期刊
WORLD JOURNAL OF STEM CELLS
卷 14, 期 4, 页码 267-286出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4252/wjsc.v14.i4.267
关键词
Words; Amino acid metabolism; Cancer stem cell; Self-renewal; Resistance
资金
- Capital's Funds for Health Improvement and Research (CFH) [2020-2-2175]
- Beijing Talents Project
This review summarizes the relationship between cancer stem cells (CSCs) and amino acid metabolism, and discusses the possible mechanisms by which amino acid metabolism regulates CSC characteristics, particularly self-renewal, survival, and stemness.
Cancer stem cells (CSCs) possess self-renewal and differentiation potential, which may be related to recurrence, metastasis, and radiochemotherapy resistance during tumor treatment. Understanding the mechanisms via which CSCs maintain self-renewal may reveal new therapeutic targets for attenuating CSC resistance and extending patient life-span. Recent studies have shown that amino acid metabolism plays an important role in maintaining the self-renewal of CSCs and is involved in regulating their tumorigenicity characteristics. This review summarizes the relationship between CSCs and amino acid metabolism, and discusses the possible mechanisms by which amino acid metabolism regulates CSC characteristics particularly self-renewal, survival and stemness. The ultimate goal is to identify new targets and research directions for elimination of CSCs.
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