期刊
CELL DEATH DISCOVERY
卷 8, 期 1, 页码 -出版社
SPRINGERNATURE
DOI: 10.1038/s41420-022-01037-x
关键词
-
类别
资金
- National Natural Science Foundation of China [81772710, 81972388]
- Project of Invigorating Health Care through Science, Technology and Education Jiangsu Provincial Key Medical Discipline [ZDXKB2016014]
This study reveals the regulatory mechanism of circDHTKD1 in lymphangiogenesis and lymph node metastasis in bladder cancer. By interacting with miR-149-5p and regulating CXCL5 expression, circDHTKD1 promotes lymphangiogenesis and recruits and activates neutrophils, contributing to lymph node metastasis in bladder cancer.
Lymph node (LN) metastasis is associated with unfavorable prognosis of bladder cancer (BCa). Although lymphangiogenesis is functionally important in LN metastasis of tumors, the potential mechanism in BCa remains unclear. Here, we clarified a regulatory mechanism of circRNA-mediated lymphangiogenesis and LN metastasis in BCa based on next-generation sequencing data. We revealed that circDHTKD1 was positively associated with LN metastasis and significantly upregulated in BCa. By analyzing the co-expression patterns of circDHTKD1 and differentially expressed mRNAs, we identified that circDHTKD1 facilitated lymphangiogenesis by upregulating CXCL5. Mechanistically, circDHTKD1 directly interacted with miR-149-5p, and antagonized the repression of miR-149-5p on CXCL5. Furthermore, circDHTKD1-induced CXCL5 expression recruited and activated neutrophils, which participated in lymphangiogenesis by secreting VEGF-C. Our study supports circDHTKD1 as a promising diagnostic and therapeutic target for LN metastasis in BCa.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据