Article
Virology
Patricia Kaaijk, Niels Swaans, Alina M. Nicolaie, Jacob P. Bruin, Renee A. J. van Boxtel, Marit M. A. de Lange, Adam Meijer, Elisabeth A. M. Sanders, Marianne A. van Houten, Nynke Y. Rots, Willem Luytjes, Josine van Beek
Summary: This study investigates the presence of influenza and other respiratory viruses in older adults with influenza-like illness (ILI). It found that influenza virus was the most commonly detected virus, followed by rhinovirus, seasonal coronavirus, respiratory syncytial virus, and human metapneumovirus. Coinfections of influenza virus with other viruses were rare. The study also suggests that influenza virus infection may reduce the risk of simultaneous infection with other viruses. However, viral persistence or coinfections did not affect the clinical outcome of ILI.
Article
Infectious Diseases
Aung H. Aung, David C. Lye, Lin Cui, Chee K. Ooi, Angela L. P. Chow
Summary: The study found that influenza, rhinoviruses, and coronaviruses are common viral pathogens in the tropics, with influenza having biannual peaks while rhinoviruses and coronaviruses circulate year-round without distinct seasonal patterns. The CDC and WHO ILI case definitions showed moderate-to-high positive likelihood ratios for diagnosing influenza, regardless of the time of year, indicating they can be applied in the tropics effectively.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Shang-Kai Hung, Chin-Chieh Wu, Avichandra Singh, Jin -Hua Li, Christian Lee, Eric H. Chou, Andrew Pekosz, Richard Rothman, Kuan-Fu Chen
Summary: The study developed and compared clinical feature-based machine learning algorithms for accurately predicting influenza infection in patients with influenza-like illness in emergency departments. The eXtreme Gradient Boosting model outperformed conventional models with superior performance, showing certain clinical features positively or negatively associated with influenza infection. This study highlights the potential of machine learning in improving early diagnosis and treatment of influenza.
BIOMEDICAL JOURNAL
(2023)
Article
Microbiology
Nicolas Malausse, Sylvie van der Werf, Nadia Naffakh, Sandie Munier
Summary: Co-infections between influenza A virus (IAV) and influenza B virus (IBV) were studied by infecting A549 cells with recombinant IAV-GFP and IBV-mCherry. Surprisingly, IBV replication was enhanced when co-infected with IAV, particularly when IAV was added 1 hour before IBV. This enhancing effect was dependent on transcription/replication of the IAV genome.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Nguyen Cong Khanh, Ashley L. Fowlkes, Ngu Duy Nghia, Tran Nhu Duong, Ngo Huy Tu, Tran Anh Tu, Jeffrey W. McFarland, Thoa Thi Minh Nguyen, Nga Thu Ha, Philip L. Gould, Pham Ngoc Thanh, Nguyen Thi Huyen Trang, Vien Quang Mai, Phuc Nguyen Thi, Satoko Otsu, Eduardo Azziz-Baumgartner, Dang Duc Anh, A. Danielle Iuliano
Summary: Influenza burden estimates based on hospitalization data in Vietnam show higher rates among children under 5 years old and adults over 65 years old, highlighting the importance of prevention and control measures, such as vaccination, in these high-risk populations.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Immunology
Willem R. Miellet, Janieke van Veldhuizen, Mioara A. Nicolaie, Rob Mariman, Hester J. Bootsma, Thijs Bosch, Nynke Y. Rots, Elisabeth A. M. Sanders, Josine van Beek, Krzysztof Trzcinski
Summary: Influenza-like illness exacerbates pneumococcal colonization in older adults, with this effect persisting beyond recovery from the illness.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Virology
Marina Beretta Duarte, Tatiana Schaffer Gregianini, Leticia G. Martins, Ana Beatriz G. Veiga
Summary: This study investigated the epidemiology of IBV infection in Rio Grande do Sul, Brazil over 17 years, and found that IBV infection is associated with age and seasonality, with a high risk of severe infection. The research also highlighted that cardiopathy, metabolic disease, and smoking are risk factors for fatality in IBV infection.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Immunology
Xuejie Liu, Tianyi Zhao, Liangliang Wang, Zhuolin Yang, Chuming Luo, Minchao Li, Huanle Luo, Caijun Sun, Huacheng Yan, Yuelong Shu
Summary: The study utilized a mosaic vaccine design strategy and genetic algorithms to optimize the influenza virus antigens and generate virus-like particles. Compared to a commercial quadrivalent inactivated influenza vaccine, the mosaic VLPs induced stronger cross-reactive antibody responses, robust T-cell responses, and provided better protection in a mouse model. These findings demonstrate the promising potential of mosaic vaccines for developing a broad influenza vaccine in the future.
Article
Public, Environmental & Occupational Health
Weizheng Shuai, Xuxin Chen, Yi Shan, Wenping Li, Wei Ma, Qiaohui Lu, Dawei Li
Summary: This study collected clinical features and CT findings of Influenza-Like Illness cases, and found that advanced age and underlying diseases are significantly associated with abnormal chest CT results, helping with the differential diagnosis of COVID-19 infection.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Computer Science, Theory & Methods
Endah Kristiani, Yuan-An Chen, Chao-Tung Yang, Chin-Yin Huang, Yu-Tse Tsan, Wei-Cheng Chan
Summary: Influenza cases are a significant global issue impacting public health and policy implementation. Reliable forecasting models play a crucial role in predicting influenza-like epidemic trends, and the integration of Ensemble Learning and deep learning models can improve prediction performance. Evaluations show that the model has a good prediction effect, with an excellent MAPE value of 8% to 15%.
FUTURE GENERATION COMPUTER SYSTEMS-THE INTERNATIONAL JOURNAL OF ESCIENCE
(2021)
Article
Multidisciplinary Sciences
Marie-Paule Gustin, Laurent Pujo-Menjouet, Philippe Vanhems
Summary: This pilot study estimated the transmission rate of H3N2 2012-influenza in a short-term Acute Care for the Elderly Unit. Nurses were found to transmit infection more frequently than medical doctors, with an average transmission rate of 1.04 per day compared to 0.38. This study provides important insights into the dynamics of influenza transmission in hospitals and can inform control measures for preventing nosocomial transmission.
SCIENTIFIC REPORTS
(2023)
Review
Public, Environmental & Occupational Health
Tim K. Tsang, Xiaotong Huang, Yiyang Guo, Eric H. Y. Lau, Benjamin J. Cowling, Dennis K. M. Ip
Summary: A systematic review found a moderate correlation between school absenteeism and influenza activity in the community, especially with illness-specific absenteeism. However, further development and optimization is needed for using school absenteeism as a predictive tool for influenza activity.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Public, Environmental & Occupational Health
Brooke M. Ramay, Jorge Jara, Maria Purificacion Moreno, Patrizia Lupo, Carlos Serrano, Juan P. Alvis, C. Sofia Arriola, Vic Veguilla, S. Cornelia Kaydos-Daniels
Summary: This study aimed to understand the proportion of clients presenting to community pharmacies with influenza-like illness (ILI), the severity of their illness, the presence of different pathogens, and their self-medication practices. The results showed that a small proportion of pharmacy visitors experienced ILI symptoms, with a significant number testing positive for respiratory viruses. In addition, inappropriate antibiotic use was detected. Therefore, guidance on proper antibiotic use is necessary in these cases.
Letter
Immunology
Amary Fall, Nicholas Gallagher, C. Paul Morris, Julie M. Norton, Andrew Pekosz, Eili Klein, Heba H. Mostafa
Summary: This article reports the circulation of enterovirus D68 in Maryland, USA in September-October 2021, which was associated with an increase in influenza-like illness. The characterized enterovirus D68 genomes belong to the B3 subclade that circulated in Europe and the United States in 2018.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Jonjee Calaor-Morin, Vina Lea Arguelles, Janiza Lianne Foronda, Alvin Tan, Evelina Lagamayo, Clyde Dapat, Socorro Lupisan
Summary: The epidemiological and molecular characteristics of RSV among children in the Philippines were studied. RSV-A was the predominant genotype, with multiple genotypes identified. RSV infection was significantly associated with clinical characteristics such as runny nose, pneumonia, and bronchitis. There was an increase in RSV-related cases among children below 24 months old.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2022)
Article
Ecology
Oliver Carroll, Evan Batzer, Siddharth Bharath, Elizabeth T. Borer, Sofia Campana, Ellen Esch, Yann Hautier, Timothy Ohlert, Eric W. Seabloom, Peter B. Adler, Jonathan D. Bakker, Lori Biederman, Miguel N. Bugalho, Maria Caldeira, Qingqing Chen, Kendi F. Davies, Philip A. Fay, Johannes M. H. Knops, Kimberly Komatsu, Jason P. Martina, Kevin S. McCann, Joslin L. Moore, John W. Morgan, Taofeek O. Muraina, Brooke Osborne, Anita C. Risch, Carly Stevens, Peter A. Wilfahrt, Laura Yahdjian, Andrew S. MacDougall
Summary: Nutrient additions can increase aboveground biomass production but also decrease its stability, with nitrogen and phosphorus disproportionately increasing interannual variability.
Article
Biodiversity Conservation
Qingqing Chen, Shaopeng Wang, Eric W. Seabloom, Andrew S. MacDougall, Elizabeth T. Borer, Jonathan D. Bakker, Ian Donohue, Johannes M. H. Knops, John W. Morgan, Oliver Carroll, Mick Crawley, Miguel N. Bugalho, Sally A. Power, Anu Eskelinen, Risto Virtanen, Anita C. Risch, Martin Schutz, Carly Stevens, Maria C. Caldeira, Sumanta Bagchi, Juan Alberti, Yann Hautier
Summary: Nutrients and herbivores have separate effects on aboveground biomass stability in grasslands, with nutrient addition increasing community composition changes over time and herbivore exclusion decreasing spatial asynchrony. However, their interaction has a weak positive effect on stability by increasing spatial asynchrony. Understanding the processes operating at different spatial scales can contribute to the conservation and management of ecosystems.
GLOBAL CHANGE BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Peng Wang, Jing Ni, Ya-Ya Chu, Qing-Qing Chen, Cong Chen, Ruo-Di Zhang, Ling-Qiong Jiang, Yan Zhao, Jun He, De-Guang Wang, Gui-Hong Wang, Hai-Feng Pan, Guo-Cui Wu
Summary: This study investigated the seroreactivity of COVID-19 vaccination and its adverse events in SLE patients, RA patients, and healthy controls. The results showed that there were no significant differences in the seroprevalence of IgG and IgM antibodies against SARS-CoV-2 and the reported adverse events among the three groups. This suggests that the COVID-19 vaccine is safe and effective for SLE and RA patients.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, General & Internal
Yong-Hua Chen, Qing-Qing Chen, Chun-Lin Wang
Summary: This case report presents a rare case of TAIRS in an 11-year-old female patient with an INSR heterozygous mutation treated with a combination of pioglitazone and flutamide for 5 years. The treatment regimen effectively reduced hemoglobin A1c, fasting insulin, and androgen levels.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Chemistry, Analytical
Yanyan Li, Chenglong Lin, Yusi Peng, Jun He, Yong Yang
Summary: A high-sensitivity and point-of-care detection method based on a magnetic SERS biosensor was developed for direct detection of SARS-CoV-2. The biosensor utilized a magnetic Fe3O4-Au nanocomposite to capture and separate the virus, and enhanced Raman signals of SARS-CoV-2. The optimized Fe3O4-Au nanocomposite resulted in high sensitivity, enabling on-site detection of inactivated SARS-CoV-2 virus within 15 minutes. The contaminated nasal and throat swab samples were accurately identified using a support vector machine, achieving a diagnostic accuracy of 100%. The combination of the magnetic SERS biosensor and support vector machine shows great potential as a point-of-care detection tool for SARS-CoV-2.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Immunology
Wen-Man Zhao, Rui Shi, Peng Wang, Jun He, Yue Chen, Ya-Ting Feng, Hai-Feng Pan, De-Guang Wang
Summary: This study aimed to investigate antibody responses to inactivated SARS-CoV-2 vaccine and vaccine-related adverse events in hemodialysis patients. The results showed no significant differences in the seroprevalences of SARS-CoV-2 antibodies and vaccine-related adverse events between hemodialysis patients and healthy controls. The inactivated SARS-CoV-2 vaccine is effective and safe in inducing near-term immunity in hemodialysis patients.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Microbiology
Yating Zhu, Chen Xing, Li Yang, Qian Li, Xiaofeng Wang, Jing Zhou, Cong Zhang, Cuiping Ren, Fahu Liu, Jun He, Bing Shen, Yinan Du, Yan Liu
Summary: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that threatens global public health. Rapid and sensitive detection methods based on CRISPR/Cas12a or Cas13a technologies have been developed for on-site detection of SFTS, with promising results shown in initial clinical validation.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Virology
Jun He, Sai Hou, Chenglong Xiong, Linjie Hu, Lei Gong, Junling Yu, Xiaoyu Zhou, Qingqing Chen, Yuan Yuan, Lan He, Meng Zhu, Weiwei Li, Yonglin Shi, Yong Sun, Haifeng Pan, Bin Su, Yihan Lu, Jiabing Wu
Summary: This study discusses the possible impact of H7N9 influenza A viruses (IAVs) on future influenza epidemics through gene reassortment events. A total of 61 human H7N9 isolates were obtained from Anhui province in China from 2013 to 2019, and bioinformatics analyses revealed the introduction of novel avian influenza A virus (AIV) subtypes through gene reassortment. The study also showed that H7N9, H9N2, and H5N1 can serve as persistent gene pools for AIVs in specific regions of China.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Immunology
Wan-Rong Luo, Xiao-Min Wu, Wei Wang, Jun-Ling Yu, Qing-Qing Chen, Xue Zhou, Xin'er Huang, Hai-Feng Pan, Zhi-Rong Liu, Yong Gao, Jun He
Summary: The ongoing global pandemic of COVID-19 has had a significant impact on global health and economy. Vaccine development has made progress, but the mutations of the virus pose challenges for vaccine development and application.
MICROBIAL PATHOGENESIS
(2022)
Article
Plant Sciences
Peter A. Wilfahrt, Eric W. Seabloom, Jonathan D. Bakker, Lori Biederman, Miguel N. Bugalho, Marc W. Cadotte, Maria C. Caldeira, Jane A. Catford, Qingqing Chen, Ian Donohue, Anne Ebeling, Nico Eisenhauer, Sylvia Haider, Robert W. Heckman, Anke Jentsch, Sally E. Koerner, Kimberly J. Komatsu, Ramesh Laungani, Andrew MacDougall, Jason P. Martina, Holly Martinson, Joslin L. Moore, Yujie Niu, Timothy Ohlert, Harry Olde Venterink, Devyn Orr, Pablo Peri, Edwin Pos, Jodi Price, Xavier Raynaud, Zhengwei Ren, Christiane Roscher, Nicholas G. Smith, Carly J. Stevens, Lauren L. Sullivan, Michelle Tedder, Pedro M. Tognetti, Ciska Veen, George Wheeler, Alyssa L. Young, Hillary Young, Elizabeth T. Borer
Summary: This study highlights the importance of both resource availability and historical abundance in determining the persistence of species dominance following environmental perturbations. Fertilization and exclusion of vertebrates influence the rate at which species lose dominance, with initial cover playing a significant role. The ability of plant species to maintain dominance following perturbations affects ecosystem functions and community compositions.
JOURNAL OF ECOLOGY
(2023)
Article
Virology
Jun He, Qingmin Mei, Yousong Peng, Jiajia Xie, Weiwei Li, Chengchao Ding, Chengcheng Jiang, Qingqing Chen, Jing Wang, Yuqing Zhang, Shuangshuang Ni, Junling Yu, Tao Liu, Weifei Yang, Lei Gong, Xiangyu Zhang, Yuan Yuan, Zhuhui Zhang, Lan He, Hongliang He, Yong Sun, Jiabing Wu, Zhirong Liu, Yong Gao
Summary: It is crucial to monitor variations in the virus genome to understand the evolution and spread of SARS-CoV-2. In this study, early isolates of SARS-CoV-2 from China were cultured in vitro and analyzed for viral infectivity and spike protein mutations. The results showed that in vitro cultured SARS-CoV-2 had a higher mutation frequency compared to infected patients, indicating diversification under favorable conditions. Monitoring viral mutations is essential for understanding virus evolution, virulence change, and preventing transmission and disease progression.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Qingqing Chen, Shaopeng Wang, Elizabeth T. Borer, Jonathan D. Bakker, Eric W. Seabloom, W. Stanley Harpole, Nico Eisenhauer, Ylva Lekberg, Yvonne M. Buckley, Jane A. Catford, Christiane Roscher, Ian Donohue, Sally A. Power, Pedro Daleo, Anne Ebeling, Johannes M. H. Knops, Jason P. Martina, Anu Eskelinen, John W. Morgan, Anita C. Risch, Maria C. Caldeira, Miguel N. Bugalho, Risto Virtanen, Isabel C. Barrio, Yujie Niu, Anke Jentsch, Carly J. Stevens, Daniel S. Gruner, Andrew S. Macdougall, Juan Alberti, Yann Hautier
Summary: Eutrophication has varying effects on different aspects of grassland ecological stability, and different stability measures are largely uncorrelated. This highlights the high dimensionality of stability and provides insights for predicting grassland responses to global environmental change.
NATURE COMMUNICATIONS
(2023)
Article
Public, Environmental & Occupational Health
Miao Lu, Qingqing Chen, Xincheng Qin, Yong Lyu, Zhongqiu Teng, Kun Li, Liang Yu, Xiaojing Jin, Hongwei Chang, Wen Wang, Dayin Hong, Yong Sung, Biao Kan, Lei Gong, Tian Qin
