Inhibition of CK2 mitigates Alzheimer’s tau pathology by preventing NR2B synaptic mislocalization

In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics

(2021) Hong Xu et al.   ACTA NEUROPATHOLOGICA

Four subgroups based on tau levels in Alzheimer’s disease observed in two independent cohorts

(2021) Flora H. Duits et al.   Alzheimers Research & Therapy

Plasma d-glutamate levels for detecting mild cognitive impairment and Alzheimer’s disease: Machine learning approaches

(2021) Chun-Hung Chang et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Tau isoforms are differentially expressed across the hippocampus in chronic traumatic encephalopathy and Alzheimer’s disease

(2021) Jonathan D. Cherry et al.   Acta Neuropathologica Communications

Accuracy of Tau Positron Emission Tomography as a Prognostic Marker in Preclinical and Prodromal Alzheimer Disease

(2021) Rik Ossenkoppele et al.   JAMA Neurology

Longitudinal plasma phosphorylated tau 181 tracks disease progression in Alzheimer’s disease

(2021) Shi-Dong Chen et al.   Translational Psychiatry

Alzheimer’s disease profiled by fluid and imaging markers: tau PET best predicts cognitive decline

(2021) Marco Bucci et al.   MOLECULAR PSYCHIATRY

Prospective longitudinal atrophy in Alzheimer’s disease correlates with the intensity and topography of baseline tau-PET

(2020) Renaud La Joie et al.   Science Translational Medicine

Transmission of tauopathy strains is independent of their isoform composition

(2020) Zhuohao He et al.   Nature Communications

Mossy cell synaptic dysfunction causes memory imprecision via miR‐128 inhibition of STIM2 in Alzheimer's disease mouse model

(2020) Manfei Deng et al.   AGING CELL

Serum Tau Proteins as Potential Biomarkers for the Assessment of Alzheimer’s Disease Progression

(2020) Eunjoo Nam et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synaptic Loss in Primary Tauopathies Revealed by [ 11 C ] UCB‐J Positron Emission Tomography

(2020) Negin Holland et al.   MOVEMENT DISORDERS

Memantine ameliorates tau protein deposition and secondary damage in the ipsilateral thalamus and sensory decline following focal cortical infarction in rats

(2020) Yu-Bin Liang et al.   NEUROSCIENCE LETTERS

Contribution of the astrocytic tau pathology to synapse loss in progressive supranuclear palsy and corticobasal degeneration

(2020) Nils Briel et al.   BRAIN PATHOLOGY

Hippocampal mossy fibers synapses in CA3 pyramidal cells are altered at an early stage in a mouse model of Alzheimer's disease

(2019) Silvia Viana da Silva et al.   JOURNAL OF NEUROSCIENCE

Tau is required for the function of extrasynaptic NMDA receptors

(2019) Noemí Pallas-Bazarra et al.   Scientific Reports

Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease

(2019) Bernard J. Hanseeuw et al.   JAMA Neurology

Memantine improves outcomes after repetitive traumatic brain injury

(2018) Zhengrong Mei et al.   BEHAVIOURAL BRAIN RESEARCH

Memantine for the Treatment of Dementia: A Review on its Current and Future Applications

(2018) Jaume Folch et al.   JOURNAL OF ALZHEIMERS DISEASE

CK2 Phosphorylating I2PP2A/SET Mediates Tau Pathology and Cognitive Impairment

(2018) Qing Zhang et al.   Frontiers in Molecular Neuroscience

Mechanisms of Cell-to-Cell Transmission of Pathological Tau

(2018) Garrett S. Gibbons et al.   JAMA Neurology

The release and trans-synaptic transmission of Tau via exosomes

(2017) Yipeng Wang et al.   Molecular Neurodegeneration

Distinct phenotypes of three-repeat and four-repeat human tau in a transgenic model of tauopathy

(2017) Megan A. Sealey et al.   NEUROBIOLOGY OF DISEASE

Endosomal Traffic Jams Represent a Pathogenic Hub and Therapeutic Target in Alzheimer’s Disease

(2017) Scott A. Small et al.   TRENDS IN NEUROSCIENCES

Blood levels of D-amino acid oxidase vs. D-amino acids in reflecting cognitive aging

(2017) Chieh-Hsin Lin et al.   Scientific Reports

The Tau/A152T mutation, a risk factor for frontotemporal‐spectrum disorders, leads to NR2B receptor‐mediated excitotoxicity

(2016) Jochen Martin Decker et al.   EMBO REPORTS

Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice

(2016) Jing L. Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer’s disease pathology

(2016) Andrea F. N. Rosenberger et al.   Journal of Neuroinflammation

Extrasynaptic NMDA receptor-induced tau overexpression mediates neuronal death through suppressing survival signaling ERK phosphorylation

(2016) Xu-Ying Sun et al.   Cell Death & Disease

Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors

(2016) Silvia Viana da Silva et al.   Nature Communications

Overactivation of NR2B-containing NMDA receptors through entorhinal-hippocampal connection initiates accumulation of hyperphosphorylated tau in rat hippocampus after transient middle cerebral artery occlusion

(2015) Cheng-Shi Xu et al.   JOURNAL OF NEUROCHEMISTRY

Tau Phosphorylation at Serine 396 Residue Is Required for Hippocampal LTD

(2015) P. Regan et al.   JOURNAL OF NEUROSCIENCE

Bumetanide for neonatal seizures—back from the cotside

(2015) Ronit M. Pressler et al.   Nature Reviews Neurology

Gene Expression Switching of Receptor Subunits in Human Brain Development

(2015) Ossnat Bar-Shira et al.   PLoS Computational Biology

Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca++ dysregulation

(2015) Jochen Martin Decker et al.   Acta Neuropathologica Communications

Memantine Attenuates Alzheimer’s Disease-Like Pathology and Cognitive Impairment

(2015) Xiaochuan Wang et al.   PLoS One

Neuronal activity regulates extracellular tau in vivo

(2014) Kaoru Yamada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Specific Disruption of Hippocampal Mossy Fiber Synapses in a Mouse Model of Familial Alzheimer's Disease

(2014) Scott A. Wilke et al.   PLoS One

Isoform transition from four-repeat to three-repeat tau underlies dendrosomatic and regional progression of neurofibrillary pathology

(2013) Makoto Hara et al.   ACTA NEUROPATHOLOGICA

A platform for discovery: The University of Pennsylvania Integrated Neurodegenerative Disease Biobank

(2013) Jon B. Toledo et al.   Alzheimers & Dementia

Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer’s Coordinating Centre

(2013) Jon B. Toledo et al.   BRAIN

Physiological release of endogenous tau is stimulated by neuronal activity

(2013) Amy M Pooler et al.   EMBO REPORTS

NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss

(2013) C Tackenberg et al.   Cell Death & Disease

Activated CaMKII Couples GluN2B and Casein Kinase 2 to Control Synaptic NMDA Receptors

(2013) Antonio Sanz-Clemente et al.   Cell Reports

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Management of moderate to severe Alzheimer’s disease: Focus on memantine

(2012) Evangelyn Dominguez et al.   Taiwanese Journal of Obstetrics & Gynecology

Distribution of Extrasynaptic NMDA Receptors on Neurons

(2012) Ronald S. Petralia   TheScientificWorldJOURNAL

Tau Protein Assembles into Isoform- and Disulfide-dependent Polymorphic Fibrils with Distinct Structural Properties

(2011) Yoshiaki Furukawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of β-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices

(2011) Gerhard Rammes et al.   NEUROPHARMACOLOGY

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic Mild Cognitive Impairment

(2010) Michael A. Yassa et al.   NEUROIMAGE

Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice

(2010) Austen J. Milnerwood et al.   NEURON

Casein Kinase 2 Regulates the NR2 Subunit Composition of Synaptic NMDA Receptors

(2010) Antonio Sanz-Clemente et al.   NEURON

Altered synaptic plasticity in the mossy fibre pathway of transgenic mice expressing mutant amyloid precursor protein

(2010) Jonathan Witton et al.   Molecular Brain

Epilepsy and Cognitive Impairments in Alzheimer Disease

(2009) Jorge J. Palop   ARCHIVES OF NEUROLOGY

Memantine Prevents Sensitivity to Excitotoxic Cell Death of Rat Cortical Neurons Expressing Human Truncated Tau Protein

(2009) Martin Cente et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta

(2009) G. Pigino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Memantine protects rat cortical cultured neurons against β-amyloid-induced toxicity by attenuating tau phosphorylation

(2008) M. S. Song et al.   EUROPEAN JOURNAL OF NEUROSCIENCE