Article
Endocrinology & Metabolism
Eder Anderson Rodrigues, Camila Moreno Rosa, Dijon Henrique Salome Campos, Felipe Cesar Damatto, Gilson Masahiro Murata, Lidiane Moreira Souza, Luana Urbano Pagan, Mariana Gatto, Jessica Yumi Brosler, Hebreia Oliveira Almeida Souza, Mario Machado Martins, Luciana Machado Bastos, Suzana Erico Tanni, Katashi Okoshi, Marina Politi Okoshi
Summary: This study evaluated the effects of SGLT2 inhibitor dapagliflozin on cardiac remodeling, myocardial function, energy metabolism, and metabolomics in rats with Type 1 DM. Long-term treatment with dapagliflozin attenuated cardiac remodeling, myocardial dysfunction, and contractile reserve impairment in Type 1 diabetic rats.Functional improvement is associated with restored pyruvate kinase and phosphofructokinase activity and attenuated metabolomics changes.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Biochemistry & Molecular Biology
Zhe Yang, Tengling Li, Jianzhong Xian, Jia Chen, Yin Huang, Qin Zhang, Xiufang Lin, Hongyun Lu, Yubi Lin
Summary: This study found that SGLT2i attenuated cardiac dysfunction and adverse remodeling in ACM by suppressing cardiac fibrosis and inflammation via reverting the HIF-2 alpha signaling pathway. This suggests that SGLT2i is a novel and available therapy for ACM.
Article
Pharmacology & Pharmacy
Jian He, Dengyue Xu, Lu Wang, Xiaohong Yu
Summary: Cardiovascular disease is a major threat to human health and the leading cause of death. It is characterized by cardiac remodeling, including hypertrophy, fibrosis, inflammation, and oxidative stress. Farrerol has been found to be effective in treating inflammation, endothelial injury, and tumors, and it may also play a role in mitigating cardiac hypertrophy and remodeling.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Shaowei Fan, Yuanhui Hu, Yaping You, Wenjing Xue, Ruoning Chai, Xuesong Zhang, Xintian Shou, Jingjing Shi
Summary: Cardiovascular disease is a group of diseases with high mortality. Pathological cardiac remodeling is the most common cardiac pathological change, and inhibiting it can delay the development of cardiovascular diseases. Resveratrol, a polyphenol compound, has various cardiovascular protective effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yu-Wen Lin, Chin-Yu Chen, Jhih-Yuan Shih, Bor-Chih Cheng, Ching-Ping Chang, Mao-Tsun Lin, Chung-Han Ho, Zhih-Cherng Chen, Sudeshna Fisch, Wei-Ting Chang
Summary: The study established a MR model in rats and found that DAPA partially restored impaired cardiac function induced by MR, reduced atrial fibrillation occurrence, and attenuated cardiac fibrosis.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Immunology
Ri-Feng Gao, Xiao Li, Hai-Yan Xiang, Heng Yang, Chun-Yu Lv, Xiao-Lei Sun, Hong-Zhang Chen, Yang Gao, Jue-Sheng Yang, Wei Luo, Yi-Qing Yang, Yan-Hua Tang
Summary: Oridonin, a covalent NLRP3 inhibitor, reduces myocardial fibrosis and preserves cardiac function in a mouse MI model, indicating its potential therapeutic effect on acute MI patients. Additionally, Oridonin decreased the expression levels of inflammatory factors and reduced myocardial macrophage and neutrophil influxes in treated mice.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Nor Hidayah Mustafa, Juriyati Jalil, Satirah Zainalabidin, Mohammed S. M. Saleh, Ahmad Yusof Asmadi, Yusof Kamisah
Summary: Cardiovascular diseases are a significant clinical burden worldwide, and heart failure is a common disease resulting from uncontrolled hypertension. Sacubitril/valsartan, a new drug combination, has been approved for patients with heart failure, but its molecular mechanism of action in cardiac remodeling is still unclear.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Siyuan Ma, Lu Chen, Junyu Yan, Mengjia Shen, Rui Zhang, Mingjue Li, Mingyuan He, Kaitong Chen, Yingqi Zhu, Hairuo Lin, Yuegang Wang, Wangjun Liao, Jianping Bin, Cankun Zheng, Yulin Liao
Summary: Surgical ventricular reconstruction (SVR) can reverse cardiac remodeling in post-MI patients with large left ventricular aneurysm, but residual remodeling and dysfunction still exist. Dapagliflozin (DAPA) can attenuate residual cardiac remodeling after SVR and improve LV function.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Jingjing Tian, Mingjun Zhang, Mengying Suo, Dian Liu, Xuyang Wang, Ming Liu, Jinyu Pan, Tao Jin, Fengshuang An
Summary: The study found that the SGLT2 inhibitor dapagliflozin (DAPA) protects against diabetic cardiomyopathy (DCM) and myocardial fibrosis by suppressing fibroblast activation and endothelial-to-mesenchymal transition (EndMT) through the AMPK alpha-mediated inhibition of the TGF-beta/Smad signaling pathway.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Kadiam C. Venkata Subbaiah, Jiangbin Wu, Wai Hong Wilson Tang, Peng Yao
Summary: FAM114A1 is upregulated in failing human and mouse hearts and plays a critical role in cardiac remodeling by regulating angiotensin II signaling and activating cardiac fibroblasts and other cardiac cells.
Article
Biochemistry & Molecular Biology
Francisco Souza-Neto, Fabian Islas, Sara Jimenez-Gonzalez, Maria Luaces, Bunty Ramchandani, Ana Romero-Miranda, Beatriz Delgado-Valero, Elena Roldan-Molina, Melchor Saiz-Pardo, Ma Angeles Ceron-Nieto, Luis Ortega-Medina, Ernesto Martinez-Martinez, Victoria Cachofeiro
Summary: This study evaluated the cardiac function and fibrosis in infarcted rats treated with MitoQ and in patients with acute myocardial infarction. The results showed that MitoQ reduced oxidative stress and improved cardiac function, and also decreased fibrosis by inhibiting endoplasmic reticulum stress.
Article
Cardiac & Cardiovascular Systems
Ryan M. Burke, Ronald A. Dirkx, Pearl Quijada, Janet K. Lighthouse, Amy Mohan, Meghann O'Brien, Wojciech Wojciechowski, Collynn F. Woeller, Richard P. Phipps, Jeffrey D. Alexis, John M. Ashton, Eric M. Small
Summary: Salinomycin as an antifibrotic agent demonstrates potent anti-fibrotic activity in cardiac fibroblasts, prevents cardiac fibrosis and functional decline in mouse models of ischemic and nonischemic heart disease, and inhibits cardiac fibroblast activation by targeting p38/MAPK and Rho signaling. Moreover, salinomycin promotes cardiomyocyte survival and improves coronary vessel density, showing promise for the treatment of heart failure patients.
CIRCULATION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Yusof Kamisah, Hamat H. Che H. Hassan
Summary: Cardiac remodeling can lead to ventricular dysfunction and progress to heart failure, a life-threatening cardiovascular disease. Ivabradine, an I-f inhibitor, is used as an adjunct to other heart failure medications in patients with chronic heart failure. This review aims to provide updated information on the therapeutic use and mechanism of action of ivabradine in heart failure. The drug reduces resting heart rate and has beneficial effects on cardiac function, structure, and quality of life, but its molecular mechanisms and role in improving heart failure are not yet fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Batoul Dia, Sahar Alkhansa, Rachel Njeim, Sarah Al Moussawi, Theresa Farhat, Antony Haddad, Mansour E. Riachi, Rashad Nawfal, William S. Azar, Assaad A. Eid
Summary: Diabetic kidney disease (DKD) is a serious complication of diabetes, and inflammation and oxidative stress are key factors in its development and progression. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have shown promise in improving renal outcomes in diabetes patients, but the specific mechanism of their renoprotective effects is still not fully understood. This study demonstrates that the drug dapagliflozin can attenuate renal injury in type 2 diabetic mice by reducing renal hypertrophy, proteinuria, tubulointerstitial fibrosis, and glomerulosclerosis through the inhibition of reactive oxygen species and inflammation. These findings provide insights into the mechanistic pathway of SGLT2i's renoprotective effects.
Article
Cardiac & Cardiovascular Systems
Kai Wang, Zhongming Li, Yan Sun, Xianling Liu, Wenjie Ma, Yinzhang Ding, Jian Hong, Lijun Qian, Di Xu
Summary: The study demonstrated that dapagliflozin has cardioprotective effects in mice with myocardial infarction, improving cardiac structure and function, attenuating cardiac fibrosis, and inhibiting inflammatory cytokines and myocardial apoptosis. Additionally, the inhibition of the PI3K/AKT/mTOR pathway may be involved in the cardioprotective role of dapagliflozin.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Gustavo Augusto Ferreira Mota, Mariana Gatto, Luana Urbano Pagan, Suzana Erico Tanni, Marina Politi Okoshi
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2023)
Review
Medicine, General & Internal
Taline Lazzarin, Carolina Rodrigues Tonon, Danilo Martins, Edson Luiz Favero, Thiago Dias Baumgratz, Filipe Welson Leal Pereira, Victor Rocha Pinheiro, Raquel Simoes Ballarin, Diego Aparecido Rios Queiroz, Paula Schmidt Azevedo, Bertha Furlan Polegato, Marina Politi Okoshi, Leonardo Zornoff, Sergio Alberto Rupp de Paiva, Marcos Ferreira Minicucci
Summary: Cardiac arrest is a significant public health problem, with a survival rate ranging from approximately 15% to 22%. Post-cardiac arrest syndrome, characterized by ischemia-reperfusion injury, is a major cause of death after resuscitation. Understanding the pathophysiology is crucial for developing new treatment strategies and improving outcomes. In addition to advancements in cardiopulmonary resuscitation, the increase in survival rates in recent decades is attributed to novel approaches in post-cardiac arrest care, including targeted temperature management, early coronary angiography, and rehabilitation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Lidiane Moreira Souza, Mariana Janini Gomes, Bruna Brasil Brandao, Luana Urbano Pagan, Mariana Gatto, Felipe Cesar Damatto, Eder Anderson Rodrigues, Thierres Hernani Dias Pontes, Patricia Aparecida Borim, Ana Angelica Henrique Fernandes, Gilson Masahiro Murata, Leonardo Antonio Mamede Zornoff, Paula Schmidt Azevedo, Katashi Okoshi, Marina Politi Okoshi
Summary: Resistance exercise is safe and effective in increasing muscle strength and improving protein metabolism and antioxidant response in myocardial-infarcted rats.
Article
Medicine, General & Internal
Byorn W. L. Tan, Bryce W. Q. Tan, Amelia L. M. Tan, Emily R. Schriver, Alba Gutierrez-Sacristan, Priyam Das, William Yuan, Meghan R. Hutch, Noelia Garcia Barrio, Miguel Pedrera Jimenez, Noor Abu-el-rub, Michele Morris, Bertrand Moal, Guillaume Verdy, Kelly Cho, Yuk-Lam Ho, Lav P. Patel, Arianna Dagliati, Antoine Neuraz, Jeffrey G. Klann, Andrew M. South, Shyam Visweswaran, David A. Hanauer, Sarah E. Maidlow, Mei Liu, Danielle L. Mowery, Ashley Batugo, Adeline Makoudjou, Patric Tippmann, Daniela Zoeller, Gabriel A. Brat, Yuan Luo, Paul Avillach, Riccardo Bellazzi, Luca Chiovato, Alberto Malovini, Valentina Tibollo, Malarkodi Jebathilagam Samayamuthu, Pablo Serrano Balazote, Zongqi Xia, Ne Hooi Will Loh, Lorenzo Chiudinelli, Clara-Lea Bonzel, Chuan Hong, Harrison G. Zhang, Griffin M. Weber, Isaac S. Kohane, Tianxi Cai, Gilbert S. Omenn, John H. Holmes, Kee Yuan Ngiam
Summary: This retrospective observational study analyzed data from 12,891 COVID-19 patients and found that age, severe COVID-19, severe acute kidney injury (AKI), and ischemic heart disease were associated with worse mortality outcomes. The severity of AKI was associated with poorer kidney function recovery, while the use of remdesivir was associated with better recovery. In patients without chronic kidney disease, age, male sex, severe AKI, and hypertension were associated with post-AKI kidney function impairment. COVID-19-associated AKI was also linked to higher mortality and worse long-term kidney function recovery.
Letter
Critical Care Medicine
Amanda G. Pereira, Nara A. Costa, Stefanie C. P. Amancio, Marina P. Okoshi, Leonardo A. M. Zornoff, Paula S. Azevedo, Marcos F. Minicucci, Sergio A. R. de Paiva, Bertha F. Polegato
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Geriatrics & Gerontology
Juan Thomaz Gabriel de Souza Ramos, Amanda Gomes Pereira, Felipe Sanches Ferrari, Morganna Freitas Andrade, Caroline Souto de Melo, Paulo Jose Fortes Villas Boas, Tainara F. Felix, Marcio de Carvalho, Mariana Souza Dorna, Paula Schmidt Azevedo, Bethan E. Phillips, Bertha Furlan Polegato, Katashi Okoshi, Silmeia Garcia Zanati Bazan, Sergio Alberto Rupp Paiva, Leonardo Antonio Mamede Zornoff, Patricia P. Reis, Marcos Ferreira Minicucci
Summary: This study identified and compared circulating miRNA levels between frail and non-frail older adults following STEMI, and explored the regulatory miRNA-gene networks and pathways involved in this condition. The results showed that frail patients had higher levels of certain miRNAs, and that these miRNAs were predicted to modulate gene expression associated with aging. Pathway enrichment analyses further revealed specific pathways regulated by miRNA target genes.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Paula Grippa Sant'Ana, Loreta Casquel de Tomasi, Gilson Masahiro Murata, Danielle Fernandes Vileigas, Gustavo Augusto Ferreira Mota, Sergio Luiz Borges de Souza, Vitor Loureiro Silva, Livia Paschoalino de Campos, Katashi Okoshi, Carlos Roberto Padovani, Antonio Carlos Cicogna
Summary: In pathological cardiac hypertrophy, the heart's energy metabolism shifts towards glucose dependence due to oxygen deficit activating HIF-1a. This study investigates the early changes and associations between HIF-1a, the glycolytic pathway, and cardiac remodeling from hypertrophy to heart failure. The results show increased left ventricular hypertrophy, diastolic function changes, severe systolic and diastolic dysfunction in heart failure, enhanced HIF-1a and glycolysis, and a shift to anaerobic metabolism from the 6th week onwards.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Biochemistry & Molecular Biology
Harrison G. Zhang, Jacqueline P. Honerlaw, Monika Maripuri, Malarkodi Jebathilagam Samayamuthu, Brendin R. Beaulieu-Jones, Huma S. Baig, Sehi L'Yi, Yuk-Lam Ho, Michele Morris, Vidul Ayakulangara Panickan, Xuan Wang, Griffin M. Weber, Katherine P. Liao, Shyam Visweswaran, Bryce W. Q. Tan, William Yuan, Nils Gehlenborg, Sumitra Muralidhar, Rachel B. Ramoni, Isaac S. Kohane, Zongqi Xia, Kelly Cho, Tianxi Cai, Gabriel A. Brat, James R. Aaron, Giuseppe Agapito, Adem Albayrak, Giuseppe Albi, Mario Alessiani, Anna Alloni, Danilo F. Amendola, Francois Angoulvant, Li L. L. J. Anthony, Bruce J. Aronow, Fatima Ashraf, Andrew Atz, Paul Avillach, Paula S. Azevedo, James Balshi, Brett K. Beaulieu-Jones, Douglas S. Bell, Antonio Bellasi, Riccardo Bellazzi, Vincent Benoit, Michele Beraghi, Jose Luis Bernal-Sobrino, Melodie Bernaux, Romain Bey, Surbhi Bhatnagar, Alvar Blanco-Martinez, Clara-Lea Bonzel, John Booth, Silvano Bosari, Florence T. Bourgeois, Robert L. Bradford, Gabriel A. Brat, Stephane Breant, Nicholas W. Brown, Raffaele Bruno, William A. Bryant, Mauro Bucalo, Emily Bucholz, Anita Burgun, Tianxi Cai, Mario Cannataro, Aldo Carmona, Charlotte Caucheteux, Julien Champ, Jin Chen, Krista Y. Chen, Luca Chiovato, Lorenzo Chiudinelli, Kelly Cho, James J. Cimino, Tiago K. Colicchio, Sylvie Cormont, Sebastien Cossin, Jean B. Craig, Juan Luis Cruz-Bermudez, Jaime Cruz-Rojo, Arianna Dagliati, Mohamad Daniar, Christel Daniel, Priyam Das, Batsal Devkota, Audrey Dionne, Rui Duan, Julien Dubiel, Scott L. DuVall, Loic Esteve, Hossein Estiri, Shirley Fan, Robert W. Follett, Thomas Ganslandt, Noelia Garcia-Barrio, Lana X. Garmire, Nils Gehlenborg, Emily J. Getzen, Alon Geva, Tobias Gradinger, Alexandre Gramfort, Romain Griffier, Nicolas Griffon, Olivier Grisel, Alba Gutierrez-Sacristan, Larry Han, David A. Hanauer, Christian Haverkamp, Derek Y. Hazard, Bing He, Darren W. Henderson, Martin Hilka, Yuk-Lam Ho, John H. Holmes, Chuan Hong, Kenneth M. Huling, Meghan R. Hutch, Richard W. Issitt, Anne Sophie Jannot, Vianney Jouhet, Ramakanth Kavuluru, Mark S. Keller, Chris J. Kennedy, Daniel A. Key, Katie Kirchoff, Jeffrey G. Klann, Isaac S. Kohane, Ian D. Krantz, Detlef Kraska, Ashok K. Krishnamurthy, Sehi L'Yi, Trang T. Le, Judith Leblanc, Guillaume Lemaitre, Leslie Lenert, Damien Leprovost, Molei Liu, Ne Hooi Will Loh, Qi Long, Sara Lozano-Zahonero, Yuan Luo, Kristine E. Lynch, Sadiqa Mahmood, Sarah E. Maidlow, Adeline Makoudjou, Alberto Malovini, Kenneth D. Mandl, Chengsheng Mao, Anupama Maram, Patricia Martel, Marcelo R. Martins, Jayson S. Marwaha, Aaron J. Masino, Maria Mazzitelli, Arthur Mensch, Marianna Milano, Marcos F. Minicucci, Bertrand Moal, Taha Mohseni Ahooyi, Jason H. Moore, Cinta Moraleda, Jeffrey S. Morris, Michele Morris, Karyn L. Moshal, Sajad Mousavi, Danielle L. Mowery, Douglas A. Murad, Shawn N. Murphy, Thomas P. Naughton, Carlos Tadeu Breda Neto, Antoine Neuraz, Jane Newburger, Kee Yuan Ngiam, Wanjiku F. M. Njoroge, James B. Norman, Jihad Obeid, Marina P. Okoshi, Karen L. Olson, Gilbert S. Omenn, Nina Orlova, Brian D. Ostasiewski, Nathan P. Palmer, Nicolas Paris, Lav P. Patel, Miguel Pedrera-Jimenez, Emily R. Pfaff, Ashley C. Pfaff, Danielle Pillion, Sara Pizzimenti, Hans U. Prokosch, Robson A. Prudente, Andrea Prunotto, Victor Quiros-Gonzalez, Rachel B. Ramoni, Maryna Raskin, Siegbert Rieg, Gustavo Roig-Dominguez, Pablo Rojo, Paula Rubio-Mayo, Paolo Sacchi, Carlos Saez, Elisa Salamanca, Malarkodi Jebathilagam Samayamuthu, L. Nelson Sanchez-Pinto, Arnaud Sandrin, Nandhini Santhanam, Janaina C. C. Santos, Fernando J. Sanz Vidorreta, Maria Savino, Emily R. Schriver, Petra Schubert, Juergen Schuettler, Luigia Scudeller, Neil J. Sebire, Pablo Serrano-Balazote, Patricia Serre, Arnaud Serret-Larmande, Mohsin Shah, Zahra Shakeri Hossein Abad, Domenick Silvio, Piotr Sliz, Jiyeon Son, Charles Sonday, Andrew M. South, Anastasia Spiridou, Zachary H. Strasser, Amelia L. M. Tan, Bryce W. Q. Tan, Byorn W. L. Tan, Suzana E. Tanni, Deanne M. Taylor, Ana I. Terriza-Torres, Valentina Tibollo, Patric Tippmann, Emma M. S. Toh, Carlo Torti, Enrico M. Trecarichi, Yi-Ju Tseng, Andrew K. Vallejos, Gael Varoquaux, Margaret E. Vella, Guillaume Verdy, Jill-Jenn Vie, Shyam Visweswaran, Michele Vitacca, Kavishwar B. Wagholikar, Lemuel R. Waitman, Xuan Wang, Demian Wassermann, Griffin M. Weber, Martin Wolkewitz, Scott Wong, Zongqi Xia, Xin Xiong, Ye Ye, Nadir Yehya, William Yuan, Alberto Zambelli, Harrison G. Zhang, Daniela Zoller, Valentina Zuccaro, Chiara Zucco
Article
Nutrition & Dietetics
Marianna Rabelo de Carvalho, Ellen Fernandes Duarte, Maria Lua Marques Mendonca, Camila Souza de Morais, Gabriel Elias Ota, Jair Jose Gaspar-Junior, Wander Fernando de Oliveira Filiu, Felipe Cesar Damatto, Marina Politi Okoshi, Katashi Okoshi, Rodrigo Juliano Oliveira, Paula Felippe Martinez, Silvio Assis de Oliveira-Junior
Summary: This study evaluated the impact of creatine supplementation on the myostatin pathway and myosin heavy chain isoforms in resistance-trained rats. Resistance training alone increased muscle weight, cross-sectional area, and collagen fraction, as well as MyHC IIx and follistatin expressions, while reducing myostatin and ActRIIB expressions. Creatine supplementation did not affect these effects.
Article
Biochemistry & Molecular Biology
Eder Anderson Rodrigues, Aline Regina Ruiz Lima, Mariana Janini Gomes, Lidiane Moreira Souza, Thierres Hernani Dias Pontes, Luana Urbano Pagan, Gilson Masahiro Murata, Felipe Cesar Damatto, Igor Carvalho Depra, Amanda Bergamo Goncalves Castro Rego, David Rafael Abreu Reyes, Leonardo Antonio Mamede Zornoff, Katashi Okoshi, Marina Politi Okoshi
Summary: Exercise plays an important role in preventing and treating cardiac remodeling and heart failure caused by myocardial infarction. This study investigated the effects of resistance exercise on structural, functional, and molecular alterations in infarcted rats. The results showed that resistance exercise improved maximum load-carrying capacity, reduced myocardial oxidative stress, and preserved myocardial metabolism, without changing cardiac structure or left ventricular function in infarcted rats.
Editorial Material
Cardiac & Cardiovascular Systems
Mariana Gatto, Gustavo Augusto Ferreira Mota, Marina Politi Okoshi
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2023)
Article
Cell Biology
Sergio Luiz Borges de Souza, Gustavo Augusto Ferreira Mota, Vitor Loureiro da Silva, Danielle Fernandes Vileigas, Paula Grippa Sant'Ana, Cristina Schmitt Gregolin, Rebeca Lopes Figueira, Sabrina Setembre Batah, Alexandre Todorovic Fabro, Gilson Masahiro Murata, Silmeia Garcia Zanati Bazan, Marina Politi Okoshi, Antonio Carlos Cicogna
Summary: We studied the effect of early exercise on the amelioration of cardiac dysfunction in rats with aortic stenosis. The results showed that early exercise improved exercise tolerance, attenuated cardiac remodeling and dysfunction, and prevented myocardial capillary rarefaction. Exercise also had beneficial effects on fatty acid transport and oxidation pathways.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Eder Anderson Rodrigues, Camila Moreno Rosa, Dijon Henrique Salome Campos, Felipe Cesar Damatto, Gilson Masahiro Murata, Lidiane Moreira Souza, Luana Urbano Pagan, Mariana Gatto, Jessica Yumi Brosler, Hebreia Oliveira Almeida Souza, Mario Machado Martins, Luciana Machado Bastos, Suzana Erico Tanni, Katashi Okoshi, Marina Politi Okoshi
Summary: This study evaluated the effects of SGLT2 inhibitor dapagliflozin on cardiac remodeling, myocardial function, energy metabolism, and metabolomics in rats with Type 1 DM. Long-term treatment with dapagliflozin attenuated cardiac remodeling, myocardial dysfunction, and contractile reserve impairment in Type 1 diabetic rats.Functional improvement is associated with restored pyruvate kinase and phosphofructokinase activity and attenuated metabolomics changes.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Review
Medicine, General & Internal
Carolina Rodrigues Tonon, Suzana Erico Tanni, Juliana Rocha, Irma Godoy, Bertha Furlan Polegato, Filipe Welson Leal Pereira, Danilo Martins, Robson Aparecido Prudente, Estefania Thome Franco, Fernando Brizola, Bruno Guedes Baldi, Marina Politi Okoshi
Summary: This article reviews the literature on OP and COVID-19-induced OP and presents an illustrative case. The study found that organizing pneumonia should be considered in the differential diagnosis of COVID-19 patients after partial pulmonary recovery.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
