Accelerating clinical-scale production of BCMA CAR T cells with defined maturation stages

CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin’s lymphoma and tumor-supportive follicular T helper cells

(2021) Mario Bunse et al.   Nature Communications

Preclinical development of a humanized chimeric antigen receptor against B cell maturation antigen for multiple myeloma

(2020) Lorena Perez-Amill et al.   HAEMATOLOGICA

Point-Of-Care CAR T-Cell Production (ARI-0001) Using a Closed Semi-automatic Bioreactor: Experience From an Academic Phase I Clinical Trial

(2020) Maria Castella et al.   Frontiers in Immunology

Next-Generation Manufacturing Protocols Enriching TSCM CAR T Cells Can Overcome Disease-Specific T Cell Defects in Cancer Patients

(2020) Silvia Arcangeli et al.   Frontiers in Immunology

Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma

(2019) Noopur Raje et al.   NEW ENGLAND JOURNAL OF MEDICINE

Manufacturing and preclinical validation of CAR T cells targeting ICAM-1 for advanced thyroid cancer therapy

(2019) Yogindra Vedvyas et al.   Scientific Reports

GMP-Compliant Manufacturing of NKG2D CAR Memory T Cells Using CliniMACS Prodigy

(2019) Lucía Fernández et al.   Frontiers in Immunology

Induction of a central memory and stem cell memory phenotype in functionally active CD4+ and CD8+ CAR T cells produced in an automated good manufacturing practice system for the treatment of CD19+ acute lymphoblastic leukemia

(2018) Franziska Blaeschke et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Generation and application of human induced-stem cell memory T cells for adoptive immunotherapy

(2018) Taisuke Kondo et al.   CANCER SCIENCE

Closed-system manufacturing of CD19 and dual-targeted CD20/19 chimeric antigen receptor T cells using the CliniMACS Prodigy device at an academic medical center

(2018) Fenlu Zhu et al.   CYTOTHERAPY

T Cells Genetically Modified to Express an Anti–B-Cell Maturation Antigen Chimeric Antigen Receptor Cause Remissions of Poor-Prognosis Relapsed Multiple Myeloma

(2018) Jennifer N. Brudno et al.   JOURNAL OF CLINICAL ONCOLOGY

CD28-ζ CAR T cells resist TGF-β repression through IL-2 signaling which can be mimicked by IL-7 and an engineered IL-7/IL-2Rβ autocrine loop

(2018) Viktória Golumba-Nagy et al.   MOLECULAR THERAPY

CAR T Cells with Enhanced Sensitivity to B Cell Maturation Antigen for the Targeting of B Cell Non-Hodgkin’s Lymphoma and Multiple Myeloma

(2018) Julia Bluhm et al.   MOLECULAR THERAPY

Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia

(2018) Jae H. Park et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

(2018) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

CAR T cell immunotherapy for human cancer

(2018) Carl H. June et al.   SCIENCE

Characterization of clinical grade CD19 chimeric antigen receptor T cells produced using automated CliniMACS prodigy system

(2018) Wei Zhang et al.   Drug Design Development and Therapy

Development of a Novel Anti-CD19 Chimeric Antigen Receptor: A Paradigm for an Affordable CAR T Cell Production at Academic Institutions

(2018) Maria Castella et al.   Molecular Therapy-Methods & Clinical Development

Automated Manufacturing of Potent CD20-Directed Chimeric Antigen Receptor T Cells for Clinical Use

(2017) Dominik Lock et al.   HUMAN GENE THERAPY

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

(2017) Sattva S. Neelapu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 1 studies of central memory-derived CD19 CAR T-cell therapy following autologous HSCT in patients with B-cell NHL

(2016) X. Wang et al.   BLOOD

Generation of clinical-grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of human B-cell malignancies

(2016) M. Sabatino et al.   BLOOD

Automated manufacturing of chimeric antigen receptor T cells for adoptive immunotherapy using CliniMACS Prodigy

(2016) Ulrike Mock et al.   CYTOTHERAPY

Automated Enrichment, Transduction, and Expansion of Clinical-Scale CD62L+T Cells for Manufacturing of Gene Therapy Medicinal Products

(2016) Christoph Priesner et al.   HUMAN GENE THERAPY

Costimulation Engages the Gear in Driving CARs

(2016) Hinrich Abken   IMMUNITY

Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells

(2016) Omkar U. Kawalekar et al.   IMMUNITY

T Cell Maturation Stage Prior to and During GMP Processing Informs on CAR T Cell Expansion in Patients

(2016) Yarne Klaver et al.   Frontiers in Immunology

Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells

(2015) Zeguo Zhao et al.   CANCER CELL

Large-scale Clinical-grade Retroviral Vector Production in a Fixed-Bed Bioreactor

(2015) Xiuyan Wang et al.   JOURNAL OF IMMUNOTHERAPY

Chimeric antigen receptor-modified T cells derived from defined CD8+ and CD4+ subsets confer superior antitumor reactivity in vivo

(2015) D Sommermeyer et al.   LEUKEMIA

Potent anti-tumor response by targeting B cell maturation antigen (BCMA) in a mouse model of multiple myeloma

(2015) Felix Oden et al.   Molecular Oncology

Tracking genetically engineered lymphocytes long-term reveals the dynamics of T cell immunological memory

(2015) Giacomo Oliveira et al.   Science Translational Medicine

Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15

(2014) Y. Xu et al.   BLOOD

Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia

(2014) M. L. Davila et al.   Science Translational Medicine

HEK293-Based Production Platform for γ-Retroviral (Self-Inactivating) Vectors: Application for Safe and Efficient Transfer of COL7A1 cDNA

(2014) Katharina Hennig et al.   Human Gene Therapy Clinical Development

Clinical-scale selection and viral transduction of human naïve and central memory CD8+ T cells for adoptive cell therapy of cancer patients

(2013) Anna Casati et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Differential Localization of T-bet and Eomes in CD8 T Cell Memory Populations

(2013) L. M. McLane et al.   JOURNAL OF IMMUNOLOGY

IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors

(2012) N. Cieri et al.   BLOOD

Cutting Edge: Generation of Memory Precursors and Functional Memory CD8+ T Cells Depends on T Cell Factor-1 and Lymphoid Enhancer-Binding Factor-1

(2012) X. Zhou et al.   JOURNAL OF IMMUNOLOGY

Phenotypic and Functional Attributes of Lentivirus-modified CD19-specific Human CD8+ Central Memory T Cells Manufactured at Clinical Scale

(2012) Xiuli Wang et al.   JOURNAL OF IMMUNOTHERAPY

Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma

(2011) C. U. Louis et al.   BLOOD

Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias

(2011) R. J. Brentjens et al.   BLOOD

A human memory T cell subset with stem cell–like properties

(2011) Luca Gattinoni et al.   NATURE MEDICINE

Wnt/ -Catenin Signaling in T-Cell Immunity and Cancer Immunotherapy

(2010) L. Gattinoni et al.   CLINICAL CANCER RESEARCH

Regulation of the Ifng locus in the context of T-lineage specification and plasticity

(2010) Anand Balasubramani et al.   IMMUNOLOGICAL REVIEWS

Hematopoietic stem cells and retroviral infection

(2010) Prabal Banerjee et al.   Retrovirology

Constitutive Activation of Wnt Signaling Favors Generation of Memory CD8 T Cells

(2009) D.-M. Zhao et al.   JOURNAL OF IMMUNOLOGY

Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

(2009) Luca Gattinoni et al.   NATURE MEDICINE

Pharmacologic Induction of CD8+ T Cell Memory: Better Living Through Chemistry

(2009) L. Gattinoni et al.   Science Translational Medicine

IL-7 and IL-15 allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes

(2008) S. Kaneko et al.   BLOOD