期刊
PHARMACEUTICS
卷 14, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics14051110
关键词
gold nanorods@CTA; NIR-II window; thermo-chemotherapy; photoacoustic imaging
资金
- Pharmaceutical Innovation Fund of Anhui Medical University [YXCX202104]
- Key Natural Science project of Anhui Provincial Education Department [KJ2021A0233, KJ2021A0782]
This study reports a novel biological nanomaterials that can enhance photothermal effects and photoacoustic imaging performance through a second near-infrared window response. The nanomaterials integrate miniature gold nanorods and cyclic ternary aptamers as a carrier for chemotherapy drugs, allowing controlled release and promoted cargo release based on laser irradiation. The nanomaterials exhibit excellent synergistic anti-cancer effect and possess thermal imaging and photoacoustic imaging properties.
In terms of synergistic cancer therapy, biological nanomaterials with a second near-infrared (NIR-II) window response can greatly increase photothermal effects and photoacoustic imaging performance. Herein, we report a novel stimuli-responsive multifunctional drug-loading system which was constructed by integrating miniature gold nanorods (GNR) as the NIR-II photothermal nanorods and cyclic ternary aptamer (CTA) composition as a carrier for chemotherapy drugs. In this system, doxorubicin hydrochloride (DOX, a chemotherapy drug) binds to the G-C base pairs of the CTA, which exhibited a controlled release behavior based on the instability of G-C base pairs in the slightly acidic tumor microenvironment. Upon the 1064 nm (NIR-II biowindow) laser irradiation, the strong photothermal and promoted cargo release properties endow gold nanorods@CTA (GNR@CTA) nanoparticles displaying excellent synergistic anti-cancer effect. Moreover, the GNR@CTA of NIR also possesses thermal imaging and photoacoustic (PA) imaging properties due to the strong NIR region absorbance. This work enables to obtaining a stimuli-responsive all-in-one nanocarrier, which are promising candidate for bimodal imaging diagnosis and chemo-photothermal synergistic therapy.
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