Article
Radiology, Nuclear Medicine & Medical Imaging
Carmine Capone, Adele Valentini, Silvia Lina Spinillo, Catherine Klersy, Anna Celentano, Maurizio Pin, Cristian Monterosso, Roberto Dore, Emilio Maria Bassi, Michela Zacchino, Giuseppe Rodolico, Angelo Guido Corsico, Lorenzo Preda, Stefano Ghio, Andrea Maria D'Armini
Summary: This study aimed to describe the radiological features of chronic thromboembolic pulmonary disease (CTEPD) and compared them with chronic thromboembolic pulmonary hypertension (CTEPH) patients. The results showed significant differences in vascular obstruction, hypoperfusion, mosaic attenuation, and signs of pulmonary hypertension between the two groups, suggesting that the absence of peripheral microvascular disease may be the reason for the absence of pulmonary hypertension in CTEPD patients.
EUROPEAN RADIOLOGY
(2021)
Article
Biology
Keisuke Miwa, Yu Taniguchi, Hiroyuki Fujii, Yoichiro Matsuoka, Hiroyuki Onishi, Kenichi Yanaka, Yu Izawa, Yasunori Tsuboi, Atsushi Kono, Noriaki Emoto, Kenichi Hirata
Summary: Poor subpleural perfusion (PSP) on dual-energy computed tomography (DE-CT) is a specific imaging finding in chronic thromboembolic pulmonary hypertension (CTEPH) and suggests a different mechanism of microvasculopathy from that in pulmonary arterial hypertension (PAH).
Review
Cardiac & Cardiovascular Systems
Aleksandra Bartnik, Joanna Pepke-Zaba, Stephen P. Hoole, Paul White, Madalina Garbi, John G. Coghlan, Fouad Taghavi, Steven Tsui, Jonathan Weir-McCall
Summary: Chronic thromboembolic pulmonary hypertension (CTEPH) is a condition that occurs in some patients with prior acute pulmonary embolism, characterized by shortness of breath, persistently elevated pulmonary pressures, and right heart failure. Surgical pulmonary endarterectomy (PEA) is effective for patients with proximal disease distribution, while balloon pulmonary angioplasty (BPA) and medical therapy are options for those with inoperable disease. Current evaluation of pulmonary hemodynamics does not accurately reflect patient symptoms, and further research is needed on how to manage symptomatic patients without pulmonary hypertension.
Article
Ophthalmology
Przemyslaw Krajewski, Monika Turczynska, Joanna Golebiewska, Marek Roik, Joanna Brydak-Godowska
Summary: This study found that CTEPH patients have microvascular changes in the retina and choroid, including decreases in mean vessel density and choroidal thickness. The presence of systemic diseases also increases the risk of vascular complications.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gudula J. A. M. Boon, Yvonne M. Ende-Verhaar, Ludo F. M. Beenen, Johan Coolen, Marion Delcroix, Marek Golebiowski, Menno Huisman, Albert T. A. Mairuhu, Lilian J. Meijboom, Saskia Middeldorp, Piotr Pruszczyk, Cornelis J. van Rooden, Anton Vonk Noordegraaf, Lucia J. M. Kroft, Frederikus A. Klok
Summary: The study found that the presence of three or more predefined radiological predictors in patients with acute PE was highly specific for predicting future CTEPH diagnosis, comparable to overall expert judgment, with the latter showing higher sensitivity. Dedicated CTPA reading for signs of CTEPH may help in early detection of CTEPH after PE, although not detecting all cases in the cohort.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jitsuro Tsukada, Yoshitake Yamada, Takashi Kawakami, Shunsuke Matsumoto, Masanori Inoue, Seishi Nakatsuka, Masahiro Okada, Keiichi Fukuda, Masahiro Jinzaki
Summary: The study found that changes in CTPA parameters can predict treatment effects after balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension, with decreased diameters of the main pulmonary artery and right atrium being independent factors predicting a decrease in mean pulmonary artery pressure.
EUROPEAN RADIOLOGY
(2021)
Article
Respiratory System
Marion Delcroix, Adam Torbicki, Deepa Gopalan, Olivier Sitbon, Frederikus A. Klok, Irene Lang, David Jenkins, Nick H. Kim, Marc Humbert, Xavier Jais, Anton Vonk Noordegraaf, Joanna Pepke-Zaba, Philippe Brenot, Peter Dorfmuller, Elie Fadel, Hossein-Ardeschir Ghofrani, Marius M. Hoeper, Pavel Jansa, Michael Madani, Hiromi Matsubara, Takeshi Ogo, Ekkehard Gruenig, Andrea D'Armini, Nazzareno Galie, Bernhard Meyer, Patrick Corkery, Gergely Meszaros, Eckhard Mayer, Gerald Simonneau
Summary: Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare complication of acute pulmonary embolism, often resulting in right heart failure. Current treatment modalities include surgery, angioplasty, and medication therapy.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Akira Nishiyama, Naoko Kawata, Hajime Yokota, Koichi Hayano, Shin Matsuoka, Ayako Shigeta, Toshihiko Sugiura, Nobuhiko Tanabe, Keiichi Ishida, Koichiro Tatsumi, Takuji Suzuki, Takashi Uno
Summary: This study investigated the potential of using CT imaging features to evaluate changes in pulmonary circulatory dynamics in patients with CTEPH undergoing PEA surgery.
ACADEMIC RADIOLOGY
(2022)
Review
Critical Care Medicine
Jenny Yang, Michael M. Madani, Ehtisham Mahmud, Nick H. Kim
Summary: CTEPH is a treatable form of pulmonary hypertension caused by persistent thromboembolic obstruction of the pulmonary arteries. Its true incidence is unclear, but it can be diagnosed using V/Q scintigraphy and advanced imaging methods. Surgical treatment can be curative, while pharmacotherapy and balloon pulmonary angioplasty are effective for inoperable patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Roman Johannes Gertz, Felix Gerhardt, Michael Pienn, Simon Lennartz, Jan Robert Kroeger, Liliana Caldeira, Lenhard Pennig, Thomas Henning Schoemig, Nils Grosse Hokamp, David Maintz, Stephan Rosenkranz, Alexander Christian Bunck
Summary: This study aimed to differentiate between acute pulmonary embolism (PE) and chronic thromboembolic pulmonary hypertension (CTEPH) using dual-layer dual-energy computed tomography (dlDECT)-derived pulmonary perfusion maps. The study found that patients with acute PE had higher iodine uptake in normal perfused lung areas compared to those with CTEPH. Additionally, after normalizing iodine density in perfusion defects, patients with acute PE had reduced average perfusion compared to both CTEPH patients and controls. dlDECT enables quantification and characterization of pulmonary perfusion patterns in acute PE and CTEPH and can enhance differentiation between the two diseases when combined with morphological CT parameters.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yuki Yamagata, Satoshi Ikeda, Sanae Kojima, Yuki Ueno, Tomoo Nakata, Seiji Koga, Chikara Ohno, Tsuyoshi Yonekura, Tsuyoshi Yoshimuta, Takako Minami, Hiroaki Kawano, Koji Maemura
Summary: This study found that patients with chronic thromboembolic pulmonary hypertension (CTEPH) show more evident right ventricular (RV) dyssynchrony compared to patients with pulmonary arterial hypertension (PAH). The reduced pulmonary arterial compliance and increased pulse pressure may delay RV free wall motion and cause RV dyssynchrony.
CIRCULATION JOURNAL
(2022)
Article
Medicine, General & Internal
Maria Wieteska-Milek, Sebastian Szmit, Michal Florczyk, Beata Kusmierczyk-Droszcz, Robert Ryczek, Milena Dzienisiewicz, Adam Torbicki, Marcin Kurzyna
Summary: The study found that during the COVID-19 pandemic, patients with PAH and CTEPH experienced high levels of fear, anxiety, and depression, with higher levels of fear observed in women and the elderly. Higher fear levels increased the likelihood of anxiety, but not depression. A history of COVID-19 increased the risk of developing both anxiety and depression in these patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Matthias Eberhard, Micheal McInnis, Marc de Perrot, Mona Lichtblau, Silvia Ulrich, Ilhan Inci, Isabelle Opitz, Thomas Frauenfelder
Summary: Dual-energy CT pulmonary angiography is highly sensitive in classifying the level of disease in patients with chronic thromboembolic pulmonary hypertension and is associated with hemodynamic improvement after surgery.
Article
Peripheral Vascular Disease
Anna Rogowska, Lukasz Obrycki, Zbigniew Kulaga, Claudia Kowalewska, Mieczyslaw Litwin
Summary: The study found that hypertensive children show signs of microcirculation remodeling and decreased neural layer of the retina, associated with hypertensive macrocirculation remodeling characterized by increased carotid intima-media thickness and elevated central systolic blood pressure.
Review
Respiratory System
Krittika Teerapuncharoen, Remzi Bag
Summary: Chronic thromboembolic pulmonary hypertension (CTEPH) is a long-term complication of pulmonary embolism (PE), and delay in diagnosis and treatment is associated with poor outcomes. High clinical suspicion and accurate interpretation of relevant imaging examinations are crucial for diagnosing CTEPH.
Editorial Material
Rheumatology
Joao Andre dos Santos Ferreira, Mariana Isabel Simao Fernandes Luis, Rui Miguel Terenas Lanca Baptista, Susana Isabel Monteiro Dias da Costa, Silvia Reis Monteiro, Lino Manuel Martins Goncalves
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2021)
Article
Medicine, General & Internal
Joao Andre Ferreira, Rui Miguel Baptista, Silvia Reis Monteiro, Lino Manuel Goncalves
Summary: The study findings suggest that the use of beta-blockers (BB) after ST-segment elevation myocardial infarction (STEMI) have not been proven beneficial in a 1-year follow-up, but may be beneficial in patients with reduced left ventricular ejection fraction.
Article
Cardiac & Cardiovascular Systems
Sofia Lazaro Mendes, Nadia Moreira, Manuel Batista, Ana Rita Ferreira, Ana Vera Marinho, David Prieto, Rui Baptista, Susana Costa, Fatima Franco, Mariano Pego, Manuel de Jesus Antunes
Summary: The study showed that in patients with severe pulmonary hypertension pre-treated with sildenafil, early post-operative hemodynamics and prognosis were slightly worse than in patients without pulmonary hypertension, but after one year, the medium to long-term mortality proved to be similar.
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2021)
Article
Cardiac & Cardiovascular Systems
Marius M. Hoeper, Miguel-Angel Gomez Sanchez, Marc Humbert, David Pittrow, Gerald Simonneau, Henning Gall, Ekkehard Gruenig, Hans Klose, Michael Halank, David Langleben, Repke J. Snijder, Pilar Escribano Subias, Lisa M. Mielniczuk, Tobias J. Lange, Jean-Luc Vachiery, Hubert Wirtz, Douglas S. Helmersen, Iraklis Tsangaris, Joan A. Barbera, Joanna Pepke-Zaba, Anco Boonstra, Stephan Rosenkranz, Silvia Ulrich, Regina Steringer-Mascherbauer, Marion Delcroix, Pavel Jansa, Iveta Simkova, George Giannakoulas, Jens Klotsche, Evgenia Williams, Christian Meier, Hossein-Ardeschir Ghofrani
Summary: The EXPERT study monitored the long-term safety of riociguat in clinical practice, showing consistent safety with clinical trials and no new safety concerns, with a lower exposure-adjusted rate of hemoptysis/pulmonary hemorrhage compared to the Phase 3 trial in PAH.
RESPIRATORY MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Hossein-Ardeschir Ghofrani, Miguel-Angel Gomez Sanchez, Marc Humbert, David Pittrow, Gerald Simonneau, Henning Gall, Ekkehard Gruenig, Hans Klose, Michael Halank, David Langleben, Repke J. Snijder, Pilar Escribano Subias, Lisa M. Mielniczuk, Tobias J. Lange, Jean-Luc Vachiery, Hubert Wirtz, Douglas S. Helmersen, Iraklis Tsangaris, Joan A. Barbera, Joanna Pepke-Zaba, Anco Boonstra, Stephan Rosenkranz, Silvia Ulrich, Regina Steringer-Mascherbauer, Marion Delcroix, Pavel Jansa, Iveta Simkova, George Giannakoulas, Jens Klotsche, Evgenia Williams, Christian Meier, Marius M. Hoeper
Summary: The EXPERT study, involving 956 CTEPH patients, demonstrated that the safety of riociguat in these patients was consistent with the known safety profile of the drug, with no new safety concerns identified.
RESPIRATORY MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Joana Maria Ribeiro, Pedro A. Sousa, Natalia Antonio, Rui Baptista, Luis Elvas, Sergio Barra, Lino Goncalves
Summary: This observational study evaluated the impact of atrial fibrillation (AF) ablation on patients with heart failure (HF) and left ventricular (LV) systolic dysfunction. The results showed that AF ablation not only improved LVEF, but also led to improvements in functional status and favorable structural remodeling of the heart.
REVISTA PORTUGUESA DE CARDIOLOGIA
(2021)
Article
Cardiac & Cardiovascular Systems
Patricia Marques-Alves, Joao Andre Ferreira, Andre Azul Freitas, Jose Paulo Almeida, Rui Baptista, Graca Castro, Rui Martins, Paulo Donato, Maria Joao Ferreira, Lino Goncalves
Summary: This study aimed to investigate left atrial functional abnormalities in hypertrophic cardiomyopathy (HCM) and hypertension patients, and determine their correlation with the extent of left ventricular fibrosis. The results showed that patients with HCM had significantly reduced left atrial mechanics, while patients with hypertension maintained normal left atrial function. Left atrial strain parameters were sensitive and specific for identifying HCM. Additionally, left atrial strain rate was associated with the degree of left ventricular fibrosis.
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2022)
Article
Biochemistry & Molecular Biology
Raquel Paulinetti Camara, Francisco das Neves Coelho, Natalia Cruz-Martins, Patricia Marques-Alves, Graca Castro, Rui Baptista, Filipa Ferreira
Summary: This study compares the incidence rates of bloodstream infection (BSI) between intravenous iloprost and epoprostenol administration. It shows that patients receiving iloprost are at a higher risk of developing BSI, with a higher mortality rate, and a higher incidence of BSI due to Gram-negative and low-virulence bacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Rui Baptista, Sara Goncalves, Ricardo Fontes-Carvalho
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Catia Santos-Ferreira, Daniela Cardoso, Benedita Paiva, Rui Baptista
Summary: This case highlights the challenges of timely diagnosis of PAH, particularly the importance of genetic screening. Despite a temporary improvement in clinical symptoms, there is still a risk of rapid progression in patients with severe haemodynamic changes.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2021)
Article
Medicine, General & Internal
Joao Ferreira, Mariana Luis, Rui Baptista, Silvia Monteiro, Lino Goncalves
Summary: This study retrospectively analyzed patients with acute pericarditis admitted to the emergency department from 2009 to 2019, identifying predictors of pericarditis recurrence. Despite discrepancies between clinical decisions and ESC guidelines, it did not lead to different outcomes.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
J. Ferreira, M. Luis, R. Baptista, S. Monteiro, L. Goncalves
EUROPEAN HEART JOURNAL
(2020)
Meeting Abstract
Cardiac & Cardiovascular Systems
G. Pessoa Amorim, D. Santos-Ferreira, A. Azul Freilas, H. Santos, A. Belo, C. Gavina, R. Terenas Baptista, S. Monteiro
EUROPEAN HEART JOURNAL
(2020)
Meeting Abstract
Cardiac & Cardiovascular Systems
J. Borges-Rosa, J. Ferreira, M. Oliveira-Santos, S. Monteiro, F. Goncalves, R. Monteiro, R. Baptista, L. Goncalves
EUROPEAN HEART JOURNAL
(2020)
Review
Cardiac & Cardiovascular Systems
Catia A. Santos-Ferreira, Monica T. Abreu, Carla Marques, Lino M. Goncalves, Rui Baptista, Henrique M. Girao
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2020)
Review
Cardiac & Cardiovascular Systems
Peiyue Zhang, Cuiyuan Huang, Haiyin Liu, Mengting Zhang, Li Liu, Yuhong Zhai, Jing Zhang, Jian Yang, Jun Yang
Summary: NFAT is a widely expressed transcriptional activator that is involved in regulating the immune system, heart and brain development, and mediating pathological processes such as cardiac hypertrophy. Oxidative stress, characterized by excessive production of reactive oxygen species, mitochondrial dysfunction, calcium overload, and subsequent lipid peroxidation, inflammation, and apoptosis, is associated with various pathological processes. Calcium overload activates NFAT through the calcium-calcineurin pathway, which is the main regulatory mode of NFAT factors. This review focuses on the effects of NFAT transcription factors on reactive oxygen species production, calcium overload, mitochondrial dysfunction, redox reactions, lipid peroxidation, inflammation, and apoptosis in response to oxidative stress. The aim is to provide a reference for understanding the functions and characteristics of NFAT in different stages of oxidative stress and related potential targets.
JOURNAL OF CARDIOLOGY
(2024)