Article
Biotechnology & Applied Microbiology
Yuying Dong, Le Li, Sitong Liu, Yuting Chen, Jian Jiao, Ying Zhao, Xuejun Zou
Summary: In this study, Photobacterium phophorium was used to test the acute toxicity of organophosphate esters (OPEs). The binding affinity between OPEs and n-octanol (C8H18O)/phospholipid bilayer (DPPC) was calculated using a combination of toxicity tests and molecular dynamics (MD) simulation. The study found a good correlation between the median effective concentration (EC50) of OPEs and binding affinity. The mode of action (MOA) for OPEs to Photobacterium phophorium was determined, showing different toxic mechanisms for different OPEs.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2023)
Article
Environmental Sciences
Min Yang, Jinjie Li, Huixian Wu
Summary: This study analyzed the applicability of luminescent bacteria in assessing the residual toxicity of chlorinated ballast water. The results showed that luminescent bacteria, especially Photobacterium phosphoreum, could provide more rapid and sensitive test results for disinfection by-products (DBPs). The study also highlighted the importance of paying attention to aromatic DBPs in ballast water.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Environmental Sciences
Jiafan Li, Tao Yuan, Yuning Ma, Zhemin Shen, Ying Tian, Li Gao, Xiaoyan Dong
Summary: This study assessed the toxicity of indoor dust using a bioluminescence test and found that organic extracts of indoor dust exhibited higher toxicity to bacteria. Laboratory dust showed the highest bacterial toxicity, while office dust had higher toxicity compared to residence dust. The comprehensive toxicity of dust on bacteria was evaluated using extract toxicity-addition method, providing important information on potential health risks in different indoor environments.
ENVIRONMENTAL RESEARCH
(2021)
Article
Environmental Sciences
Dan Wang, Linming Bai, Xiaochuan Huang, Wei Yan, Shanshan Li
Summary: This study investigated the toxicity of a typical metal-organic framework (MOF) material and found it to be highly toxic to luminescent bacteria. The toxicity was found to be size-dependent, with smaller particles exhibiting greater toxicity. Furthermore, the toxicity was mainly attributed to the nanoparticles themselves rather than the released metal ions.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Multidisciplinary
Dan Wang, Linming Bai, Shanshan Li, Wei Yan
Summary: This study investigates the variations of bioluminescence and gene expression in the luminescent bacteria Photobacterium phosphoreum T3 and Vibrio qinghaiensis sp.-Q67, showing that bioluminescence is density-dependent and controlled by quorum sensing. The different response modes of these two strains to autoinducers suggest their potential application in toxicity assessment of different compounds.
APPLIED SCIENCES-BASEL
(2022)
Article
Biotechnology & Applied Microbiology
Thirumurugan Keerthanaa, Selvakumar Boobalan, Desingu Kamalanathan, Gopalu Karunakaran, Kattakgoundar Govindaraj Sudha, Manoharan Aarthi, Mohan Prasanna Rajeshkumar
Summary: The use of elicitors increases the levels of specific compounds, especially apigenin, in green leafy vegetables. This approach is important for promoting the synthesis of phytochemicals and has potential applications in cancer prevention.
PLANT CELL TISSUE AND ORGAN CULTURE
(2022)
Article
Microbiology
Sandra Fuertes-Perez, Miriam Abele, Christina Ludwig, Rudi F. Vogel, Maik Hilgarth
Summary: This study aimed to investigate the impact of modified atmosphere packaging (MAP) on the growth of spoiling photobacteria on meat. The results showed that both high oxygen MAP and oxygen-free MAP have a certain inhibitory effect on the growth of photobacteria, but an increase in oxygen concentration leads to enhanced oxidative stress and changes in protein accumulation and energy metabolism. Under anaerobic conditions, the metabolism of photobacteria in meat shifts and shows a stress response. The findings highlight the importance of MAP in meat preservation.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zehui Dong, Kim Olofsson, Javier A. Linares-Pasten, Eva Nordberg Karlsson
Summary: One of the important applications of lipases is to modify oils and fats to meet the specific requirements of various industries. In this study, the preference of two lipases, RML and ROL, for oleate and stearate was investigated and related to their respective enzyme structures. The results showed that RML had a higher preference for stearate compared with ROL, which may be attributed to the stabilization effect of Trp88 in RML.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Tingting Guo, Xiaojuan Wang, Yang Shu, Jianhua Wang
Summary: This study evaluated the behavior of 1-alkyl-3-methylimidazolium dicyanamide ionic liquids with different alkyl side-chain lengths, showing that longer alkyl side-chains increased toxicity. The findings provide insight into the potential hazards of ILs and their interactions with proteins and cells.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Agronomy
Marioara Nicoleta Caraba, Diana Larisa Roman, Ion Valeriu Caraba, Adriana Isvoran
Summary: This study investigates the effects of aclonifen and its soil metabolites on aqueous and soil environments. The results indicate that aclonifen significantly inhibits the activities of enzymes in the soil, and high doses of aclonifen make it difficult for the enzyme activity to recover. The computational analysis shows that aclonifen and its metabolites have moderate acute toxicity to aquatic organisms and can bind to soil enzymes, potentially inhibiting their activities.
Article
Biochemistry & Molecular Biology
Meiqing Zhu, Xiaohui Pang, Kangquan Wang, Long Sun, Yi Wang, Rimao Hua, Ce Shi, Xiaofan Yang
Summary: This study investigates the binding mechanism of chiral PTCs to BSA and explores their potential toxicity to environmental organisms. The results indicate that hydrophobic interactions dominate the binding process, with S-PTC exhibiting stronger binding ability than R-PTC. Furthermore, both configurations of PTC can induce conformational changes in BSA and affect the microenvironment around its amino acid residues, with S-PTC having a more significant effect.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Walid Guerrab, Jihane Akachar, Meryem El Jemli, Abdul-Malik Abudunia, Rachida Ouaabou, Katim Alaoui, Azeddine Ibrahimi, Youssef Ramli
Summary: Hydantoins are an important class of compounds with remarkable biological and pharmacological properties. This study successfully synthesized hydantoin derivatives and evaluated their cytotoxic activity. The synthesized compounds showed significant inhibitory effects on cell lines, suggesting their potential as anticancer drugs.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Bahar Gok, Yasemin Budama-Kilinc, Serda Kecel-Gunduz
Summary: The increase in the aging population worldwide has led scientists to research on preventing the aging process, with synthetic peptides emerging as potential molecules for developing anti-aging products. This study investigates the interaction of a synthetic peptide called Syn-Ake with matrix metalloproteinases (MMPs) and Sirtuin 1 (SIRT1), targets of anti-aging activity, using in silico approaches. In addition, the peptide's antioxidant activity and safety profile were assessed using in vitro methods. The study concludes that Syn-Ake shows promise in anti-aging formulations due to its high efficacy and safety profile.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Environmental Sciences
Xiangfeng Yao, Jingwen Zhang, Can Wang, Qian Wang, Xianxu Li, Dexin Zhang, Jinhua Wang, Lusheng Zhu, Jun Wang
Summary: This study evaluated the toxic effects of dibutyl phthalate (DBP) on pakchoi (Brassica campestris L.), a typical vegetable crop. DBP exposure reduced the emergence of pakchoi and inhibited plant growth, pigmentation, and quality. DBP also induced oxidative damage, with increased reactive oxygen species levels and activation of antioxidant enzymes. Furthermore, DBP directly interacted with antioxidant enzymes at the molecular level. This study provides important information on the risk of DBP toxicity to vegetable crops.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Environmental Sciences
Naima Hamid, Muhammad Junaid, Rakia Manzoor, Marriya Sultan, Ong Meng Chuan, Jun Wang
Summary: This review summarizes the global distribution of PFAS in surface water and assesses its ecological and human risks. It highlights the bioaccumulation of PFAS in aquatic organisms and the toxicological effects on both animals and humans. The study emphasizes the importance of human biomonitoring and molecular docking analysis in understanding the toxicity of PFAS. Furthermore, it discusses the challenges and future perspectives for mitigating the pollution and ecological risks associated with PFAS.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
