snoRNAs: functions and mechanisms in biological processes, and roles in tumor pathophysiology

Small nucleolar RNAs (snoRNAs), a type of non-coding RNA, are widely present in the nucleoli of eukaryotic cells and play an important role in rRNA modification. With the recent increase in research on snoRNAs, new evidence has emerged indicating that snoRNAs also participate in tRNA and mRNA modification. Studies suggest that numerous snoRNAs, including tumor-promoting and tumor-suppressing snoRNAs, are not only dysregulated in tumors but also show associations with clinical prognosis. In this review, we summarize the reported functions of snoRNAs and the possible mechanisms underlying their role in tumorigenesis and cancer development to guide the snoRNA-based clinical diagnosis and treatment of cancer in the future.

Automated summary

snoRNAs play important roles in rRNA modification and participate in tRNA and mRNA modification as well. Dysregulated snoRNAs, including both tumor-promoting and tumor-suppressing snoRNAs, are associated with clinical prognosis in tumors.