Article
Radiology, Nuclear Medicine & Medical Imaging
Anna Sorensen, David Gimarc, Miranda Bice, Kristyn Hare, Paul A. Anderson, Andrew Ross
Summary: A multidisciplinary fracture liaison service (FLS) can be implemented to evaluate osteoporosis treatment and secondary fracture prevention for patients after vertebroplasty, resulting in improved outcomes and increased likelihood of treatment modification and diagnostic testing for patients evaluated by FLS.
JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY
(2021)
Article
Endocrinology & Metabolism
Gershon Zinger, Amit Davidson, Noa Sylvetsky, Yedin Levy, Amos Peyser
Summary: This study evaluated the essential factors in determining the cost-effectiveness of fracture liaison services (FLSs). The analysis found that medication cost is the critical component in determining whether the FLS program saves or loses more than it costs. The study suggests that prescribing less expensive drugs for osteoporosis treatment can significantly reduce the cost of FLS programs.
ENDOCRINE PRACTICE
(2023)
Article
Endocrinology & Metabolism
Carmelinda Ruggiero, Marta Baroni, Giuseppe Rocco Talesa, Alessandro Cirimbilli, Valentina Prenni, Valentina Bubba, Luca Parretti, Riccardo Bogini, Giuliana Duranti, Auro Caraffa, Virginia Boccardi, Patrizia Mecocci, Giuseppe Rinonapoli
Summary: The interdisciplinary FLS care pathway can effectively improve adherence to secondary prevention of fragility fractures, reduce healthcare facility admission, and improve long-term survival for older adults with hip fractures.
ARCHIVES OF OSTEOPOROSIS
(2022)
Article
Endocrinology & Metabolism
U. Tarantino, C. Greggi, V. V. Visconti, I Cariati, R. Bonanni, B. Gasperini, R. Iundusi, E. Gasbarra, P. Tranquilli Leali, M. L. Brandi
Summary: Frailty fractures, especially femoral fractures, place a significant socioeconomic burden on the healthcare system globally. The fracture liaison service (FLS) represents a multidisciplinary approach to post-fracture care for frail patients. The Italian Society of Orthopaedics and Traumatology (SIOT) is working towards accrediting multiple FLS centers throughout Italy.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Anthony Delbar, Arnaud Pflimlin, Isabelle Delabriere, Camille Ternynck, Christophe Chantelot, Francois Puisieux, Bernard Cortet, Julien Paccou
Summary: The study at Lille University Hospital assessed persistence with osteoporosis treatment in patients from the Fracture Liaison Service over a period of 1 year. The results showed a high persistence rate at 12 months but dropped at 24 months. Independent predictors of non-persistence included follow-up performed by a general practitioner and treatment with zoledronic acid.
Article
Endocrinology & Metabolism
Lisanne Vranken, Irma J. A. de Bruin, Annemariek H. M. Driessen, Piet P. M. Geusens, John A. Eisman, Jacqueline R. Center, Robert Y. van der Velde, Heinrich M. J. Janzing, Sjoerd Kaarsemaker, Joop P. van den Bergh, Caroline E. Wyers
Summary: Fracture liaison services (FLS) are effective in preventing secondary fractures. This study evaluated whether FLS care is associated with reduced subsequent fracture and mortality risk over a 3-year follow-up period. The results showed that FLS care was associated with a lower mortality risk and lower subsequent major/hip fracture risk in the first year for patients with a major/hip index fracture, but not for patients with a non-major/non-hip fracture.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
T. Ong, R. Copeland, C. N. Thiam, G. Cerda Mas, L. Marshall, O. Sahota
Summary: The integration of a vertebral fracture identification service into a Fracture Liaison Service is possible and has shown a significant increase in fracture detection rate. However, future FLS planning to incorporate such a service into their clinical practice should consider the increased workload.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Geriatrics & Gerontology
Isabel Geiger, Christian Kammerlander, Christine Hoefer, Ruth Volland, Joerg Trinemeier, Martina Henschelchen, Thomas Friess, Wolfgang Boecker, Leonie Sundmacher
Summary: The study aims to evaluate whether a coordinated care programme can reduce the secondary fracture rate for patients with fragility hip fractures in Germany, by implementing systematic diagnostics, falls prevention programmes, and guideline-adherent interventions based on the Fracture Liaison Services model. The findings will shed light on potential barriers to FLS implementation in the German healthcare system.
Article
Endocrinology & Metabolism
Antonio Naranjo, Amparo Molina, Adrian Quevedo, Francisco J. Rubino, Fernando Sanchez-Alonso, Carlos Rodriguez-Lozano, Soledad Ojeda
Summary: The study analyzed the long-term persistence of treatment in fracture liaison service (FLS) and found that most patients started treatment within five years, although the persistence rate decreased over time.
ARCHIVES OF OSTEOPOROSIS
(2021)
Article
Endocrinology & Metabolism
D. Gonzalez-Quevedo, V Perez-del-Rio, D. Moriel-Garceso, N. Fernandez-Arroyabe, G. Garcia-Melendez, M. Montanez-Ruiz, M. Bravo-Bardaji, D. Garcia-de-Quevedo, I Tamimi
Summary: Osteoporosis is often underdiagnosed, but the implementation of Fracture Liaison Service (FLS) protocol has shown to increase prescription of anti-osteoporotic drugs and reduce all-cause mortality significantly.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
N. Li, J. P. van den Bergh, A. Boonen, C. E. Wyers, S. P. G. Bours, M. Hiligsmann
Summary: This study assessed the lifetime cost-effectiveness of a fracture liaison service (FLS) compared to no-FLS in the Netherlands and found that FLS was cost-effective for patients aged 50 years and older with a recent fracture. The implementation of FLS could lead to lifetime health-economic benefits.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Rafael Pinedo-Villanueva, Edward Burn, Christopher Maronga, Cyrus Cooper, M. Kassim Javaid
Summary: Osteoporotic-related fractures lead to patient disability and burden on health care systems. Fracture liaison services (FLSs) provide effective secondary fracture prevention, but are not widely available. This study developed an economic model to estimate the benefits and budget impact of FLSs and support their international implementation.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Marie Doussiere, Claire Jesson, Laetitia Diep, Jimmy Menis, Corinne Fauvet, Patrice Fardellone, Vincent Goeb
Summary: This study describes the characteristics of 337 patients seen by the fracture liaison service of the Amiens University Hospital for at least two osteoporotic fractures between 2009 and 2019. Results showed that recurrent fracture occurs rapidly after the index fracture. Rheumatological and therapeutic managements are not sufficient, mainly because of cognitive disorders or patients' refusal.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Smita Nayak, Andrea Singer, Susan L. Greenspan
Summary: The study evaluated the cost-effectiveness of secondary fracture prevention intervention for Medicare beneficiaries, showing that the intervention was more effective and less expensive than usual care. It resulted in cost savings and increased quality-adjusted life-years, making it a recommended strategy for improving outcomes and reducing healthcare costs.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Endocrinology & Metabolism
Nannan Li, Lei Si, Annelies Boonen, Joop P. van den Bergh, Mickael Hiligsmann
Summary: This study, based on a model, suggests that fracture liaison services (FLS) in China could potentially lead to lifelong cost savings in patients who have experienced a fracture. However, Chinese-specific real-world data is needed to confirm these findings.
ARCHIVES OF OSTEOPOROSIS
(2022)
Article
Orthopedics
Hasan R. Mohammad, Andrew Judge, David W. Murray
Summary: This study explored the influence of surgeon caseload and usage on the revision rates of unicompartmental knee arthroplasty (UKA). The results showed that an increase in caseload and usage can improve the revision rates of UKA. For surgeons using cemented UKA, a usage rate of 20% or more and a caseload of 10 or more cases per year resulted in a 10-year survival rate of 90%.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Orthopedics
Hasan R. Mohammad, Andrew Judge, David W. Murray
Summary: For patients requiring knee arthroplasty, they are becoming younger. It is currently unknown what the relative performances of cemented and cementless UKAs are in different age groups. Through matching patients and surgical factors, it was found that younger patients had higher revision rates in both cemented and cementless UKA groups, and cementless fixation had lower long-term revision rates compared to cemented fixation in the younger age group with significantly lower rates of aseptic loosening.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Endocrinology & Metabolism
Micheal O. Breasail, Camille Pearse, Ayse Zengin, Landing Jarjou, Cyrus Cooper, Peter R. Ebeling, Ann Prentice, Kate A. Ward
Summary: This study aimed to describe musculoskeletal aging in Gambian adults. The results showed bone loss in all sites and a faster rate of loss in women in some indicators. Therefore, musculoskeletal health is an important challenge for resource-limited countries.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
John A. Kanis, Eugene McCloskey, Nicholas C. Harvey, Cyrus Cooper, Rene Rizzoli, Bess Dawson-Hughes, Stefania Maggi, Jean-Yves Reginster
Summary: This position paper discusses the rationale for separate diagnostic and intervention thresholds in osteoporosis, and concludes that the current BMD-based diagnostic criteria should be retained.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Leena Elhussein, Annika M. M. Jodicke, Ying He, Antonella Delmestri, Danielle E. Robinson, Victoria Y. Strauss, Daniel Prieto-Alhambra
Summary: This study identified three distinct groups of older people with complex health needs based on healthcare resource use or frailty. Compared to the hospitalisation cohort, the frailty and polypharmacy cohorts had more comorbidities and higher use of preventive therapies.
Article
Geriatrics & Gerontology
Ayse Zengin, Micheal O. Breasail, Camille M. Parsons, Landing M. Jarjou, Ramatoulie E. Janha, Modou Jobe, Ann Prentice, Cyrus Cooper, Peter R. Ebeling, Kate A. Ward
Summary: This study investigated the sex differences in associations between cardiac workload, arterial stiffness, peripheral vascular calcification (PVC) and physical function in Gambian adults. The results revealed significant differences between men and women in these associations, with the differences partly mediated by fat mass index.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Geriatrics & Gerontology
Leo D. Westbury, Charlotte Beaudart, Olivier Bruyere, Jane A. Cauley, Peggy Cawthon, Alfonso J. Cruz-Jentoft, Elizabeth M. Curtis, Kristine Ensrud, Roger A. Fielding, Helena Johansson, John A. Kanis, Magnus K. Karlsson, Nancy E. Lane, Laetitia Lengele, Mattias Lorentzon, Eugene McCloskey, Dan Mellstrom, Anne B. Newman, Claes Ohlsson, Eric Orwoll, Jean-Yves Reginster, Eva Ribom, Bjorn E. Rosengren, John T. Schousboe, Eric J. Shiroma, Nicholas C. Harvey, Elaine M. Dennison, Cyrus Cooper
Summary: The performance of recent sarcopenia definitions in terms of thresholds employed, concordance in individuals, and prediction of important health-related outcomes such as death is limited. This study addressed these limitations in a large multinational cohort study.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Medicine, General & Internal
Joanna McLaughlin, Ruth Kipping, Amanda Owen-Smith, Hugh McLeod, Samuel Hawley, J. Mark Wilkinson, Andrew Judge
Summary: This study aimed to assess the impact of BMI policies on access to hip replacement surgery in England. The study found that the implementation of BMI policies led to a decrease in surgery rates, while areas without policies saw an increase in rates, exacerbating health inequalities. It is recommended to no longer use BMI policies involving extra waiting time or mandatory BMI thresholds to reduce access to hip replacement surgery.
Article
Orthopedics
Rafael Pinedo-Villanueva, Spyros Kolovos, Edward Burn, Antonella Delmestri, Lindsay K. K. Smith, Andrew Judge, Sarah R. R. Kingsbury, Martin H. H. Stone, Philip G. G. Conaghan
Summary: Follow-up visits after primary hip or knee replacement surgery have been recommended, but their benefits have not been specifically examined. This study found that patients attending follow-up visits had a higher risk of revision surgery.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Endocrinology & Metabolism
Shengyu Lu, Nicholas R. Fuggle, Leo D. Westbury, Micheal O. Breasail, Gregorio Bevilacqua, Kate A. Ward, Elaine M. Dennison, Sasan Mahmoodi, Mahesan Niranjan, Cyrus Cooper
Summary: By combining computer vision and machine learning techniques with clinical risk factors and bone density measurements, researchers found that the accuracy of fracture risk assessment can be improved. This approach has the potential to make the information offered by HR-pQCT more accessible and applicable to healthcare professionals.
Article
Endocrinology & Metabolism
Farirayi Kowo-Nyakoko, Celia L. Gregson, Tafadzwa Madanhire, Lynda Stranix-Chibanda, Ruramayi Rukuni, Amaka C. Offiah, Lisa K. Micklesfield, Cyrus Cooper, Rashida A. Ferrand, Andrea M. Rehman, Kate A. Ward
Summary: This study aimed to compare and validate the Greulich and Pyle (GP) and Tanner and Whitehouse 3 (TW3) methods for evaluating bone age in sub-Saharan Africa (SSA). The results showed that there was a difference between bone age and chronological age in boys using both GP and TW3 methods, while there was no significant difference in girls. Furthermore, the agreement between GP method and chronological age improved as children got older.
Article
Endocrinology & Metabolism
Chor-Wing Sing, Tzu-Chieh Lin, Sharon Bartholomew, J. Simon Bell, Corina Bennett, Kebede Beyene, Pauline Bosco-Levy, Brian D. Bradbury, Amy Hai Yan Chan, Manju Chandran, Cyrus Cooper, Maria de Ridder, Caroline Y. Doyon, Cecile Droz-Perroteau, Ganga Ganesan, Sirpa Hartikainen, Jenni Ilomaki, Han Eol Jeong, Douglas P. Kiel, Kiyoshi Kubota, Edward Chia-Cheng Lai, Jeff L. Lange, E. Michael Lewiecki, Julian Lin, Jiannong Liu, Joe Maskell, Mirhelen Mendes de Abreu, James O'Kelly, Nobuhiro Ooba, Alma B. Pedersen, Albert Prats-Uribe, Daniel Prieto-Alhambra, Simon Xiwen Qin, Ju-Young Shin, Henrik T. Sorensen, Kelvin Bryan Tan, Tracy Thomas, Anna-Maija Tolppanen, Katia M. C. Verhamme, Grace Hsin-Min Wang, Sawaeng Watcharathanakij, Stephen J. Wood, Ching-Lung Cheung, Ian C. K. Wong
Summary: In this international study, the researchers analyzed the incidence of hip fractures, post-fracture treatment, and all-cause mortality following hip fractures across different countries and regions. They used patient-level healthcare data from 19 countries and identified 4,115,046 hip fractures from 2005 to 2018. The study revealed variations in the global epidemiology of hip fractures and post-fracture outcomes, highlighting the need for interventions to reduce the burden of osteoporotic fractures.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Orthopedics
S. R. Kingsbury, L. K. K. Smith, R. Pinedo-Villanueva, A. Judge, R. West, J. M. Wright, M. H. Stone, P. G. Conaghan
Summary: This study conducted a systematic review and analysis of large datasets to provide recommendations for follow-up after total hip and knee arthroplasty. The recommendations suggest regular follow-up from 1 to 10 years post-surgery, with clinical and radiological evaluation at 10 years.
Article
Cell Biology
Mark A. Burton, Emma S. Garratt, Matthew O. Hewitt, Hanan Y. Sharkh, Elie Antoun, Leo D. Westbury, Elaine M. Dennison, Nicholas C. Harvey, Cyrus Cooper, Julia L. Macisaac, Michael S. Kobor, Harnish P. Patel, Keith M. Godfrey, Karen A. Lillycrop
Summary: Insulin resistance in muscle in older individuals is associated with differential DNA methylation, with muscle mass and body composition playing a significant role in these methylation changes.
Article
Public, Environmental & Occupational Health
Kathryn R. Hesketh, Janis Baird, Sarah R. Crozier, Keith M. Godfrey, Nicholas C. Harvey, Cyrus Cooper, Esther M. F. van Sluijs
Summary: This study aimed to explore the relationship between activity behaviors before/during pregnancy and later parenthood. The results showed that women who sat for long periods of time before/during pregnancy were more sedentary 4-7 years postpartum, and those who engaged in moderate-/strenuous exercise before/during pregnancy were more active in later parenthood.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2023)