Article
Materials Science, Multidisciplinary
Jiawei Liu, Honglei Kang, Wenying Wei, Rong Tu, Takashi Goto, Feng Li, Honglian Dai
Summary: Bioactive calcium and magnesium phosphate bone adhesive (MPBA) is a promising material for the treatment of bone fractures and implant fixation. It has the advantages of easy preparation, strong adhesion, and biological activity, and can effectively restore bone strength and promote bone regeneration.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Applied
Flavio de Sousa Santos, Almir Spinelli, Nico Scharnagl, Thiago Ferreira da Conceicao
Summary: This study investigated the properties of pectin coatings crosslinked with Ba2+ or Ca2+ ions on AZ31 magnesium alloy, and found that the coatings crosslinked with Ba2+ exhibited better swelling resistance and corrosion protection. These results indicate that pectin is a suitable polymer for preparing efficient, sustainable, and biodegradable coatings for magnesium alloys.
PROGRESS IN ORGANIC COATINGS
(2023)
Review
Biochemistry & Molecular Biology
Sanja Vujovic, Jana Desnica, Dragana Stanisic, Irena Ognjanovic, Momir Stevanovic, Gvozden Rosic
Summary: This review article analyzes and discusses the applications of magnesium (Mg) and Mg-based materials in reconstructive oral and maxillofacial surgery, including guided bone regeneration, dental implantology, fixation of facial bone fractures, and soft tissue regeneration.
Article
Chemistry, Applied
Mengna Tian, Zhangfei Lin, Wenyan Tang, Wenpeng Wu, Li Wang, Jinglai Zhang
Summary: Electrophoretic deposition was used to prepare bioactive glass-chitosan coating loaded with tetracycline on AZ31B magnesium alloy. The coating exhibited improved corrosion resistance, antibacterial activity, and osteogenic induction properties. It has potential for application in medical devices and bone implant materials.
PROGRESS IN ORGANIC COATINGS
(2023)
Review
Engineering, Biomedical
Navdeep Singh, Uma Batra, Kamal Kumar, Neeraj Ahuja, Anil Mahapatro
Summary: Mg and its alloys are promising candidates for biodegradable bone implants, cardiovascular stents, and wound closing devices. However, their rapid degradation rate hinders their clinical applications. Bio-functional surface coatings have emerged as a competent strategy to provide effective corrosion resistance and meet diverse clinical requirements.
BIOACTIVE MATERIALS
(2023)
Review
Materials Science, Multidisciplinary
Khulud Jaraba, Anil Mahapatro
Summary: This article introduces biodegradable metallic alloys and their applications, and discusses the influence of metal processing on the microstructure and properties of the alloys.
Article
Materials Science, Multidisciplinary
Xinwei Xiao, Shuai Xu, Dashan Sui, Haiming Zhang
Summary: Electric assisted plasticity is a promising technology for improving the formability of hard-deformed materials like Mg alloys. The electroplastic effect (EPE) affects the material's strength and suppresses deformation twinning, while facilitating the activation of non-basal slip.
Article
Materials Science, Coatings & Films
Shuo Chen, Chengdong Zhang, Dongqin Xiao, Feng Shi, Kang Liu, Yongxian Wan, Ke Duan, Jie Weng, Gang Feng, Yiran Yin
Summary: Ta2O5 and Mg-incorporated Ta2O5 coatings prepared by the sol-gel method showed promising effects in improving the in vitro response of rabbit bone marrow mesenchymal stem cells, including enhanced cell viability, proliferation, osteoblastic differentiation, as well as increased corrosion resistance and water wettability. The Mg-incorporated Ta2O5 coating demonstrated the greatest improvements, likely due to the nanostructures and elements release of Mg and Ta from the coatings.
SURFACE & COATINGS TECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Pegah Goudarzi, Mohammad Moazami-Goudarzi, Afshin Masoudi
Summary: One issue with Fe-based biodegradable alloys is their slow degradation rate and ferromagnetic nature limiting their application in MRI. This study investigated the effects of copper addition on the powder processing, microstructure, and performance of Fe-35Mn alloy. Results showed that copper promoted phase transformation, densification, and strength, but also increased corrosion rate.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Metallurgy & Metallurgical Engineering
K. S. Duran, N. Hernandez, L. M. Rueda, C. A. Hernandez-Barrios, A. E. Coy, F. Viejo
Summary: This study developed multilayer barrier-bioactive coatings to enhance the corrosion resistance of magnesium alloy and promote the growth of apatite-like phases. However, an increase in salt content led to the formation of porous coatings, affecting the corrosion resistance of magnesium alloy.
JOURNAL OF MAGNESIUM AND ALLOYS
(2021)
Article
Chemistry, Applied
Tengle Wang, Qi Guo, Tian C. Zhang, Yu-Xin Zhang, Shaojun Yuan
Summary: This study reported a facile, low-cost and large-scale preparation method for superhydrophobic coatings on magnesium alloy. The synthesized superhydrophobic diatomite powder exhibited excellent superhydrophobicity with water contact angle of circa 157 degrees. The resulting composite coating delivered superior corrosion resistance and anti-icing performance, making it suitable for practical applications in anti-corrosion for Mg alloy.
PROGRESS IN ORGANIC COATINGS
(2022)
Article
Materials Science, Multidisciplinary
Kui Xue, Pei-Hong Tan, Ze-Hui Zhao, Lan-Yue Cui, M. Bobby Kannan, Shuo-Qi Li, Cheng-Bao Liu, Yu-Hong Zou, Fen Zhang, Zhuo-Yuan Chen, Rong-Chang Zeng
Summary: In this research work, a Mg(OH)2 coating was formed on the surface of micro arc oxidation (MAO) coated AZ31 alloy through a low temperature hydrothermal method, incorporating sodium alginate (SA) and beta-cyclodextrin (beta-CD)@curcumin (Cur). The coating exhibited excellent corrosion protection, multi-antibacterial ability and almost no toxicity to the cells. The photothermal performance of the coating was achieved through the light absorption of encapsulated Cur by beta-CD, while SA enhanced the binding force between the drug and the substrate.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Review
Materials Science, Multidisciplinary
Meifeng He, Lvxin Chen, Meng Yin, Shengxiao Xu, Zhenyu Liang
Summary: Magnesium alloy is a third-generation biomedical material that promotes bone tissue regeneration. It has the advantages of biodegradability, closer Young's modulus to human bone, osteoinductive and antimicrobial properties. However, its rapid corrosion rate and mechanical integrity compromise pose challenges for bone implantation. Various machining, alloying, and optimization techniques are used to improve the properties of magnesium implants. The review also investigates the corrosion and wear behavior of magnesium alloys and the impact of coating on biocompatibility and corrosion properties.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2023)
Article
Engineering, Biomedical
Zhenglong Dou, Shuiling Chen, Jiacheng Wang, Li Xia, Manfred F. Maitz, Qiufen Tu, Wentai Zhang, Zhilu Yang, Nan Huang
Summary: In order to control the corrosion of magnesium bioresorbable stents, a built-up composite film consisting of multiple layers was developed. This film provides corrosion resistance and biological functions. The composite film showed synergistic effects, maintaining the mechanical integrity of the stents for up to 3 months and achieving complete biodegradation and re-endothelialization.
BIOACTIVE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Mozhgan Keshavarz, Parvin Alizadeh
Summary: The use of alginate-coated 58S BG scaffolds enhances viability and osteogenic differentiation of hMSCs, leading to accelerated osteogenic gene expression and increased antibacterial properties, making it a promising candidate for bone regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Food Science & Technology
Mustofa Ahda, Irwandi Jaswir, Alfi Khatib, Qamar Uddin Ahmed, Sharifah Nurul Akilah Syed Mohamad
Summary: Cosmos caudatus, also known as Ulam raja or kenikir, is a plant that is widely used in traditional medicine due to its pharmacological activities and beneficial effects on human health. Its leaves contain various beneficial compounds such as flavonoids, phenolics, and essential oils. It has been reported to have multiple activities, including antidiabetes, antioxidant, anti-inflammation, antibacterial, antifungal, anti-osteoporosis, anticancer, antihypertensive, and hepato-protective properties.
INTERNATIONAL JOURNAL OF FOOD PROPERTIES
(2023)
Article
Chemistry, Physical
Pedram Sotoudeh Bagha, Carlo Paternoster, Mehrdad Khakbiz, Saeed Sheibani, Navid Gholami, Diego Mantovani
Summary: Fe-Mn-based alloys have gained attention for their tunable mechanical properties and degradation behavior suitable for biomedical applications. However, their corrosion rate is often too low for cardiovascular device applications. In this study, a resorbable bimodal multi-phase alloy was designed to accelerate the corrosion rate, but concerns of toxicity arose. Surface modification with nitrogen plasma immersion ion implantation was used to control the corrosion rate and improve cell viability.
Review
Food Science & Technology
Mustofa Ahda, Irwandi Jaswir, Alfi Khatib, Qamar Uddin Ahmed, Nurkhasanah Mahfudh, Yunita Dewi Ardini
Summary: This review aims to evaluate the effectiveness of selected herbal medicines in reducing blood glucose levels and identify the chemical compounds responsible. The mechanisms of action of different herbal medicines may vary.
INTERNATIONAL JOURNAL OF FOOD PROPERTIES
(2023)
Review
Biochemistry & Molecular Biology
Nabilah Zulkefli, Che Nur Mazadillina Che Zahari, Nor Hafiza Sayuti, Ammar Akram Kamarudin, Norazalina Saad, Hamizah Shahirah Hamezah, Hamidun Bunawan, Syarul Nataqain Baharum, Ahmed Mediani, Qamar Uddin Ahmed, Ahmad Fahmi Harun Ismail, Murni Nazira Sarian
Summary: Wounds caused by diabetes and obesity are a significant problem in healthcare. Unhealthy lifestyles and habits exacerbate the condition. Flavonoids have been shown to promote wound healing due to their anti-inflammatory, angiogenesis, re-epithelialization, and antioxidant effects. This review compiles existing evidence on the use of flavonoids as safe wound-healing agents, discusses current limitations, and provides future perspectives.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Md. Mahmudul Hasan, Qamar Uddin Ahmed, Jalifah Latip, Siti Zaiton Mat So'ad, Muhammad Taher, Awis Sukarni Mohmad Sabere, Zainula Miruddin Zakaria
Summary: This study aimed to evaluate the in vitro antidiabetic potential of betulinic acid and stigmasterol from Tetracera indica and determine if they contribute to the antidiabetic effect. Both compounds showed significant antidiabetic potential and may be considered as safe antidiabetic agents.
Article
Dentistry, Oral Surgery & Medicine
Fransiskus Andrianto Tjiptowidjojo, Judy Chia-Chun Yuan, Sangeeta Yadav, Adam Reshan, Cortino Sukotjo, Alvin G. Wee
Summary: The purpose of this study is to understand the current status, challenges, and responsibilities of prosthodontics program directors (PPDs) in US dental schools, and assess the professional needs of program directors (PDs) to better support their roles. According to the survey, there is a lack of gender and racial diversity among PPDs, and the biggest challenge they face is workload, followed by budget and fiscal constraints. To improve efficiency, they emphasize on learning time management and continuous clinical training of newer advances.
JOURNAL OF PROSTHODONTICS-IMPLANT ESTHETIC AND RECONSTRUCTIVE DENTISTRY
(2023)
Article
Chemistry, Physical
Arief Cahyanto, Michella Liemidia, Elin Karlina, Myrna Nurlatifah Zakaria, Khairul Anuar Shariff, Cortino Sukotjo, Ahmed El-Ghannam
Summary: The study investigated the effect of silica calcium phosphate composites (Si-CaP) and calcium hydroxide (Ca(OH)2) on the mechanical and biological properties of carbonate apatite (CO(3)Ap) cement. It was found that adding 3% Si-CaP and 7% Ca(OH)2 resulted in the highest compressive strength. Soaking the cement in simulated body fluid (SBF) showed the formation of apatite layer and an increase in Ca, P, and Si elements. This combination of additives improved the compressive strength and demonstrated good bioactivity, making CO(3)Ap cement a potential biomaterial for bone and dental engineering applications.
Article
Pharmacology & Pharmacy
Ahmad Safiyyu'd-din Bin Hisamuddin, Ruth Naomi, Khairul Aiman Bin Manan, Hasnah Bahari, Fezah Othman, Hashim Embong, Amin Ismail, Qamar Uddin Ahmed, Siti Hadizah Jumidil, Mohd Khairi Hussain, Zainul Amiruddin Zakaria
Summary: The objective of this study is to assess the effect of purple sweet potato leaf (PSPL) extract on diabetic retinopathy (DR) of streptozotocin (STZ)-induced male Sprague-Dawley (SD) rats. The results show that the 400 mg/kg dose of PSPL extract demonstrated the most significant effects in reducing blood glucose levels, increasing insulin levels, and restoring oxidative stress markers in serum and retina.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Engineering, Biomedical
Leonardo P. Faverani, Sarah Hashemi Astaneh, Monique Goncalves da Costa, Leonardo A. Delanora, Tiburtino J. Lima-Neto, Stefany Barbosa, Maretaningtias Dwi Ariani, Christos Takoudis, Cortino Sukotjo
Summary: This study aimed to evaluate the effect of functionalization of collagen membranes on bone repair of critical defects in rat calvaria and subcutaneous biocompatibility. The results showed that collagen membranes treated with atomic layer deposition of TiO2 for 150 cycles exhibited better bioactive potential in the process of defect repair.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Biophysics
Rathosivan Gopal, Muhammad Faiz Md Shakhih, Mariaulpa Sahalan, Te Chuan Lee, Hendra Hermawan, Sivakumar Sivalingam, Suhaini Kadiman, Syafiqah Saidin
Summary: Immobilizing Factor VII (FVII) on polycaprolactone (PCL) membranes through cross-linkage polydopamine (PDA) grafting provides a solution for postoperative bleeding following cardiac surgeries. The membranes were evaluated for their physio-chemical properties, thermal behavior, FVII release profile, and biocompatibility. The results show that the membranes have good biocompatibility and the ability to prolong blood coagulation, highlighting their potential application as cardiac bleeding sealant.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Nor Hafiza Sayuti, Nabilah Zulkefli, Jen Kit Tan, Norazalina Saad, Syarul Nataqain Baharum, Hamizah Shahirah Hamezah, Hamidun Bunawan, Qamar Uddin Ahmed, Humaira Parveen, Sayeed Mukhtar, Meshari A. Alsharif, Murni Nazira Sarian
Summary: This study found that PMEE can provide neuroprotection against H2O2-induced oxidative stress by activating multiple signaling pathways, and PMEE may serve as a preventative therapy for neurodegenerative diseases.
Article
Plant Sciences
Md Mahmudul Hasan, Priya Madhavan, Nur Adelina Ahmad Noruddin, Wai Kwan Lau, Qamar Uddin Ahmed, Aditya Arya, Zainul Amiruddin Zakaria
Summary: This study investigates the cardioprotective effects of arjunolic acid (AA) via MyD88-dependant TLR4 downstream signaling marker expression. The results suggest that AA can decrease the expression of TLR4, indicating possible cardioprotective effects.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Md. Abdur Rashid Mia, Qamar Uddin Ahmed, Sahena Ferdosh, Abul Bashar Mohammed Helaluddin, Syed Najmul Hejaz Azmi, Fatimah Ammar Al-Otaibi, Humaira Parveen, Sayeed Mukhtar, Mohammad Z. Ahmed, Md. Zaidul Islam Sarker
Summary: This study evaluated the anti-obesity and antihyperlipidemic effects of Phaleria macrocarpa fruit using in vitro, computational, and in vivo assays. The results confirmed that the fruit possesses lipase and HMG-CoA reductase inhibitors, indicating its potential as a lipid-lowering and anti-obesity herbal medicine.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Al'aina Yuhainis Firus Khan, Ridhwan Abdul Wahab, Qamar Uddin Ahmed, Alfi Khatib, Zalikha Ibrahim, Tanzina Sharmin Nipun, Hapizah Nawawi, Syed Najmul Hejaz Azmi, Md. Zaidul Islam Sarker, Zainul Amiruddin Zakaria, Saad Alkahtani, Abdullah A. Alkahtane
Summary: This study investigated the anticancer property of Bezoar (PB) extract and identified the metabolites responsible for its anticancer effect. It was found that the PB extract contained four potential active compounds, including cholest-7-en-3-beta-ol,4,4-dimethyl-,acetate; 4-androsten-4-ol-3,17-dione; isolongifolol, and gallic acid. These compounds exhibited anticancer activity by binding to proteins through hydrophobic interactions.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Dentistry, Oral Surgery & Medicine
William Phillip Pereira Da Silva, Leonardo Alan Delanora, Barbara Ribeiro Rios, Maria Eloise de Sa Simon, Cortino Sukotjo, Leonardo P. Faverani
Summary: This study compared senile rats (SENIL) with young ovariectomized rats (OXV) to select a critical animal model for assessing bone repair with implant installation. The results showed that the SENIL group had lower cell viability, more critical gene expression, lower alkaline phosphatase activity, and mineralization nodules. In vivo histometric and biomechanical analysis also indicated inferior bone condition in the SENIL group. Confocal microscopy revealed fragile bones in the SENIL group. Microtomography results were similar between the groups. These findings suggest that the senile model can provide a more critical bone condition for investigating biomaterial properties and topographic changes.
JOURNAL OF APPLIED ORAL SCIENCE
(2023)
Article
Engineering, Biomedical
Jianqiu Yang, Zhenzhen Huang, Jiang Tan, Jingye Pan, Shixuan Chen, Wenbing Wan
Summary: By functionalizing a decellularized pomelo peel with an adhesive hydrogel and antibacterial materials, the hybrid wound dressing can effectively inhibit bacterial infection, promote granulation tissue formation and angiogenesis, and reduce scar formation during wound healing.
BIOACTIVE MATERIALS
(2024)
Article
Engineering, Biomedical
Yong Mei, Xiaohua Qin, Zhenyu Yang, Shiyao Song, Xiaoting Liu, Chong Wu, Jieying Qian, Xiaowan Huang, Yunjiao Zhang, Weiling He
Summary: This article presents a novel nanoparticle for treating KRAS-TP53 co-mutation in gastrointestinal cancers. The nanoparticle can degrade mutant p53 proteins (mutp53) and deliver the drug AMG510 to inhibit mutant KRAS and mutp53 signaling pathways. The results show that the nanoparticle can effectively reduce cell proliferation and migration, and demonstrate remarkable therapeutic efficacy in a tumor-bearing mouse model.
BIOACTIVE MATERIALS
(2024)
