Review
Pharmacology & Pharmacy
Yuting Shan, Lee Cheung, Yuqi Zhou, Yingbo Huang, R. Stephanie Huang
Summary: This review summarizes the current knowledge on sex differences in adverse drug reactions (ADRs) of commonly used psychotropic, cardiovascular, and analgesic medications. The main findings suggest that more than half of the evaluated ADRs show a sex difference in occurrence rate, with some medications causing more adverse reactions in women and others in men.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Juan Tamargo, Ricardo Caballero, Eva Delpon
Summary: There are significant differences between men and women with heart failure (HF), including the distribution of HF types and response to treatment. However, current clinical guidelines do not provide specific recommendations for women with HF, particularly in terms of drug efficacy and safety.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Endocrinology & Metabolism
L. C. Hendriksen, P. D. van der Linden, A. L. M. Lagro-Janssen, P. M. L. A. van den Bemt, S. J. Siiskonen, M. Teichert, J. G. Kuiper, R. M. C. Herings, B. H. Stricker, L. E. Visser
Summary: The study identified significant sex-related differences in specific drug-adverse drug reaction combinations, with the most substantial differences observed in anticoagulants and diuretics. Women were found to have lower risk of certain adverse reactions like haematuria, haemoptysis, and subdural hemorrhage with anticoagulants, but a higher risk of rectal bleeding. Women also had a higher risk of admission compared to men when using thiazide diuretics causing hypokalaemia and hyponatraemia.
BIOLOGY OF SEX DIFFERENCES
(2021)
Article
Medicine, Research & Experimental
Daria Schetz, Tara Elizabeth Scott, Wojciech Waldman, Jacek Sein Anand, Marek Wiergowski, Ivan Kocic
Summary: This study compares the incidence of adverse drug reactions (ADR) of antidepressive agents, benzodiazepines, and antipsychotics plus mood stabilizers (AaMS) in Poland and Australia during the COVID-19 pandemic and before. The results show a significant increase in ADR reports in Poland, with the highest increase seen in antidepressive agents. In Australia, there is a modest increase in ADR reports for antidepressive agents and a significant increase for benzodiazepines.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Anesthesiology
Joshua Aviram, Gil M. Lewitus, Yelena Vysotski, Paula Berman, Anna Shapira, Shiri Procaccia, David Meiri
Summary: Studies have shown that women are more susceptible to adverse effects from conventional drugs. This study aimed to investigate the differences of medical cannabis-related adverse effects between women and men in patients with chronic noncancer pain. The results showed that women reported more medical cannabis-related adverse effects, possibly due to both the inherent sex effect and the consumption of specific phytocannabinoid compositions.
Article
Pharmacology & Pharmacy
Clemence Lacroix, Anais Maurier, Berenger Largeau, Alexandre Destere, Eve-Marie Thillard, Milou Drici, Joelle Micallef, Annie Pierre Jonville-Bera
Summary: Pharmacovigilance and pharmacoepidemiology studies have shown that there are sex differences in adverse drug reactions, and it is important to consider these differences for increasing drug safety. This article provides an overview of the topic, including epidemiology, mechanisms, and methods for assessing sex differences in drug safety. Many studies have found a higher risk for women with most drugs that involve sex differences, but it is necessary to consider physiological, methodological, and subjective factors when interpreting these results. Clinical trials should also enroll more women to better evaluate sex differences in both efficacy and pharmacovigilance. Additionally, personalized prescriptions should take into account the pharmacological rationale behind the observed association between sex and drug safety profile.
Review
Chemistry, Medicinal
Adelina Lombrea, Mirabela Romanescu, Narcisa Jianu, Minodora Andor, Maria Suciu, Dana Emilia Man, Corina Danciu, Cristina Adriana Dehelean, Valentina Buda
Summary: Pharmacological responses vary by sex in several illnesses. This review summarizes sex differences in pharmaceutical response in SARS-CoV-2 infection, dyslipidemia, and diabetes mellitus. In SARS-CoV-2 infection, men may respond better to genomic vaccinations and females to antiviral medications. In dyslipidemia, women tend to have higher HDL-C and lower LDL-C levels. Statins reduce dementia risk differently in males and females. In diabetes mellitus, females may have a higher risk of developing certain complications. Further research is needed to develop personalized treatment strategies for males and females.
Article
Chemistry, Medicinal
Andreea C. Brabete, Lorraine Greaves, Mira Maximos, Ella Huber, Alice Li, Me-Linh Le
Summary: Drug-related adverse events are often under-reported, and there is a need to focus more on sex and gender factors in order to understand and prevent these occurrences. This scoping review analyzes adverse drug reactions reported in international pharmacovigilance databases and examines the gender differences in the reported outcomes. Additional research is needed to identify the relationship between sex and gender factors and the occurrence and reporting of adverse drug reactions.
Article
Clinical Neurology
Johanna Seifert, Fabienne Fuehrmann, Matthias A. Reinhard, Rolf R. Engel, Xueqiong Bernegger, Stefan Bleich, Susanne Stuebner, Eckart Ruether, Sermin Toto, Renate Grohmann, Marcel Sieberer, Waldemar Greil
Summary: Analysis of drug utilization data from psychiatric inpatients with major depressive disorder revealed that men and women were equally likely to use psychotropic drugs, but there were differences in specific drug classes between genders. Women were more likely to receive treatment with multiple psychotropic drugs, while men were more commonly treated with monotherapy. The study also found that certain psychotropic drugs were preferred in the treatment of men compared to women, with some sex differences showing variability over time.
JOURNAL OF NEURAL TRANSMISSION
(2021)
Article
Pharmacology & Pharmacy
Fei Yee Lee, Farida Islahudin, Abdul Halim Abdul Gafor, Hin-Seng Wong, Sunita Bavanandan, Shamin Mohd Saffian, Adyani Md Redzuan, Mohd Makmor-Bakry
Summary: This study aimed to investigate the relationship between CYP3A5*3 polymorphism and adverse drug reactions (ADRs) of antihypertensive drugs in chronic kidney disease (CKD) patients. The results showed that CYP3A5*3 polymorphism was not associated with antihypertensive-related ADRs in CKD patients. The factors associated with antihypertensive-related ADRs were anemia and poor medication adherence.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Yan-zhong Han, Yu-ming Guo, Peng Xiong, Fei-lin Ge, Jing Jing, Ming Niu, Xu Zhao, Zhao-fang Bai, Hai-bo Song, Xiao-he Xiao, Jia-bo Wang
Summary: This study found that the aging population is more susceptible to liver-related ADRs, with the relative risk increasing exponentially with age. It is important to address risk management for older adults when using drugs with a high correlation to the risk of ADRs.
FRONTIERS IN MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Asad Shabbir, Krishnaraj Sinhji Rathod, Rayomand Syrus Khambata, Amrita Ahluwalia
Summary: Coordinated molecular responses are crucial for effective management of both acute and chronic inflammation. There are significant gender differences in the incidence and inflammatory mechanisms of vascular diseases. Regulation of host inflammation may be more effective than acute treatments.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021
(2021)
Review
Medicine, General & Internal
Andre Farkouh, Christoph Baumgaertel, Roman Gottardi, Margit Hemetsberger, Martin Czejka, Alexandra Kautzky-Willer
Summary: There is increasing evidence of sex differences in the action of anti-inflammatory drugs, with women being at significantly higher risk of adverse effects. Men tend to have stronger anti-thrombotic activity with COX-inhibitors, while women are more sensitive to corticosteroids when their estradiol levels are high. Research on sex differences in drug effectiveness and safety is growing, but findings are often anecdotal and controversial, with a lack of systematic sex-differentiated reporting in clinical trials.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Chun-Lan Zhuang, Zhi-Jie Lin, Zhao-Feng Bi, Ling-Xian Qiu, Fang-Fang Hu, Xiao-Hui Liu, Bi-Zhen Lin, Ying-Ying Su, Hui-Rong Pan, Tian-Ying Zhang, Shou-Jie Huang, Yue-Mei Hu, You-Lin Qiao, Feng-Cai Zhu, Ting Wu, Jun Zhang, Ning-Shao Xia
Summary: Concerns over vaccine safety contribute to vaccine hesitancy, but a study found that inflammation-related adverse reactions following vaccination may indicate a stronger immune response. A scoring model was developed to quantify inflammation reactions, with a high score correlating with a robust vaccine-induced antibody level.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Pharmacology & Pharmacy
Maria Antonietta Barbieri, Emanuela Elisa Sorbara, Alessandro Battaglia, Giuseppe Cicala, Vincenzo Rizzo, Edoardo Spina, Paola Maria Cutroneo
Summary: This study analyzed adverse drug reactions (ADRs) related to drugs used in the treatment of multiple sclerosis (MS). The majority of reported ADRs were not serious and were more commonly reported by female patients aged 18-65. The most common ADRs were related to general body and administration site conditions. Some unexpected ADRs, including dyslipidemia, abortion, alopecia, vitamin D deficiency, breast cancer, and hypothyroidism, were found. Further research is needed to increase awareness of the safety profiles of new drugs.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Plant Sciences
Bianca Badescu, Valentina Buda, Mirabela Romanescu, Adelina Lombrea, Corina Danciu, Olivia Dalleur, Angele Modupe Dohou, Victor Dumitrascu, Octavian Cretu, Monica Licker, Delia Muntean
Summary: The rise of multidrug-resistant pathogens poses a global health threat, and the search for alternative solutions to combat them is challenging. The World Health Organization has prioritized fighting drug resistance, calling for the discovery of new antibiotics. Essential oils have gained interest as potential antimicrobial agents, but research progress is limited.
Review
Plant Sciences
Zorita Diaconeasa, Cristian I. Iuhas, Huseyin Ayvaz, Mustafa Mortas, Anca Farcas, Mihaela Mihai, Corina Danciu, Andreea Stanila
Summary: The amount of global food waste is rapidly increasing due to population growth, economic growth, lifestyle, and diet changes. As people focus on healthy diets rich in fruits and vegetables, significant quantities of agro-industrial waste containing bioactive compounds, such as anthocyanins, are produced. Recent years have seen an interest in extracting and recovering anthocyanins from food waste using eco-friendly extraction methods.
Review
Biochemistry & Molecular Biology
Mirabela Romanescu, Camelia Oprean, Adelina Lombrea, Bianca Badescu, Ana Teodor, George D. Constantin, Minodora Andor, Roxana Folescu, Delia Muntean, Corina Danciu, Olivia Dalleur, Stefan Laurentiu Batrina, Octavian Cretu, Valentina Oana Buda
Summary: Combating antimicrobial resistance (AMR) is a major global health issue recognized by the WHO in 2021. Inappropriate antibiotic use and legislative gaps have accelerated the progression of AMR, posing a serious threat to humans, animals, and the environment. Essential oils (EOs) have shown consistent antimicrobial activity, but their use in clinical settings is limited due to methodological differences and lack of in vivo data. This review explores the concept of AMR, global strategies, and the potential of EOs as alternative therapies against high priority pathogens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Chemical
Bianca Baul, Adriana Ledeti, Denisa Circioban, Amalia Ridichie, Titus Vlase, Gabriela Vlase, Francisc Peter, Ionut Ledeti
Summary: The stability of APIs and pharmaceutical formulations is crucial in pharmaceutical research and technology. Various factors such as light, air exposure, temperature, humidity, formulation composition, and packaging materials can affect the quality and stability of APIs and finished pharmaceutical products. This study analyzed the degradation kinetics of the antihypertensive drug moxonidine in different solid mixtures using FTIR spectroscopy and thermoanalytical methods. The results showed that excipients have a stabilizing effect on moxonidine, but the decomposition mechanism is complex.
Article
Plant Sciences
Adelina Lombrea, Alexandra-Denisa Semenescu, Ioana Zinuca Magyari-Pavel, Maris Turks, Jevgenija Luginina, Uldis Peipins, Delia Muntean, Cristina Adriana Dehelean, Stefania Dinu, Corina Danciu
Summary: Malignant melanoma is a pressing problem in the developing world, and new therapeutic agents are urgently needed. Semisynthesis is an essential method for improving the efficacy and activity of natural product precursors. Two novel semisynthetic derivatives of betulinic acid were designed and showed increased antiproliferative and cytotoxic activity against melanoma cells compared to the parent compound. Additionally, these derivatives exhibited antibacterial and antifungal activity. This study highlights the potential of these derivatives in treating melanoma and microbial infections.
Review
Chemistry, Medicinal
Adelina Lombrea, Mirabela Romanescu, Narcisa Jianu, Minodora Andor, Maria Suciu, Dana Emilia Man, Corina Danciu, Cristina Adriana Dehelean, Valentina Buda
Summary: Pharmacological responses vary by sex in several illnesses. This review summarizes sex differences in pharmaceutical response in SARS-CoV-2 infection, dyslipidemia, and diabetes mellitus. In SARS-CoV-2 infection, men may respond better to genomic vaccinations and females to antiviral medications. In dyslipidemia, women tend to have higher HDL-C and lower LDL-C levels. Statins reduce dementia risk differently in males and females. In diabetes mellitus, females may have a higher risk of developing certain complications. Further research is needed to develop personalized treatment strategies for males and females.
Article
Multidisciplinary Sciences
Alexandra Ioana Moatar, Aimee Rodica Chis, Mirabela Romanescu, Paula-Diana Ciordas, Diana Nitusca, Catalin Marian, Cristian Oancea, Ioan-Ovidiu Sirbu
Summary: This study evaluated the early level of circulating miR-195 in Covid-19 patients and found it to be a potential biomarker of disease severity. miR-195 is associated with several clinical and paraclinical parameters and can effectively discriminate between severe and mild forms of the disease. The study also suggests a possible role of miR-195 in long Covid and chronic fatigue syndrome.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Andreea Roxana Ungureanu, Violeta Popovici, Camelia Oprean, Corina Danciu, Verginica Schroder, Octavian Tudorel Olaru, Dragos Paul Mihai, Liliana Popescu, Emanuela-Alice Luta, Carmen Lidia Chitescu, Cerasela Elena Gird
Summary: This research evaluated the cytotoxicity of three vegetal extracts on endothelial cells and brine shrimp larvae, and found that they can be safely used for human consumption and pharmaceutical formulations. Through molecular docking simulations and algorithm prediction, potential interactions between the extracts and phytocompounds related to apoptosis were discovered.
Article
Chemistry, Medicinal
Larisa Bora, Andrada Iftode, Ana Maria Mut, Lavinia Lia Vlaia, Gheorghe-Emilian Olteanu, Delia Muntean, Cristina Adriana Dehelean, Valentina Buda, Georgeta Hermina Coneac, Corina Danciu
Summary: Skin tags, also known as fibroepithelial polyps (FPs) or acrochordons, are soft, pigmented excrescences that occur in 50-60% of the population, mainly in their forties. Various methods like surgical removal, cauterization, laser irradiation, and cryosurgery have been used to eliminate FPs, but over-the-counter treatments are also of interest to patients due to their non-invasive nature. This study aimed to evaluate the efficacy of a modern-pharmaceutical-formulation-type poloxamer-based binary hydrogel with Origanum vulgare L. essential oil as an active ingredient in treating FPs. The results showed positive changes in physiological skin parameters, a reduction in the number of lesions, and histological changes in the epidermis, dermis, and fibrovascular cores of FPs, suggesting the potential of the OEO-PbH treatment.