Article
Cell Biology
Yusuf Olgar, Aysegul Durak, Ceylan Bitirim, Erkan Tuncay, Belma Turan
Summary: By studying the alterations in KCNQ1/KCNE1-current (I-Ks) in the aging heart and the effects of insulin treatment on I-Ks, it was found that insulin can significantly improve heart function in aged rats by reversing the depressed I-Ks.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Plant Sciences
Ankita Mohanty, Koushik Chakraborty, Subhankar Mondal, Priyanka Jena, Rajendra K. Panda, Kailash C. Samal, Krishnendu Chattopadhyay
Summary: This study investigates the variability of rice tolerance to salinity stress at the seedling and reproductive stages, and the influence of ion exclusion and tissue tolerance on salt tolerance. The results reveal that ion exclusion alone is sufficient for seedling stage tolerance, while a balance between ion exclusion and tissue tolerance is crucial for prolonged salt tolerance at the reproductive stage.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2023)
Article
Agronomy
Jing Pan, Xian Xue, Cuihua Huang, Fei Peng, Jie Liao, Shaoxiu Ma, Quangang You, Tao Wang
Summary: Increasing salinization poses a threat to the growth of halophytes in saline habitats. Soil beneficial microorganisms, such as arbuscular mycorrhizal fungi (AMF) and plant growth-promoting rhizobacteria (PGPR), have the potential to promote salt tolerance of halophytes. However, the responses of different halophytes to microbial inoculations vary. Co-inoculation of AMF and PGPR can enhance biomass accumulation, nutrient absorption, ion homeostasis, and selective ion transportation in halophytes, reducing the negative effects of salt stress.
Article
Plant Sciences
Yue Qu, Rongxia Guan, Lili Yu, Oliver Berkowitz, Rakesh David, James Whelan, Melanie Ford, Stefanie Wege, Lijuan Qiu, Matthew Gilliham
Summary: GmSALT3 is a major gene determining salt tolerance in soybean, which improves the ability of soybean plants to cope with saline stress through regulation of root response. Genes related to oxidation reduction, calcium signaling, vesicle trafficking, and diffusion barrier formation are upregulated in salt-tolerant soybean lines.
PHYSIOLOGIA PLANTARUM
(2022)
Article
Biochemistry & Molecular Biology
Justin J. Lee, Jawad Alzamil, Saba Rehman, Wanling Pan, Henrik Dimke, R. Todd Alexander
Summary: Activation of the basolateral calcium sensing receptor (CaSR) increases claudin-14 expression in the renal tubular thick ascending limb (TAL), leading to reduced paracellular calcium permeability and increased urinary Ca2+ excretion. This process involves signaling through PLC-stimulated p38 pathway and inhibition of Sp1-mediated repression.
Article
Biochemistry & Molecular Biology
Alvaro R. R. Ruiz-Fernandez, Leonardo Campos, Felipe Villanelo, Jose Antonio Garate, Tomas Perez-Acle
Summary: This study integrates molecular dynamics simulations and machine learning techniques to explore the physiological implications of nanosecond pulsed electric field (nsPEF). It uncovers a new and underexplored phenomenon, protein-mediated electroporation. By focusing on the voltage-sensing domain (VSD) of the NaV1.5 sodium cardiac channel, the researchers analyze the structures that form pores under nsPEF stimulation, providing insights into the defibrillation effect of nsPEF. The findings reveal that the selected VSD of NaV1.5 forms pores in a distinct manner from traditional VSD opening, expanding our understanding of nsPEF and its interaction with protein channels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alvaro R. Ruiz-Fernandez, Leonardo Campos, Felipe Villanelo, Sebastian E. Gutierrez-Maldonado, Tomas Perez-Acle
Summary: Nanosecond Pulsed Electric Field (nsPEF) can induce ion channel gating within a very short period of time, leading to the formation of nanopores. The composition of the cell membrane, specifically cholesterol content, may play a crucial role in the response of ion channels to external electric fields. Additionally, the application of nsPEF can cause major conformational changes in the Voltage Sensing Domain (VSD) of voltage-gated Ca2+ channels, potentially leading to pore formation across the VSD, a novel effect named protein mediated electroporation.
Article
Cell Biology
Kelath Murali Manoj, Nikolai Bazhin, Hirohisa Tamagawa
Summary: This study presents a macroscopic cellular electrophysiological model based on the molecular structure and redox properties of its components, focusing on ion distribution imbalance inside and outside cells and the generation of transmembrane potential. The model includes variations in TMP for different types of potentials and a projection of impulse conduction in neurons. Ultimately, outcomes based on bioenergetic equilibriums provide a comprehensive rationale for the phenomena discussed.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shijin Wang, Cheng Chen, Linna Yu, Johannes Mueller, Vanessa Rausch, Sebastian Mueller
Summary: The study demonstrates that endothelial cells (ECs) can promote hepcidin expression by reacting to surrounding iron and regulating the upstream SMAD pathway. Utilizing EC-derived BMP6, a hepatocyte-endothelial coculture system is established to fully recapitulate iron regulation by hepcidin.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Genetics & Heredity
Bruno Hernandez-Cravero, Sofia Gallino, Jeremy Florman, Cecilia Vranych, Philippe Diaz, Ana Belen Elgoyhen, Mark J. Alkema, Diego de Mendoza
Summary: The nematode Caenorhabditis elegans requires exogenous cholesterol for survival, and the endocannabinoid 2-arachidonoylglycerol (2-AG) plays a key role in cholesterol mobilization. The insulin/IGF-1 signaling pathway and UNC-31/CAPS are essential for 2-AG-mediated stimulation of cholesterol mobilization.
Article
Chemistry, Multidisciplinary
Bao-ming Wu, Jaree Bargaineer, Ling Zhang, Tao Yang, Zhi-gang Xiong, Tian-dong Leng
Summary: Oxidative stress is closely related to neurodegenerative diseases and acute injuries. The study found that hydrogen peroxide can increase ASIC1a expression and activation through the JNK signaling pathway, shedding light on the pathogenesis of neurological disorders involving ROS and ASIC1a activation.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Immunology
Shuang Wei, Chun-Yu Qiu, Ying Jin, Ting-Ting Liu, Wang-Ping Hu
Summary: TNF-α rapidly enhances ASIC-mediated functional activity through a p38 MAPK pathway, sensitizing ASICs in primary sensory neurons and exacerbating pain.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Immunology
Shumin Tan
Summary: Host colonization by a pathogen requires proper sensing and response to environmental cues, with the ionic milieu playing a critical role. The abundant ions, such as chloride and potassium, have been identified as important environmental cues in host-pathogen interactions, with studies focusing on how they are exploited and manipulated during infection and colonization. Further research is needed to fully understand the role of these abundant ions and their impact on pathogen response to cues in host-pathogen interactions.
INFECTION AND IMMUNITY
(2021)
Article
Cell Biology
Qian Liu, Shujuan Guo, Yanli Huang, Xiuqun Wei, Li Liu, Fangjun Huo, Ping Huang, Yafei Wu, Weidong Tian
Summary: Objective of this study was to explore the role and therapeutic function of TRPA1 in periodontitis. The study found that TRPA1 inhibitor significantly reduced oxidative and apoptotic levels in inflammatory cells, as well as reduced oxidative stress and apoptosis in periodontitis mice.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Plant Sciences
Xin Wei, Chunyan Gao, Chunhao Chang, Zhonghua Tang, Dewen Li
Summary: This study found that exogenous trehalose has a positive regulatory effect on Catharanthus roseus under low-temperature stress, increasing plant chlorophyll content and antioxidant enzyme activity. However, trehalose application inhibited the accumulation of alkaloids in C. roseus. Additionally, trehalose significantly increased the expression of 4 enzyme genes involved in alkaloids metabolism.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Food Science & Technology
Yun Guo, Sen Shi, Nan Yang, Mei-Xin Tang, Ze-Jia Duan, Xiao-Rui Guo, Zhong-Hua Tang
Summary: The aim of this study was to assess the nutrient composition, polyphenol profile, and antioxidative properties of four common wild edible ferns in northeastern China. The samples were found to have high levels of total phenolic and total flavonoid contents, and showed antioxidant capacity. They also exhibited different accumulation of polyphenol profiles. The study suggests that wild edible ferns are rich in nutrition and have potential as a natural source of antioxidants.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Plant Sciences
Xuanming Dong, Liben Pan, Zhonghua Tang
Summary: This study reveals the genomic characterization, functional features, and expression patterns of the CrBES1 family in Catharanthus roseus, providing a foundation for further research on the functional aspects of this family and flower development.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Environmental Sciences
Hamid M. Behzad, Muhammad Arif, Shihui Duan, Alireza Kavousi, Min Cao, Jiuchan Liu, Yongjun Jiang
Summary: This study investigated the water uptake and transpiration relationships of four coexisting woody species in a karst forest ecosystem. The study found that the dominant water sources differed between soil-dominated and rock-dominated habitats, and that transpiration and water-use efficiency varied between rainy and dry seasons.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Applied
Lili Fan, Li Lin, Ye Zhang, Sining Li, Zhonghua Tang
Summary: This study qualitatively and quantitatively characterized anthocyanins from different genotypes of Lonicera caerulea L. harvested from northeast China, and measured their reactive oxygen species (ROS) scavenging activity. The key antioxidant component was identified as cyanidin-3,5-diglucoside based on its correlation with ROS scavenging activity.
Article
Biochemistry & Molecular Biology
Siqiu Xiao, Dewen Li, Zhonghua Tang, Hongling Wei, Ying Zhang, Jing Yang, Chunjian Zhao, Ying Liu, Wei Wang
Summary: This study comprehensively evaluated the effects of supplementary UV-B (sUV-B) radiation on the photosynthetic characteristics and content of secondary metabolites in Eucommia ulmoides Oliver leaves. The results showed that sUV-B radiation promoted leaf growth and increased the content of chlorophylls and secondary metabolites. Transcriptome analysis revealed differential expression of genes related to signal transduction and metabolic pathways, which might contribute to the physiological changes and increased content of chlorogenic acid in E. ulmoides. This study provides valuable insights into the effects of sUV-B radiation on leaf growth and secondary metabolites in E. ulmoides.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Forestry
Wenqiu Cao, Muhammad Arif, Zhen Cui, Changxiao Li
Summary: This research studied the effects of trace elements on the growth, physiological traits, tolerances, and accumulation characteristics in Ligustrum obtusifolium saplings in western China, filling a knowledge gap in phytoremediation strategies in that region. The results showed a significant decrease in chlorophyll content and biomass as trace element concentration increased, and the net growth of L. obtusifolium was significantly reduced under Cr stress. The antioxidant enzyme activity of L. obtusifolium increased under different trace element stresses.
Article
Plant Sciences
Jie Zheng, Muhammad Arif, Xinrui He, Xiaolin Liu, Changxiao Li
Summary: Understanding the maintenance mechanisms and diversity of plant species is crucial for biodiversity conservation. Dam-induced water level fluctuations have a significant impact on riparian diversity, including taxonomic, phylogenetic, and functional diversity. This study evaluated plant diversity and environmental drivers in the Three Gorges Reservoir Region in China to determine how ecological processes and inundation gradients affect plant community assembly. The results showed that alpha diversity decreased with increasing inundation gradients and had positive correlations with soil organic matter. Beta diversity was mainly influenced by species turnover and nestedness, with spatial factors explaining the highest beta diversity followed by inundation gradients, soil properties, and climate variables. The study highlights the importance of environmental and spatial gradients in shaping plant communities and the need to protect seed sources and dispersal pathways in restoration projects.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Environmental Sciences
Xinrui He, Muhammad Arif, Jie Zheng, Xilu Ni, Zhongxun Yuan, Qiang Zhu, Jifei Wang, Dongdong Ding, Changxiao Li
Summary: This study examines the distribution pattern of plant species diversity along an elevation gradient and identifies the driving factors affecting diversity and community assembly. The diversity of both the shrub layer and the herb layer is highest at mid-elevation, highlighting the importance of protecting mid-elevation ecosystems. Climatic and topographic factors have a greater impact on species composition changes compared to spatial distance. In the herb layer, climatic, topographic, and spatial factors contribute more to community assembly than in shrub communities. Improving the environment or introducing herbs could aid in the restoration of these areas.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2023)
Article
Environmental Sciences
Amin Hira, Muhammad Arif, Nowsherwan Zarif, Zarmina Gul, Liu Xiangyue, Cao Yukun
Summary: Riparian buffers and stream channel widths have significant ecological influences on riparian health indicators (RHIs) in river networks. This study examines the response of RHIs in the upper and lower Indus River basins (IRB) and finds that in the lower Indus basin (LIB), riparian buffer and stream channel widths have the most considerable influence on RHIs, while stressors have a significant influence on habitat, plant cover, regeneration, erosion, and exotics. In the upper Indus basin (UIB), stressors also adversely affect these RHIs.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2023)
Article
Agronomy
Jiajia Li, Muhammad Arif, Dongdong Ding, Xin Hu, Qianwen Gen, Fan Yin, Changxiao Li
Summary: Research reveals that the soil methanotrophic community has greater diversity and a more complex co-occurrence network in vegetation-covered areas. Soil nitrogen, catalase, and plant diversity influence the stability and diversity of the community. The assembly process of the community is primarily influenced by soil pH and plant diversity, transitioning from stochastic to deterministic processes during vegetation restoration.
Article
Environmental Sciences
Li Jiajia, Muhammad Arif, Li Changxiao
Summary: Investigating the responses of rare and abundant methanotrophic taxa to environmental change and their assembly processes in riparian soil. Abundant taxa showed higher network complexity in grasslands and woodlands, while rare taxa exhibited broader environmental adaptation capabilities. Rare taxa were phylogenetically clustered closer together, while the assembly of abundant taxa was dominated by stochastic processes. Soil pH played an important role in regulating the assembly processes of both subcommunities.
LAND DEGRADATION & DEVELOPMENT
(2023)
Article
Forestry
Haiyan Huang, Xiaoqian Song, Lu Jin, Yu Shi, Haisheng He, Zhonghua Zhang, Zhonghua Tang, Wenjie Wang
Summary: This study examines the link between tree species composition and diversity and microbial carbon deposition. The findings show that tree species diversity and importance values are positively correlated with soil microbial residual carbon. The importance values of AM-associated tree species and tree species diversity have significant impacts on soil microbial residual carbon. Increasing the importance values of AM-associated tree species can significantly increase soil microbial residual carbon.
Review
Environmental Sciences
Mathieu Nsenga Kumwimba, Bo Zhu, Alexandros I. Stefanakis, Fidelis O. Ajibade, Mawuli Dzakpasu, Elisa Soana, Tao Wang, Muhammad Arif, Diana Kavidia Muyembe, Temitope Deborah Agboola
Summary: This paper reviews key methods to tackle diffuse pollution in agricultural and urban watersheds, including source reduction, pollutant retention, nutrient recycling, and purification of eutrophic water bodies. It suggests that integrating constructed wetlands with other control technologies can enhance comprehensive purification of diffuse pollution. The review proposes a systematic approach based on water, soil, and microbiota components, maximizing the regulating services of agroecosystems through land use/cover types.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ying Zhang, Dandan Du, Hongling Wei, Shengnan Xie, Xuchen Tian, Jing Yang, Siqiu Xiao, Zhonghua Tang, Dewen Li, Ying Liu
Summary: In this study, the growth and developmental capacity of Eucommia ulmoides axillary buds were analyzed using transcriptomes and endogenous hormone analysis. The results identified differentially expressed genes related to plant hormone signal transduction and amino acid biosynthesis pathway in the buds. Furthermore, it was found that IAA synthesis and signal transduction play a crucial role in morphological changes during bud germination.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)