Article
Multidisciplinary Sciences
Endale Worku, Demissie Assegu Fenta, Musa Mohammed Ali
Summary: This study aimed to determine the prevalence of bacterial caused newborn sepsis, associated factors, and the antimicrobial susceptibility profile of bacteria in Sidama Regional State, Ethiopia. The study found that Klebsiella species were the predominant bacteria causing sepsis among newborns, followed by non-lactose fermenting Gram-negative bacteria and Enterococcus species. Most recovered bacteria were resistant to commonly used antibiotics. Pre-term, mode of delivery, and types of respiratory support were significantly associated with the occurrence of sepsis caused by bacteria.
SCIENTIFIC REPORTS
(2022)
Article
Critical Care Medicine
Federico C. Angriman, Laura R. Rosella, Patrick T. Lawler, Dennis M. Ko, Claudio Martin, Hannah C. Wunsch, Damon Scales
Summary: This study identified risk factors for major cardiovascular events in adult sepsis survivors, including age, sex, diabetes, hypertension, atrial fibrillation, chronic kidney disease, and sepsis characteristics. These findings have important implications for future research.
CRITICAL CARE MEDICINE
(2023)
Article
Infectious Diseases
Tsega Cherkos Dawit, Reiye Esayas Mengesha, Mohamedawel Mohamedniguss Ebrahim, Mengistu Hagazi Tequare, Hiluf Ebuy Abraha
Summary: The study revealed a higher incidence of nosocomial sepsis among adult ICU patients of ACSH, with the use of mechanical ventilator and longer ICU stay being significant predictors. Moreover, the isolates showed resistance to multiple antibiotics.
BMC INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Jiyong Jian, Zeqiang Xie, Liang Chen
Summary: This study investigated risk factors for death due to S. maltophilia bacteremia and found that the APACHE II score was an independent predictor. TMP/SMX or minocycline may be the first choice for the treatment of S. maltophilia bacteremia.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Immunology
Yajun He, Jiqian Xu, Xiaopu Shang, Xiangzhi Fang, Chenggang Gao, Deyi Sun, Lu Yao, Ting Zhou, Shangwen Pan, Xiaojing Zou, Huaqing Shu, Xiaobo Yang, You Shang
Summary: ICU-acquired infection is a common cause of poor prognosis in sepsis patients in intensive care units (ICUs). This study developed a model that accurately predicts the risk of ICU-acquired infections in sepsis patients and identified independent predictors of these infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Neurosciences
Masashi Mizuguchi, Akiko Shibata, Mariko Kasai, Ai Hoshino
Summary: Acute encephalopathy is a complex disorder affected by various genetic and environmental risk factors, including pathogenic microorganisms, drugs, and genetic mutations or polymorphisms. These factors alter immune response, metabolism, and neuronal excitation, complicating the pathologic process. However, they also provide potential targets for prevention and treatment of acute encephalopathy.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Oncology
Yanqiu Wang, Xi Liang, Shujun Wang, Yuying Wang, Ling Qin, Danni Chen, Yanlin Jiang, Hao Zhang
Summary: This study investigated the risk factors for elevated D-dimer levels after breast cancer surgery. It found that T stage, neoadjuvant chemotherapy, blood loss, surgery type, diabetes, and elevated leukocyte and neutrophil counts were significant risk factors. These findings can contribute to the development of more precise preventive measures and interventions.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Ignacio Lagger, Eliana Garino, Oscar Martinez, Eduardo Knorre, Glenda Ernst, Adriana Laura Burgueno
Summary: This study aimed to identify risk factors for drug-resistant epilepsy by comparing the characteristics of patients with drug-sensitive epilepsy and drug-resistant epilepsy. The results showed that risk factors for drug-resistant epilepsy included febrile seizures, focal epilepsy, focal seizures with loss of consciousness, structural etiology, and abnormal MRI.
Article
Chemistry, Medicinal
Keiichiro Yoshioka, Mitsuhiro Abe, Yuki Shiko, Ken Koshikawa, Yohei Kawasaki, Shunichiro Iwasawa, Jiro Terada, Kenji Tsushima, Koichiro Tatsumi, Takuji Suzuki
Summary: This study retrospectively investigated 304 patients who received Nab-PTX treatment and found that 41 patients developed drug induced lung injury (DILI), with most cases being asymptomatic. Older age, pre-existing interstitial lung changes, and combined drugs with gemcitabine were identified as independent risk factors for Nab-PTX-induced lung injury.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Hematology
Jun-Ying Li, Hong-Fei Wang, Ping Yin, Di Li, Di-Le Wang, Peng Peng, Wei-Hua Wang, Lan Wang, Xiao-Wei Yuan, Jin-Yuan Xie, Fan Zhou, Nian Xiong, Feng Shao, Chun-Xiu Wang, Xiang Tong, Hao Ye, Wen-Jun Wan, Ben-De Liu, Wen-Zhu Li, Qian Li, Liang V. Tang, Yu Hu, Gregory Y. H. Lip
Summary: The study found that severe and non-severe hospitalized COVID-19 patients have nearly 6 times and 3 times higher odds of developing symptomatic VTE compared to general medical inpatients. VTE commonly develops at a median of 21 days after symptom onset and independent risk factors include advancing age, cancer, longer interval from symptom onset to admission, lower fibrinogen, and higher D-dimer levels.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Medicine, General & Internal
Yanqing Wen, Hong Chen, Xin Ming, Xiaoyan Chen, Wei Zhou
Summary: This study aimed to assess the risk factors, pathogenic bacteria, and drug sensitivity of maternal sepsis in full-term pregnant women. Cesarean section, temperature, white blood cell count, procalcitonin, C-reactive protein, and neutrophil ratio were found to be associated with sepsis. Escherichia coli was the most common pathogen in positive blood cultures, with high sensitivity to certain antibiotics.
Article
Pediatrics
Qian Hu, Wen Liang, Qiuwei Yi, Yuejie Zheng, Wenjian Wang, Yuhui Wu
Summary: This study summarizes the clinical features of severe influenza in children and identifies the high-risk factors for influenza-related deaths, aiming to raise awareness among pediatricians. The study found that neurological disorders such as acute necrotizing encephalopathy (ANE) are more significant in children with severe influenza after the COVID-19 pandemic. Influenza virus infection can cause serious multisystem complications such as acute respiratory distress syndrome (ARDS) and ANE, and D-dimer has predictive value for early diagnosis and determination of the prognosis of children with severe influenza.
FRONTIERS IN PEDIATRICS
(2023)
Article
Nutrition & Dietetics
Qinyu Chang, Yiqun Zhu, Guowei Zhou, Huaying Liang, Dianwu Li, Jun Cheng, Pinhua Pan, Yan Zhang
Summary: This study investigated the association between serum vitamin D concentrations and adult-onset asthma. The results showed that individuals with optimal vitamin D levels had a reduced risk of incident asthma compared to those with deficient levels. The protective effect of vitamin D was modified by sleep patterns and genetic susceptibility.
FRONTIERS IN NUTRITION
(2023)
Article
Medicine, General & Internal
David R. Jacobs, Jessica G. Woo, Alan R. Sinaiko, Stephen R. Daniels, Johanna Ikonen, Markus Juonala, Noora Kartiosuo, Terho Lehtimaki, Costan G. Magnussen, Jorma S. A. Viikari, Nanhua Zhang, Lydia A. Bazzano, Trudy L. Burns, Ronald J. Prineas, Julia Steinberger, Elaine M. Urbina, Alison J. Venn, Olli T. Raitakari, Terence Dwyer
Summary: This prospective cohort study found that childhood cardiovascular risk factors, including BMI, systolic blood pressure, lipid levels, and smoking, were associated with cardiovascular events in adulthood. Childhood risk factors and the change in risk score between childhood and adulthood were associated with midlife cardiovascular events.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Clinical Neurology
Alyssa Denton, Lilian Thorpe, Alexandra Carter, Adriana Angarita-Fonseca, Karen Waterhouse, Lizbeth Hernandez Ronquillo
Summary: This study aimed to explore the difference between 3 definitions of drug-resistant epilepsy (DRE) and clinical predictors of DRE in adults and older adults. The study found that using the ILAE definition appeared to be the most consistent through an extended follow-up, and the failure to respond to the first anti-seizure medication was the sole significant risk factor for DRE in the cohort after considering the age group.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Qipeng Xie, Caiyi Chen, Haiying Li, Jiheng Xu, Lei Wu, Yuan Yu, Shuwei Ren, Hongyan Li, Xiaohui Hua, Huiying Yan, Dapang Rao, Huxiang Zhang, Honglei Jin, Haishan Huang, Chuanshu Huang
Article
Pharmacology & Pharmacy
Yu Liu, Shirui Huang, Mengjiao Kuang, Huiyan Wang, Qipeng Xie
Summary: The study showed that LARGE1 is downregulated in NSCLC and associated with advanced tumor stage and poorer prognosis. However, high LARGE1 is correlated with improved survival in patients receiving adjuvant chemotherapy, suggesting its potential role in enhancing the efficacy of chemotherapy in NSCLC patients.
PHARMACOGENOMICS & PERSONALIZED MEDICINE
(2021)
Article
Oncology
Shirui Huang, Xiaohui Hua, Mengjiao Kuang, Junlan Zhu, Haiqi Mu, Zhongxian Tian, Xiaoqun Zheng, Qipeng Xie
Summary: In this study, miR-190 was found to play an important role in the development of bladder cancer (BC) by downregulating CDKN1B and promoting the malignant transformation of bladder epithelial cells. These findings suggest that miR-190 may enhance BC cell transformation by inhibiting CDKN1B, providing a deeper understanding of its regulatory role in BC.
CANCER CELL INTERNATIONAL
(2021)
Article
Infectious Diseases
Teng Zhou, Mengjiao Kuang, Shirui Huang, Jizhen Li, Qipeng Xie
Summary: This study retrospectively analyzed data of CNSI patients with CSF culture positive in Wenzhou City from 2012 to 2020, revealing differences in pathogen characteristics and antibiotic susceptibilities among different age groups, which can guide the selection of empiric antibiotics in clinical practice.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Infectious Diseases
Suipeng Chen, Mengjiao Kuang, Ying Qu, Shirui Huang, Binbin Gong, Suzhen Lin, Huiyan Wang, Guiye Wang, Hongqun Tao, Jian Yu, Zuqin Yang, Minghua Jiang, Qipeng Xie
Summary: This study compared the differences in serum cytokines and chemokines between full-term neonates with sepsis and those without infection. The results showed that the levels of many cytokines were significantly increased in neonates with sepsis, indicating an excessive pro-inflammatory response. Chemokines were involved in the anti-infection defense of neonates, but could also lead to damage.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Biochemistry & Molecular Biology
Qipeng Xie, Xiaohui Hua, Chao Huang, Xin Liao, Zhongxian Tian, Jiheng Xu, Yunping Zhao, Guosong Jiang, Haishan Huang, Chuanshu Huang
Summary: Studies have shown that SOX2 promotes invasion in BC cells through both the SKP2-Sp1-HUR-FOXO1 and nucleolin-MMP2 axes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Xiaohui Hua, Daimin Xiang, Mengxin Guo, Xiaohui Qian, Ruifan Chen, Tengda Li, Zhongxian Tian, Jiheng Xu, Chao Huang, Qipeng Xie, Chuanshu Huang
Summary: In this study, it was discovered that isorhapontigenin (ISO) initiates autophagic responses and inhibits bladder cancer (BC) invasion by activating the RAC1 protein translation and MKK7/JNK phosphorylation. The inhibition of autophagy was found to be crucial for ISO's inhibition of BC invasion. Mechanistic studies revealed that ISO inhibits miR-365a transcription, leading to upregulation of RAC1 translation, through the Dicer/miR145/SOX2/miR365a/RAC1 cascade, which in turn activates MKK7/JNK and induces autophagy.
CELL DEATH & DISEASE
(2022)