Article
Biochemistry & Molecular Biology
Jing Xia, Jun Chen, Manoj Kumar Vashisth, Huijie Jia, Hui Hua, Xiao-jian Wu, Xiao-bo Wang
Summary: This study demonstrates for the first time the inhibitory effect of marimastat on cell senescence and suggests a potential mechanism involving the restoration of autophagy dysfunction and suppression of mTOR.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Angel Cayo, Raul Segovia, Whitney Venturini, Rodrigo Moore-Carrasco, Claudio Valenzuela, Nelson Brown
Summary: Cellular senescence is a unique form of proliferative arrest triggered by various stimuli, characterized by changes in cell morphology and function. The activation of mTOR and autophagy play crucial roles in regulating different aspects of cellular senescence. Understanding and targeting the interconnected pathways of mTOR and autophagy could be key in developing anti-cancer therapies involving pro-senescence drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xuan Feng, Zhi Wei, Xiang Tao, Yan Du, Jing Wu, Yinhua Yu, Huandi Yu, Hongbo Zhao
Summary: Autophagy plays a crucial role in the development and function of trophoblast cells during pregnancy. The protein PLAC8 promotes autophagy in trophoblasts and contributes to their proliferation. Understanding the mechanism of PLAC8-induced autophagy may lead to novel treatment strategies for various gestational diseases.
Article
Biochemistry & Molecular Biology
Nagarajan Maharajan, Gwang-Won Cho
Summary: The study found that CQ may reduce senescence in hBM-MSCs and mouse heart tissues, and enhance AMPK/SIRT1 activation and autophagy in both models. CQ also lowered the gene expression of inflammation markers in D-Gal-induced aging mouse heart tissues.
Article
Cardiac & Cardiovascular Systems
Xianli Wang, Shaokun Yu, Yuting Jian, Hongmin Pan, Jiannan Guo, Jian Wu, Wei Guo
Summary: The study found that hydrogen sulfide (H2S) can prevent oxidative stress injury in extravillous trophoblasts by decreasing ROS concentration, maintaining mitochondrial membrane stability, and promoting apoptosis-inhibiting protein expression in cells.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Diana Pintye, Reka Eszter Sziva, Maxim Mastyugin, Marianna Torok, Sonako Jacas, Agnes Lo, Saira Salahuddin, Zsuzsanna K. Zsengeller
Summary: Preeclampsia (PE), a syndrome specific to pregnancy, affects 5-7% of patients and currently has no effective treatment. Early abnormal placental development leads to oxidative stress and release of reactive oxygen species (ROS) in the placenta, resulting in downstream signaling, stabilization of Hypoxia Inducible Factor 1A (HIF1A), and transcription of anti-angiogenic factors sFLT1 and sEng. This study found that the nitroxide-type antioxidant molecule HMP could reduce placental oxidative stress and alleviate PE symptoms in vitro.
Article
Developmental Biology
Haoyue Hu, Wenqian Chen, Zixin Tao, Zhiju Li, Jiexing He, You Peng, Jing Ma, Huiting Wen, Jing Li, Xuefei Wang, Mei Zhong
Summary: This study found that CsA may have therapeutic effects against preeclampsia by activating autophagy. The results showed that CsA alleviated PE-like symptoms, reduced placental necrosis and senescence, and upregulated autophagic protein levels.
Article
Pharmacology & Pharmacy
Anna Li, Man Zhao, Zexin Yang, Zhenya Fang, Weiyi Qi, Changqing Zhang, Meijuan Zhou, Junjun Guo, Shuxian Li, Xietong Wang, Meihua Zhang
Summary: The protective effect of 6-Gingerol against placental injury in preeclampsia was demonstrated through reducing oxidative stress and inhibiting excessive mitophagy caused by mitochondrial dysfunction.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hamid-Reza Kohan-Ghadr, Brooke Armistead, Mikaela Berg, Sascha Drewlo
Summary: Irisin is a newly discovered exercise-mediated polypeptide hormone. Studies have shown that Irisin protects against cell death by reducing pro-apoptotic signaling cascades, inducing DNA repair pathways, and inhibiting Caspase 3 activity. Additionally, Irisin acts through the Akt signaling pathway to prevent apoptosis, increase levels of anti-apoptotic BCL2, and reduce ROS levels. These findings provide new insights into the role of Irisin in promoting cell survival and preventing apoptosis in the human placenta under pathological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Antonietta Notaro, Marianna Lauricella, Diana Di Liberto, Sonia Emanuele, Michela Giuliano, Alessandro Attanzio, Luisa Tesoriere, Daniela Carlisi, Mario Allegra, Anna De Blasio, Giuseppe Calvaruso, Antonella D'Anneo
Summary: Methyl gallate (MG), a gallotannin found in plants, showed potential as an anti-tumor phytomolecule for colon cancer treatment. It reduced the viability of HCT116 colon cancer cells but had no effect on differentiated Caco-2 cells. MG induced early ROS generation and ER stress, leading to autophagy and apoptotic cell death. The increase in p53 played a crucial role in the mechanism, which was tightly linked to oxidative injury.
Editorial Material
Cell Biology
Jaejin Kim, Yeonghyeon Lee, Taerang Jeon, Mi-Sung Kim, Chanhee Kang
Summary: Autophagy plays a dual role in maintaining cellular homeostasis and promoting cellular senescence, with selective autophagy coordinating stress support networks in senescent cells. Targeting selective autophagy may provide new therapeutic strategies for disrupting the homeostatic state of senescent cells.
Article
Food Science & Technology
Fengge Wang, Miao Liu, Peng Lin, Jishui Wang, Lihua Zhang, Haiyan Zhang, Miaomiao Qu, Shuxiong Chen, Dongmei Man
Summary: Preeclampsia is a serious complication of pregnancy, with accumulation of trophoblastic reactive oxygen species and placental dysfunction as potential pathogenic bases. Astragaloside IV (AS IV), a major active component of Astragalus membranaceus, protects trophoblasts from oxidative stress-induced damage by activating the Nrf2-Keap1-p62 feedback loop.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Yuan Zhang, Tun Sun, Meng Li, Yanling Lin, Yue Liu, Shusheng Tang, Chongshan Dai
Summary: Ivermectin can induce apoptotic cell death in human neuroblastoma cells, promoting ROS production, mitochondrial dysfunction, and autophagy, while inhibiting the Akt/mTOR pathway. Autophagy inhibition improved Ivermectin-induced oxidative stress and apoptotic cell death in these cells.
Article
Biochemistry & Molecular Biology
Andrea Pirkovic, Aleksandra Vilotic, Suncica Borozan, Mirjana Nacka-Aleksic, Zanka Bojic-Trbojevic, Milica Jovanovic Krivokuca, Maurizio Battino, Francesca Giampieri, Dragana Dekanski
Summary: The bioactive compound oleuropein derived from olives was evaluated for its effects on damage induced by hydrogen peroxide in human trophoblast cells in vitro. The study found that oleuropein had cytoprotective effects by improving antioxidant status, preventing protein and lipid damage, and reducing iNOS levels.
Article
Virology
Rui-hua Zhang, Hong-liang Zhang, Pei-yao Li, Chun-hong Li, Jing-ping Gao, Jun Li, Tong Xu, Xue-jing Wang, Cun-lian Wang, Hui-chen Zhang, Ming-ju Xu, Shu-fei Tian
Summary: The study found that H9N2 influenza virus induces autophagy, and inhibiting autophagy can reduce viral titer. Blocking autophagy suppressed the H9N2 virus-induced increase in oxidative stress, decreasing reactive oxygen species production and increasing superoxide dismutase 1 levels.