 is involved in insulin-dependent glucose uptake and lipogenesis in white adipocytes, and its deficiency may result in reduced insulin responsiveness and atrophy of white adipose tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Cui-Zan Cai, Chuanbin Yang, Xu-Xu Zhuang, Ning-Ning Yuan, Ming-Yue Wu, Jie-Qiong Tan, Ju-Xian Song, King-Ho Cheung, Huanxing Su, Yi-Tao Wang, Bei-Sha Tang, Christian Behrends, Siva Sundara Kumar Durairajan, Zhenyu Yue, Min Li, Jia-Hong Lu
Summary: NRBF2, a component of the class III phosphatidylinositol 3-kinase (PtdIns3K) complex, plays a crucial role in modulating autophagosome maturation and APP-CTF degradation by interacting with RAB7 and maintaining its activity. This study reveals a novel mechanism by which NRBF2 regulates autophagy and protein degradation associated with Alzheimer's disease.