Article
Cell Biology
Serena Marcozzi, Maria Elisa Giuliani, Giovanni Lai, Robertina Giacconi, Francesco Piacenza, Giorgia Bigossi, Marco Malavolta
Summary: This perspective review explores the mechanisms and implications of senescent cell spreading on frailty, as well as its therapeutic development. The focus is on emerging age-related biological factors, such as microbiome and virome alterations, and their significant contribution to the accumulation rate of senescent cells. These factors particularly affect the musculoskeletal system and cerebral functions, two key domains of frailty. Understanding these mechanisms can lead to the development of tailored interventions for diverse patients.
Article
Geriatrics & Gerontology
Jack Feehan, Nicholas Tripodi, Vasso Apostolopoulos
Summary: Cellular senescence is a critical part of human anti-tumor defence, but the accumulation of senescent cells with age can lead to various pathologies. Immunosenescence, the senescent change in immune cells, has a wide range of physiological effects and is partially responsible for many diseases associated with aging. Understanding the effects and mechanisms of immunosenescence can improve disease outcomes and prevention in older adults, and lead to new treatments for common illnesses.
Article
Biochemistry & Molecular Biology
Hoang-Phuong Nguyen, Viet Anh Bui, Ai-Xuan Thi Hoang, Phong Van Nguyen, Dac-Tu Nguyen, Hien Thi Mai, Hai-Anh Le, Thanh-Luan Nguyen, Nhung Thi My Hoang, Liem Thanh Nguyen, Xuan-Hung Nguyen
Summary: This study evaluated the correlation between peripheral blood indices and the expansion of CD8(+) T cells and NK cells in elderly lung cancer patients. CD8(+) T cells and NK cells were able to expand about 500 times from the peripheral blood of these patients. The expansion of these immune cells was inversely correlated with peripheral blood indices. These findings are important for immune therapy in lung cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Geriatrics & Gerontology
Wanxue He, Kun Xiao, Min Fang, Lixin Xie
Summary: Sepsis is a life-threatening organ dysfunction caused by dysregulated host responses to infection, with elderly individuals displaying increased susceptibility and mortality due to immune dysfunction. Alterations in immune cells of elderly sepsis patients, including endothelial cells, neutrophils, monocytes, macrophages, natural killer cells, dendritic cells, T lymphocytes, and B lymphocytes, largely contribute to their poor prognosis and increased mortality. Recent studies on elderly mice and sepsis patients have investigated changes affecting both innate and adaptive immune cells, shedding light on potential new therapeutic strategies.
Review
Biochemistry & Molecular Biology
Leane Perim Rodrigues, Vitoria Rodrigues Teixeira, Thuany Alencar-Silva, Bianca Simonassi-Paiva, Rinaldo Wellerson Pereira, Robert Pogue, Juliana Lott Carvalho
Summary: Aging is a natural physiological process that leads to various challenges due to cell senescence, which can have negative consequences for health. Immunosenescence, as a result of aging, alters the functionality of the immune system.
CYTOKINE & GROWTH FACTOR REVIEWS
(2021)
Review
Cell Biology
Davide L. Vetrano, Federico Triolo, Stefania Maggi, Richard Malley, Thomas A. Jackson, Andrea Poscia, Roberto Bernabei, Luigi Ferrucci, Laura Fratiglioni
Summary: The relationship between infections and frailty, as well as the impact of frailty on immune response in older adults, have been studied. Evidence suggests that there is a link between infections and frailty, and frailty may lead to impaired immune response in older ages. However, more research is needed to develop personalized immunization strategies for older adults.
AGEING RESEARCH REVIEWS
(2021)
Review
Cell Biology
Juana Serrano-Lopez, Beatriz Martin-Antonio
Summary: Advances in society and health have led to increased life expectancy, but aging also brings complications such as inflammaging, which can impact autoimmunity, neurodegenerative diseases, and cancer development. Inflammaging is related to imbalanced immune responses and can be naturally acquired with age or accelerated by external triggers. Different molecules and inflammatory processes play key roles in these events.
Article
Biochemistry & Molecular Biology
Lian Wang, Liwei Mao, Weihua Xiao, Peijie Chen
Summary: This article discusses the phenotypic changes of natural killer cells during aging and their inhibitory effects on immune responses. The host environment, cytokine regulation, and other factors have significant impacts on the function of natural killer cells. Different lifestyle management interventions can modulate the number and cytotoxic activity of natural killer cells, which is important for rebuilding the immune barrier in elderly individuals.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Marcello Pinti, Lara Gibellini, Domenico Lo Tartaro, Sara De Biasi, Milena Nasi, Rebecca Borella, Lucia Fidanza, Anita Neroni, Leonarda Troiano, Claudio Franceschi, Andrea Cossarizza
Summary: In this study, we analyzed the levels of 62 cytokines and growth factors in healthy centenarians and middle-aged controls. We found an increase in pro-inflammatory cytokines in centenarians, as well as other cytokines involved in inflammation. Anti-inflammatory cytokines did not show an increase, except for the Th2-shifting cytokine IL-19. Several growth factors involved in regulating immunity were also upregulated in centenarians. Principal component analysis showed that pro and anti-inflammatory cytokines contributed the most to the observed data variability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Xin Chen, Lei Jiang, Xuesong Liu
Summary: This review discusses the contributions of natural killer (NK) cells in cancer treatment, explores the current strategies at harnessing NK cells for cancer treatment, and highlights the importance of NK cell-mediated therapies in the next wave of cancer immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Kyeong Jin Yoon, Aram Ahn, Soo Hong Park, Seung Hee Kwak, Seong Eun Kwak, Wonsang Lee, Yong Ryoul Yang, Minji Kim, Hyun Mu Shin, Hang-Rae Kim, Hyo Youl Moon
Summary: This study confirmed that 4 weeks of treadmill exercise can significantly improve metabolic function in aged mice, including increased lean mass and decreased fat mass, while decreasing the expression level of the senescence marker p16 in white adipose tissue. Exercise also induced changes in immune-cell subsets in the stromal vascular fraction of WAT, as well as activating pathways involved in the interaction between WAT and immune cells, particularly NK cells, in aged mice. These results suggest that exercise has a profound effect on immune-cell distribution and senescent-cell scavenging in WAT of aged mice, ultimately affecting overall energy metabolism towards a more youthful state.
Review
Immunology
Ivon Johanna Rodriguez, Nicolas Lalinde Ruiz, Manuela Llano Leon, Laura Martinez Enriquez, Maria del Pilar Montilla Velasquez, Juan Pablo Ortiz Aguirre, Oscar Mauricio Rodriguez Bohorquez, Esteban Alejandro Velandia Vargas, Edgar Debray Hernandez, Carlos Alberto Parra Lopez
Summary: Aging leads to alterations in immune response, termed immunosenescence, characterized by decreased naive T cells and increased expression of CD57 and KLRG1 in memory T cells in older adults. Proinflammatory cytokines increase and telomere length decrease in old adult T cells. The heterogeneity and biases among studies hinder robust statistical analysis for identifying flow cytometry markers of T cell immunosenescence phenotype.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tomoyuki Soma, Makoto Nagata
Summary: The prevalence of asthma in older adults is increasing due to the global increase in life expectancy. Understanding the pathophysiology of asthma in older patients is crucial for providing timely treatment, as it is associated with poor clinical outcomes. Age-related changes in the immune system and lung parenchyma contribute to the development of asthma in the elderly. Immunosenescence, which involves impaired immune response and chronic low-grade inflammation, plays a significant role in late-onset adult asthma and asthma in the elderly. This article discusses the impact of immunosenescence on immune response and the combination of type 2 inflammation and inflammaging in asthma in the elderly, as well as age-related features in the immune system and lung structure.
Article
Medicine, General & Internal
Leah Zuroff, Ayman Rezk, Koji Shinoda, Diego A. Espinoza, Yehezqel Elyahu, Bo Zhang, Andrew A. Chen, Russell T. Shinohara, Dina Jacobs, Roy N. Alcalay, Thomas F. Tropea, Alice Chen-Plotkin, Alon Monsonego, Rui Li, Amit Bar-Or
Summary: In the study comparing untreated MS patients with normal controls, it was found that MS patients exhibited early and persistent redistribution of naive and memory CD4 T-cell compartments. While most CD4 and CD8 T-cell aging trajectories were similar between groups, MS patients demonstrated abnormal age-associated increases, particularly in patients over 60.
Article
Cell Biology
Kristie Kim, Tesfahun Dessale Admasu, Alexandra Stolzing, Amit Sharma
Summary: In the context of aging and age-related diseases, Natural Killer (NK) cells have been identified as a crucial cell type for immune clearance of senescent cells. NK cell-based therapies have emerged as promising alternatives to drug-based treatments for age-related diseases and debility.
Article
Genetics & Heredity
Kazutaka Akagi, Kenneth A. Wilson, Subhash D. Katewa, Mauricio Ortega, Jesse Simons, Tyler A. Hilsabeck, Subir Kapuria, Amit Sharma, Heinrich Jasper, Pankaj Kapahi
Article
Genetics & Heredity
Sven Lang, Tyler A. Hilsabeck, Kenneth A. Wilson, Amit Sharma, Neelanjan Bose, Deanna J. Brackman, Jennifer N. Beck, Ling Chen, Mark A. Watson, David W. Killilea, Sunita Ho, Arnold Kahn, Kathleen Giacomini, Marshall L. Stoller, Thomas Chi, Pankaj Kapahi
Review
Biochemistry & Molecular Biology
Meseret Derbew Molla, Birhanu Ayelign, Gashaw Dessie, Zeleke Geto, Tesfahun Dessale Admasu
LIPIDS IN HEALTH AND DISEASE
(2020)
Article
Geriatrics & Gerontology
Tesfahun Dessale Admasu, Diogo Barardo, Li Fang Ng, Krishna Chaithanya Batchu, Amaury Cazenave-Gassiot, Markus R. Wenk, Jan Gruber
Summary: The increasing population aged 65 and above poses significant challenges in social, economic, and medical aspects, prompting the emergence of pharmacological interventions targeting mechanisms of aging. Psora-4, an inhibitor of the potassium channel, has shown potential as a CR mimetic by extending lifespan in nematodes and modulating stress response genes. Its discovery as a novel avenue for mimicking CR and extending a healthy lifespan highlights its role in energy metabolism and potential synergistic effects with other lifespan-extending drugs.
Review
Cell Biology
Tesfahun Dessale Admasu, Michael Rae, Alexandra Stolzing
Summary: Cellular senescence is a stable cell cycle arrest state in response to stress or damage, which can limit the replication of old, damaged, and precancerous cells in the short term. Secondary senescence refers to the induction of non-senescent cells to undergo senescence by primary senescent cells, through paracrine and juxtacrine mechanisms.
AGEING RESEARCH REVIEWS
(2021)
Article
Cell Biology
Kristie Kim, Tesfahun Dessale Admasu, Alexandra Stolzing, Amit Sharma
Summary: In the context of aging and age-related diseases, Natural Killer (NK) cells have been identified as a crucial cell type for immune clearance of senescent cells. NK cell-based therapies have emerged as promising alternatives to drug-based treatments for age-related diseases and debility.
Article
Cell Biology
Tesfahun Dessale Admasu, Kristie Kim, Michael Rae, Roberto Avelar, Ryan L. Gonciarz, Abdelhadi Rebbaa, Joao Pedro de Magalhaes, Adam R. Renslo, Alexandra Stolzing, Amit Sharma
Summary: Senescent cells can spread the senescent phenotype to other cells through secretory factors. Previous characterizations of paracrine senescence were unreliable due to mixed populations of senescent and non-senescent cells. This study isolates senescent cells using DPP4 as a surface marker and enriches the percentage of paracrine senescence. The researchers observe ferroptosis dysregulation and ferrous iron accumulation in both primary and paracrine senescent cells and identify a potential senolytic approach.
Article
Multidisciplinary Sciences
Gizaw Mamo Gebeyehu, Dereje Getachew Feleke, Meseret Derbew Molla, Tesfahun Dessale Admasu