Review
Chemistry, Medicinal
Ankita Sood, Damanpreet Kaur Lang, Rajwinder Kaur, Balraj Saini, Sandeep Arora
Summary: Treatment for breast cancer remains challenging, with aromatase inhibitors showing significantly improved efficacy and safety compared to other drugs.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Thomas Bachelot, Paul Cottu, Sylvie Chabaud, Florence Dalenc, Djelila Allouache, Suzette Delaloge, Jean-Philippe Jacquin, Julien Grenier, Laurence Venat Bouvet, Apurna Jegannathen, Mario Campone, Francesco Del Piano, Marc Debled, Anne-Claire Hardy-Bessard, Sylvie Giacchetti, Marie-Ange Mouret-Reynier, Philippe Barthelemy, Laure Kaluzinski, Audrey Mailliez, Eric Legouffe, Matthew Sephton, Judith Bliss, Jean-Luc Canon, Frederique Penault-Llorca, Jerome Lemonnier, David Cameron, Fabrice Andre
Summary: This study investigated the effect of adding everolimus to adjuvant therapy in early breast cancer and found that among high-risk patients, adding everolimus to adjuvant endocrine therapy did not improve disease-free survival. Tolerability was also a concern, with more than half of the patients discontinuing everolimus treatment before the study completion.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Bjorn-Erik Bertelsen, Kristin Viste, Thomas Helland, Magnus Hagland, Havard Soiland, Jurgen Geisler, Tone Hoel Lende, Per Eystein Lonning, Jorn Sagen, Gunnar Mellgren, Bjorg Almas
Summary: This study developed a liquid chromatography-tandem mass spectrometry (MS/MS) method for simultaneous measurement of serum levels of third-generation aromatase inhibitors (AIs) and ultra-low levels of estrogens. The method is highly valuable for studying drug efficacy and compliance.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Oncology
Sara Caceres, Beatriz Monsalve, Angela Alonso-Diez, Belen Crespo, Maria Jose Illera, Paloma Jimena de Andres, Gema Silvan, Juan Carlos Illera
Summary: Through experimental studies on canine and human inflammatory breast cancer, it was found that anti-aromatase and anti-sulfatase therapies have inhibitory effects on tumors in vitro, while anti-sulfatase can increase tumor progression; letrozole effectively reduces tumor progression by decreasing estrogen levels.
Article
Radiology, Nuclear Medicine & Medical Imaging
Su Hyun Lee, Myoung-jin Jang, Heera Yoen, Youkyoung Lee, Yeon Soo Kim, Ah Reum Park, Su Min Ha, Soo-Yeon Kim, Jung Min Chang, Nariya Cho, Woo Kyung Moon
Summary: Background parenchymal enhancement (BPE) at surveillance breast MRI is associated with future second breast cancer risk in women with a personal history of breast cancer.
Article
Oncology
Tiago Augusto, Cristina Amaral, Yuanzhong Wang, Shiuan Chen, Cristina F. Almeida, Natercia Teixeira, Georgina Correia-da-Silva
Summary: The study explores the role of autophagy in response to Ana and Let treatments and the effects of combining the PI3K inhibitor BYL-719 with AIs in AI-resistant breast cancer cell lines. Results demonstrate that Ana and Let treatments do not induce autophagy in resistant breast cancer cells, while the combination with BYL-719 shows different mechanisms in decreasing cell viability depending on the type of AI.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Review
Biochemistry & Molecular Biology
Rosalin Mishra, Hima Patel, Samar Alanazi, Mary Kate Kilroy, Joan T. Garrett
Summary: The PI3K pathway is crucial in cancer development and is a promising therapeutic target. Clinical trials are ongoing to evaluate the efficacy and potential risks associated with PI3K inhibitors in overcoming resistance to current therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Jing Xu, Bo Cao, Chunyu Li, Guohui Li
Summary: Breast cancer is a global health concern. Endocrine therapy is crucial in treating estrogen-positive breast cancer, but it often leads to osteoporosis-related adverse events. These events increase the risk of fractures and reduce the patients' quality of life. This review explores the possibility of endocrine therapy-induced osteoporosis in estrogen-positive breast cancer treatment and discusses the mechanisms involved and the potential of drug therapies and combinations.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Molly B. Moravek, Rafael Confino, Angela K. Lawson, Kristin N. Smith, Ralph R. Kazer, Susan C. Klock, William J. Gradishar, Jacqueline S. Jeruss, Mary Ellen Pavone
Summary: The study compared recurrence and survival in breast cancer patients who pursued fertility preservation (FP) and those who did not, finding that regardless of receptor status, patients undergoing FP had similar outcomes. Age and parity were the main factors influencing the likelihood of pursuing FP, and breast cancer stage had minimal impact on this decision.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Chemistry, Medicinal
Amit Kumar Jana, Jyotsana Singh, Asha Ganesher, Amit Kumar, Arpita Banerjee, Deepak Kumar, Sarvesh Kumar Verma, Ashok Kumar Sharma, Rabi Sankar Bhatta, Rituraj Konwar, Gautam Panda
Summary: A new chemical entity, benzoxazine, was designed for improving anti-breast cancer activity. Compound 13d, as a lead compound, induced apoptosis, cell cycle arrest, and loss of mitochondrial membrane potential in breast cancer cells. In a rat syngenic mammary tumor model, both 13d and 13d-f showed significant tumor regression without causing any mortality.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Oncology
Raffaella D'Onofrio, Isabella Sperduti, Federico Piacentini, Monica Barbolini, Claudia Omarini, Angela Toss, Laura Cortesi, Elena Barbieri, Fabio Canino, Massimo Dominici, Luca Moscetti
Summary: Aromatase inhibitors (AIs) as an upfront strategy are associated with the lowest TE incidence. The switch strategy increases the risk of TE events, while the addition of CDK4/6 inhibitors significantly increases TE incidence.
CLINICAL BREAST CANCER
(2023)
Article
Medicine, General & Internal
Milana A. Bergamino, Elena Lopez-Knowles, Gabriele Morani, Holly Tovey, Lucy Kilburn, Eugene F. Schuster, Anastasia Alataki, Margaret Hills, Hui Xiao, Chris Holcombe, Anthony Skene, John F. Robertson, Ian E. Smith, Judith M. Bliss, Mitch Dowsett, Maggie C. U. Cheang
Summary: This study aimed to identify biomarkers for the response of ER+/HER2+ breast cancers to AI treatment. The results showed that HER2-E is a standardized biomarker associated with poor response to AI and worse prognosis in ER+/HER2+ breast cancers. HRD, TP53 mutational score, and immune-tumor tolerance are predictive biomarkers for poor response to AI. Additionally, new molecular subtypes identify non-HER2-E tumors that do not respond to AI and have an increased risk of relapse.
Article
Cell Biology
Tiago V. Augusto, Cristina Amaral, Cristina F. Almeida, Natercia Teixeira, Georgina Correia-da-Silva
Summary: The study investigated the effects of AIs on breast cancer cells and found that non-steroidal AIs induce cell senescence while Exe promotes autophagy, impacting hormonal environment. In hormone-enriched conditions, AIs block estrogen signaling, whereas in hormone-depleted conditions, AR and ERα crosstalk occurs.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Review
Oncology
Li Huifang, Gao Jie, Feng Yi
Summary: Aromatase inhibitors are the most commonly used endocrine therapy for breast cancer patients, but they often cause adverse reactions such as muscle and joint pain, fatigue, anxiety, depression, and sleep disturbances. The rapid decline of hormones leads to inflammation and bone loss. Therefore, studying poor adherence from the perspective of neuro-immuno-endocrine is of great significance for clinical intervention.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Silvia Riondino, Vincenzo Formica, Elena Valenzi, Cristina Morelli, Valeria Flaminio, Ilaria Portarena, Francesco Torino, Mario Roselli
Summary: This study aimed to identify a cut-off point of body mass index (BMI) that would have a significant prognostic impact on stage I-II BC patients receiving AI treatment. The results showed that a BMI cut-off >29 was associated with a deteriorating disease-free survival (DFS) in AI-treated BC patients, indicating that obesity is a risk factor for recurrence in breast cancer.
Article
Medicine, General & Internal
Beata Szymanska, Zofia Marchewka, Brygida Knysz, Agnieszka Piwowar
Summary: This study measured the levels of low molecular weight proteins in urine of HIV-infected patients and found that certain protein levels are of significance in assessing kidney damage in HIV patients during antiretroviral therapy.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Cell Biology
Izabela Kokot, Sylwester Mazurek, Agnieszka Piwowar, Roman Szostak, Marcin Jedryka, Ewa Maria Kratz
Summary: Endometriosis is a common gynecological disease for young women, but there is no specific biomarker for diagnosis. A study using infrared spectroscopy and discriminant analysis successfully differentiated three groups: women with endometriosis, women with other gynecological disorders, and healthy women.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Immunology
Monika Stepien, Malgorzata Zalewska, Brygida Knysz, Natalia Swiatoniowska-Lonc, Beata Jankowska-Polanska, Lukasz Laczmanski, Agnieszka Piwowar, Amadeusz Kuzniarski
Summary: The aim of this study was to evaluate and compare the effectiveness of different vaccines in Poland's mass vaccination program and investigate the most common side effects. The study found that 100% of patients responded to the vaccines, with convalescents having higher antibody levels after the first dose but a decrease after the second dose. Moderna vaccine generated the highest antibody titers after both doses, and fever was identified as a significant factor in higher antibody levels.
Article
Biochemistry & Molecular Biology
Justyna Niepsuj, Grzegorz Franik, Pawel Madej, Agnieszka Piwowar, Anna Bizon
Summary: In women with polycystic ovary syndrome (PCOS), factors such as body mass index, waist-to-hip ratio, age, and glucose concentration significantly affect oxLDL-C and FRAP levels. Furthermore, there is a correlation between FRAP and oxLDL-C levels in the whole group and in insulin-sensitive women. Additionally, the concentration of Anti-Mullerian hormone is negatively related to oxLDL-C and FRAP levels.
Review
Biochemistry & Molecular Biology
Justyna Chojdak-Lukasiewicz, Anna Bizon, Marta Waliszewska-Prosol, Agnieszka Piwowar, Slawomir Budrewicz, Anna Pokryszko-Dragan
Summary: This study reviews the role of SIRTs in the physiology and pathology of the central nervous system (CNS) and discusses their crucial involvement in neuroinflammation, neurodegeneration, and metabolic alterations. The understanding of SIRTs' role in various CNS diseases provides an opportunity to identify relevant markers of disease progression and potential therapeutic targets.
Article
Oncology
Kamila Boszkiewicz, Helena Moreira, Ewa Sawicka, Anna Szyjka, Agnieszka Piwowar
Summary: Progressive industrialization, urbanization, and consumerism have led to increased contamination of the environment with endocrine-disrupting compounds (EDCs), which play a crucial role in the rise of hormone-dependent cancers, including breast cancer. This study aimed to investigate the impact of exposure to specific xenoestrogens, commonly found in daily life (aluminum in antiperspirants and deodorants; chromium (III) in dietary supplements and drugs), on the effectiveness of hormone therapy in breast cancer treatment. In vitro tests were conducted on breast cancer cell lines exposed to xenoestrogens, drugs, and their combinations, and the results showed that such exposure can impair the efficacy of hormone therapy.
Article
Biochemistry & Molecular Biology
Anna Bizon, Justyna Chojdak-Lukasiewicz, Aleksandra Koltuniuk, Slawomir Budrewicz, Anna Pokryszko-Dragan, Agnieszka Piwowar
Summary: This study evaluated oxidative stress parameters in the serum of patients with relapsing-remitting multiple sclerosis (RRMS), and found associations between these parameters and clinical/laboratory markers. AOPP and FRAP concentrations were higher in male patients. There were correlations between AOPP and inflammation markers, and differences in AOPP among subgroups receiving different treatments.
Article
Medicine, Research & Experimental
Monika Stepien, Natalia Swiatoniowska-Lonc, Brygida Knysz, Beata Jankowska-Polanska, Amadeusz Kuzniarski, Agnieszka Piwowar, Malgorzata Zalewska
Summary: This study aimed to evaluate the levels of anti-SARS-CoV-2 immunoglobulin G (IgG) antibodies in convalescents and individuals without a past infection, and to assess socio-clinical factors associated with participants' humoral responses. The results showed the presence of anti-SARS-CoV-2 IgG antibodies in convalescents and in some individuals without a past infection, and the antibody levels were related to the severity of the symptoms.
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Kamila Boszkiewicz, Agnieszka Piwowar
Summary: One-third of breast cancer patients with diabetes have a 40% higher risk of mortality. Metalloestrogens may reduce the effectiveness of aromatase inhibitors (AIs), but high glucose conditions have a greater impact on their activity. Therefore, controlling hyperglycemia and individualized treatment regimens may have important therapeutic implications for cancer patients with diabetes.
ACTA POLONIAE PHARMACEUTICA
(2023)
Article
Public, Environmental & Occupational Health
Agnieszka Piwowar, Eddie Czwojdzinski, Zofia Marchewka, Aleksandra Adamczuk, Natalia Swiatoniowska-Lonc, Beata Jankowska-Polanska
Summary: The study found that treatment satisfaction and adherence are important factors in the pharmaceutical treatment of patients with ischemic heart disease. Factors influencing patient adherence include family history, anemia, drug side effects, and satisfaction with treatment. Increasing patient awareness of treatment should be an important goal for future educational activities.
INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Anna Bizon, Justyna Chojdak-Lukasiewicz, Slawomir Budrewicz, Anna Pokryszko-Dragan, Agnieszka Piwowar
Summary: This study aimed to investigate the alterations in the antioxidant balance in patients with RRMS and the factors influencing it. The study included 161 patients and 29 healthy individuals, and measured the activity of SOD, GPx, and CAT, as well as the concentration of IL-6, LPO, TOS, and TAS. The results showed decreased GPx activity and increased CAT activity in patients with RRMS compared to the control group, and these activities were influenced by gender and disease-modifying therapies. The findings suggest that enhancing GPx activity may be a potential therapeutic strategy for mitigating oxidative stress in RRMS.
Article
Pharmacology & Pharmacy
Anna Bizon, Agnieszka Piwowar
Summary: The expression of recombinant paraoxonase 1 (PON1) in the human embryonic kidney (HEK293F) cell line was investigated. It was demonstrated that the HEK293F platform is useful for obtaining recombinant human PON1 protein. The addition of high-density lipoprotein increased serum arylesterase and lactonase activity of PON1, while low-density lipoprotein, copper ions, and iron ions decreased PON1 activity.
ACTA POLONIAE PHARMACEUTICA
(2023)
Article
Medicine, Research & Experimental
Monika Stepien, Natalia Swiatoniowska-Lonc, Brygida Knysz, Beata Jankowska-Polanska, Amadeusz Kuzniarski, Agnieszka Piwowar, Malgorzata Zalewska
Summary: This study aimed to evaluate the levels of anti-SARS-CoV-2 IgG antibodies in convalescents and individuals not previously infected, and to assess factors associated with participants' humoral responses. The results showed the presence of antibodies in some convalescents and previously uninfected individuals, but also observed that some individuals did not have detectable antibodies despite a previous infection.
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2023)