Article
Endocrinology & Metabolism
Weirong Xing, Sheila Pourteymoor, Yian Chen, Subburaman Mohan
Summary: Studies show that targeted deletion of the Cldn12 gene in mice increases articular cartilage, potentially by promoting articular chondrocyte phenotype.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, Research & Experimental
Xinyue Zhang, Xiaohua Pu, Caixia Pi, Jing Xie
Summary: FGF7, also known as KGF, plays a crucial role in tissue development, wound repair, tumorigenesis, and immune reconstruction. It directs cellular synaptic extension and facilitates functional gap junction communication in the skeletal system. Additionally, it promotes osteogenic differentiation and regulates key molecules in cartilage. However, the molecular mechanism of FGF7 in chondrocyte behaviors and cartilage diseases remains unknown.
Review
Cell Biology
Kai Sun, Jiachao Guo, Xudong Yao, Zhou Guo, Fengjing Guo
Summary: Growth differentiation factor 5 (GDF-5) plays a critical role in cartilage development and maintenance, and its dysregulation is linked to the pathogenesis of osteoarthritis (OA). Studies have shown the protective effects of GDF-5 against cartilage degeneration, making it a potential therapeutic candidate for OA treatment, despite current limitations in its clinical application.
CELL PROLIFERATION
(2021)
Article
Nanoscience & Nanotechnology
Yu Zhu, Yi Sun, Biyu Rui, Junqing Lin, Junjie Shen, Huimin Xiao, Xuanzhe Liu, Yimin Chai, Jia Xu, Yunlong Yang
Summary: This study developed a granular hydrogel (GH) for cartilage regeneration that overcomes the limitations of widely used elastic hydrogels. The GH, composed of hyaluronic acid, polyethylene glycol, and gelatin, showed excellent potential in promoting volume expansion, morphology recovery, and chondrogenic phenotype improvement of encapsulated chondrocytes. The GH also stimulated hyaline cartilage matrix deposition and connection, leading to hyaline-like cartilage regeneration in in vivo models. The study suggests the feasibility of GHs as in situ chondrocyte deploying scaffolds and provides new insights for designing hydrogel scaffolds for cartilage tissue engineering.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Shibo Xu, Linna Chang, Xingjun Zhao, Yanan Hu, Yiyi Lin, Zhenhua Chen, Xiuli Ren, Xifan Mei
Summary: In this study, a multifunctional heterostructure nanoplatform with near-infrared sensitivity was developed for the treatment of osteoarthritis. The results showed that this nanoplatform could reduce cartilage damage and promote cartilage regeneration, providing a promising strategy for osteoarthritis treatment.
ACTA BIOMATERIALIA
(2022)
Article
Orthopedics
Y. He, M. Zhang, J. Song, M. L. Warman
Summary: The study showed that cell-depleted areas within MCC cartilage are not repopulated by new cells in adult mice after diphtheria toxin-mediated chondrocyte killing.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Biochemistry & Molecular Biology
Yen-Hsiang Huang, Huai-An Chen, Chih-Hao Chen, Han-Tsung Liao, Chang-Yi Kuo, Jyh-Ping Chen
Summary: In this study, injectable cryogel microbeads were fabricated as scaffolds for delivering chondrocytes in cartilage tissue engineering. The cryogel microbeads showed uniform shape and size, high porosity, and good injectability. In vitro and in vivo experiments demonstrated the proliferation, migration, and differentiated phenotype of chondrocytes in the cryogel scaffold, as well as the retention ability, biocompatibility, and biodegradability of the scaffold. Furthermore, the injected chondrocyte/cryogel microbead constructs were able to form functional neocartilage tissues.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Endocrinology & Metabolism
Zihuan Yang, Weishi Li, Chunli Song, Huijie Leng
Summary: CTGF is a multifunctional protein that plays different roles in different cells and conditions. CTGF antibodies have the potential to be a new drug for osteoarthritis. Abnormal CTGF expression is associated with inflammation and cartilage degeneration, making CTGF a potential therapeutic target for osteoarthritis treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Yan Zhou, Jianghua Ming, Yaming Li, Bochun Li, Ming Deng, Yonggang Ma, Zhonghui Chen, Yubiao Zhang, Jia Li, Shiqing Liu
Summary: Exosomal miRNA-126-3p derived from SFCs can effectively suppress chondrocyte inflammation and cartilage degeneration, exerting anti-apoptotic and anti-inflammatory effects on articular cartilage, suggesting therapeutic potential for OA treatment.
CELL DEATH DISCOVERY
(2021)
Article
Medicine, Research & Experimental
Murad Aladal, Wei You, Rongxiang Huang, Jianghong Huang, Zhiqin Deng, Li Duan, Daping Wang, Wencui Li, Wei Sun
Summary: This article explores the potential of fibronectin 1 (FN1) in cartilage tissue engineering, highlighting its role in promoting chondrocyte differentiation and inhibiting apoptosis. It suggests that further research on FN1 could provide new insights and advanced applications in treating osteoarthritis and cartilage degeneration.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Chemistry, Medicinal
Jhi Biau Foo, Qi Hao Looi, Chee Wun How, Sau Har Lee, Maimonah Eissa Al-Masawa, Pei Pei Chong, Jia Xian Law
Summary: Exosomes are small extracellular vesicles secreted by cells for intercellular communication, with miRNAs being a promising therapeutic factor for cartilage regeneration. They can promote chondrocyte proliferation and matrix secretion, reduce scar tissue formation, and decrease inflammation, but the optimization of exosome therapy for cartilage injuries is still lacking.
Review
Biotechnology & Applied Microbiology
Yanxi Liu, Karan M. Shah, Jian Luo
Summary: Articular cartilage is avascular and has limited ability to repair itself, leading to degenerative joint diseases. Current clinical treatments often result in mechanically inferior cartilage. Understanding factors affecting cartilage homeostasis and exploring emerging regenerative approaches are crucial for future treatment options.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Ping Luo, Tingting Zhao, Hong He
Summary: The study demonstrates that IL-38 can alleviate inflammatory responses in chondrocytes by inhibiting the expression of inflammatory cytokines and related pathways. IL-38 limits inflammation and delays cartilage degeneration in the TMJ.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Liang He, Ziwei Xu, Xin Niu, Rong Li, Fanhua Wang, Yu You, Jingduo Gao, Lei Zhao, Karan M. Shah, Jian Fan, Mingyao Liu, Jian Luo
Summary: This study reveals that GPRC5B can inhibit cartilage degradation, promote cartilage regeneration, and protect against osteoarthritis. The findings were validated in vitro experiments and a mouse model, and the study also identified the regulatory role of the AKT-mTOR-autophagy signaling pathway.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Endocrinology & Metabolism
Tori Kroon, Neharika Bhadouria, Paul Niziolek, Daniel Edwards, Roy Choi, Erica L. Clinkenbeard, Alexander Robling, Nilsson Holguin
Summary: Intervertebral disc degeneration, a leading cause of low back pain, lacks pharmacological treatment options. This study demonstrated that neutralization of sclerostin and/or dkk1 could stimulate Wnt signaling and enhance intervertebral disc structure in mice. The findings suggest that anti-sclerostin antibody may contribute to the restoration of intervertebral disc health.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Soil Science
Lei Wang, Hui Zhang, Jing Wang, Jidong Wang, Yongchun Zhang
Summary: Long-term N fertilization decreased the abundance of the nifH gene significantly and altered the structure and diversity of the soil diazotrophic community. High N fertilization rates reduced the relative abundance of nifH-harboring microorganisms, especially potential N2-fixers like Cyanobacteria. Soil pH had a greater impact on diazotrophic community diversity and structure compared to soil organic matter and nitrogen forms, while soil available phosphorus content mainly regulated diazotrophs abundance.
APPLIED SOIL ECOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Leini Wang, Gang He, Wenhao Wang, Xiaofen Xu, Bo He, Xiaoyu Wu, Yongchun Zhang
Summary: This article investigates the performance of solution-derived amorphous cerium oxide (CeO2) as a gate dielectric with a smooth surface. Electrical analysis demonstrates that a 3 nm Al2O3 passivation layer derived from ALD helps reduce leakage current in CeO2 MOS capacitors. Additionally, the article integrates solution-processed In2O3 thin-film transistors (TFTs) based on an optimized Al2O3/CeO2 bilayer dielectric for the first time. Results show that the annealed In2O3/Al2O3/CeO2 TFT demonstrates high performance and stability.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2022)
Article
Environmental Sciences
Cong Xu, Jidong Wang, Di Wu, Chuanzhe Li, Lei Wang, Cheng Ji, Yongchun Zhang, Yuchun Ai
Summary: The study found that organic amendment application in infertile soils can enhance soil organic carbon sequestration and reduce greenhouse gas emissions, but high application rates may decrease sequestration efficiency. Spent mushroom residue showed greater potential in sequestering SOC and promoting soil aggregates. Mechanical OA application can save agricultural costs and achieve higher net ecosystem economic benefits.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Horticulture
Xin Li, Zhen Wang, Liuyan Yang, Junxu Xu, Yongchun Zhang
Summary: The study identified candidate genes related to the petaloidy of stamens in Hippeastrum hybridum by analyzing the differential expression of genes between normal stamens and petaloid stamens. Results indicated that the expression level of B- and C-class MADS-box genes is associated with the petaloidy of stamens in H. hybridum, providing insights for double-flower breeding in this species.
JOURNAL OF HORTICULTURAL SCIENCE & BIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Wenhao Wang, Gang He, Hai Yu, Qian Gao, Leini Wang, Xiaofen Xu, Yongchun Zhang, Xiaoyu Wu, Bo He
Summary: In this study, solution-processed TFTs with InLaO as the channel layer were prepared with improved electrical performance compared to In2O3 TFT. The results demonstrate the potential application of aqueous solution technology for future low-cost, energy-efficient, large-scale, and high-performance electronics.
PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE
(2022)
Article
Agronomy
Jing Huang, Chunquan Zhu, Yali Kong, Xiaochuang Cao, Lianfeng Zhu, Yongchun Zhang, Yunwang Ning, Wenhao Tian, Hui Zhang, Yijun Yu, Junhua Zhang
Summary: The application of biochar increased the biomass of rice under salt stress and improved soil nutrient conditions and bacterial community structure.
Article
Biochemistry & Molecular Biology
Shunliang Zheng, Yi Wang, Jiashuo Wu, Siyao Wang, Huaifu Wei, Yongchun Zhang, Jianbo Zhou, Yue Shi
Summary: In this study, the molecular weight and molecular weight distribution of low molecular weight fucosylated glycosaminoglycan sodium (LFG-Na) were successfully determined using high performance size exclusion chromatography coupled with multi angle laser light scattering and refractive index detector (HPSEC-MALLS-RID). The acceptance criteria of LFG-Na were established, and the potency of anti-iXase was determined using the APTT assay. The results suggest that HPSEC-MALLS-RID and bioactivity assays are critical quality control methods for LFG-Na and provide a feasible strategy to control the quality of other polysaccharide medicines.
Article
Energy & Fuels
Yongchun Zhang, Haijun Mao, Hao Zhang, Yueli Li, Yanfang Jiang, Jiarui Li
Summary: The Daniudi gas field is characterized by complex reservoir types, including fractures, karst caves, and dissolution pores. Optimizing acid fracturing processes can effectively improve the productivity of tight and low-permeability carbonate rock reservoirs.
Article
Materials Science, Multidisciplinary
Qian Yang, Zhiqiang Zhang, Tiangang Zhang, Xuecheng Lu, Zhiyong Guo, Yiran Cao, Hao Wang, Yongchun Zhang
Summary: The microstructure and texture characteristics of laser-clad Ti2C/CeO2/β-Ti composite coatings were investigated. The β-Ti matrix exhibited equiaxed recrystallization grains with high-angle grain boundaries (HAGB). Well-developed Ti2C dendrites were found to grow through multiple β-Ti grains. The β-Ti grains near Ti2C showed higher geometrically necessary dislocation (GND) density compared to those far away from Ti2C. Additionally, weak texture {111} (1 1 0) and {001} (100) were observed in the β-Ti matrix, while a similar rotated cube texture {001} (110) formed in both Ti2C and CeO2. Special orientation relationships, {100}β_Ti//{100}Ti2C and {100}β_Ti//{100}Ti2C, were found between Ti2C and β-Ti.
Article
Horticulture
Jiao Zhu, Yongchun Zhang, Lin Zhou, Liuyan Yang
Summary: The present study investigated the effects of LED light quality on the growth and flowering of saffron. Monochromatic red light showed positive effects on saffron growth, advanced flowering, and increased stigma yield. It also regulated the phytohormones and enzyme activity in the corms. This study provides valuable guidance for exploring modern techniques to promote saffron flower and stigma yield.
SCIENTIA HORTICULTURAE
(2022)
Article
Multidisciplinary Sciences
Licheng Zhang, Jie Yuan, Mingqing Zhang, Yongchun Zhang, Limin Wang, Juan Li
Summary: The objective of this study was to determine the effects of different fertilizer treatments and crop rotations on crop yield stability. The results showed that long-term annual P-B-O rotation combined with recommended fertilization significantly increased crop yield and maintained yield stability.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Jie Yuan, Kun Shi, Xiaoyue Zhou, Lei Wang, Cong Xu, Hui Zhang, Guopeng Zhu, Chengcheng Si, Jidong Wang, Yongchun Zhang
Summary: Sweet potato is highly dependent on arbuscular mycorrhizal fungi (AMF) and potassium (K) for optimizing morphology and nutrient uptake. This study found that AMF inoculation improved root morphology in sweet potato mainly through K application. Additionally, a specific AMF, Claroideoglomus etunicatum (CE), promoted root dry matter accumulation and K allocation in high-KIUE genotype Xu28. These findings provide insights into the interaction between K, AMF, and sweet potato, contributing to the scientific application of AMF in sweet potato cultivation.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Oncology
Yaping Wu, Zhiying Chen, Wei Li, Fengguang Wang, Yongchun Zhang
Summary: This article reported a case of primary squamous cell carcinoma (PSCC) of the breast and described the treatment process and outcomes of the patient. The study suggests that surgical treatment, paclitaxel and cisplatin chemotherapy regimens, and adjuvant radiotherapy have certain efficacy for PSCC of the breast, and immunotherapy may prolong the survival of patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Agronomy
Jianwei Zhang, Yan Zhou, Longmei Wu, Lei Xu, Cong Xu, Dong Liang, Yanfeng Ding, Yongchun Zhang, Jidong Wang, Ganghua Li
Summary: The study investigated the effect of three integrated reduced basal and increased topdressing fertilizer rate (RBIT) treatments on rice growth and nutritional status under different weathers. It was found that the treatments had varying effects on rice yield, depending on the daytime temperature and light conditions. The combination of RBIT with straw incorporation significantly increased rice yield under low daytime temperature and light conditions.
Article
Cell Biology
Emily M. Rabjohns, Rishi R. Rampersad, Arin Ghosh, Katlyn Hurst, Amanda M. Eudy, Jaime M. Brozowski, Hyun Ho Lee, Yinshi Ren, Anthony Mirando, Justin Gladman, Jessica L. Bowser, Kathryn Berg, Sachin Wani, Stuart H. Ralston, Matthew J. Hilton, Teresa K. Tarrant
Summary: Paget's Disease of Bone (PDB) is a metabolic bone disease characterized by dysregulated osteoclast function. Our study found that GRK3, a negative regulator of GPCR signaling, is relevant to the regulation of osteoclast differentiation and may be involved in the pathogenesis of PDB and other metabolic bone diseases associated with osteoclast activation.