Article
Instruments & Instrumentation
Salmann Ali, Khulla Naseer, Irshad Hussain, Javaria Qazi
Summary: The study evaluated ATR-FTIR spectroscopy for diagnosing HCV and DENV infected freeze-dried sera, showing promising results in distinguishing between the two viruses. The combination of ATR-FTIR with multivariate data classification algorithms demonstrated high classification accuracy, making it a potential tool for differential diagnosis.
INFRARED PHYSICS & TECHNOLOGY
(2021)
Article
Instruments & Instrumentation
Salmann Ali, Khulla Naseer, Javaria Qazi
Summary: This research work aimed to assess the potential of ATR-FTIR spectroscopy to distinguish healthy sera samples from HCV infected freeze-dried sera samples and develop a new reagent-free diagnostic tool. The study found clear variations in the ATR-FTIR spectra between the two sample groups, especially in the two specific spectral regions. Multivariate classification algorithms, including PCA and LDA, were used and achieved high accuracy in discriminating HCV and healthy samples.
INFRARED PHYSICS & TECHNOLOGY
(2022)
Article
Medical Laboratory Technology
Aniello Primiano, Silvia Persichilli, Flavio Di Giacinto, Gabriele Ciasca, Silvia Baroni, Pietro Manuel Ferraro, Marco De Spirito, Andrea Urbani, Jacopo Gervasoni
Summary: The study evaluated the combination of infrared spectroscopy with chemometric analysis as a screening method to identify patients requiring confirmation by HPLC-FL analysis for cystinuria diagnosis. The results showed that this approach was both sensitive and specific for detection of the disorder.
CLINICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Dongheyu Zhang, Yuntao Guo, Liyang Zhang, Yao Wang, Siqi Peng, Simeng Duan, Lin Geng, Xiao Zhang, Wei Wang, Mengjie Yang, Guizhen Wu, Jiayi Chen, Zihao Feng, Xinyuan Wang, Yue Wu, Haotian Jiang, Qikang Zhang, Jingjun Sun, Shenwei Li, Yuping He, Meng Xiao, Yingchun Xu, Hongqiu Wang, Peipei Liu, Qun Zhou, Haiyun Luo
Summary: This study established an integrated system that uses artificial intelligence and infrared spectroscopy technology for rapid COVID-19 screening, and combines it with a disinfection module to prevent secondary infections. The experimental results showed that the system has high sensitivity, specificity, and accuracy, and also has efficient inactivation effect on bacteria.
ANALYTICAL CHEMISTRY
(2022)
Article
Instruments & Instrumentation
Khulla Naseer, Salmann Ali, Javaria Qazi
Summary: This study demonstrates the potential of ATR-FTIR spectroscopy combined with chemometric data classification algorithms for differential diagnosis of Salmonella typhi and dengue infected freeze-dried sera samples. PCA and LDA algorithms were used to achieve accurate classification and differentiation with high accuracy.
INFRARED PHYSICS & TECHNOLOGY
(2021)
Article
Agronomy
Ana Lopez-Malvar, Rogelio Santiago, Rosa Ana Malvar, Daniel Martin, Ines Pereira dos Santos, Luis A. E. Batista de Carvalho, Laura Faas, Leonardo D. Gomez, Ricardo M. F. da Costa
Summary: In this study, high and low saccharification efficiency groups of maize stover showed significant differences in cell wall composition, as revealed by FTIR-ATR spectroscopy. The results provided insights into the relationship between cell wall composition and biorefining potential, and identified new targets for future research on lignocellulosic bioconversion. The application of FTIR-ATR spectroscopy allowed for a rapid and comprehensive assessment of cell wall compositional features in contrasting groups of saccharification efficiency.
Article
Chemistry, Analytical
Shayma Shaikh, Deep Kumari Yadav, Rakesh Rawal
Summary: Oral Submucous Fibrosis (OSMF) is a precancerous condition with high malignant potential, requiring less invasive and cost-effective screening and diagnostic methods. ATR-FTIR spectroscopy combined with total salivary protein estimation can effectively differentiate OSMF from Healthy Control (HC). However, larger sample sizes are needed to evaluate its potential as a screening tool for early OSMF diagnosis.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Hancheng Lin, Zhimin Wang, Yiwen Luo, Zijie Lin, Guanghui Hong, Kaifei Deng, Ping Huang, Yiwen Shen
Summary: This study investigated the metabolic abnormalities in the myocardium and biofluids of diabetic mice using ATR-FTIR spectroscopy. The results showed significant differences in lipid function groups, phosphate macromolecules, protein compositions, and carbohydrates between the diabetic and control groups. A prediction model for DCM severity was developed and showed good linear correlations with spectra for plasma, saliva, urine, and combination of plasma and saliva. This study demonstrates the potential of biofluid infrared spectro-diagnostic models for non/miniinvasive assessment of DCM.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Multidisciplinary Sciences
Helina Heino, Lassi Rieppo, Tuija Mannisto, Mikko J. Sillanpaa, Vesa Mantynen, Simo Saarakkala
Summary: ATR-FTIR spectroscopy coupled with machine learning-based PLS-DA was used to study the detection of SARS-CoV-2 from nasopharyngeal swab samples. The results indicate that the ATR-FTIR spectrum contains specific information for SARS-CoV-2 infection, but the diagnostic performance is moderate.
SCIENTIFIC REPORTS
(2022)
Article
Thermodynamics
R. Skvorcnskiene, I. Kiminaite, L. Vorotinskiene, A. Jancauskas, R. Paulauskas
Summary: Today's society faces the dual challenge of resource depletion and waste accumulation. There is a growing demand to replace conventional plastics with bioplastics in the market, but the sustainability of bioplastics compared to conventional plastics remains a subject of debate due to limited research. This study investigates the degradation characteristics of bioplastics in soil (ATR-FTIR), their thermal stability under pyrolysis, and their suitability for waste-to-energy conversion using thermal analysis (TG) and evolved gas analysis (FTIR). The biodegradation experiments reveal that only corn starch-based bioplastics can completely and rapidly degrade in soil, while other bio-based and petroleum-based plastics only undergo color change and softening. This indicates that bioplastics undergo thermochemical alteration and closely resemble conventional plastics, necessitating proper recycling or conversion into energy to avoid becoming a source of microplastics. Thermogravimetric analysis coupled with evolved gas analysis (TGA-FTIR) shows that the gas yield from bioplastics ranges from 80-99%, with degradation onset occurring at temperatures ranging from 203.0-272.5 degrees C in a nitrogen environment, or 10-20 degrees C lower in a steam-enriched environment. The main volatile products of bioplastics pyrolysis are carboxylic compounds, alkanes, alkenes, aromatic hydrocarbons, amines, CO, and CO2, depending significantly on the chemical composition of the plastic.
Article
Chemistry, Multidisciplinary
Elena C. L. Rigante, Cosima D. Calvano, Rosaria A. Picca, Simona Armenise, Tommaso R. Cataldi, Luigia Sabbatini
Summary: The stony sculptural composition of the Nativity Scene in Altamura's Cathedral reveals a complex history of multiple modifications from the 16th to the 20th century, with evidence of the use of various organic materials and painting techniques in different sampling zones.
APPLIED SCIENCES-BASEL
(2021)
Article
Environmental Sciences
Agata Egea-Corbacho, Ana Pilar Martin-Garcia, Ana A. Franco, Gemma Albendin, Juana M. Arellano, Rocio Rodriguez-Barroso, M. Dolores Coello, Dolores Coello, Jose F. Cabello, Iria Iglesias Prado, Erik-jan Malta
Summary: This study investigates the impact of microplastics (MP) on aquaculture systems, covering water intake, purification treatment, culture tanks, feed, and the organism. The study shows that purification systems can reduce the entry of MP from the environment, but new MP are observed in the sea bass tank, mainly due to added feed and materials used in aquaculture systems. Different types of MP are found in the sea bass samples. Consideration and reduction of other entry routes are necessary to prevent MP from reaching the human consumer in aquaculture facilities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Oncology
Carlos A. Meza Ramirez, Helen Stringfellow, Raj Naik, Emma J. Crosbie, Maria Paraskevaidi, Ihtesham U. Rehman, Pierre Martin-Hirsch
Summary: This study explores the potential of a non-invasive test for early detection of endometrial cancer, utilizing urine samples analysis and infrared spectroscopy technology to identify and predict spectral biomarkers for cancer detection.
Article
Chemistry, Analytical
Abolfazl Dashti, Yannick Weesepoel, Judith Muller-Maatsch, Hadi Parastar, Farzad Kobarfard, Bahram Daraei, Hassan Yazdanpanah
Summary: The feasibility of portable Fourier transform infrared spectroscopy combined with multivariate classification techniques for meat classification and halal meat species certification was assessed in this study. The results showed that the combination of Fourier transform infrared spectroscopy and multivariate classification techniques can accurately and rapidly classify meat samples and certify halal meat species.
MICROCHEMICAL JOURNAL
(2022)
Article
Health Care Sciences & Services
Francis L. Martin, Camilo L. M. Morais, Andrew W. Dickinson, Tarek Saba, Thomas Bongers, Maneesh N. Singh, Danielle Bury
Summary: Saliva can be used as a liquid biopsy for screening lung cancer and prostate cancer. By analyzing the bioconstituents in saliva samples using infrared spectroscopy and principal component analysis, a highly accurate model can be built for the detection of these cancers in primary care settings.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Multidisciplinary Sciences
Hirohito Abo, Benoit Chassaing, Akihito Harusato, Miguel Quiros, Jennifer C. Brazil, Vu L. Ngo, Emilie Viennois, Didier Merlin, Andrew T. Gewirtz, Asma Nusrat, Timothy L. Denning
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Moon K. Han, Raeda Anderson, Emilie Viennois, Didier Merlin
Article
Biotechnology & Applied Microbiology
Emilie Viennois, Adani Pujada, Junsik Sung, Chunhua Yang, Andrew T. Gewirtz, Benoit Chassaing, Didier Merlin
NPJ BIOFILMS AND MICROBIOMES
(2020)
Article
Cell Biology
Emilie Viennois, Alexis Bretin, Philip E. Dube, Alexander C. Maue, Charlene Jg Dauriat, Nicolas Barnich, Andrew T. Gewirtz, Benoit Chassaing
Article
Biochemistry & Molecular Biology
Emilie Viennois, Benoit Chassaing
Summary: The study found that dietary emulsifiers consumption is associated with the development of colorectal cancer, enhancing intestinal tumor development in mice without being related to chronic intestinal inflammation, but rather impacted by the proliferative status of the intestinal epithelium and the composition of intestinal microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Xiaolin Sheng, Dandan Liu, Sujani K. Gamage, Ying Luo, Emilie Viennois, Didier Merlin, Suri S. Iyer
Summary: The study found that the fecal IAP levels were significantly lower in mice with severe colitis compared to those with mild colitis. Mice treated with anti-TNF-Alpha showed significantly higher levels of IAP compared to untreated mice.
Article
Microbiology
Sabrine Naimi, Emilie Viennois, Andrew T. Gewirtz, Benoit Chassaing
Summary: The study found that many commonly used emulsifiers can directly alter the gut microbiota in a way that promotes intestinal inflammation. While some emulsifiers had similar impacts on the microbiota, others, such as lecithin, did not significantly affect the microbiota in the model. Various carrageenans and gums were found to have particularly detrimental impacts on microbiota density, composition, and expression of pro-inflammatory molecules.
Article
Chemistry, Multidisciplinary
Dandan Liu, Emilie Viennois, Jieqiong Fang, Didier Merlin, Suri S. Iyer
Summary: The association of MMP-9 and TNF-alpha levels with colitis severity was investigated using an established IL10-/- mouse model. Assays using cap and release mesoporous silica nanoparticles were developed to detect fecal MMP-9 and serum TNF-alpha. The assays effectively detected MMP-9 and TNF-alpha, but signal amplification is needed for clinical sensitivity.
Editorial Material
Gastroenterology & Hepatology
Emilie Viennois, Andrew T. Gewirtz, Benoit Chassaing
Article
Biochemical Research Methods
Hemendra Ghimire, Emilie Viennois, Xinjie Hu, Gengsheng Qin, Didier Merlin, A. G. Unil Perera
Summary: This study utilized infrared spectrometry and data analysis techniques to investigate colitis-induced alterations in molecular components of serum samples. Through the analysis of samples from ulcerative colitis patients and healthy volunteers, five identifying spectral signatures were found, and one of them showed high sensitivity and specificity, suggesting it could be a reliable diagnostic test for human patients.
JOURNAL OF BIOPHOTONICS
(2022)
Review
Gastroenterology & Hepatology
Maite Casado-Bedmar, Emilie Viennois
Summary: MicroRNAs (miRNAs) and intestinal microbiota play important roles in the pathophysiology of inflammatory bowel disease (IBD), and their bidirectional communication has therapeutic potential. This review discusses the mechanisms through which miRNAs and intestinal microbiota interact, and the diagnostic power and therapeutic potential resulting from their communication after fecal transplantation, probiotics intake, or anti-miRNAs or miRNA mimics administration.
JOURNAL OF CROHNS & COLITIS
(2022)
Review
Gastroenterology & Hepatology
Jaber Alfaifi, Adeline Germain, Anne-Charlotte Heba, Djesia Arnone, Laura Gailly, Ndeye Coumba Ndiaye, Emilie Viennois, Benedicte Caron, Laurent Peyrin-Biroulet, Natacha Dreumont
Summary: This article reviews the published studies on microRNA (miRNA) expression in inflammatory bowel disease (IBD), including miRNAs extracted from blood, tissue, and stool samples. The main mechanisms of miRNA involvement in IBD and their potential use as biomarkers are discussed.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Biology
Olivier Merlin-Zhang, Junsik Sung, Emilie Viennois
Review
Gastroenterology & Hepatology
Emilie Viennois, Andrew T. Gewirtz, Benoit Chassaing
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2019)
Article
Medicine, Research & Experimental
Emilie Viennois, Benoit Chassaing, Anika Tahsin, Adani Pujada, Lixin Wang, Andrew T. Gewirtz, Didier Merlin